3-(2,2,2-trimethylhydrazine)propionate has been researched along with carnitine in 59 studies
| Studies (3-(2,2,2-trimethylhydrazine)propionate) | Trials (3-(2,2,2-trimethylhydrazine)propionate) | Recent Studies (post-2010) (3-(2,2,2-trimethylhydrazine)propionate) | Studies (carnitine) | Trials (carnitine) | Recent Studies (post-2010) (carnitine) |
|---|---|---|---|---|---|
| 251 | 35 | 105 | 9,625 | 750 | 3,016 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.39) | 18.7374 |
| 1990's | 6 (10.17) | 18.2507 |
| 2000's | 22 (37.29) | 29.6817 |
| 2010's | 22 (37.29) | 24.3611 |
| 2020's | 7 (11.86) | 2.80 |
| Authors | Studies |
|---|---|
| Kalviņs, IJ; Khagi, KB; Lukevics, E; Meirena, DV; Mezapuķe, RJ; Molodchina, TN; Shutenko, ZV; Simkhovich, BZ | 1 |
| Meĭrena, DV; Shutenko, ZhV; Simkhovich, BZ; Stivrinia, MI; Vitolinia, RO | 1 |
| Beauseigneur, F; Bezard, J; Boichot, J; Clouet, P; Demarquoy, J; Gresti, J; Niot, I; Rochette, L; Tsoko, M | 1 |
| Kalvins, I; Sahartova, O; Shatz, V | 1 |
| Clouet, P; Demarquoy, J; Galland, S; Guyonnet, D; Le Borgne, F | 1 |
| Asaka, N; Kirimoto, T; Miyake, H; Muranaka, Y | 1 |
| Beauseigneur, F; Clouet, P; Demarquoy, J; Gresti, J; Tsoko, M | 1 |
| Harashima, H; Hayashi, M; Ise, S; Kiwada, H; Kuwajima, M; Lu, Km; Sei, M; Shima, K; Sugiyama, Y | 1 |
| Demarquoy, J; Ecosse, D; Galland, S; Georges, B; Grand-Jean, F; Isoir, M; Le Borgne, F | 1 |
| Asaka, N; Hayashi, Y; Kirimoto, T; Matsuura, N; Miyake, H; Muranaka, Y | 1 |
| Hayashi, Y; Kirimoto, T; Matsuura, N; Miyake, H; Tajima, K | 1 |
| Aoyagi, T; Eto, Y; Hayashi, Y; Kirimoto, T; Matsumoto, A; Momomura, S; Omata, M; Sugiura, S; Yokoyama, I; Yonekura, K | 1 |
| Krähenbühl, S; Thormann, W; Vernez, L | 1 |
| Auer, L; Brooks, H; Krähenbühl, S; Solioz, M; Spaniol, M; Stieger, B; Zimmermann, A | 1 |
| Dambrova, M; Kalvinsh, I; Liepinsh, E | 1 |
| Beier, K; Kaufmann, P; Krähenbühl, S; März, W; Scharnagl, H; Spaniol, M; Török, M; Wüthrich, J | 1 |
| Baumane, L; Boucher, JL; Dzintare, M; Kalvinsh, I; Lauberte, L; Meirena, D; Sjakste, J; Sjakste, N | 1 |
| André, A; Clouet, P; Degrace, P; Demaison, L; Demizieux, L; Gresti, J; Tsoko, M | 1 |
| Daĭia, D; Dambrova, M; Kalvin'sh, I; Kir'ianova, O; Liepin'sh, E | 1 |
| Baumane, L; Boucher, JL; Dzintare, M; Kalvinsh, I; Kleschyov, AL; Meirena, D; Münzel, T; Sjakste, J; Sjakste, N; Sydow, K | 1 |
| Arduini, A; Carminati, P; Giannessi, F; Giarrizzo, MG; Peschechera, A; Ricciolini, R; Russo, F; Scalibastri, M | 1 |
| Sakvarelidze, EP | 1 |
| Dambrova, M; Kalvinsh, I; Kirjanova, O; Liepinsh, E; Loca, D; Pugovichs, O; Vilskersts, R | 1 |
| Calvani, M; Fanello, D; Indiveri, C; Oppedisano, F | 1 |
| Belozertseva, I; Cirule, H; Dambrova, M; Kalvinsh, I; Liepinsh, E; Pugovichs, O; Svalbe, B; Zorenko, T; Zvejniece, L | 1 |
| Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Pugovics, O; Skapare, E; Svalbe, B; Vilskersts, R | 2 |
| Bach, M; Fork, C; Geerts, A; Golz, S; Grigat, S; Gründemann, D; Schömig, E | 1 |
| Chlopicki, S; Dambrova, M; Grinberga, S; Kalvinsh, I; Liepinsh, E; Mateuszuk, L; Vilskersts, R | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Kalvinsh, I; Kuka, J; Liepinsh, E; Skapare, E; Svalbe, B; Vilskersts, R; Zvejniece, L | 1 |
| Al-Shabanah, OA; Aleisa, AM; Darweesh, AQ; Fatani, AG; Rizwan, L; Sayed-Ahmed, MM | 1 |
| Krähenbühl, S; Mevissen, M; Novakova, K; Schürch, R; Stieger, B; Todesco, L | 1 |
| Dambrova, M; Liepinsh, E; Muceniece, R; Pugovics, O; Svalbe, B; Vavers, E; Zvejniece, L | 1 |
| Dambrova, M; Grinberga, S; Kalvinsh, I; Konrade, I; Kuka, J; Liepinsh, E; Pugovics, O; Skapare, E | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Kalvinsh, I; Kuka, J; Liepinsh, E; Svalbe, B; Vilskersts, R | 1 |
| Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Makrecka, M; Pugovics, O; Vilskersts, R | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makrecka, M; Pugovics, O; Sevostjanovs, E; Skapare, E; Vavers, E | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Mezhapuke, R; Vilskersts, R; Zharkova-Malkova, O | 1 |
| Dambrova, M; Grinberga, S; Kalvins, I; Konrade, I; Liepins, E; Petrovska, R; Pugovics, O; Skapare-Makarova, E; Tirzite, D | 1 |
| Dambrova, M; Grinberga, S; Liepins, J; Liepinsh, E; Makrecka, M; Pugovics, O; Sevostjanovs, E; Svalbe, B; Volska, K | 1 |
| Andrianovs, V; Dambrova, M; Grinberga, S; Gustina, D; Kalvinsh, I; Kazaks, A; Kuka, J; Leitans, J; Liepinsh, E; Lola, D; Loza, E; Makrecka, M; Pugovics, O; Tars, K; Zelencova, D | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Gustina, D; Kuka, J; Liepins, J; Liepinsh, E; Loza, E; Makrecka-Kuka, M; Pugovics, O; Zharkova-Malkova, O | 1 |
| Beitnere, U; Dzirkale, Z; Isajevs, S; Klusa, V; Rumaks, J; Svirskis, S | 1 |
| Bonifacio, A; Bouitbir, J; Kaufmann, P; Krähenbühl, S; Roberts, PA; Singh, F; Urwyler, A | 1 |
| Csajka, C; Panchaud, A | 1 |
| Arduini, A; Zammit, VA | 1 |
| Blank, C; Dünnwald, T; Gmeiner, G; Schobersberger, W | 1 |
| Jargin, SV | 1 |
| Cirule, H; Dambrova, M; Grinberga, S; Hartmane, D; Liepinsh, E; Makarova, E; Sevostjanovs, E; Zharkova-Malkova, O | 1 |
| Constantin, D; Constantin-Teodosiu, D; Greenhaff, PL; Leighton, B; Porter, C; Poucher, SM | 1 |
| Degrace, P; Du, ZY; Li, DL; Li, JM; Li, LY; Limbu, SM; Pan, H; Wang, WL | 1 |
| Berge, RK; Bjørndal, B; Hallström, S; Lindquist, C; Rossmann, CR; Svardal, A | 1 |
| Berge, RK; Bjørndal, B; Lindquist, C; Lund, A; Nygård, O; Skorve, J; Slettom, G; Svardal, A | 1 |
| Cherednichenko, VR; Gureev, AP; Kalinina, YI; Popov, VN; Reznikova, KA; Sadovnikova, IS; Shaforostova, EA; Valuyskikh, VV; Vitkalova, IY | 1 |
| Calarco, A; Di Cristo, F; Digilio, FA; Galderisi, U; Melone, MAB; Peluso, G; Rosano, C; Saturnino, C; Sinicropi, MS | 1 |
| Gureev, AP; Popov, VN; Shaforostova, EA; Vitkalova, IY | 1 |
| Gryaznova, MV; Gureev, AP; Ignatyeva, DA; Popov, VN; Shaforostova, EA; Volodina, DE | 1 |
| Gureev, AP; Popov, VN; Shaforostova, EA; Volodina, DE | 1 |
| Bode, LM; Eggers, M; Jahn, D; Jasper, J; Lubitz, W; Moser, J; Neubauer, K; Piskol, F; Reijerse, E; Slusarenko, A | 1 |
3 review(s) available for 3-(2,2,2-trimethylhydrazine)propionate and carnitine
| Article | Year |
|---|---|
Mildronate: cardioprotective action through carnitine-lowering effect.
Topics: Cardiotonic Agents; Cardiovascular Agents; Carnitine; Energy Metabolism; Humans; Methylhydrazines | 2002 |
[Biochemical mechanisms of mildronate action during ischemic stress].
Topics: Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Humans; Methylhydrazines; Myocardial Ischemia; Myocardium; Oxidative Stress; Treatment Outcome | 2004 |
Story behind meldonium-from pharmacology to performance enhancement: a narrative review.
Topics: Athletes; Athletic Performance; Cardiovascular Diseases; Carnitine; Doping in Sports; Humans; Metabolic Diseases; Methylhydrazines; Nervous System Diseases | 2017 |
2 trial(s) available for 3-(2,2,2-trimethylhydrazine)propionate and carnitine
| Article | Year |
|---|---|
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
Topics: Adult; Betaine; Cardiovascular Agents; Carnitine; Diet; Female; Humans; Male; Meat; Methylhydrazines; Middle Aged; Young Adult | 2011 |
Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis.
Topics: Adult; Atherosclerosis; Cardiovascular Agents; Carnitine; Diet; Female; HEK293 Cells; Humans; Male; Methylamines; Methylhydrazines; Organic Cation Transport Proteins; Seafood; Solute Carrier Family 22 Member 5 | 2013 |
54 other study(ies) available for 3-(2,2,2-trimethylhydrazine)propionate and carnitine
| Article | Year |
|---|---|
3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties.
Topics: Animals; Cardiotonic Agents; Carnitine; Creatine Kinase; Epinephrine; gamma-Butyrobetaine Dioxygenase; Heart; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Methylhydrazines; Mixed Function Oxygenases; Myocardium; Rats; Rats, Inbred Strains | 1988 |
[Prevention of ischemic myocardial damage by reducing the intracellular free carnitine level].
Topics: Animals; Carnitine; Cell Membrane; Coronary Disease; gamma-Butyrobetaine Dioxygenase; Male; Methylhydrazines; Mixed Function Oxygenases; Myocardium; Rabbits; Rats | 1987 |
Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor.
Topics: Animals; Body Weight; Carnitine; Fatty Acids; gamma-Butyrobetaine Dioxygenase; Liver; Male; Methylhydrazines; Mixed Function Oxygenases; Organ Size; Oxidation-Reduction; Rats; Rats, Wistar | 1995 |
HPLC analysis of mildronate and its analogues in plasma.
Topics: Carnitine; Chromatography, High Pressure Liquid; Methylhydrazines | 1993 |
Purification and characterization of the rat liver gamma-butyrobetaine hydroxylase.
Topics: Animals; Ascorbic Acid; Betaine; Carnitine; Catalase; Catalysis; Chromatography, Affinity; Enzyme Inhibitors; Ferrous Compounds; gamma-Butyrobetaine Dioxygenase; Hydroxylation; Ketoglutaric Acids; Kinetics; Ligands; Liver; Male; Methylhydrazines; Mixed Function Oxygenases; Molecular Weight; Rats; Rats, Wistar | 1998 |
Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts.
Topics: Administration, Oral; Animals; Cardiovascular Agents; Carnitine; Coronary Circulation; Glucose; Glycolysis; Heart; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Insulin; Lactic Acid; Male; Methylhydrazines; Myocardial Contraction; Oxidation-Reduction; Palmitates; Phosphates; Rats; Rats, Sprague-Dawley | 1998 |
Hypolipidaemic effects of fenofibrate are not altered by mildronate-mediated normalization of carnitine concentration in rat liver.
Topics: Animals; Carnitine; Cholesterol; Fenofibrate; Hypolipidemic Agents; Ketone Bodies; Liver; Male; Methylhydrazines; Muscle, Skeletal; Myocardium; Phospholipids; Rats; Rats, Wistar; Triglycerides | 1998 |
Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.
Topics: Animals; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Fibroblasts; In Vitro Techniques; Kidney; Male; Methylhydrazines; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Rats; Rats, Sprague-Dawley | 1999 |
Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate.
Topics: Animals; Biological Transport; Carnitine; Cell Division; Cell Membrane; Cells, Cultured; In Vitro Techniques; Male; Methylhydrazines; Mice; Muscle, Skeletal; Rats; Rats, Wistar | 2000 |
Effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on tissue carnitine and lipid levels in rats.
Topics: Animals; Carnitine; Enzyme Inhibitors; gamma-Butyrobetaine Dioxygenase; Heart; Lipid Metabolism; Liver; Male; Methylhydrazines; Mixed Function Oxygenases; Myocardium; Rats; Rats, Sprague-Dawley | 2000 |
Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts.
Topics: Animals; Carnitine; Enzyme Inhibitors; gamma-Butyrobetaine Dioxygenase; Heart Function Tests; Hemodynamics; In Vitro Techniques; Lactic Acid; Male; Methylhydrazines; Mixed Function Oxygenases; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Nifedipine; Rats; Rats, Sprague-Dawley; Ventricular Fibrillation | 2000 |
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
Topics: Animals; Calcium-Transporting ATPases; Cardiovascular Agents; Carnitine; Hexokinase; Isoenzymes; Male; Methylhydrazines; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2000 |
Analysis of carnitine and acylcarnitines in urine by capillary electrophoresis.
Topics: Carnitine; Electrophoresis, Capillary; Humans; Methylhydrazines; Reference Standards | 2000 |
Development and characterization of an animal model of carnitine deficiency.
Topics: Animals; Base Sequence; Biological Transport; Carnitine; Carrier Proteins; Disease Models, Animal; DNA Primers; gamma-Butyrobetaine Dioxygenase; Kidney; Kinetics; Male; Membrane Proteins; Methylhydrazines; Microvilli; Mixed Function Oxygenases; Organic Cation Transport Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Solute Carrier Family 22 Member 5; Up-Regulation | 2001 |
Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with trimethylhydraziniumpropionate.
Topics: Acyl-CoA Oxidase; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Electron Transport; Ketone Bodies; Lipids; Lipoproteins; Liver; Liver Diseases; Methylhydrazines; Mitochondria, Liver; Oxidation-Reduction; Oxidoreductases; Palmitates; Rats; Rats, Sprague-Dawley | 2003 |
Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.
Topics: Adjuvants, Immunologic; Animals; Betaine; Carnitine; Lipopolysaccharides; Male; Methylhydrazines; Nitric Oxide; Rats; Rats, Wistar; Sepsis | 2004 |
Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat.
Topics: Animals; Biological Transport; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Esterification; Fatty Acids; Gene Expression Regulation; In Vitro Techniques; Lipoprotein Lipase; Male; Methylhydrazines; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Oxygen Consumption; Palmitic Acid; Perfusion; Rats; Rats, Wistar; RNA, Messenger; Triglycerides | 2004 |
Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.
Topics: Animals; Aorta, Thoracic; Betaine; Carnitine; Ditiocarb; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Electron Spin Resonance Spectroscopy; Endothelium; Male; Methylhydrazines; Muscle, Smooth, Vascular; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Vasodilation | 2004 |
Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life.
Topics: Animals; Animals, Newborn; Cardiovascular Agents; Carnitine; Female; Heart; Lactation; Liver; Methylhydrazines; Milk; Muscles; Palmitates; Pregnancy; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triglycerides | 2005 |
[Change of concentration of L-carnitine in blood and other tissues in rats on a background of the alcohol intake and influence of mildronate on its level].
Topics: Alcoholism; Animals; Cardiovascular Agents; Carnitine; Ethanol; Male; Methylhydrazines; Rats; Rats, Inbred Strains; Tissue Distribution | 2006 |
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.
Topics: Animals; Betaine; Cardiovascular Agents; Carnitine; Chromatography, High Pressure Liquid; Coronary Circulation; gamma-Butyrobetaine Dioxygenase; In Vitro Techniques; Injections, Intraperitoneal; Male; Methylhydrazines; Myocardial Infarction; Myocardium; Rats; Rats, Wistar | 2006 |
Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein.
Topics: Animals; Antiporters; Biological Transport; Carnitine; Dose-Response Relationship, Drug; Kinetics; Liposomes; Membrane Transport Proteins; Methylhydrazines; Mitochondria, Liver; Protein Binding; Rats; Time Factors | 2008 |
Effect of inhibiting carnitine biosynthesis on male rat sexual performance.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Behavior, Animal; Betaine; Carnitine; Chromatography, Liquid; Chymases; Dose-Response Relationship, Drug; Male; Methylhydrazines; Rats; Sexual Behavior, Animal; Sperm Motility; Spermatozoa; Tandem Mass Spectrometry; Testosterone; Time Factors | 2008 |
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
Topics: Animals; Betaine; C-Peptide; Carnitine; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Heart; Hexokinase; Male; Methylhydrazines; Mice; Mice, Inbred ICR; Myocardium; RNA, Messenger; Up-Regulation | 2008 |
The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate.
Topics: Animals; Biological Transport; Carnitine; Chickens; Cloning, Organism; Female; Humans; Membrane Transport Proteins; Methylhydrazines; Organic Cation Transport Proteins; Polymerase Chain Reaction; Rats; Solute Carrier Family 22 Member 5 | 2009 |
Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice.
Topics: Animals; Aorta; Atherosclerosis; Betaine; Cardiovascular Agents; Carnitine; Energy Metabolism; Female; Lipids; Male; Methylhydrazines; Mice; Mice, Knockout; Rats; Rats, Wistar | 2009 |
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animals; Blood Glucose; Cardiovascular Agents; Carnitine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructosamine; Heart; Hyperalgesia; Hypoglycemic Agents; In Vitro Techniques; Lipids; Male; Methylhydrazines; Myocardial Ischemia; Pain Threshold; Rats; Rats, Wistar | 2009 |
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Topics: Animals; Betaine; Biomarkers; Blood Glucose; Body Weight; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; Glucose; Heart; Hemodynamics; Lipids; Liver; Liver Glycogen; Male; Methylhydrazines; Myocardium; Rats; Rats, Wistar; Time Factors; Toxicity Tests, Chronic | 2009 |
Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Animals; Antineoplastic Agents, Alkylating; Cardiomyopathies; Carnitine; Creatine Kinase, MB Form; Cyclophosphamide; Disease Models, Animal; L-Lactate Dehydrogenase; Male; Methylhydrazines; Rats; Rats, Wistar; Risk Factors | 2010 |
The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.
Topics: Animals; Biological Transport; Carnitine; Cell Line; Cell Membrane; Gene Expression Regulation; Humans; Kidney; Kidney Tubules, Proximal; Male; Methylhydrazines; Organic Cation Transport Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Solute Carrier Family 22 Member 5; Vitamin B Deficiency | 2010 |
Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Betaine; Brain Infarction; Carnitine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extremities; Infarction, Middle Cerebral Artery; Locomotion; Male; Methylhydrazines; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Rotarod Performance Test; Tandem Mass Spectrometry; Vibrissae | 2011 |
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Topics: Animals; Cardiovascular Agents; Carnitine; Endothelium, Vascular; Hypertension; Male; Methylhydrazines; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Survival Rate; Vitamin B Complex | 2011 |
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Topics: Animals; Betaine; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Chromatography, Liquid; Drug Interactions; Fatty Acids; Male; Methylhydrazines; Mitochondria, Heart; Mitochondrial Membranes; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Tandem Mass Spectrometry; Vitamin B Complex | 2012 |
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Gene Expression Regulation; Male; Methylhydrazines; Mitochondria; Myocardial Infarction; Myocardial Reperfusion Injury; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Peroxisomes; PPAR alpha; Rats; Rats, Wistar; Transcription Factors | 2013 |
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
Topics: Animals; Aorta; Betaine; Cardiovascular Agents; Carnitine; Drug Therapy, Combination; Endothelium, Vascular; Glucose; Male; Methylhydrazines; Rats; Rats, Wistar | 2013 |
Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Brain; Carnitine; Carnitine Acyltransferases; Cell Respiration; Hypoxia; Male; Methylhydrazines; Mitochondria; Neuroprotective Agents; Oxygen; Rats; Rats, Wistar | 2014 |
Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase.
Topics: Calorimetry; Carnitine; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; gamma-Butyrobetaine Dioxygenase; Humans; Indicators and Reagents; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Methylhydrazines; Models, Molecular; Molecular Conformation; Protein Binding; Recombinant Proteins; Structure-Activity Relationship | 2014 |
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
Topics: Animals; Betaine; Biosynthetic Pathways; Carbon Isotopes; Carnitine; Choline; Chromatography, High Pressure Liquid; Gastrointestinal Tract; Methylamines; Methylhydrazines; Microbiota; Rats; Rats, Wistar; Statistics, Nonparametric; Tandem Mass Spectrometry | 2014 |
Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Biomarkers; Brain; Brain-Derived Neurotrophic Factor; Carnitine; Glutamate Decarboxylase; GPI-Linked Proteins; Haloperidol; Male; Maze Learning; Memory; Methylhydrazines; Nerve Tissue Proteins; Neuroprotective Agents; Rats; Rats, Wistar; Stress, Physiological | 2014 |
Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency.
Topics: Animals; Apoptosis; Biomarkers; Carnitine; Deficiency Diseases; Disease Models, Animal; Energy Metabolism; Glycogenolysis; Male; Methylhydrazines; Muscle Contraction; Muscle Development; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Muscular Atrophy; Random Allocation; Rats, Sprague-Dawley | 2015 |
Outbreak in meldonium positive laboratory tests: are we missing something?
Topics: Carnitine; Half-Life; Humans; Methylhydrazines; Substance Abuse Detection | 2016 |
A tennis lesson: sharp practice in the science behind the Sharapova case.
Topics: Athletes; Cardiovascular Agents; Carnitine; Doping in Sports; Female; Heart; Humans; Methylhydrazines; Muscle, Skeletal; Performance-Enhancing Substances; Tennis | 2016 |
Meldonium (Mildronate): Primum nоn nocere.
Topics: Adjuvants, Immunologic; Animals; Cardiovascular Agents; Cardiovascular Diseases; Carnitine; Humans; Methylhydrazines; Randomized Controlled Trials as Topic | 2016 |
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
Topics: Animals; Betaine; Biological Transport; Carnitine; Furosemide; Male; Methylhydrazines; Mice; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Tissue Distribution | 2017 |
Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent.
Topics: Animals; Carnitine; Energy Metabolism; Glycogen; Liver; Male; Methylhydrazines; Motor Activity; Muscle, Skeletal; Myocardium; Rats, Wistar; Rats, Zucker; RNA, Messenger; Solute Carrier Family 22 Member 5 | 2017 |
Inhibited fatty acid β-oxidation impairs stress resistance ability in Nile tilapia (Oreochromis niloticus).
Topics: Aeromonas hydrophila; Ammonia; Animal Feed; Animals; Carnitine; Cichlids; Diet; Dietary Supplements; Fatty Acids; Fish Diseases; Gram-Negative Bacterial Infections; Methylhydrazines; Mitochondria; Nitrogen; Oxidation-Reduction; Random Allocation; Stress, Physiological | 2017 |
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis.
Topics: Animals; Cardiovascular Agents; Carnitine; Fatty Acids; Liver; Male; Methylhydrazines; Mitochondria; Oxidation-Reduction; Rats; Rats, Wistar; Triglycerides | 2018 |
Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats.
Topics: Animals; Carnitine; Cell Proliferation; Kynurenine; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Methylhydrazines; Mitochondria; NAD; Niacinamide; Oxidation-Reduction; Peroxisomes; Rats; Tryptophan | 2020 |
Long-term mildronate treatment increased Proteobacteria level in gut microbiome, and caused behavioral deviations and transcriptome change in liver, heart and brain of healthy mice.
Topics: Animals; Behavior, Animal; Brain; Carnitine; Gastrointestinal Microbiome; Heart; Liver; Methylhydrazines; Mice; Proteobacteria; Transcriptome | 2020 |
The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity.
Topics: Animals; Carnitine; Cell Line; Cell Survival; Disease Models, Animal; Drosophila melanogaster; Drug Evaluation, Preclinical; Humans; Huntington Disease; Longevity; Methylhydrazines; Mice; Molecular Docking Simulation; Protein Aggregation, Pathological; Signal Transduction; Solute Carrier Family 22 Member 5; Transfection; Treatment Outcome | 2020 |
[The effect of L-carnitine depletion induced by long-term therapy of mice with meldonium on brain mitochondrial balance].
Topics: Animals; Brain; Carnitine; Methylhydrazines; Mice; Mitochondria | 2021 |
Effect of l-carnitine and mildronate on the mitochondrial metabolism of heart and bacterial composition of the gut microbiome in ageing mice.
Topics: Aging; Animals; Bifidobacterium; Cardiovascular Agents; Carnitine; DNA, Mitochondrial; Female; Gastrointestinal Microbiome; Male; Methylhydrazines; Mice; Mice, Inbred C57BL; Mitochondria, Heart | 2022 |
Neuroprotective effect of mildronate and L-carnitine on the cognitive parameters of aged mice and mice with LPS-induced inflammation.
Topics: Animals; Carnitine; Cognition; DNA, Mitochondrial; Fatty Acids; Glucose; Inflammation; Lipopolysaccharides; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Rats, Wistar | 2022 |
Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface.
Topics: Cardiovascular Diseases; Carnitine; Disulfides; Escherichia coli; Flavin Mononucleotide; Humans; Methylamines; Methylhydrazines; Mixed Function Oxygenases; Mutagenesis; Oxidoreductases; Oxygenases; Sulfinic Acids | 2022 |