Page last updated: 2024-09-03

3-(2,2,2-trimethylhydrazine)propionate and betaine

3-(2,2,2-trimethylhydrazine)propionate has been researched along with betaine in 14 studies

Compound Research Comparison

Studies
(3-(2,2,2-trimethylhydrazine)propionate)
Trials
(3-(2,2,2-trimethylhydrazine)propionate)
Recent Studies (post-2010)
(3-(2,2,2-trimethylhydrazine)propionate)
Studies
(betaine)
Trials
(betaine)
Recent Studies (post-2010) (betaine)
251351054,2131981,878

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's7 (50.00)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clouet, P; Demarquoy, J; Galland, S; Guyonnet, D; Le Borgne, F1
Baumane, L; Boucher, JL; Dzintare, M; Kalvinsh, I; Lauberte, L; Meirena, D; Sjakste, J; Sjakste, N1
Baumane, L; Boucher, JL; Dzintare, M; Kalvinsh, I; Kleschyov, AL; Meirena, D; Münzel, T; Sjakste, J; Sjakste, N; Sydow, K1
Dambrova, M; Kalvinsh, I; Kirjanova, O; Liepinsh, E; Loca, D; Pugovichs, O; Vilskersts, R1
Belozertseva, I; Cirule, H; Dambrova, M; Kalvinsh, I; Liepinsh, E; Pugovichs, O; Svalbe, B; Zorenko, T; Zvejniece, L1
Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Pugovics, O; Skapare, E; Svalbe, B; Vilskersts, R2
Chlopicki, S; Dambrova, M; Grinberga, S; Kalvinsh, I; Liepinsh, E; Mateuszuk, L; Vilskersts, R1
Dambrova, M; Liepinsh, E; Muceniece, R; Pugovics, O; Svalbe, B; Vavers, E; Zvejniece, L1
Dambrova, M; Grinberga, S; Kalvinsh, I; Konrade, I; Kuka, J; Liepinsh, E; Pugovics, O; Skapare, E1
Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Makrecka, M; Pugovics, O; Vilskersts, R1
Cirule, H; Dambrova, M; Grinberga, S; Mezhapuke, R; Vilskersts, R; Zharkova-Malkova, O1
Cirule, H; Dambrova, M; Grinberga, S; Gustina, D; Kuka, J; Liepins, J; Liepinsh, E; Loza, E; Makrecka-Kuka, M; Pugovics, O; Zharkova-Malkova, O1
Cirule, H; Dambrova, M; Grinberga, S; Hartmane, D; Liepinsh, E; Makarova, E; Sevostjanovs, E; Zharkova-Malkova, O1

Trials

1 trial(s) available for 3-(2,2,2-trimethylhydrazine)propionate and betaine

ArticleYear
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:9

    Topics: Adult; Betaine; Cardiovascular Agents; Carnitine; Diet; Female; Humans; Male; Meat; Methylhydrazines; Middle Aged; Young Adult

2011

Other Studies

13 other study(ies) available for 3-(2,2,2-trimethylhydrazine)propionate and betaine

ArticleYear
Purification and characterization of the rat liver gamma-butyrobetaine hydroxylase.
    Molecular and cellular biochemistry, 1998, Volume: 178, Issue:1-2

    Topics: Animals; Ascorbic Acid; Betaine; Carnitine; Catalase; Catalysis; Chromatography, Affinity; Enzyme Inhibitors; Ferrous Compounds; gamma-Butyrobetaine Dioxygenase; Hydroxylation; Ketoglutaric Acids; Kinetics; Ligands; Liver; Male; Methylhydrazines; Mixed Function Oxygenases; Molecular Weight; Rats; Rats, Wistar

1998
Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Betaine; Carnitine; Lipopolysaccharides; Male; Methylhydrazines; Nitric Oxide; Rats; Rats, Wistar; Sepsis

2004
Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.
    European journal of pharmacology, 2004, Jul-08, Volume: 495, Issue:1

    Topics: Animals; Aorta, Thoracic; Betaine; Carnitine; Ditiocarb; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Electron Spin Resonance Spectroscopy; Endothelium; Male; Methylhydrazines; Muscle, Smooth, Vascular; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Vasodilation

2004
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.
    Journal of cardiovascular pharmacology, 2006, Volume: 48, Issue:6

    Topics: Animals; Betaine; Cardiovascular Agents; Carnitine; Chromatography, High Pressure Liquid; Coronary Circulation; gamma-Butyrobetaine Dioxygenase; In Vitro Techniques; Injections, Intraperitoneal; Male; Methylhydrazines; Myocardial Infarction; Myocardium; Rats; Rats, Wistar

2006
Effect of inhibiting carnitine biosynthesis on male rat sexual performance.
    Physiology & behavior, 2008, Oct-20, Volume: 95, Issue:3

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Behavior, Animal; Betaine; Carnitine; Chromatography, Liquid; Chymases; Dose-Response Relationship, Drug; Male; Methylhydrazines; Rats; Sexual Behavior, Animal; Sperm Motility; Spermatozoa; Tandem Mass Spectrometry; Testosterone; Time Factors

2008
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
    Life sciences, 2008, Oct-24, Volume: 83, Issue:17-18

    Topics: Animals; Betaine; C-Peptide; Carnitine; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Heart; Hexokinase; Male; Methylhydrazines; Mice; Mice, Inbred ICR; Myocardium; RNA, Messenger; Up-Regulation

2008
Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice.
    Pharmacology, 2009, Volume: 83, Issue:5

    Topics: Animals; Aorta; Atherosclerosis; Betaine; Cardiovascular Agents; Carnitine; Energy Metabolism; Female; Lipids; Male; Methylhydrazines; Mice; Mice, Knockout; Rats; Rats, Wistar

2009
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:6

    Topics: Animals; Betaine; Biomarkers; Blood Glucose; Body Weight; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; Glucose; Heart; Hemodynamics; Lipids; Liver; Liver Glycogen; Male; Methylhydrazines; Myocardium; Rats; Rats, Wistar; Time Factors; Toxicity Tests, Chronic

2009
Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
    Behavioural brain research, 2011, Sep-12, Volume: 222, Issue:1

    Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Betaine; Brain Infarction; Carnitine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extremities; Infarction, Middle Cerebral Artery; Locomotion; Male; Methylhydrazines; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Rotarod Performance Test; Tandem Mass Spectrometry; Vibrissae

2011
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
    Journal of cardiovascular pharmacology and therapeutics, 2012, Volume: 17, Issue:2

    Topics: Animals; Betaine; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Chromatography, Liquid; Drug Interactions; Fatty Acids; Male; Methylhydrazines; Mitochondria, Heart; Mitochondrial Membranes; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Tandem Mass Spectrometry; Vitamin B Complex

2012
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:8

    Topics: Animals; Aorta; Betaine; Cardiovascular Agents; Carnitine; Drug Therapy, Combination; Endothelium, Vascular; Glucose; Male; Methylhydrazines; Rats; Rats, Wistar

2013
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
    Life sciences, 2014, Nov-11, Volume: 117, Issue:2

    Topics: Animals; Betaine; Biosynthetic Pathways; Carbon Isotopes; Carnitine; Choline; Chromatography, High Pressure Liquid; Gastrointestinal Tract; Methylamines; Methylhydrazines; Microbiota; Rats; Rats, Wistar; Statistics, Nonparametric; Tandem Mass Spectrometry

2014
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 120, Issue:5

    Topics: Animals; Betaine; Biological Transport; Carnitine; Furosemide; Male; Methylhydrazines; Mice; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Tissue Distribution

2017