293b cpd has been researched along with hmr 1556 in 10 studies
| Studies (293b cpd) | Trials (293b cpd) | Recent Studies (post-2010) (293b cpd) | Studies (hmr 1556) | Trials (hmr 1556) | Recent Studies (post-2010) (hmr 1556) |
|---|---|---|---|---|---|
| 100 | 0 | 16 | 48 | 0 | 13 |
| Protein | Taxonomy | 293b cpd (IC50) | hmr 1556 (IC50) |
|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 1 | Cavia porcellus (domestic guinea pig) | 0.12 | |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | 0.12 | |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | 0.12 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bleich, M; Brendel, J; Brüggemann, A; Busch, AE; Gerlach, U; Greger, R; Lang, HJ; Paulus, EF; Suessbrich, H; Weidmann, K | 1 |
| Wermuth, CG | 1 |
| Beekman, JD; Gerlach, U; Sipido, KR; Spätjens, RL; Stengl, M; van Opstal, JM; Volders, PG; Vos, MA | 1 |
| Gerlach, U; Heitzmann, D; Lang, F; Ranta, F; Ris, F; Rösler, M; Su, J; Ullrich, S; Warth, R; Wittekindt, OH | 1 |
| Dong, MQ; Gao, Z; Lau, CP; Li, GR; Tseng, GN | 1 |
| Cemerikic, D; Dragovic, S; Knezevic, A; Milovanovic, A; Milovanovic, J; Nesovic-Ostojic, J; Popadic, D | 1 |
| Ducroq, J; Legrand, JC; Puddu, PE; Rouet, R; Sallé, L | 1 |
| Carbonell-Pascual, B; Ferrero, JM; Harmati, G; Jost, N; Kohajda, Z; Koncz, I; Kristóf, A; Nánási, PP; Papp, JG; Papp, R; Varró, A; Virág, L | 1 |
| Ducroq, J; Gérard, JL; Puddu, PE; Rouet, R; Sallé, L | 1 |
| Bøtker, HE; Elkjær, CC; Hansen, J; Jespersen, NR; Johnsen, J; Nielsen, JM; Sørensen, CB | 1 |
1 review(s) available for 293b cpd and hmr 1556
| Article | Year |
|---|---|
Selective optimization of side activities: another way for drug discovery.
Topics: Animals; Biological Availability; Combinatorial Chemistry Techniques; Databases, Factual; Drug Design; Humans; Patents as Topic; Pharmaceutical Preparations; Structure-Activity Relationship | 2004 |
9 other study(ies) available for 293b cpd and hmr 1556
| Article | Year |
|---|---|
Synthesis and activity of novel and selective I(Ks)-channel blockers.
Topics: Animals; Chromans; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Sulfonamides; Xenopus laevis | 2001 |
Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.
Topics: Adrenergic beta-Agonists; Anilides; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Chromans; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Ventricles; Isoproterenol; Myocytes, Cardiac; Potassium Channel Blockers; Potassium Channels; Propanolamines; Receptors, Adrenergic, beta; Sulfonamides; Ventricular Function; Wakefulness | 2003 |
Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.
Topics: 4-Aminopyridine; Animals; Cell Line, Tumor; Chromans; Gene Expression; Insulin; Insulin Secretion; Insulin-Secreting Cells; KCNQ1 Potassium Channel; Membrane Potentials; Rats; Sulfonamides; Tetraethylammonium; Tolbutamide | 2005 |
Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells.
Topics: Action Potentials; Adrenergic beta-Agonists; Barium; Cells, Cultured; Chromans; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Humans; Isoproterenol; Isoquinolines; KCNQ1 Potassium Channel; Kidney; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Recombinant Proteins; Sulfonamides; Transfection | 2006 |
Absence of KCNQ1-dependent K+ fluxes in proximal tubular cells of frog kidney.
Topics: Alanine; Animals; Barium; Chromans; In Vitro Techniques; KCNQ1 Potassium Channel; Kidney Tubules, Proximal; Kinetics; Membrane Potentials; Perfusion; Phenylalanine; Potassium; Potassium Channel Blockers; Rana esculenta; RNA, Messenger; Sodium; Sulfonamides | 2007 |
I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Delayed Rectifier Potassium Channels; Epinephrine; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purkinje Fibers; Rabbits; Sotalol; Sulfonamides | 2011 |
Analysis of the contribution of I(to) to repolarization in canine ventricular myocardium.
Topics: Action Potentials; Animals; Chromans; Dogs; Female; Heart Conduction System; Heart Ventricles; Male; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Sulfonamides; Ventricular Function | 2011 |
I(Ks) blockade in border zone arrhythmias from guinea-pig ventricular myocardium submitted to simulated ischemia and reperfusion.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Chromans; Electrophysiological Phenomena; Female; Guinea Pigs; Heart; Heart Ventricles; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Sulfonamides; Tachycardia | 2012 |
Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition.
Topics: Animals; Chromans; KCNQ1 Potassium Channel; Male; Potassium Channel Blockers; Protective Agents; Rats; Rats, Wistar; Sulfonamides; Time Factors | 2020 |