27-hydroxycholesterol has been researched along with t0901317 in 7 studies
| Studies (27-hydroxycholesterol) | Trials (27-hydroxycholesterol) | Recent Studies (post-2010) (27-hydroxycholesterol) | Studies (t0901317) | Trials (t0901317) | Recent Studies (post-2010) (t0901317) |
|---|---|---|---|---|---|
| 345 | 11 | 214 | 567 | 3 | 330 |
| Protein | Taxonomy | 27-hydroxycholesterol (IC50) | t0901317 (IC50) |
|---|---|---|---|
| Chain A, Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.1 | |
| Chain A, Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.1 | |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | 0.0386 | |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | 2.3 | |
| Presenilin-1 | Homo sapiens (human) | 4.5 | |
| Presenilin-2 | Homo sapiens (human) | 4.5 | |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | 1.6113 | |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.4688 | |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | 0.0223 | |
| Gamma-secretase subunit APH-1B | Homo sapiens (human) | 4.5 | |
| Nicastrin | Homo sapiens (human) | 4.5 | |
| Nuclear receptor ROR-beta | Homo sapiens (human) | 10 | |
| Gamma-secretase subunit APH-1A | Homo sapiens (human) | 4.5 | |
| Bile acid receptor | Homo sapiens (human) | 5.3 | |
| Gamma-secretase subunit PEN-2 | Homo sapiens (human) | 4.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, W; Chiang, JY; Li, T | 1 |
| Cheng, D; Garner, B; Kim, WS | 1 |
| Bussolino, F; Morello, F; Mulatero, P; Noghero, A; Saglio, E; Schiavone, D; Veglio, F; Verhovez, A; Williams, TA | 1 |
| Garenc, C; Riendeau, V | 1 |
| Bartholomew, C; Borthwick, F; Graham, A; Taylor, JM | 1 |
| Bae, SS; Eo, SK; Jang, H; Kim, K; Kim, SM; Lee, SA; Park, YC; Son, Y | 1 |
| Boucau, MC; Candela, P; Fenart, L; Gosselet, F; Saint-Pol, J | 1 |
7 other study(ies) available for 27-hydroxycholesterol and t0901317
| Article | Year |
|---|---|
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Topics: ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol, HDL; Genes, Reporter; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Intestinal Mucosa; Intestines; Lipid Metabolism; Molecular Sequence Data; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Steroid; Response Elements; Rifampin; RNA, Messenger; Sulfonamides; Transcription, Genetic; Up-Regulation | 2007 |
Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
Topics: alpha-Synuclein; Blotting, Western; Cell Line; Cell Line, Tumor; DNA-Binding Proteins; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Liver X Receptors; Neuroblastoma; Oligodendroglia; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Up-Regulation | 2008 |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Topics: Anticholesteremic Agents; Benzoates; Benzylamines; Cells, Cultured; Chemokines; Cholesterol; E-Selectin; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Liver X Receptors; Orphan Nuclear Receptors; RNA Interference; RNA, Messenger; Signal Transduction; Sulfonamides; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2009 |
Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells.
Topics: Apoptosis; Cell Growth Processes; Cell Membrane; Cell Survival; Cells, Cultured; Flow Cytometry; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Lysosomes; Macrophages; Muscle, Smooth, Vascular; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides; U937 Cells | 2009 |
Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cholestanetriol 26-Monooxygenase; Cholesterol; Cyclic CMP; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Homeostasis; Hydrocarbons, Fluorinated; Hydroxycholesterols; Immunoblotting; Lipid Metabolism; Lipoproteins, LDL; Liver X Receptors; Macrophages; Mice; Mutation; Orphan Nuclear Receptors; Phosphoproteins; Polyisoprenyl Phosphates; Probucol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transfection; Triglycerides; Up-Regulation | 2010 |
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages.
Topics: Animals; Cell Line; Chromones; Hydrocarbons, Fluorinated; Hydroxycholesterols; Liver X Receptors; Macrophages; Morpholines; Orphan Nuclear Receptors; Pertussis Toxin; Plaque, Atherosclerotic; Pyrimidines; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2013 |
Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Anticholesteremic Agents; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; Cholesterol; Cholesterol, HDL; Coculture Techniques; Dose-Response Relationship, Drug; Endothelial Cells; Hydrocarbons, Fluorinated; Hydroxycholesterols; Neuroglia; Protein Transport; Rats; Sulfonamides; Tritium; Up-Regulation | 2013 |