27-hydroxycholesterol has been researched along with simvastatin in 7 studies
| Studies (27-hydroxycholesterol) | Trials (27-hydroxycholesterol) | Recent Studies (post-2010) (27-hydroxycholesterol) | Studies (simvastatin) | Trials (simvastatin) | Recent Studies (post-2010) (simvastatin) |
|---|---|---|---|---|---|
| 345 | 11 | 214 | 8,442 | 1,730 | 3,630 |
| Protein | Taxonomy | 27-hydroxycholesterol (IC50) | simvastatin (IC50) |
|---|---|---|---|
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | 1.164 | |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | 4.426 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 0.7843 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 9.5 | |
| Insulin receptor | Rattus norvegicus (Norway rat) | 0.0034 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.0034 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | 0.0111 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.049 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 6.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amati, B; Crosignani, A; Del Puppo, M; Galli Kienle, M; Petroni, ML; Podda, M; Zuin, M | 1 |
| Babiker, A; Ellis, E; Hansson, M; Hunt, MC; Schmitz, G | 1 |
| Laaksonen, R; Lehtimäki, T; Lütjohann, D; Päivä, H; Thelen, KM | 1 |
| Del Puppo, M; Dotti, MT; Federico, A; Ginanneschi, F; Magni, A; Malandrini, A; Mignarri, A; Monti, L; Santorelli, FM; Tessa, A | 2 |
| Lütjohann, D; Stellaard, F; Sudhop, T; von Bergmann, K | 1 |
| Carecchio, M; Del Puppo, M; Di Bella, D; Dotti, MT; Magistrelli, L; Mignarri, A; Monti, L | 1 |
1 trial(s) available for 27-hydroxycholesterol and simvastatin
| Article | Year |
|---|---|
Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration.
Topics: Aged; Anticholesteremic Agents; Cholagogues and Choleretics; Cholesterol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Hypercholesterolemia; Liver Cirrhosis, Biliary; Male; Middle Aged; Simvastatin; Ursodeoxycholic Acid | 2001 |
6 other study(ies) available for 27-hydroxycholesterol and simvastatin
| Article | Year |
|---|---|
Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages.
Topics: Cell Differentiation; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholesterol; Culture Media, Serum-Free; Humans; Hydroxycholesterols; Macrophage Colony-Stimulating Factor; Macrophages; Monocytes; RNA, Messenger; Simvastatin; Steroid Hydroxylases; Time Factors | 2003 |
High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.
Topics: Adult; Aged; Atorvastatin; Biomarkers; Brain; Cholesterol; Female; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin | 2006 |
Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism.
Topics: Adult; Anticholesteremic Agents; Cytochrome P450 Family 7; Female; Humans; Hydroxycholesterols; Male; Mutation; Simvastatin; Spastic Paraplegia, Hereditary; Steroid Hydroxylases; Treatment Outcome; Young Adult | 2014 |
Treatment of SPG5 with cholesterol-lowering drugs.
Topics: Anticholesteremic Agents; Ezetimibe; Follow-Up Studies; Humans; Hydroxycholesterols; Siblings; Simvastatin; Spastic Paraplegia, Hereditary | 2015 |
The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies.
Topics: Adult; Azetidines; Bile Acids and Salts; Biomarkers; Cholesterol; Diet, Vegan; Drug Therapy, Combination; Feces; Female; Humans; Hydroxycholesterols; Hypolipidemic Agents; Lipid Metabolism; Male; Middle Aged; Phytosterols; Reproducibility of Results; Retrospective Studies; Simvastatin; Up-Regulation | 2017 |
SPG5 siblings with different phenotypes showing reduction of 27-hydroxycholesterol after simvastatin-ezetimibe treatment.
Topics: Adult; Anticholesteremic Agents; Brain; Cytochrome P450 Family 7; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxycholesterols; Middle Aged; Phenotype; Siblings; Simvastatin; Spastic Paraplegia, Hereditary; Steroid Hydroxylases; Treatment Outcome | 2017 |