27-hydroxycholesterol has been researched along with nutlin-3a in 1 studies
| Studies (27-hydroxycholesterol) | Trials (27-hydroxycholesterol) | Recent Studies (post-2010) (27-hydroxycholesterol) | Studies (nutlin-3a) | Trials (nutlin-3a) | Recent Studies (post-2010) (nutlin-3a) |
|---|---|---|---|---|---|
| 345 | 11 | 214 | 698 | 1 | 504 |
| Protein | Taxonomy | 27-hydroxycholesterol (IC50) | nutlin-3a (IC50) |
|---|---|---|---|
| Protein Mdm4 | Homo sapiens (human) | 4.6273 | |
| Cellular tumor antigen p53 | Homo sapiens (human) | 1.0388 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.07 | |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | 0.1832 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhasarathy, A; Ghribi, O; Hammer, KD; Ohm, JE; Raza, S; Roche, C; Schommer, J | 1 |
1 other study(ies) available for 27-hydroxycholesterol and nutlin-3a
| Article | Year |
|---|---|
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.
Topics: Acetanilides; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Imidazoles; MCF-7 Cells; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Receptors, Estrogen; RNA Interference; Selective Estrogen Receptor Modulators; Signal Transduction; Thiourea; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2015 |