27-hydroxycholesterol has been researched along with 25-hydroxycholesterol in 37 studies
| Studies (27-hydroxycholesterol) | Trials (27-hydroxycholesterol) | Recent Studies (post-2010) (27-hydroxycholesterol) | Studies (25-hydroxycholesterol) | Trials (25-hydroxycholesterol) | Recent Studies (post-2010) (25-hydroxycholesterol) |
|---|---|---|---|---|---|
| 345 | 11 | 214 | 853 | 3 | 243 |
| Protein | Taxonomy | 27-hydroxycholesterol (IC50) | 25-hydroxycholesterol (IC50) |
|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 0.3 | |
| Sterol regulatory element-binding protein 2 | Homo sapiens (human) | 0.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 12 (32.43) | 29.6817 |
| 2010's | 12 (32.43) | 24.3611 |
| 2020's | 5 (13.51) | 2.80 |
| Authors | Studies |
|---|---|
| Bledsoe, RK; Collins, JL; Consler, TG; Galardi, CM; Lambert, MH; Li, D; McKee, DD; Moore, JT; Moore, LB; Parks, DJ; Russel, JS; Spencer, TA; Watson, MA; Willson, TM | 1 |
| Banie, H; Karlsson, L; Kuei, C; Liu, C; Lovenberg, TW; Mani, NS; Qin, N; Sun, S; Sutton, SW; Wu, J; Yang, XV; Yu, J; Zhang, L | 1 |
| Choi, TA; Franzblau, SG; Knölker, HJ; Schmidt, AW; Theumer, G | 1 |
| Corsini, A; Fumagalli, R; Paoletti, R; Quarato, P; Raiteri, M; Verri, D | 1 |
| Larsson, O; Sjövall, J; Zhang, J | 1 |
| Björkhem, I; Furster, C; Lund, E; Wikvall, K | 1 |
| Dricu, A; Sjövall, J; Zhang, J | 1 |
| Akwa, Y; Baulieu, EE; el-Etr, M; Sjövall, J; Zhang, J | 1 |
| Heyman, RA; Lala, DS; Lazarchik, SB; Mangelsdorf, DJ; Parker, KL; Syka, PM | 1 |
| Jondal, M; Sjövall, J; Xue, Y; Zhang, J | 1 |
| Norlin, M; Wikvall, K | 1 |
| Li, D; Spencer, TA | 1 |
| Russell, DW | 1 |
| Hayashi, K; Kajiyama, G; Kambe, M; Shingu, T; Yamagata, T; Yasunobu, Y | 1 |
| Aviram, M; Grenadir, E; Hayek, T; Hoffman, A; Mahmood, S; Milo, S; Vaya, J | 1 |
| Hultén, LM; Norén, K; Ohlsson, BG; Rosklint, T; Wiklund, O | 1 |
| Crowley, JR; Dudley-Rucker, N; Frolov, A; Ory, DS; Schaffer, JE; Zielinski, SE | 1 |
| Diczfalusy, U; Kaikkonen, J; Nyyssönen, K; Salonen, JT; Tuomainen, TP | 1 |
| Guan, JZ; Matsui, J; Murakami, H; Suda, T; Tamasawa, N; Yamato, K | 1 |
| Chen, G; Chen, W; Head, DL; Mangelsdorf, DJ; Russell, DW | 1 |
| Erickson, SK; Hylemon, P; Li, X; Ma, Y; Pandak, WM; Ren, S; Yin, L | 1 |
| Hara, T; Honda, A; Ikegami, T; Matsuzaki, Y; Miyazaki, T; Numazawa, M; Shirai, M; Xu, G; Yamashita, K | 1 |
| Björkhem, I; Deng, HX; Donkervoort, S; Hansson, M; Madrid, RE; Schöls, L; Schüle, R; Siddique, N; Siddique, T; Yang, Y | 1 |
| Dasari, B; Ghribi, O; Meiers, C; Prasanthi, JR; Singh, BB | 1 |
| Andreollo, NA; de Faria, EC; Menezes, FH; Moura, FA; Nadruz-Junior, W; Nakandakare, E; Nunes, VS; Petrucci, O; Quintão, EC; Rogerio, F; Scherrer, DZ; Sposito, AC; Virginio, VW | 1 |
| Biasi, F; Cagno, V; Civra, A; Donalisio, M; Lembo, D; Leonarduzzi, G; Poli, G | 1 |
| Liebisch, G; Matysik, S; Pataj, Z; Schmitz, G | 1 |
| Biasi, F; Caccia, C; Cagno, V; Calfapietra, S; Civra, A; Dorma, N; Lembo, D; Leoni, V; Poli, G; Rossin, D | 1 |
| Abreu, L; Antenora, A; Arnoldi, A; Baets, J; Bassi, MT; Bauer, P; Bis, DM; Björkhem, I; Criscuolo, C; De Jonghe, P; Deconinck, T; Filla, A; Fischer, I; Fraidakis, MJ; Hauser, S; Höflinger, P; Jägle, C; Jardim, LB; Klopstock, T; Lourenco, CM; Marques, W; Martinuzzi, A; Martus, P; Meisner, C; Paucar, M; Rattay, TW; Saute, JA; Scarlato, M; Schöls, L; Schüle, R; Smets, K; Stendel, C; Wiethoff, S; Züchner, S | 1 |
| Babin, PJ; Banneau, G; Benyounes, I; Castelnovo, G; Coupry, I; Debs, R; Durr, A; Ewenczyk, C; Goizet, C; Guissart, C; Hajage, D; Humbert, L; Labauge, P; Lafourcade, A; Lamari, F; Lavie, J; Lesca, G; Marelli, C; Mochel, F; Monin, ML; Odent, S; Ollagnon, E; Petit, E; Pilliod, J; Rainteau, D; Stevanin, G; Thauvin-Robinet, C; Ullmann, U; Wolf, C | 1 |
| Cagno, V; Civra, A; Francese, R; Gamba, P; Lembo, D; Poli, G; Testa, G | 1 |
| Bhattacharya, S; Bodziak, ML; Browne, RW; Fellows Maxwell, K; Hagemeier, J; Jakimovski, D; Ramanathan, M; Weinstock-Guttman, B; Zivadinov, R | 1 |
| Aldini, G; Cagno, V; Civra, A; Colzani, M; Francese, R; Lembo, D; Leoni, V; Poli, G | 1 |
| Abe, A; Aikawa, SI; Hiraoka, M; Matsuzawa, F; Niimura, Y | 1 |
| Biasi, F; Boglione, L; Caccia, C; Civra, A; Cusato, J; D'Avolio, A; Di Perri, G; Lembo, D; Leoni, V; Poli, G | 1 |
| Bromfield, JJ; Cronin, JG; Davies, D; Griffiths, WJ; Horlock, AD; Ormsby, TJR; Owens, SE; Sheldon, IM; Wang, Y | 1 |
| Anjum, FR; Behboudi, S; Jackson, B; Kamble, N; Patil, A; Reddy, VRAP; Ubachukwu, CC | 1 |
1 review(s) available for 27-hydroxycholesterol and 25-hydroxycholesterol
| Article | Year |
|---|---|
Oxysterol biosynthetic enzymes.
Topics: Animals; Bile Acids and Salts; Biological Transport; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hydroxycholesterols; Liver; Molecular Structure; Steroid Hydroxylases; Sterols | 2000 |
3 trial(s) available for 27-hydroxycholesterol and 25-hydroxycholesterol
| Article | Year |
|---|---|
Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.
Topics: Adult; Cholesterol; Fatty Acids; Ferritins; Humans; Hydroxycholesterols; Male; Middle Aged; Oxidation-Reduction | 2003 |
Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial.
Topics: Adolescent; Adult; Atorvastatin; Biomarkers; Case-Control Studies; Cell Proliferation; Cross-Sectional Studies; Cytochrome P450 Family 7; Disease Progression; Double-Blind Method; Family; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Induced Pluripotent Stem Cells; Male; Middle Aged; Mutation; Neurites; Oxysterols; Pedigree; Severity of Illness Index; Spastic Paraplegia, Hereditary; Steroid Hydroxylases; Young Adult | 2017 |
Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5.
Topics: Adolescent; Adult; Anticholesteremic Agents; Atorvastatin; Bile Acids and Salts; Child; Cholesterol; Cohort Studies; Cytochrome P450 Family 7; Deoxycholic Acid; Female; Humans; Hydroxycholesterols; Infant; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neurologic Examination; Oxysterols; Resveratrol; ROC Curve; Spastic Paraplegia, Hereditary; Steroid Hydroxylases; Young Adult | 2018 |
33 other study(ies) available for 27-hydroxycholesterol and 25-hydroxycholesterol
| Article | Year |
|---|---|
Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
Topics: Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Nucleus; Cell-Free System; Chlorocebus aethiops; Cholesterol; Cholic Acids; DNA-Binding Proteins; Energy Transfer; Fluorescence; Histone Acetyltransferases; Hydroxycholesterols; Ketocholesterols; Liver X Receptors; Models, Molecular; Molecular Sequence Data; Nuclear Receptor Coactivator 1; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Stereoisomerism; Sterols; Structure-Activity Relationship; Transcription Factors; Tryptophan | 2001 |
Oxysterols direct B-cell migration through EBI2.
Topics: 14-alpha Demethylase Inhibitors; Animals; B-Lymphocytes; Cell Line; Cell Movement; Chlorocebus aethiops; Clotrimazole; COS Cells; Humans; Hydroxycholesterols; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Spleen; Swine; T-Lymphocytes | 2011 |
Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Cholestanols; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxidation-Reduction; Stereoisomerism; Structure-Activity Relationship | 2013 |
Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes.
Topics: Animals; Arteries; Cell Division; Cholesterol; Homeostasis; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lipoproteins; Male; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, LDL | 1995 |
7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts.
Topics: Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Fibroblasts; Humans; Hydroxycholesterols; Hydroxylation; Hydroxymethylglutaryl CoA Reductases; Oxidation-Reduction; Substrate Specificity | 1995 |
24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver.
Topics: Animals; Cholestanetriol 26-Monooxygenase; Cholesterol; Cytochrome P-450 Enzyme System; Hydroxycholesterols; Hydroxylation; Liver; Mitochondria, Liver; Steroid Hydroxylases; Swine | 1993 |
Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase.
Topics: Aryl Hydrocarbon Hydroxylases; Cell Line; Cell Line, Transformed; Cholestenones; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dexamethasone; Humans; Hydrocortisone; Hydroxycholesterols; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metyrapone; Pregnenolone; Steroid Hydroxylases; Tumor Cells, Cultured | 1997 |
Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Cholestenones; Cholesterol; Cholic Acids; Fetus; Hydroxycholesterols; Hydroxylation; Microsomes; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Schwann Cells; Substrate Specificity | 1997 |
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Chlorocebus aethiops; DNA-Binding Proteins; Fushi Tarazu Transcription Factors; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Hydroxycholesterols; Kinetics; Luminescent Proteins; Molecular Sequence Data; Receptors, Cytoplasmic and Nuclear; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Steroidogenic Factor 1; Transcription Factors; Transcription, Genetic; Transfection | 1997 |
7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes.
Topics: Animals; Apoptosis; Hydroxycholesterols; Hydroxylation; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes | 1997 |
Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxycholesterols; Microsomes, Liver; Pregnenolone; Substrate Specificity; Swine | 1998 |
Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols.
Topics: Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Humans; Hydroxycholesterols; Stereoisomerism | 2000 |
Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Autoantibodies; Autoantigens; Autoimmune Diseases; Coronary Artery Disease; Coronary Vasospasm; Female; Humans; Hydroxycholesterols; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Risk Factors | 2001 |
Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Coronary Artery Disease; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Mice; Mice, Mutant Strains; Oxidation-Reduction | 2001 |
Oxysterols induce interleukin-1beta production in human macrophages.
Topics: Arteriosclerosis; Caspase 1; Cells, Cultured; Gene Expression; Humans; Hydroxycholesterols; Interleukin-1; Interleukin-6; Lipopolysaccharides; Macrophages; RNA, Messenger | 2002 |
NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
Topics: Carrier Proteins; Cells, Cultured; Cholesterol; Cholesterol, LDL; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fibroblasts; Filipin; Gas Chromatography-Mass Spectrometry; Genes, Reporter; Glycoproteins; Humans; Hydroxycholesterols; Intracellular Signaling Peptides and Proteins; Lipoproteins; Lipoproteins, LDL; Liver X Receptors; Luciferases; Membrane Glycoproteins; Microscopy, Fluorescence; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Orphan Nuclear Receptors; Oxygen; Phenotype; Receptors, Cytoplasmic and Nuclear; Skin; Sterols; Transfection; Vesicular Transport Proteins | 2003 |
Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation.
Topics: Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Northern; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Drug Therapy, Combination; Hydroxycholesterols; Ketoconazole; Lipid Metabolism; Lipoproteins; Liver X Receptors; Male; Microsomes, Liver; Orphan Nuclear Receptors; Peroxisome Proliferators; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA; RNA, Messenger; Steroids; Transcription Factors; Up-Regulation | 2003 |
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; DNA-Binding Proteins; Hepatocytes; Humans; Hydroxycholesterols; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orphan Nuclear Receptors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Sulfotransferases; Transfection | 2007 |
Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes.
Topics: Animals; Cholestanetriol 26-Monooxygenase; Chromatography, High Pressure Liquid; Cytosol; Hepatocytes; Humans; Hydroxycholesterols; Mice; Mice, Knockout; Rats; Sulfotransferases; Sulfuric Acid Esters; Transfection | 2007 |
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.
Topics: Animals; Calibration; Chromatography, Liquid; Humans; Hydroxycholesterols; Microsomes, Liver; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.
Topics: Adult; Bile Acids and Salts; Cytochrome P450 Family 7; Female; Heterozygote; Homozygote; Humans; Hydroxycholesterols; Male; Middle Aged; Neurodegenerative Diseases; Parents; Phosphorylation; Spastic Paraplegia, Hereditary; Steroid Hydroxylases; tau Proteins | 2010 |
Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.
Topics: Cell Line; Chemokine CCL2; Drug Interactions; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Hydroxycholesterols; Interleukin-6; Interleukin-8; Ketocholesterols; Liver X Receptors; Macular Degeneration; Orphan Nuclear Receptors; Oxidation-Reduction; Platelet-Derived Growth Factor; Retinal Pigment Epithelium; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity.
Topics: Aged; Aged, 80 and over; Arteries; C-Reactive Protein; Female; Humans; Hydroxycholesterols; Inflammation; Male; Middle Aged; Peripheral Arterial Disease | 2015 |
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol.
Topics: Animals; Antiviral Agents; Cell Proliferation; Cells, Cultured; Human papillomavirus 16; Humans; Hydroxycholesterols; Papillomavirus Infections; Picornaviridae Infections; Rhinovirus; Rotavirus; Rotavirus Infections; Virus Inactivation | 2014 |
Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.
Topics: Biomarkers; Chromatography, Liquid; Erythrocytes; Humans; Hydroxycholesterols; Ketocholesterols; Niemann-Pick Disease, Type C; Plasma; Stereoisomerism; Tandem Mass Spectrometry; Xanthomatosis, Cerebrotendinous | 2016 |
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Gene Expression Regulation; HeLa Cells; Herpes Simplex; Herpesvirus 1, Human; Humans; Hydroxycholesterols; Interleukin-6; NF-kappa B; Vero Cells; Virus Replication | 2017 |
25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes.
Topics: Animals; Caco-2 Cells; Cell Line; Chlorocebus aethiops; Endosomes; Humans; Hydroxycholesterols; Immunity, Innate; Rotavirus; Rotavirus Infections; Virion; Virus Internalization | 2018 |
Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study.
Topics: Adolescent; Adult; Aged; Apolipoproteins; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Ketocholesterols; Longitudinal Studies; Male; Mass Spectrometry; Middle Aged; Multiple Sclerosis; Oxysterols; Prospective Studies; Young Adult | 2019 |
Modulation of cell proteome by 25-hydroxycholesterol and 27-hydroxycholesterol: A link between cholesterol metabolism and antiviral defense.
Topics: Antiviral Agents; Humans; Hydroxycholesterols; Proteome | 2020 |
Esterification of side-chain oxysterols by lysosomal phospholipase A2.
Topics: Animals; Catalysis; Cholesterol; Esterification; Humans; Hydroxycholesterols; Lysosomes; Macrophages; Mice; Oxysterols; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipases A2; Sphingosine | 2020 |
Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers.
Topics: Adult; Biomarkers; Carrier State; Elasticity Imaging Techniques; Female; Genotype; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hydroxycholesterols; Liver; Male; Prospective Studies | 2021 |
Oxysterols protect bovine endometrial cells against pore-forming toxins from pathogenic bacteria.
Topics: Animals; Bacteria; Bacterial Proteins; Cattle; Endometrium; Female; Hemolysin Proteins; Hydroxycholesterols; Stromal Cells; Virulence Factors | 2021 |
Inhibition of Marek's Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro.
Topics: Animals; Antiviral Agents; Chick Embryo; Chickens; Hydroxycholesterols; Interferon Type I; Interferon-alpha; Marek Disease; Virus Replication | 2023 |