Page last updated: 2024-09-03

27-hydroxycholesterol and 24-hydroxycholesterol

27-hydroxycholesterol has been researched along with 24-hydroxycholesterol in 60 studies

Compound Research Comparison

Studies (27-hydroxycholesterol)	Trials (27-hydroxycholesterol)	Recent Studies (post-2010) (27-hydroxycholesterol)	Studies (24-hydroxycholesterol)	Trials (24-hydroxycholesterol)	Recent Studies (post-2010) (24-hydroxycholesterol)
345	11	214	6	0	2
345	11	214	232	9	120

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (5.00)	18.2507
2000's	25 (41.67)	29.6817
2010's	29 (48.33)	24.3611
2020's	3 (5.00)	2.80

Authors

Authors	Studies
Bledsoe, RK; Collins, JL; Consler, TG; Galardi, CM; Lambert, MH; Li, D; McKee, DD; Moore, JT; Moore, LB; Parks, DJ; Russel, JS; Spencer, TA; Watson, MA; Willson, TM	1
Björkhem, I; Furster, C; Lund, E; Wikvall, K	1
Akwa, Y; Baulieu, EE; el-Etr, M; Sjövall, J; Zhang, J	1
Babiker, A; Diczfalusy, U	1
Li, D; Spencer, TA	1
Björkhem, I; Norlin, M; Toll, A; Wikvall, K	1
Russell, DW	1
Björkhem, I; Diczfalusy, U; Hassan, M; Lütjohann, D; Meaney, S; Sakinis, A; von Bergmann, K; Wennmalm , A	1
Andersson, U; Babiker, A; Björkhem, I; Diczfalusy, U; Lütjohann, D; Pikuleva, I; Starck, L; von Bahr, S	1
Björkhem, I; Dame, C; Fahnenstich, H; Locatelli, S; Lütjohann, D; Schmolling, J; von Bergmann, K	1
Björkhem, I; Diczfalusy, U; Leoni, V; Masterman, T; Meaney, S; Patel, P	1
Bayer, T; Björkhem, I; Bogdanovic, N; Bretillon, L; Diczfalusy, U; Heverin, M; Lütjohann, D; Pikuleva, I; Winblad, B	1
Burkard, I; Rentsch, KM; von Eckardstein, A	1
Björkhem, I; Diczfalusy, U; Hillert, J; Leoni, V; Masterman, T; Mousavi, FS; Wahlund, LO; Wretlind, B	1
Bergmann, KV; Heun, R; Kerksiek, A; Kölsch, H; Lütjohann, D; Maier, W	1
Janatuinen, T; Knuuti, J; Laaksonen, R; Lehtimäki, T; Lütjohann, D; Thelen, KM; Vesalainen, R; von Bergmann, K	1
Laaksonen, R; Lehtimäki, T; Lütjohann, D; Päivä, H; Thelen, KM	1
Björkhem, I; Diczfalusy, U; Heverin, M; Leoni, V; Meaney, S	1
Burkard, I; Rentsch, KM; Vollenweider, P; von Eckardstein, A; Waeber, G	1
Björkhem, I	1
Chen, G; Chen, W; Head, DL; Mangelsdorf, DJ; Russell, DW	1
De Vries, HE; Dijkstra, CD; Floris, S; Lütjohann, D; Sonke, M; Teunissen, CE	1
Björkhem, I; Eggertsen, G; Floren, CH; Hansson, M; Meaney, S; Olin, M; van't Hooft, F; von Bahr, S	1
Irle, E; Koschack, J; Lütjohann, D; Schmidt-Samoa, C	1
Diaz-Arrastia, R; Hudak, A; Lütjohann, D; Madden, C; Moore, C; Vega, GL; Weiner, MF	1
Hara, T; Honda, A; Ikegami, T; Matsuzaki, Y; Miyazaki, T; Numazawa, M; Shirai, M; Xu, G; Yamashita, K	1
Feist, G; Ghribi, O; Rantham Prabhakara, JP; Schommer, E; Thomasson, S; Thompson, A	1
Andreasen, N; Besga, A; Björkhem, I; Julin, P; Kivipelto, M; Leoni, V; Oksengård, AR; Soininen, H; Solomon, A; Svensson, L; Wahlund, LO; Winblad, B	1
Dipatre, PL; Dodder, NG; Heo, GY; Huang, S; Liao, WL; Mast, N; Pikuleva, IA; Reem, RE; Turko, IV	1
Biasi, F; Gamba, P; Gargiulo, S; Guglielmotto, M; Leonarduzzi, G; Mauro, A; Poli, G; Sottero, B; Tamagno, E; Testa, G; Viña, J	1
Chew, ES; Halliwell, B; Huang, H; Huang, SH; Lee, CY; Lim, EC; Loke, WM; Looi, WF; Quek, AM; Seet, RC	1
Jeitner, TM; Reiss, AB; Voloshyna, I	1
Björkhem, I; Cedazo-Mínguez, A; Folkesson, R; Gil-Bea, FJ; Heverin, M; Ismail, MA; Mateos, L; Schöls, L; Schüle, R	1
Cedazo-Mínguez, A; Ismail, MA; Mateos, L; Winblad, B	1
Becker, JT; Evans, RW; Hughes, TM; Kuller, LH; Lopez, OL; Rosano, C; Sutton-Tyrrell, K	1
Jessen, F; Kölsch, H; Kornhuber, J; Lewczuk, P; Lütjohann, D; Maier, W; Meichsner, S; Popp, J	1
Emanuelsson, I; Norlin, M	1
Acimovic, J; Ali, Z; Båvner, A; Björkhem, I; Heverin, M; Leitersdorf, E; Lövgren-Sandblom, A; Meiner, V; Olin, M; Shafaati, M	1
Chen, GG; Cruceanu, C; Freemantle, E; Mechawar, N; Turecki, G	1
Caccia, C; Leoni, V	1
Boucau, MC; Candela, P; Fenart, L; Gosselet, F; Saint-Pol, J	1
Acimovic, J; Ali, Z; Björkhem, I; Fickert, P; Fischler, B; Heverin, M; Lövgren-Sandblom, A; Olin, M; Schöls, L; Schüle, R; Trauner, M	1
Barkhof, F; Killestein, J; Lütjohann, D; Polman, CH; Popescu, V; Rijkers, E; Teunissen, CE; van de Kraats, C; Vrenken, H	1
Björkhem, I; Brodin, L; Leoni, V; Lövgren-Sandblom, A; Meaney, S; Pålhagen, S; Salveson, L; Svenningsson, P; Winge, K	1
Baila-Rueda, L; Bea, AM; Cenarro, A; Civeira, F; de Castro-Orós, I; Jarauta, E; Mateo-Gallego, R	1
Biasi, F; Gamba, P; Gargiulo, S; Giaccone, G; Guglielmotto, M; Iuliano, L; Leonarduzzi, G; Mauro, A; Monteleone, D; Poli, G; Tamagno, E; Testa, G; Zerbinati, C	1
Badilli, U; Biasi, F; Calfapietra, S; Cavalli, R; Gamba, P; Gargiulo, S; Guina, T; Leonarduzzi, G; Maina, M; Poli, G; Testa, G	1
Andreollo, NA; de Faria, EC; Menezes, FH; Moura, FA; Nadruz-Junior, W; Nakandakare, E; Nunes, VS; Petrucci, O; Quintão, EC; Rogerio, F; Scherrer, DZ; Sposito, AC; Virginio, VW	1
Bandaru, VV; Haughey, NJ	1
Axelsson, M; Björkhem, I; Karrenbauer, VD; Lycke, J; Malmeström, C; Novakova, L; Zetterberg, H	1
Kuo, SH; Liu, N; Liu, XG; Song, QY; Wang, HL; Wang, MW; Wang, YY	1
Angeloni, C; Bandini, E; Cardenia, V; Hrelia, S; Lorenzini, A; Malaguti, M; Rodriguez-Estrada, MT	1
An, Y; Feng, L; Liu, Q; Lu, Y; Wang, C; Xiao, R; Yu, H	1
Björkhem, I; Leoni, V; Svenningsson, P	1
Goikolea, J; Loera-Valencia, R; Maioli, S; Merino-Serrais, P; Parrado-Fernandez, C	1
Bhattacharya, S; Bodziak, ML; Browne, RW; Fellows Maxwell, K; Hagemeier, J; Jakimovski, D; Ramanathan, M; Weinstock-Guttman, B; Zivadinov, R	1
Alkatout, I; Bornemann, V; Eckmann-Scholz, C; Elessawy, M; Klein, A; Lütjohann, D; Maass, N; Pecks, U; Segger, L	1
Biasi, F; Boglione, L; Caccia, C; Civra, A; Cusato, J; D'Avolio, A; Di Perri, G; Lembo, D; Leoni, V; Poli, G	1
Bölükbasi, B; Kerksiek, A; Laufs, U; Lütjohann, D; Parhofer, KG; Stellaard, F	1
Cui, S; Feng, W; Hao, L; Ju, M; Liu, W; Wang, L; Wang, T; Xiao, R	1

Reviews

8 review(s) available for 27-hydroxycholesterol and 24-hydroxycholesterol

Article	Year
Oxysterol biosynthetic enzymes. Biochimica et biophysica acta, 2000, Dec-15, Volume: 1529, Issue:1-3 Topics: Animals; Bile Acids and Salts; Biological Transport; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hydroxycholesterols; Liver; Molecular Structure; Steroid Hydroxylases; Sterols	2000
Oxysterols and Alzheimer's disease. Acta neurologica Scandinavica. Supplementum, 2006, Volume: 185 Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Brain; Humans; Hydroxycholesterols; Hypercholesterolemia	2006
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. Journal of internal medicine, 2006, Volume: 260, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Cholesterol; Cholesterol 24-Hydroxylase; Homeostasis; Humans; Hydroxycholesterols; Infant; Rats; Steroid Hydroxylases	2006
Oxysterol derivatives of cholesterol in neurodegenerative disorders. Current medicinal chemistry, 2011, Volume: 18, Issue:10 Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholesterol; Humans; Hydroxycholesterols; Multiple Sclerosis; Neurodegenerative Diseases; Paraplegia; Structure-Activity Relationship	2011
Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. Biochemical pharmacology, 2013, Jul-01, Volume: 86, Issue:1 Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Cholesterol; Humans; Hydroxycholesterols; Neurodegenerative Diseases; Oxidation-Reduction	2013
Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. Journal of Alzheimer's disease : JAD, 2016, Volume: 51, Issue:1 Topics: Alzheimer Disease; Cholesterol; Cognitive Dysfunction; Databases, Bibliographic; Humans; Hydroxycholesterols	2016
On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review). The Journal of steroid biochemistry and molecular biology, 2019, Volume: 188 Topics: Animals; Blood-Brain Barrier; Cytochrome P450 Family 7; Humans; Hydroxycholesterols; Neurodegenerative Diseases; Neurons; Oxidation-Reduction; Steroid Hydroxylases	2019
Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment. The Journal of steroid biochemistry and molecular biology, 2019, Volume: 190 Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Brain; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 24-Hydroxylase; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Risk Factors	2019

Trials

1 trial(s) available for 27-hydroxycholesterol and 24-hydroxycholesterol

Article	Year
Effect of pravastatin on plasma sterols and oxysterols in men. European journal of clinical pharmacology, 2006, Volume: 62, Issue:1 Topics: Adult; Brain; Cholesterol; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pravastatin; Sterols	2006

Other Studies

51 other study(ies) available for 27-hydroxycholesterol and 24-hydroxycholesterol

Article	Year
Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Nucleus; Cell-Free System; Chlorocebus aethiops; Cholesterol; Cholic Acids; DNA-Binding Proteins; Energy Transfer; Fluorescence; Histone Acetyltransferases; Hydroxycholesterols; Ketocholesterols; Liver X Receptors; Models, Molecular; Molecular Sequence Data; Nuclear Receptor Coactivator 1; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Stereoisomerism; Sterols; Structure-Activity Relationship; Transcription Factors; Tryptophan	2001
24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. Biochimica et biophysica acta, 1993, Feb-24, Volume: 1166, Issue:2-3 Topics: Animals; Cholestanetriol 26-Monooxygenase; Cholesterol; Cytochrome P-450 Enzyme System; Hydroxycholesterols; Hydroxylation; Liver; Mitochondria, Liver; Steroid Hydroxylases; Swine	1993
Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. The Biochemical journal, 1997, Feb-15, Volume: 322 ( Pt 1) Topics: Animals; Astrocytes; Brain; Cells, Cultured; Cholestenones; Cholesterol; Cholic Acids; Fetus; Hydroxycholesterols; Hydroxylation; Microsomes; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Schwann Cells; Substrate Specificity	1997
Transport of side-chain oxidized oxysterols in the human circulation. Biochimica et biophysica acta, 1998, Jun-15, Volume: 1392, Issue:2-3 Topics: Adult; Biological Transport; Cholesterol; Esterification; Female; Humans; Hydroxycholesterols; Indicator Dilution Techniques; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Mass Spectrometry; Middle Aged; Oxidation-Reduction	1998
Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. Steroids, 2000, Volume: 65, Issue:9 Topics: Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Humans; Hydroxycholesterols; Stereoisomerism	2000
24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). Journal of lipid research, 2000, Volume: 41, Issue:10 Topics: Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Chromatography, Gas; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxycholesterols; Hydroxylation; Ketocholesterols; Liver; Microsomes; Recombinant Proteins; Substrate Specificity; Swine; Transfection	2000
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. Journal of lipid research, 2001, Volume: 42, Issue:1 Topics: Blood Circulation; Cholesterol; Deuterium; Half-Life; Humans; Hydroxycholesterols; Organ Specificity; Oxygen; Oxygen Isotopes; Time Factors	2001
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. Journal of lipid research, 2001, Volume: 42, Issue:3 Topics: Adolescent; Animals; Cell Line; Child; Child, Preschool; Cholestadienols; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; COS Cells; Cytochrome P-450 Enzyme System; Dehydrocholesterols; Gene Expression; Humans; Hydroxycholesterols; Infant; Recombinant Proteins; Smith-Lemli-Opitz Syndrome; Steroid Hydroxylases; Substrate Specificity; Transfection	2001
Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:6 Topics: Brain; Cholesterol; Erythroblastosis, Fetal; Fetus; Humans; Hydroxycholesterols; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Longitudinal Studies	2001
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. Journal of lipid research, 2003, Volume: 44, Issue:4 Topics: Biomarkers; Blood-Brain Barrier; Cerebrospinal Fluid; Deuterium; Hemorrhage; Humans; Hydroxycholesterols; Male; Meningitis; Middle Aged; Oxidation-Reduction; Polyneuropathies; Sterols	2003
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. Journal of lipid research, 2004, Volume: 45, Issue:1 Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain; Female; Humans; Hydroxycholesterols; Male; Mice; Mice, Transgenic; Middle Aged; Mixed Function Oxygenases; Water	2004
Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. Journal of lipid research, 2004, Volume: 45, Issue:4 Topics: Chromatography, High Pressure Liquid; Humans; Hydroxycholesterols; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity	2004
Diagnostic use of cerebral and extracerebral oxysterols. Clinical chemistry and laboratory medicine, 2004, Volume: 42, Issue:2 Topics: Adult; Aged; Brain Diseases; Female; Humans; Hydroxycholesterols; Male; Middle Aged	2004
Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. Neuroscience letters, 2004, Sep-30, Volume: 368, Issue:3 Topics: Aged; Analysis of Variance; Dementia; Female; Humans; Hydroxycholesterols; Male; Middle Aged	2004
High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. Journal of clinical pharmacology, 2006, Volume: 46, Issue:7 Topics: Adult; Aged; Atorvastatin; Biomarkers; Brain; Cholesterol; Female; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin	2006
Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis, 2007, Volume: 194, Issue:1 Topics: Adult; Aged; Chemistry, Clinical; Cholesterol, HDL; Cholesterol, LDL; Chromatography, High Pressure Liquid; Circadian Rhythm; Esterification; Female; Humans; Hydroxycholesterols; Male; Menstrual Cycle; Middle Aged; Reference Values; Triglycerides	2007
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell metabolism, 2007, Volume: 5, Issue:1 Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; DNA-Binding Proteins; Hepatocytes; Humans; Hydroxycholesterols; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orphan Nuclear Receptors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Sulfotransferases; Transfection	2007
24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. Journal of neuroscience research, 2007, May-15, Volume: 85, Issue:7 Topics: Acute Disease; Animals; Biomarkers; Cholesterol; Cholesterol 24-Hydroxylase; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Hydroxycholesterols; Macrophages; Male; Multiple Sclerosis; Rats; Rats, Inbred Lew; Steroid Hydroxylases	2007
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. Journal of internal medicine, 2007, Volume: 261, Issue:5 Topics: Adult; Base Sequence; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholestanol; Exons; Female; Humans; Hydroxycholesterols; Mutation; Pedigree; RNA, Messenger; Xanthomatosis, Cerebrotendinous	2007
Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. Neurobiology of aging, 2009, Volume: 30, Issue:6 Topics: Female; Hippocampus; Humans; Hydroxycholesterols; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Statistics as Topic	2009
Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. Brain injury, 2008, Volume: 22, Issue:7-8 Topics: Acute Disease; Adolescent; Adult; Biomarkers; Brain; Cholesterol; Female; Head Injuries, Closed; Humans; Hydroxycholesterols; Male; Middle Aged; Trauma Severity Indices	2008
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. Journal of lipid research, 2009, Volume: 50, Issue:2 Topics: Animals; Calibration; Chromatography, Liquid; Humans; Hydroxycholesterols; Microsomes, Liver; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2009
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. Journal of neurochemistry, 2008, Volume: 107, Issue:6 Topics: alpha-Synuclein; Analysis of Variance; Apoptosis; Cell Line, Tumor; Dopamine; Drug Combinations; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Neuroblastoma; Norepinephrine; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase	2008
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. Neuroscience letters, 2009, Oct-02, Volume: 462, Issue:1 Topics: Age Factors; Aged; Alzheimer Disease; Apolipoproteins E; Brain; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cognition Disorders; Female; Genotype; Humans; Hydroxycholesterols; Lanosterol; Male; Middle Aged; Organ Size; Sex Factors	2009
Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. Journal of proteome research, 2011, Jan-07, Volume: 10, Issue:1 Topics: Cell Membrane; Cholestanetriol 26-Monooxygenase; Cholestenes; Cholesterol; Cholesterol 24-Hydroxylase; Humans; Hydroxycholesterols; Isotope Labeling; Mass Spectrometry; Nitrogen Isotopes; Reproducibility of Results; Retina; Steroid Hydroxylases; Temporal Lobe	2011
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging cell, 2011, Volume: 10, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Apoptosis; Brain; CD36 Antigens; Cell Line, Tumor; Genistein; Glutathione; Glutathione Disulfide; Humans; Hydroxycholesterols; Integrin beta Chains; NADPH Oxidases; Necrosis; Neurons; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Plaque, Amyloid; Quercetin; Reactive Oxygen Species; Up-Regulation	2011
Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? Free radical biology & medicine, 2011, Jun-15, Volume: 50, Issue:12 Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Allantoin; Biomarkers; Deoxyguanosine; F2-Isoprostanes; Free Radicals; Humans; Hydroxycholesterols; Hydroxyeicosatetraenoic Acids; Ketocholesterols; Male; Middle Aged; Oxidative Stress; Smoking	2011
Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. The Journal of biological chemistry, 2011, Jul-22, Volume: 286, Issue:29 Topics: Angiotensinogen; Animals; Astrocytes; Brain; Cerebral Cortex; Cholesterol, Dietary; Hippocampus; Humans; Hydroxycholesterols; Liver X Receptors; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Oxidation-Reduction; Rats; Renin-Angiotensin System; Spastic Paraplegia, Hereditary; Up-Regulation	2011
side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. Neuro-degenerative diseases, 2012, Volume: 10, Issue:1-4 Topics: Angiotensin-Converting Enzyme 2; Animals; Brain; Cells, Cultured; Hydroxycholesterols; Neurons; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Up-Regulation	2012
Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2012, Volume: 30, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Brain; Cerebrovascular Disorders; Cognition Disorders; Cohort Studies; Female; Humans; Hydroxycholesterols; Magnetic Resonance Imaging; Male; Retrospective Studies	2012
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. Journal of neurochemistry, 2012, Volume: 123, Issue:2 Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Biomarkers; Cholesterol; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Up-Regulation	2012
Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. Neuroscience letters, 2012, Sep-06, Volume: 525, Issue:1 Topics: Apoptosis; Caspase 3; Caspase 7; Cell Differentiation; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; Hydroxycholesterols; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Staurosporine	2012
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. Journal of lipid research, 2013, Volume: 54, Issue:4 Topics: Animals; Brain; Cholestanetriol 26-Monooxygenase; Cholesterol; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Synthase; Liver X Receptors; Male; Mice; Mice, Knockout; Mice, Transgenic; Orphan Nuclear Receptors	2013
Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6 Topics: Adult; Cholesterol; Female; Gas Chromatography-Mass Spectrometry; Gene Expression; Humans; Hydroxycholesterols; Liver X Receptors; Male; Middle Aged; Mixed Function Oxygenases; Orphan Nuclear Receptors; Postmortem Changes; Prefrontal Cortex; Statistics, Nonparametric; Suicide	2013
Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. Brain research, 2013, Jun-23, Volume: 1517 Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Anticholesteremic Agents; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; Blood-Brain Barrier; Brain; Capillary Permeability; Cattle; Cholesterol; Cholesterol, HDL; Coculture Techniques; Dose-Response Relationship, Drug; Endothelial Cells; Hydrocarbons, Fluorinated; Hydroxycholesterols; Neuroglia; Protein Transport; Rats; Sulfonamides; Tritium; Up-Regulation	2013
Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. PloS one, 2013, Volume: 8, Issue:7 Topics: Adult; Aged; Animals; Cholesterol; Female; Humans; Hydroxycholesterols; Male; Mice; Middle Aged; Oxidation-Reduction	2013
Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 2014, Volume: 20, Issue:4 Topics: Adult; Brain; Cholesterol; Female; Gas Chromatography-Mass Spectrometry; Homeostasis; Humans; Hydroxycholesterols; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Nerve Degeneration	2014
Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. Neuroscience letters, 2013, Oct-25, Volume: 555 Topics: Aged; Case-Control Studies; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Parkinson Disease; Time Factors	2013
Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. Biochemical and biophysical research communications, 2014, Apr-11, Volume: 446, Issue:3 Topics: Adolescent; Adult; Aged; Bile Acids and Salts; Body Mass Index; Carotid Intima-Media Thickness; Case-Control Studies; Desmosterol; Female; Humans; Hydroxycholesterols; Hyperlipidemia, Familial Combined; Lanosterol; Male; Middle Aged; Young Adult	2014
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. Aging cell, 2014, Volume: 13, Issue:3 Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Disease Progression; Humans; Hydroxycholesterols; Neurons; Oxidative Stress; Up-Regulation	2014
Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. PloS one, 2014, Volume: 9, Issue:5 Topics: Antioxidants; beta-Cyclodextrins; Cell Line, Tumor; Cell Survival; Chemokine CCL2; Gene Expression Regulation; Humans; Hydroxycholesterols; Inflammation; Inflammation Mediators; Integrin beta1; Interleukin-8; Matrix Metalloproteinase 9; Nanoparticles; Neurodegenerative Diseases; Quercetin	2014
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. Free radical research, 2015, Volume: 49, Issue:2 Topics: Aged; Aged, 80 and over; Arteries; C-Reactive Protein; Female; Humans; Hydroxycholesterols; Inflammation; Male; Middle Aged; Peripheral Arterial Disease	2015
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. BMC neuroscience, 2014, Dec-24, Volume: 15 Topics: Adult; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Female; Humans; Hydroxycholesterols; Male; Mass Spectrometry	2014
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. Journal of the neurological sciences, 2015, Nov-15, Volume: 358, Issue:1-2 Topics: Adolescent; Adult; Biomarkers; Female; Humans; Hydroxycholesterols; Immunologic Factors; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Natalizumab; Treatment Outcome; Young Adult	2015
Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169 Topics: Animals; Antioxidants; Brassica; Catalase; Cholesterol; Exercise Test; Female; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hydroxycholesterols; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Oxidation-Reduction; Oxidative Stress; Oxygen; Physical Conditioning, Animal; Phytochemicals; Plant Extracts; Principal Component Analysis; Rats; Rats, Wistar; Sterols	2017
Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. Lipids in health and disease, 2016, Oct-10, Volume: 15, Issue:1 Topics: Aged; Alzheimer Disease; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Female; Humans; Hydroxycholesterols; Male; Mass Spectrometry; Middle Aged	2016
Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study. Journal of lipid research, 2019, Volume: 60, Issue:7 Topics: Adolescent; Adult; Aged; Apolipoproteins; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Ketocholesterols; Longitudinal Studies; Male; Mass Spectrometry; Middle Aged; Multiple Sclerosis; Oxysterols; Prospective Studies; Young Adult	2019
Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses. Lipids in health and disease, 2019, Oct-25, Volume: 18, Issue:1 Topics: Adult; Cholesterol; Female; Fetal Blood; Fetal Growth Retardation; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Infant, Newborn; Phytosterols; Placenta; Pregnancy; Sitosterols	2019
Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers. The Journal of steroid biochemistry and molecular biology, 2021, Volume: 210 Topics: Adult; Biomarkers; Carrier State; Elasticity Imaging Techniques; Female; Genotype; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hydroxycholesterols; Liver; Male; Prospective Studies	2021
Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum. British journal of clinical pharmacology, 2021, Volume: 87, Issue:11 Topics: Brain; Cholesterol; Female; Humans; Hydroxycholesterols; Male; Oxysterols	2021
Regulation of Th17/Treg Balance by 27-Hydroxycholesterol and 24S-Hydroxycholesterol Correlates with Learning and Memory Ability in Mice. International journal of molecular sciences, 2022, Apr-15, Volume: 23, Issue:8 Topics: Animals; Hydroxycholesterols; Interleukin-17; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Oxysterols; T-Lymphocytes, Regulatory	2022