Page last updated: 2024-09-04

25-hydroxyprotopanaxadiol and ginsenosides

25-hydroxyprotopanaxadiol has been researched along with ginsenosides in 18 studies

Compound Research Comparison

Studies
(25-hydroxyprotopanaxadiol)
Trials
(25-hydroxyprotopanaxadiol)
Recent Studies (post-2010)
(25-hydroxyprotopanaxadiol)
Studies
(ginsenosides)
Trials
(ginsenosides)
Recent Studies (post-2010) (ginsenosides)
210194,821613,179

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.11)29.6817
2010's13 (72.22)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Hao, M; Hill, DL; Rayburn, ER; Wang, H; Wang, W; Zhang, R; Zhao, Y1
Rayburn, ER; Wang, H; Wang, W; Zhang, R; Zhao, Y1
Hao, M; Wang, H; Wang, W; Zhang, R; Zhao, Y1
Bi, XL; Cao, JQ; Guo, YM; Piao, HR; Wang, P; Yuan, HN; Zhang, SJ; Zhao, YQ1
Bi, XL; Piao, HR; Wang, P; Xu, J; Yuan, HN; Zhao, YQ1
Bi, X; Jiang, B; Liu, W; Liu, Y; Mou, Y; Wang, P; Xia, X; Zhao, Y1
Cai, S; Shi, CH; Suo, H; Tang, X; Yang, L; Zhang, X; Zhao, Y1
Bi, X; Fan, D; Hou, Y; Jiang, B; Liu, Y; Mou, T; Wang, P; Xia, X; Zhao, Y1
Cao, JQ; Liu, YF; Qu, FZ; Wang, XD; Zhang, XS; Zhao, C; Zhao, YQ1
Guo, S; Su, G; Wang, X; Zhang, X; Zhao, C; Zhao, Y1
Li, D; Li, Z; Liu, Y; Shen, S; Wang, W; Yu, J; Zhang, R; Zhang, Y1
Li, Z; Liu, C; Liu, X; Wang, Z; Yu, J; Zhang, C1
Guo, J; Liu, Y; Wang, X; Xu, Z; Zhao, Y1
Cao, JQ; Guo, JH; Wang, XD; Zhao, YQ; Zhou, WX1
Guo, J; Su, G; Wang, X; Yuan, W; Zhao, Y1
De Wang, X; Li, T; Li, Y; Yuan, WH; Zhao, YQ1
Cui, X; Li, X; Liu, LP; Piao, HR; Xing, DL; Zhang, QG; Zhao, YQ; Zhou, S1
Li, T; Su, G; Zhao, Y1

Other Studies

18 other study(ies) available for 25-hydroxyprotopanaxadiol and ginsenosides

ArticleYear
Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides.
    The Prostate, 2008, Jun-01, Volume: 68, Issue:8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Fibroblasts; G1 Phase; Ginsenosides; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Xenograft Model Antitumor Assays

2008
Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action.
    Cancer letters, 2009, Jun-18, Volume: 278, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Ginsenosides; Humans; Mice; Pancreatic Neoplasms; Proto-Oncogene Proteins c-mdm2; Triterpenes; Xenograft Model Antitumor Assays

2009
Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors.
    European journal of drug metabolism and pharmacokinetics, 2011, Volume: 35, Issue:3-4

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Chromatography, Liquid; Dose-Response Relationship, Drug; Fruit; Ginsenosides; Humans; Injections, Intravenous; Male; Mice; Mice, Nude; Panax; Pancreatic Neoplasms; Tandem Mass Spectrometry; Tissue Distribution; Xenograft Model Antitumor Assays

2011
Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Ginsenosides; Humans; Inhibitory Concentration 50

2012
Synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol analogs incorporating natural amino acids.
    Steroids, 2013, Volume: 78, Issue:2

    Topics: Amino Acids; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Ginsenosides; Humans

2013
Anti-tumor activity of three novel derivatives of ginsenoside on colorectal cancer cells.
    Steroids, 2014, Volume: 80

    Topics: Antineoplastic Agents, Phytogenic; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Ginsenosides; HCT116 Cells; HT29 Cells; Humans; Molecular Conformation; Panax; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2014
Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: preparation and evaluation.
    International journal of nanomedicine, 2014, Volume: 9

    Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Emulsions; Female; Ginsenosides; Male; Nanomedicine; Rats; Rats, Wistar; Sapogenins; Solubility; Surface-Active Agents

2014
Anti-tumor activity of three ginsenoside derivatives in lung cancer is associated with Wnt/β-catenin signaling inhibition.
    European journal of pharmacology, 2014, Nov-05, Volume: 742

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; G1 Phase Cell Cycle Checkpoints; Ginsenosides; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Panax; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2014
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
    Bioorganic & medicinal chemistry letters, 2014, Dec-01, Volume: 24, Issue:23

    Topics: Acetates; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Cell Proliferation; Ginsenosides; Humans; Molecular Structure; Neoplasms; Panax; Structure-Activity Relationship

2014
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
    Biotechnology letters, 2016, Volume: 38, Issue:1

    Topics: Antineoplastic Agents; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; Ginsenosides; Humans; Panax; Sapogenins; Signal Transduction; Stomach Neoplasms

2016
Anticancer 20(R)-dammarane-3β,12β,20,25-tetrol-loaded polymeric micelles: Preparation, quantification and pharmacokinetics.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Jun-01, Volume: 1022

    Topics: Animals; Antineoplastic Agents; Chromatography, Liquid; Ginsenosides; Male; Micelles; Particle Size; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry

2016
Inhibitory effects and mechanism of 25-OH-PPD on glomerular mesangial cell proliferation induced by high glucose.
    Environmental toxicology and pharmacology, 2016, Volume: 44

    Topics: Animals; Calcium; Cell Line; Cell Proliferation; Cell Size; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Ginsenosides; Glucose; Glutathione Peroxidase; Hypertrophy; Malondialdehyde; Membrane Proteins; Mesangial Cells; Protective Agents; Rats; Superoxide Dismutase

2016
Synthesis of novel 25-hydroxyprotopanaxadiol derivatives by methylation and methoxycarbonylation using dimethyl carbonate as a environment-friendly reagent and their anti-tumor evaluation.
    Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19

    Topics: Antineoplastic Agents; Cell Line, Tumor; Formates; Ginsenosides; HeLa Cells; Humans; Indicators and Reagents; Inhibitory Concentration 50

2016
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
    Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4

    Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Ginsenosides; Humans; Structure-Activity Relationship; Succinic Acid; Sulfonic Acids

2017
Non-protein amino acid derivatives of 25-methoxylprotopanaxadiol/25-hydroxyprotopanaxadioland their anti-tumour activity evaluation.
    Steroids, 2018, Volume: 129

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Ginsenosides; HCT116 Cells; Humans

2018
2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells.
    European journal of pharmacology, 2020, Aug-15, Volume: 881

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Ginsenosides; Humans; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms

2020
The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria.
    Chemico-biological interactions, 2021, Apr-25, Volume: 339

    Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Connexin 43; Connexins; Down-Regulation; Fibrosis; Gap Junction alpha-5 Protein; Gap Junctions; Ginsenosides; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1; Transforming Growth Factor beta1; Up-Regulation

2021
Anti-hepatic fibrosis effects of AD-2 affecting the Raf-MEK signaling pathway and inflammatory factors in thioacetamide-induced liver injury.
    Journal of food science, 2021, Volume: 86, Issue:6

    Topics: Animals; Chemical and Drug Induced Liver Injury, Chronic; Ginsenosides; Inflammation; Liver Cirrhosis; Male; Mice; Mitogen-Activated Protein Kinase Kinases; Panax; raf Kinases; Signal Transduction; Thioacetamide

2021