24,25-epoxycholesterol has been researched along with t0901317 in 12 studies
| Studies (24,25-epoxycholesterol) | Trials (24,25-epoxycholesterol) | Recent Studies (post-2010) (24,25-epoxycholesterol) | Studies (t0901317) | Trials (t0901317) | Recent Studies (post-2010) (t0901317) |
|---|---|---|---|---|---|
| 65 | 0 | 18 | 567 | 3 | 330 |
| Protein | Taxonomy | 24,25-epoxycholesterol (IC50) | t0901317 (IC50) |
|---|---|---|---|
| Chain A, Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.1 | |
| Chain A, Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.1 | |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | 0.0386 | |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | 2.3 | |
| Presenilin-1 | Homo sapiens (human) | 4.5 | |
| Presenilin-2 | Homo sapiens (human) | 4.5 | |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | 1.6113 | |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.4688 | |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | 0.0223 | |
| Gamma-secretase subunit APH-1B | Homo sapiens (human) | 4.5 | |
| Nicastrin | Homo sapiens (human) | 4.5 | |
| Nuclear receptor ROR-beta | Homo sapiens (human) | 10 | |
| Gamma-secretase subunit APH-1A | Homo sapiens (human) | 4.5 | |
| Bile acid receptor | Homo sapiens (human) | 5.3 | |
| Gamma-secretase subunit PEN-2 | Homo sapiens (human) | 4.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaudet, EJ; Binz, JG; Collins, JL; Fivush, AM; Galardi, CM; Kliewer, SA; Lewis, MC; Moore, LB; Morgan, DG; Parks, DJ; Plunket, KD; Tippin, TK; Watson, MA; Whitney, KD; Willson, TM; Wilson, JG | 1 |
| Cutler, S; Hasegawa, H; Li, L; Liu, J; Medina, JC; Shan, B; Zhu, L | 1 |
| Barbosa, M; Cheng, JF; Fukushima, C; Jack, R; Ogiku, T; Sakurai, N; Takedomi, K; Xu, K; Yang, G; Zapf, J; Zhang, SH | 1 |
| Lindquist, J; Macsari, I; Neelissen, J; Ohberg, L; Sjödin, J; Swahn, BM; Viklund, J | 1 |
| Bukhtiyarov, Y; Chen, G; Claremon, DA; Dong, C; Fan, KY; Gregg, RE; Guo, J; Hardy, A; Howard, L; Kandpal, G; Krosky, P; Lala, D; Leftheris, K; Lindblom, PR; Lipinski, K; Liu, Z; Lotesta, SD; McGeehan, GM; McKeever, BM; Meng, S; Noto, PB; Shimada, J; Singh, SB; Tice, CM; Van Orden, R; Wu, Z; Zhao, W; Zhao, Y; Zheng, Y; Zhou, J; Zhuang, L | 1 |
| Bledsoe, RK; Boggs, S; Collins, JL; Lambert, MH; McKee, DD; Miller, AB; Moore, J; Moore, L; Nichols, J; Parks, D; Watson, M; Williams, S; Willson, TM; Wisely, B | 1 |
| Kaneko, E; Makishima, M; Matsuda, M; Shimomura, I; Tachibana, Y; Yamada, Y | 1 |
| Duniec-Dmuchowski, Z; Ellis, E; Kocarek, TA; Strom, SC | 1 |
| Ai, N; Ekins, S; Hagey, LR; Krasowski, MD; Reschly, EJ; Welsh, WJ | 1 |
| Bussolino, F; Morello, F; Mulatero, P; Noghero, A; Saglio, E; Schiavone, D; Veglio, F; Verhovez, A; Williams, TA | 1 |
| Kim, YS; Trasino, SE; Wang, TT | 1 |
| Chen, X; Li, L; Liao, Q; Wu, Y; Zeng, J | 1 |
12 other study(ies) available for 24,25-epoxycholesterol and t0901317
| Article | Year |
|---|---|
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Topics: Administration, Oral; Amines; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Availability; Cell-Free System; Cholesterol; Cholesterol, HDL; DNA-Binding Proteins; Genes, Reporter; Humans; Intestine, Small; Liver X Receptors; Macrophages; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; Structure-Activity Relationship; Up-Regulation | 2002 |
Discovery and optimization of a novel series of liver X receptor-alpha agonists.
Topics: Administration, Oral; Animals; Cholesterol; DNA-Binding Proteins; Fluorescence Polarization; Hydrocarbons, Fluorinated; Ligands; Liver X Receptors; Male; Molecular Structure; Orphan Nuclear Receptors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Sulfonamides | 2006 |
Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.
Topics: Benzoates; Benzylamines; Binding Sites; Computer Simulation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Profiling; Hydrocarbons, Fluorinated; Ligands; Liver X Receptors; Models, Molecular; Molecular Structure; Oligonucleotide Array Sequence Analysis; Orphan Nuclear Receptors; Phenazocine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterols; Structure-Activity Relationship; Sulfonamides | 2008 |
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Topics: Amides; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Brain; Cell Line; Computer Simulation; DNA-Binding Proteins; Genes, Reporter; Humans; Lactates; Liver X Receptors; Mice; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Sulfonamides; Up-Regulation | 2009 |
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Topics: Benzylamines; Binding Sites; Crystallography, X-Ray; Drug Design; Drug Discovery; Humans; Liver X Receptors; Orphan Nuclear Receptors; Piperazines; Pyrimidines; Structure-Activity Relationship; Sulfones | 2016 |
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
Topics: Anticholesteremic Agents; Binding Sites; Cholesterol; Crystallography, X-Ray; DNA-Binding Proteins; Histidine; Humans; Hydrocarbons, Fluorinated; Hydrogen Bonding; In Vitro Techniques; Ligands; Liver; Liver X Receptors; Models, Molecular; Mutagenesis, Site-Directed; Orphan Nuclear Receptors; Protein Conformation; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Sulfonamides; Tryptophan | 2003 |
Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
Topics: Animals; Anticholesteremic Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Nucleus; Cholesterol; DNA-Binding Proteins; Dose-Response Relationship, Drug; Ergosterol; Genes, Reporter; Glutathione Transferase; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Intestinal Mucosa; Ligands; Liver; Liver X Receptors; Mice; Models, Chemical; Orphan Nuclear Receptors; Phytosterols; Protein Binding; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Time Factors; Transfection | 2003 |
Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.
Topics: Adult; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Cell Line; Cells, Cultured; Cholesterol; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Infant; Liver X Receptors; Male; Middle Aged; Orphan Nuclear Receptors; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sulfonamides; Transfection | 2007 |
Ligand specificity and evolution of liver X receptors.
Topics: Androstenes; Animals; Benzoates; Benzylamines; Carbazoles; Cell Line, Tumor; Cholesterol; Ciona intestinalis; DNA-Binding Proteins; Evolution, Molecular; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Liver X Receptors; Mice; Molecular Structure; Orphan Nuclear Receptors; Phylogeny; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Sulfonamides; Xenopus laevis; Zebrafish | 2008 |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Topics: Anticholesteremic Agents; Benzoates; Benzylamines; Cells, Cultured; Chemokines; Cholesterol; E-Selectin; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Liver X Receptors; Orphan Nuclear Receptors; RNA Interference; RNA, Messenger; Signal Transduction; Sulfonamides; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2009 |
Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.
Topics: ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cholesterol; DNA-Binding Proteins; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Liver X Receptors; Male; Neoplasms, Hormone-Dependent; Orphan Nuclear Receptors; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured | 2009 |
Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.
Topics: Antiviral Agents; Benzoates; Benzylamines; Cell Line; Cholesterol; Dose-Response Relationship, Drug; Hepacivirus; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Liver X Receptors; Orphan Nuclear Receptors; Sulfonamides; Ubiquitin-Protein Ligases; Virus Internalization | 2012 |