24,25-epoxycholesterol has been researched along with gw 3965 in 7 studies
| Studies (24,25-epoxycholesterol) | Trials (24,25-epoxycholesterol) | Recent Studies (post-2010) (24,25-epoxycholesterol) | Studies (gw 3965) | Trials (gw 3965) | Recent Studies (post-2010) (gw 3965) |
|---|---|---|---|---|---|
| 65 | 0 | 18 | 235 | 0 | 164 |
| Protein | Taxonomy | 24,25-epoxycholesterol (IC50) | gw 3965 (IC50) |
|---|---|---|---|
| Alpha-glucosidase MAL32 | Saccharomyces cerevisiae S288C | 4.8 | |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | 0.47 | |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | 0.5691 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beaudet, EJ; Binz, JG; Collins, JL; Fivush, AM; Galardi, CM; Kliewer, SA; Lewis, MC; Moore, LB; Morgan, DG; Parks, DJ; Plunket, KD; Tippin, TK; Watson, MA; Whitney, KD; Willson, TM; Wilson, JG | 1 |
| Barbosa, M; Cheng, JF; Fukushima, C; Jack, R; Ogiku, T; Sakurai, N; Takedomi, K; Xu, K; Yang, G; Zapf, J; Zhang, SH | 1 |
| Lindquist, J; Macsari, I; Neelissen, J; Ohberg, L; Sjödin, J; Swahn, BM; Viklund, J | 1 |
| Bukhtiyarov, Y; Chen, G; Claremon, DA; Dong, C; Fan, KY; Gregg, RE; Guo, J; Hardy, A; Howard, L; Kandpal, G; Krosky, P; Lala, D; Leftheris, K; Lindblom, PR; Lipinski, K; Liu, Z; Lotesta, SD; McGeehan, GM; McKeever, BM; Meng, S; Noto, PB; Shimada, J; Singh, SB; Tice, CM; Van Orden, R; Wu, Z; Zhao, W; Zhao, Y; Zheng, Y; Zhou, J; Zhuang, L | 1 |
| Ai, N; Ekins, S; Hagey, LR; Krasowski, MD; Reschly, EJ; Welsh, WJ | 1 |
| Bussolino, F; Morello, F; Mulatero, P; Noghero, A; Saglio, E; Schiavone, D; Veglio, F; Verhovez, A; Williams, TA | 1 |
| Chen, X; Li, L; Liao, Q; Wu, Y; Zeng, J | 1 |
7 other study(ies) available for 24,25-epoxycholesterol and gw 3965
| Article | Year |
|---|---|
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Topics: Administration, Oral; Amines; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Availability; Cell-Free System; Cholesterol; Cholesterol, HDL; DNA-Binding Proteins; Genes, Reporter; Humans; Intestine, Small; Liver X Receptors; Macrophages; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; Structure-Activity Relationship; Up-Regulation | 2002 |
Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.
Topics: Benzoates; Benzylamines; Binding Sites; Computer Simulation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Profiling; Hydrocarbons, Fluorinated; Ligands; Liver X Receptors; Models, Molecular; Molecular Structure; Oligonucleotide Array Sequence Analysis; Orphan Nuclear Receptors; Phenazocine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterols; Structure-Activity Relationship; Sulfonamides | 2008 |
Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
Topics: Amides; Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Brain; Cell Line; Computer Simulation; DNA-Binding Proteins; Genes, Reporter; Humans; Lactates; Liver X Receptors; Mice; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Sulfonamides; Up-Regulation | 2009 |
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Topics: Benzylamines; Binding Sites; Crystallography, X-Ray; Drug Design; Drug Discovery; Humans; Liver X Receptors; Orphan Nuclear Receptors; Piperazines; Pyrimidines; Structure-Activity Relationship; Sulfones | 2016 |
Ligand specificity and evolution of liver X receptors.
Topics: Androstenes; Animals; Benzoates; Benzylamines; Carbazoles; Cell Line, Tumor; Cholesterol; Ciona intestinalis; DNA-Binding Proteins; Evolution, Molecular; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Liver X Receptors; Mice; Molecular Structure; Orphan Nuclear Receptors; Phylogeny; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Sulfonamides; Xenopus laevis; Zebrafish | 2008 |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Topics: Anticholesteremic Agents; Benzoates; Benzylamines; Cells, Cultured; Chemokines; Cholesterol; E-Selectin; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Liver X Receptors; Orphan Nuclear Receptors; RNA Interference; RNA, Messenger; Signal Transduction; Sulfonamides; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2009 |
Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.
Topics: Antiviral Agents; Benzoates; Benzylamines; Cell Line; Cholesterol; Dose-Response Relationship, Drug; Hepacivirus; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Liver X Receptors; Orphan Nuclear Receptors; Sulfonamides; Ubiquitin-Protein Ligases; Virus Internalization | 2012 |