Page last updated: 2024-08-26

22-hydroxycholesterol and pregnenolone

22-hydroxycholesterol has been researched along with pregnenolone in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19908 (20.00)18.7374
1990's15 (37.50)18.2507
2000's10 (25.00)29.6817
2010's7 (17.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tuckey, RC1
Calkins, JH; Guo, H; Lin, T; Sigel, MM1
Grochowski, D; Szamatowicz, M2
Hoogerbrugge, JW; Rommerts, FF; Teerds, KJ1
Cupp, JR; Vickery, LE1
Degenhart, HJ; Huijmans, JG; Kortleve, DJ; Visser, HK1
Degenhart, HJ; Huijmans, JG; Kortleve, DJ1
Alsema, GJ; Degenhart, HJ; Hoogerbrugge, J1
Brannian, JD; Christianson, H; Flynn, S; Kurz, SG1
Darbeida, H; Durand, P; Picard-Hagen, N1
Abayasekara, RE; Flint, AP1
Risbridger, GP; Sun, XR1
Abayasekara, DR; Flint, AP; Michael, AE; Webley, GE1
Clark, BJ; Stocco, DM; Wells, J1
Cornejo Maciel, MF; Cymeryng, CB; Dada, LA; Finkielstein, CV; Mele, PG; Mendez, CF; Neuman, MI; Paz, C; Podestá, EJ1
Miura, R; Morishima, N; Sugano, S1
Colás, B; López-Ruiz, MP; Marinero, MJ; Oliva, JL; Penalva, V; Prieto, JC1
Cooke, BA; Dirami, G1
Bosc, MJ; Nicolle, A1
Deis, RP; Stocco, CO1
Colonna, C; Cymeryng, CB; Dada, LA; Mendez, CF; Podestá, EJ1
Burns, CJ; Gyles, S; Jones, PM; Persaud, SJ; Sayed, SB; Whitehouse, BJ1
Huang, BM; Lai, HY; Liu, MY; Tsai, ML; Yang, BC; Yang, HY1
Benahmed, M; Besset, V; Dacheux, F; Gasnier, F; Goddard, I; Mauduit, C; Rey, C; Tabone, E1
Huang, MC; Miller, WL1
Jezová, M; Kolena, J; Vrsanská, S1
Goldman, JM; Murr, AS1
Cheng, J; Fu, JL; Zhou, ZC1
CHAUDHURI, AC; DORFMAN, RI; GUT, M; HARADA, Y; SHIMIZU, K1
Bose, HS; Culty, M; Hales, DB; Han, Z; Hauet, T; Li, W; Miller, WL; Papadopoulos, V; Wall, CT; Yao, ZX1
Cui, LB; Hong, X; Song, L; Wang, XR; Wang, YB; Zhang, ZD1
Chen, JF; Hong, X; Qu, JH; Song, L; Sun, H; Wang, SL; Wang, XR; Wang, YB; Xu, XL1
Chen, W; Sheu, HM; Tsai, JC; Tsai, SJ; Zouboulis, CC1
Acquier, A; García, MM; Gomez, NV; Gorostizaga, A; Mendez, CF; Paz, C; Suarez, G1
Davydov, R; Gilep, A; Hoffman, BM; Smil, D; Strushkevich, N; Usanov, S; Yantsevich, A1
Chebbi, S; Hullin-Matsuda, F; Kobayashi, T; Martinez-Arguelles, DB; Papadopoulos, V; Venugopal, S1
Hatoya, S; Inaba, T; Ito, M; Kawate, N; Morii, H; Ohta, Y; Takahashi, K; Takahashi, M; Tamada, H; Yoshida, K1
Azhar, S; Guo, Z; Hu, Z; Li, J; Ma, Z; Shen, WJ; Wang, M; Zhou, Q1
Efimova, VS; Isaeva, LV; Novikova, LA; Rubtsov, MA1

Other Studies

40 other study(ies) available for 22-hydroxycholesterol and pregnenolone

ArticleYear
Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 42, Issue:8

    Topics: Animals; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Female; Humans; Hydroxycholesterols; Hydroxylation; Mitochondria; Placenta; Pregnenolone; Rats

1992
Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis.
    Endocrinology, 1990, Volume: 127, Issue:3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Hydroxycholesterols; Interleukin-2; Leydig Cells; Male; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Recombinant Proteins; Testosterone

1990
[The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. II. Effects of LH, hCG, dbcAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolone and testosteron
    Ginekologia polska, 1989, Volume: 60, Issue:5

    Topics: Animals; Bucladesine; Cells, Cultured; Chorionic Gonadotropin; Culture Media; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Humans; Hydroxycholesterols; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; NAD; NADP; Pregnenolone; Rats; Rats, Inbred Strains; Stimulation, Chemical; Testosterone

1989
[The role of gonadotropins, cyclic AMP, 22-R-OH-cholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. III. Mechanisms responsible for "desensitization" of the Leydig cells of rats caused by high doses of hCG].
    Ginekologia polska, 1989, Volume: 60, Issue:5

    Topics: Aldehyde-Lyases; Animals; Bucladesine; Cells, Cultured; Chorionic Gonadotropin; Culture Media; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Humans; Hydroxycholesterols; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Mixed Function Oxygenases; NAD; NADP; Pregnenolone; Rats; Rats, Inbred Strains; Steroid 17-alpha-Hydroxylase; Testosterone

1989
In vitro effects of ethylene-dimethane sulfonate (EDS) on Leydig cells: inhibition of steroid production and cytotoxic effects are dependent on species and age of rat.
    Molecular and cellular endocrinology, 1988, Volume: 55, Issue:1

    Topics: Adenosine Triphosphate; Aging; Alkylating Agents; Animals; Cells, Cultured; Hydroxycholesterols; Leydig Cell Tumor; Leydig Cells; Liver; Luteinizing Hormone; Male; Mesylates; Mice; Pregnenolone; Proteins; Rats; Sertoli Cells; Sexual Maturation; Species Specificity; Testicular Neoplasms; Testis

1988
Adrenodoxin with a COOH-terminal deletion (des 116-128) exhibits enhanced activity.
    The Journal of biological chemistry, 1989, Jan-25, Volume: 264, Issue:3

    Topics: Adrenodoxin; Amino Acid Sequence; Animals; Carboxypeptidases; Cattle; Cholesterol; Cytochrome P-450 Enzyme System; Hydroxycholesterols; Kinetics; Molecular Weight; NADH Dehydrogenase; Peptide Fragments; Pregnenolone; Structure-Activity Relationship; Trypsin

1989
Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells.
    Acta endocrinologica, 1981, Volume: 97, Issue:2

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cholestadienols; Cholesterol; Corticosterone; Cyclic AMP; Desmosterol; Hydroxycholesterols; Ketocholesterols; Male; Pregnenolone; Rats; Sterols

1981
Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria.
    Acta endocrinologica, 1982, Volume: 100, Issue:4

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Binding Sites; Cattle; Cells, Cultured; Cholesterol; Chromatography, Gas; Corticosterone; Cytochrome P-450 Enzyme System; Hydroxycholesterols; Male; Mitochondria; Pregnenolone; Rats; Rats, Inbred Strains

1982
Side chain cleavage of hydroxylated sterols by bovine adrenal cortex mitochondria: observation of 25-hydroxylase activity during incubation at pH 7.80.
    Journal of steroid biochemistry, 1980, Volume: 13, Issue:5

    Topics: Adrenal Cortex; Animals; Cattle; Cholestanetriol 26-Monooxygenase; Hydrogen-Ion Concentration; Hydroxycholesterols; Hydroxylation; Mitochondria; Pregnenolone; Steroid Hydroxylases

1980
Loss of low-density lipoprotein utilization by regressing porcine luteal cells: effects of protein kinase C activation.
    Biology of reproduction, 1995, Volume: 52, Issue:4

    Topics: Animals; Aprotinin; Corpus Luteum; Enzyme Activation; Estrus; Female; Hydroxycholesterols; Insulin; Lipoproteins, LDL; Luteolysis; Pregnenolone; Progesterone; Protein Kinase C; Sodium Selenite; Swine; Tetradecanoylphorbol Acetate; Transferrin

1995
Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 55, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adrenodoxin; Aminoglutethimide; Animals; Calcium Chloride; Cells, Cultured; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Ferredoxin-NADP Reductase; Glucocorticoids; Hydroxycholesterols; Metyrapone; Mitochondria; Pregnenolone; RNA, Messenger; Sheep; Steroids

1995
A novel phospholipase C inhibitor U73122, inhibits phospholipase C-independent processes in rat luteal cells.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: Animals; Bucladesine; Cells, Cultured; Chorionic Gonadotropin; Corpus Luteum; Cyclic AMP; Estrenes; Female; Gonadotropins, Equine; Hydroxycholesterols; Luteinizing Hormone; Pregnenolone; Progesterone; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases

1993
Site of macrophage inhibition of luteinizing hormone-stimulated testosterone production by purified leydig cells.
    Biology of reproduction, 1994, Volume: 50, Issue:2

    Topics: Androstenedione; Animals; Bucladesine; Cholera Toxin; Culture Media, Conditioned; Dehydroepiandrosterone; Hydroxycholesterols; Kinetics; Leydig Cells; Luteinizing Hormone; Macrophages; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Testis; Testosterone

1994
Mode of action of prostaglandin F2 alpha in human luteinized granulosa cells: role of protein kinase C.
    Molecular and cellular endocrinology, 1993, Volume: 97, Issue:1-2

    Topics: Bucladesine; Calcium; Cells, Cultured; Cholera Toxin; Cloprostenol; Colforsin; Cyclic AMP; Dinoprost; Female; Granulosa Cells; Humans; Hydroxycholesterols; Luteinizing Hormone; Pregnenolone; Progesterone; Protein Kinase C; Tetradecanoylphorbol Acetate

1993
The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells.
    Endocrinology, 1993, Volume: 133, Issue:6

    Topics: Animals; Bucladesine; Hydrogen Peroxide; Hydroxycholesterols; Leydig Cell Tumor; Mice; Mitochondria; Neoplasm Proteins; Pregnenolone; Progesterone; Proteins; Steroids; Tumor Cells, Cultured

1993
Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland.
    Biochimica et biophysica acta, 1996, Feb-29, Volume: 1310, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Arachidonic Acid; Corticosterone; Cyclic AMP; Endopeptidases; Hydroxycholesterols; In Vitro Techniques; Kinetics; Male; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Pregnenolone; Progesterone; Protease Inhibitors; Rats; Rats, Wistar; Zona Fasciculata

1996
Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome p-450scc system: accumulation of the intermediate modulated by the adrenodoxin level.
    Journal of biochemistry, 1996, Volume: 120, Issue:4

    Topics: Adrenodoxin; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Hydroxycholesterols; Magnetic Resonance Spectroscopy; Mass Spectrometry; Osmolar Concentration; Pregnenolone

1996
Specific effect of arachidonic acid on 17beta-hydroxysteroid dehydrogenase in rat Leydig cells.
    FEBS letters, 1998, Jan-23, Volume: 422, Issue:1

    Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androstenediol; Androstenedione; Animals; Arachidonic Acid; Cholesterol; Hydroxycholesterols; Leydig Cells; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Testosterone

1998
Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells.
    Toxicology and applied pharmacology, 1998, Volume: 150, Issue:2

    Topics: Administration, Oral; Animals; Aromatase; Cell Separation; Chorionic Gonadotropin; Cyclic AMP; Dopamine Agonists; Ergolines; Hydroxycholesterols; Iodine Radioisotopes; Leydig Cells; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, LH; Serotonin Antagonists; Signal Transduction; Testosterone

1998
Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves.
    Animal reproduction science, 1998, Apr-16, Volume: 51, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Animals; Cattle; Cells, Cultured; Chorionic Gonadotropin; Dehydroepiandrosterone; Female; Hydroxycholesterols; Ovarian Follicle; Ovulation; Pregnenolone; Progesterone; Theca Cells; Time Factors

1998
Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy.
    Biology of reproduction, 1999, Volume: 60, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; Animals; Bucladesine; Calcium Channel Blockers; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Female; Gallic Acid; Gestational Age; Hydroxycholesterols; Luteal Cells; Luteinizing Hormone; Phosphodiesterase Inhibitors; Pregnancy; Pregnenolone; Progesterone; Rats; Rats, Wistar; Sheep

1999
Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase.
    Endocrinology, 1999, Volume: 140, Issue:7

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Arginine; Corticosterone; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydroxycholesterols; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Ornithine; Pregnenolone; Rats; Rats, Wistar; Zona Fasciculata

1999
Cyclic AMP-induced expression of steroidogenic acute regulatory protein is dependent upon phosphoprotein phosphatase activities.
    Journal of molecular endocrinology, 2000, Volume: 24, Issue:2

    Topics: Adrenal Cortex; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydroxycholesterols; Isoenzymes; Kinetics; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoproteins; Pregnenolone; Progesterone; Protein Tyrosine Phosphatases; Steroids

2000
The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells.
    Life sciences, 2001, Jan-12, Volume: 68, Issue:8

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Bucladesine; Cadmium; Calcium Channel Blockers; Calcium Channels; Chorionic Gonadotropin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Hydroxycholesterols; Lead; Leydig Cell Tumor; Leydig Cells; Male; Mice; Organometallic Compounds; Phosphoproteins; Pregnenolone; Progesterone; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured

2001
Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action.
    Endocrinology, 2001, Volume: 142, Issue:6

    Topics: Androstenedione; Animals; Cells, Cultured; Cholera Toxin; Cholesterol; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dehydroepiandrosterone; Dinoprostone; Gene Expression; Growth Inhibitors; Hydroxycholesterols; Interleukin-6; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Leydig Cells; Luteinizing Hormone; Lymphokines; Male; Mitochondria; Phosphoproteins; Pregnenolone; Receptors, Cytokine; Receptors, OSM-LIF; RNA, Messenger; Swine; Testis; Testosterone

2001
Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system.
    Endocrinology, 2001, Volume: 142, Issue:6

    Topics: Adrenodoxin; Animals; Blotting, Western; Carbon Radioisotopes; Cholesterol Side-Chain Cleavage Enzyme; COS Cells; Ferredoxin-NADP Reductase; Gene Expression; Humans; Hydroxycholesterols; Mitochondria; Phosphoproteins; Pregnenolone; Progesterone; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Steroids; Transfection

2001
Luteinization factor-stimulated steroidogenesis in porcine granulosa cells.
    General physiology and biophysics, 2001, Volume: 20, Issue:2

    Topics: Animals; Biological Factors; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; Female; Follicle Stimulating Hormone; Granulosa Cells; Hydroxycholesterols; Pregnenolone; Progesterone; Swine

2001
Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway.
    Toxicology, 2002, Feb-28, Volume: 171, Issue:2-3

    Topics: Acetates; Animals; Chorionic Gonadotropin; Disinfectants; Estradiol; Female; Fresh Water; Gonadotropins, Equine; Hydroxycholesterols; Organ Culture Techniques; Ovarian Follicle; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Time Factors

2002
The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression.
    Toxicology, 2003, May-03, Volume: 187, Issue:2-3

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hydroxycholesterols; Leydig Cells; Male; Manganese; Mitochondria; Phosphoproteins; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Steroids; Stimulation, Chemical; Testosterone

2003
Biosynthesis of pregnenolone from 22-hydroxycholesterol.
    The Journal of biological chemistry, 1962, Volume: 237

    Topics: Cholesterol; Hydroxycholesterols; Pregnenolone

1962
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.
    Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:2

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Cholesterol; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Gonadotropins; Humans; Hydroxycholesterols; Immunoblotting; In Vitro Techniques; Kinetics; Leydig Cells; Ligands; Male; Mice; Mitochondria; Mutation; Mutation, Missense; Oligonucleotides; Oligonucleotides, Antisense; Peptides; Phosphoproteins; Pregnenolone; Protein Binding; Protein Biosynthesis; Receptors, GABA-A; RNA, Small Interfering; Steroids; Time Factors; Transcription, Genetic; Transfection

2005
Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1).
    Journal of toxicology and environmental health. Part A, 2007, Volume: 70, Issue:11

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line, Tumor; Cell Survival; Cholera Toxin; Chorionic Gonadotropin; Cyclic AMP; DNA Replication; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Endocrine Disruptors; Humans; Hydroxycholesterols; Leydig Cell Tumor; Male; Mice; Mitochondria; Phosphoproteins; Phthalic Acids; Pregnenolone; Progesterone; RNA, Messenger; Testicular Neoplasms

2007
Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway.
    Toxicology letters, 2008, Jan-04, Volume: 176, Issue:1

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cholera Toxin; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxycholesterols; Insecticides; Leydig Cell Tumor; Male; Mice; Nitriles; Phosphoproteins; Pregnenolone; Progesterone; Pyrethrins; RNA, Messenger; Signal Transduction

2008
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
    Experimental dermatology, 2010, Volume: 19, Issue:5

    Topics: 17-alpha-Hydroxyprogesterone; Cell Line, Transformed; Cholesterol; Chorionic Gonadotropin; Colforsin; Cyclic CMP; Dehydroepiandrosterone; Dexamethasone; Female; Fibroblast Growth Factor 9; Humans; Hydroxycholesterols; Insulin; Insulin-Like Growth Factor I; Interleukin-1beta; Pregnenolone; Progesterone; Sebaceous Glands; Testosterone

2010
Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.
    Chemico-biological interactions, 2012, Sep-30, Volume: 199, Issue:3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Base Sequence; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Cisplatin; Humans; Hydroxycholesterols; In Vitro Techniques; Leydig Cells; Male; Mice; Mice, Inbred BALB C; Pregnenolone; Reactive Oxygen Species; RNA, Messenger; Testosterone

2012
Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.
    Biochemistry, 2015, Dec-08, Volume: 54, Issue:48

    Topics: Animals; Cattle; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Electron Spin Resonance Spectroscopy; Humans; Hydroxycholesterols; Hydroxylation; Oxidation-Reduction; Pregnenolone

2015
Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells.
    The Journal of biological chemistry, 2016, Dec-09, Volume: 291, Issue:50

    Topics: Animals; Bacterial Toxins; Biological Transport, Active; Bucladesine; Cell Line, Tumor; Cell Membrane; Hemolysin Proteins; Hydroxycholesterols; Leydig Cells; Male; Mice; Mitochondria; Pregnenolone; Rats

2016
Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats.
    Andrologia, 2018, Volume: 50, Issue:1

    Topics: Aging; Animals; Chorionic Gonadotropin; Hydroxycholesterols; Lepidium; Leydig Cells; Male; Plant Extracts; Pregnenolone; Rats; Testosterone

2018
Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis.
    Reproductive biology and endocrinology : RB&E, 2017, Mar-16, Volume: 15, Issue:1

    Topics: Adrenal Cortex Neoplasms; Animals; Blotting, Western; Catalase; Cell Line, Tumor; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP Response Element-Binding Protein; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hydrogen Peroxide; Hydroxycholesterols; Mice; Oxidants; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Pregnenolone; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Steroids; Superoxide Dismutase

2017
Analysis of In Vivo Activity of the Bovine Cholesterol Hydroxylase/Lyase System Proteins Expressed in Escherichia coli.
    Molecular biotechnology, 2019, Volume: 61, Issue:4

    Topics: Adrenodoxin; Animals; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Escherichia coli; Ferredoxin-NADP Reductase; Gene Expression; Genetic Engineering; Hydroxycholesterols; Mass Spectrometry; NADP; Pregnenolone; Recombinant Proteins

2019