20-hydroxy-5,8,11,14-eicosatetraenoic acid and nifedipine

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with nifedipine in 2 studies

Compound Research Comparison

Studies (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Trials (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Recent Studies (post-2010) (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Studies (nifedipine)	Trials (nifedipine)	Recent Studies (post-2010) (nifedipine)
640	13	233	16,024	2,496	1,505

Protein Interaction Comparison

Protein	Taxonomy	nifedipine (IC50)
perilipin-5	Homo sapiens (human)	7.133
perilipin-1	Homo sapiens (human)	9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	8.376
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	0.0429
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	0.035
Cytochrome P450 1A2	Homo sapiens (human)	0.3
Cytochrome P450 3A4	Homo sapiens (human)	10
Adenosine receptor A3	Homo sapiens (human)	7.214
Cytochrome P450 2C9	Homo sapiens (human)	3.06
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	10
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	7.214
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	0.0385
Potassium voltage-gated channel subfamily A member 5	Homo sapiens (human)	6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	Rattus norvegicus (Norway rat)	1.12
Adenosine receptor A1	Homo sapiens (human)	7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2	Rattus norvegicus (Norway rat)	1.12
C-C chemokine receptor type 2	Homo sapiens (human)	2.191
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	7.214
Cytochrome P450 2J2	Homo sapiens (human)	3.06
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	0.4733
Voltage-dependent L-type calcium channel subunit alpha-1C	Mus musculus (house mouse)	1.2
Voltage-dependent L-type calcium channel subunit alpha-1S	Mus musculus (house mouse)	1.2
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	0.035
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	0.0394
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	2.02
Potassium channel subfamily K member 2	Bos taurus (cattle)	8.2
Indoleamine 2,3-dioxygenase 2	Mus musculus (house mouse)	1.5
Voltage-dependent L-type calcium channel subunit alpha-1D	Mus musculus (house mouse)	1.2
Voltage-dependent L-type calcium channel subunit alpha-1F	Mus musculus (house mouse)	1.2

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aebly, MR; Gebremedhin, D; Harder, DR; Jacobs, ER; Lange, AR; Narayanan, J	1
Holstein-Rathlou, NH; Jensen, LJ; Ngo, AT; Riemann, M; Torp-Pedersen, C	1

Other Studies

2 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and nifedipine

Article	Year
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. The Journal of physiology, 1998, Mar-15, Volume: 507 ( Pt 3) Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cats; Cerebral Arteries; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Primers; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Membrane Potentials; Mixed Function Oxygenases; Molecular Sequence Data; Muscle, Smooth, Vascular; Nifedipine; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Vasoconstriction; Vasoconstrictor Agents	1998
Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo. BMC physiology, 2013, May-12, Volume: 13 Topics: Animals; Arterioles; Calcium Channels, L-Type; Cromakalim; Cytochrome P-450 Enzyme System; Glyburide; Hydroxyeicosatetraenoic Acids; KATP Channels; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase; Oxygen; Retinoic Acid 4-Hydroxylase; Vasoconstriction; Vasodilation	2013

Article

Year

Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current.

The Journal of physiology, 1998, Mar-15, Volume: 507 ( Pt 3)

Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cats; Cerebral Arteries; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Primers; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Membrane Potentials; Mixed Function Oxygenases; Molecular Sequence Data; Muscle, Smooth, Vascular; Nifedipine; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Vasoconstriction; Vasoconstrictor Agents

1998

Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo.

BMC physiology, 2013, May-12, Volume: 13

Topics: Animals; Arterioles; Calcium Channels, L-Type; Cromakalim; Cytochrome P-450 Enzyme System; Glyburide; Hydroxyeicosatetraenoic Acids; KATP Channels; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase; Oxygen; Retinoic Acid 4-Hydroxylase; Vasoconstriction; Vasodilation

2013