Page last updated: 2024-09-03

20-hydroxy-5,8,11,14-eicosatetraenoic acid and ng-nitroarginine methyl ester

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with ng-nitroarginine methyl ester in 19 studies

Compound Research Comparison

Studies
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Trials
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Recent Studies (post-2010)
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Studies
(ng-nitroarginine methyl ester)
Trials
(ng-nitroarginine methyl ester)
Recent Studies (post-2010) (ng-nitroarginine methyl ester)
6401323312,6401172,342

Protein Interaction Comparison

ProteinTaxonomy20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50)ng-nitroarginine methyl ester (IC50)
Neutrophil elastaseHomo sapiens (human)2.7
Nitric oxide synthase, endothelialHomo sapiens (human)2.1
Nitric oxide synthase, brainHomo sapiens (human)1.1167
Nitric oxide synthase, inducibleMus musculus (house mouse)2.6
Nitric oxide synthase, inducibleHomo sapiens (human)8
Collagenase 3Homo sapiens (human)2.7

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's12 (63.16)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balazy, M; Falck, JR; Lu, M; Reddy, KM; Wang, W; Zhu, Y1
McGiff, JC; Oyekan, AO1
Fulton, D; McGiff, JC; Oyekan, AO; Quilley, J; Youseff, T1
Hercule, HC; Oyekan, AO1
Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ1
Falck, JR; Frisbee, JC; Lombard, JH; Murali Krishna, U; Roman, RJ1
Escalante, BA; McGiff, JC; Oyekan, AO1
Chang, HH; Jiang, M; Laniado-Schwartzman, M; Nasjletti, A; Wang, J; Wang, MH; Zand, BA1
Baines, AD; Ho, P1
Brands, MW; Chang, HH; Du, J; Falck, JR; Huang, H; Raju, VT; Wang, CY; Wang, MH; Zhou, Y1
Harder, DR; Miyata, N; Renic, M; Roman, RJ; Takeuchi, K1
Metea, MR; Newman, EA1
Chen, YJ; Li, J; Quilley, J1
Chen, JR; Yang, HY1
De Mey, JG; Hilgers, RH1
Anjaiah, S; Falck, JR; Lombard, JH; Raffai, G; Roman, RJ; Wang, J; Weinberg, B1
Gąsiorowska, A; Kompanowska-Jezierska, E; Kuczeriszka, M; Olszyński, KH; Sadowski, J1
Froogh, G; Huang, A; Jiang, H; Kandhi, S; Le, Y; Luo, M; Qin, J; Sun, D1
Aslan, M; Basralı, F; Nasırcılar Ülker, S; Özcan, F; Özen, N; Şentürk, ÜK; Ülker, P1

Other Studies

19 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and ng-nitroarginine methyl ester

ArticleYear
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney.
    The Journal of general physiology, 1996, Volume: 108, Issue:6

    Topics: Angiotensin II; Animals; Cell Membrane; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Loop of Henle; Naphthalenes; NG-Nitroarginine Methyl Ester; Patch-Clamp Techniques; Penicillamine; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium

1996
Functional response of the rat kidney to inhibition of nitric oxide synthesis: role of cytochrome p450-derived arachidonate metabolites.
    British journal of pharmacology, 1998, Volume: 125, Issue:5

    Topics: Animals; Arachidonic Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Viral Proteins

1998
Renal cytochrome P450 omega-hydroxylase and epoxygenase activity are differentially modified by nitric oxide and sodium chloride.
    The Journal of clinical investigation, 1999, Volume: 104, Issue:8

    Topics: Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mixed Function Oxygenases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Nitroprusside; Rats; Rats, Sprague-Dawley; Sodium Chloride

1999
Role of NO and cytochrome P-450-derived eicosanoids in ET-1-induced changes in intrarenal hemodynamics in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Dansyl Compounds; Eicosanoids; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Hemodynamics; Hydroxyeicosatetraenoic Acids; Indomethacin; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Renal Artery; Renal Circulation; Vascular Resistance

2000
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles

2001
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats.
    Microcirculation (New York, N.Y. : 1994), 2001, Volume: 8, Issue:2

    Topics: Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Hypertension; Hypoxia; In Vitro Techniques; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Dahl; Vascular Resistance; Vasodilation

2001
Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule.
    American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:1

    Topics: Animals; Arachidonic Acid; Biological Transport; Cytochrome P-450 Enzyme System; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Rubidium Radioisotopes; Signal Transduction

2002
Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.
    American journal of physiology. Renal physiology, 2003, Volume: 285, Issue:2

    Topics: Animals; Baculoviridae; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Peroxynitrous Acid; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Recombinant Proteins

2003
20-HETE-mediated vasoconstriction by hemoglobin-O2 carrier in Sprague-Dawley but not Wistar rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:3

    Topics: Animals; Blood Substitutes; Hemoglobins; Hemostasis; Hydroxyeicosatetraenoic Acids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxygen; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Vasoconstriction

2005
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats.
    American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:5

    Topics: Age Factors; Amides; Animals; Blood Pressure; Female; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney Cortex; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pregnancy; Pregnancy, Animal; Rats; Regional Blood Flow; Sulfones

2005
Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:1

    Topics: Animals; Brain; Cerebrovascular Circulation; Formamides; Hemoglobins; Hydroxyeicosatetraenoic Acids; Male; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Time Factors; Vasoconstriction

2006
Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Amidines; Animals; Arterioles; Calcium Signaling; Caproates; Cyclic N-Oxides; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Eye Proteins; Hydrazines; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Miconazole; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Photolysis; Proadifen; Purinergic Antagonists; Rats; Rats, Long-Evans; Retinal Vessels; Signal Transduction; Vasoconstriction; Vasodilation; Vasomotor System

2006
Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:5

    Topics: Aldehyde Reductase; Animals; Antioxidants; Arachidonic Acid; Benzothiazoles; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Hydroxyeicosatetraenoic Acids; Hypoglycemic Agents; Indomethacin; Insulin; Kidney; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Phthalazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Spin Labels; Tyrosine

2008
Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:7

    Topics: Animals; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Soybean Proteins

2008
Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1.
    British journal of pharmacology, 2009, Volume: 156, Issue:8

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bosentan; Calcium Channel Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Gap Junctions; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Paracrine Communication; Phenylephrine; Rats; Rats, Inbred WKY; Receptors, Endothelin; Sulfonamides; Sympathetic Nervous System; Vasoconstriction; Vasoconstrictor Agents

2009
Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats.
    Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:7

    Topics: Amides; Animals; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP4A; Endothelin-1; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypoxia; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Microscopy, Video; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Sulfones; Vascular Resistance; Vasoconstriction

2010
Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake.
    Acta physiologica (Oxford, England), 2011, Volume: 201, Issue:4

    Topics: Animals; Arachidonic Acid; Blood Pressure; Citrulline; Cytochrome P-450 Enzyme System; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sodium, Dietary; Thiourea

2011
Female-favorable attenuation of coronary myogenic constriction via reciprocal activations of epoxyeicosatrienoic acids and nitric oxide.
    American journal of physiology. Heart and circulatory physiology, 2016, 06-01, Volume: 310, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Arterial Pressure; Coronary Vessels; Cytochrome P-450 CYP4A; Enzyme Inhibitors; Epoxide Hydrolases; Female; Genotype; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Mechanotransduction, Cellular; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phenotype; Sex Factors; Vasoconstriction

2016
Effect of 20-HETE inhibition on L-NAME-induced hypertension in rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:3

    Topics: Amidines; Animals; Blood Pressure; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Tissue Culture Techniques; Vascular Resistance; Vasoconstriction; Vasodilation

2018