20-hydroxy-5,8,11,14-eicosatetraenoic acid and n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine in 58 studies

Compound Research Comparison

Studies (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Trials (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Recent Studies (post-2010) (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Studies (n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine)	Trials (n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine)	Recent Studies (post-2010) (n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine)
640	13	233	81	0	37

Protein Interaction Comparison

Protein	Taxonomy	n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine (IC50)
Cytochrome P450 1A2	Homo sapiens (human)	0.461
Cytochrome P450 3A4	Homo sapiens (human)	0.1
Cytochrome P450 2D6	Homo sapiens (human)	0.1
Cytochrome P450 2C9	Homo sapiens (human)	2.935
Cytochrome P450 2C19	Homo sapiens (human)	0.272
Prostaglandin G/H synthase 2	Ovis aries (sheep)	2.3

Research

Studies (58)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	33 (56.90)	29.6817
2010's	22 (37.93)	24.3611
2020's	3 (5.17)	2.80

Authors

Authors	Studies
Doi, M; Ishimoto, T; Kameo, K; Kametani, S; Miyata, N; Sato, M; Sato-Watanabe, M; Seki, T; Taniguchi, K; Tomishima, Y; Ueki, T; Yasuda, Y	1
Amada, H; Ishii, T; Kameo, K; Kobayashi-Matsunaga, Y; Miyata, N; Sato, M; Taniguchi, K	1
Cambj-Sapunar, L; Harder, DR; Hudetz, AG; Kametani, S; Kehl, F; Maier, KG; Miyata, N; Okamoto, H; Roman, RJ; Schulte, ML; Zagorac, D	1
Amaral, SL; Greene, AS; Maier, KG; Roman, RJ; Schippers, DN	1
Cambj-Sapunar, L; Harder, DR; Roman, RJ; Yu, M	1
Flasch, AK; Hoagland, KM; Roman, RJ	1
Abraham, NG; Byun, K; Falck, JR; Jiang, M; Kemp, R; Laniado-Schwartzman, M; Mezentsev, A; Miano, JM; Nasjletti, A	1
Chen, P; Edwards, PA; Falck, JR; Guo, M; Roman, RJ; Scicli, AG; Wygle, D	1
Akhtar, S; Benter, IF; Canatan, H; Yousif, MH	1
Edwards, PA; Falck, JR; Guo, M; Roman, RJ; Scicli, AG	1
Laniado-Schwartzman, M; Miyata, N; Seki, T; Wang, MH	1
Doggrell, SA	1
Metea, MR; Newman, EA	1
Bies, RR; Graham, SH; Kochanek, PM; Poloyac, SM; Zhang, Y	1
Caron, N; Flamion, B; Imig, JD; Joly, E; Kramp, R; Michel, A; Seqqat, R	1
Blanton, A; Hercule, H; Nsaif, R; Oyekan, A	1
Flasch, AK; Lopez, B; Roman, RJ; Ryan, RP; Sarkis, A; Williams, JM	1
Badzyńska, B; Kompanowska-Jezierska, E; Kuczeriszka, M	1
Anjaiahh, S; Falck, JR; Roman, RJ; Sharma, M; Williams, JM	1
Cheng, J; Deng, H; Ishizuka, T; Kemp, R; Nasjletti, A; Schwartzman, ML; Singh, H	1
Bridges, AS; Hall, JE; Kornbluth, S; Paine, MF; Tidwell, RR; Wang, MZ; Wu, JQ; Zeldin, DC	1
Falck, JR; Harder, DR; Koehler, RC; Li, C; Liu, X; Roman, RJ	1
Avner, ED; Jia, G; Park, F; Roman, RJ; Sweeney, WE	1
Graham, SH; Klamerus, MM; Miller, TM; Mu, Y; Poloyac, SM; Rohan, LC	1
Ao, Y; Cheng, H; Li, Y; Lv, X; Peng, R; Wan, J; Yang, J	1
Dunn, KM; Falck, J; Flasch, AK; Harder, DR; Renic, M; Roman, RJ	1
Akbulut, T; Avner, ED; Birudaraju, S; Falck, JR; Jia, G; Mueller, B; Park, F; Roman, RJ; Sweeney, WE	1
Cao, S; Harder, DR; Koehler, RC; Kwansa, H; Roman, RJ; Wang, LC	1
Akhtar, S; Benter, IF; Dahly-Vernon, AJ; Dunn, KM; Roman, RJ; Yousif, MH	1
Benter, IF; Roman, RJ; Yousif, MH	1
Croft, KD; Mori, TA; Ong, SL; Temple, SE; Vickers, JJ; Whitworth, JA; Wu, JH; Zhang, Y	1
Alexanian, A; Flasch, A; Miller, B; Roman, RJ; Rufanova, VA; Sorokin, A	1
Azma, T; Hama-Tomioka, K; Hatakeyama, N; Hatano, Y; Kikuchi, H; Kinoshita, H; Matsuda, N; Nakahata, K	1
Benter, IF; Yousif, MH	1
Abraham, NG; Cheng, J; Falck, JR; Goli, M; Gotlinger, K; Inoue, K; Schwartzman, ML; Sodhi, K; Wu, CC	1
Barden, A; Beilin, LJ; Croft, KD; Puddey, IB; Tsai, IJ	1
Bao, Y; Han, Y; Huo, D; Li, W; Shen, X; Sun, C; Tan, J; Wang, X; Zeng, Q	1
Cervenka, L; Hammock, BD; Husková, Z; Hwang, SH; Imig, JD; Kopkan, L; Kramer, HJ; Sporková, A; Varcabová, S	1
Harris, NR; Leskova, W; Wang, Z; Yadav, AS	1
Falck, JR; Florence, MA; Gebremedhin, D; Gerges, NZ; Harder, DR; Kumar, SN; Renic, M; Roman, RJ	1
Carter, EL; Crafa, DA; Harder, DR; Kibler, KK; Koehler, RC; Kwansa, H; Martin, LJ; Roman, RJ; Yang, ZJ	1
Li, J; Li, QX; Tian, T; Wang, MY; Xie, XF	1
Fernandez, MM; Gonzalez, D; Nowicki, S; Roman, RJ; Williams, JM	1
Lai, G; Liu, X; Wu, J; Zhao, Y	1
Cseplo, P; Csiszar, A; Koller, A; Sonntag, WE; Sosnowska, D; Springo, Z; Tarantini, S; Toth, P; Tucsek, Z; Ungvari, Z	1
Baker, RC; Chen, BB; Fan, F; Johnson, DA; Liu, H; Orozco, LD; Perkins, E; Roman, RJ	1
Armstrong, JS; Bhalala, US; Koehler, RC; Kulikowicz, E; Lee, JH; Martin, LJ; Wang, B; Yang, ZJ; Zhu, J	1
Alexander, H; Clark, RS; Kochanek, PM; Manole, MD; Poloyac, SM; Shaik, JS; Tudorascu, DL	1
Che, D; Chen, J; Hammock, BD; Huang, F; Huang, H; Liu, Y; Qiu, K; Wang, J; Wang, MH; Yang, X	1
Ćosić, A; Drenjančević, I; Mihalj, M; Mišir, M; Novak, S; Renić, M; Vesel, M	1
Amaral, LM; Cunningham, MW; Faulkner, JL; LaMarca, B; Murphy, S; Plenty, NL; Wallace, K	1
Amorosi, CJ; Dunham, MJ; Fowler, DM; Gallis, B; Kowalski, JP; McDonald, MG; Nath, A; Paco, L; Ray, S; Rettie, AE; Sitko, KA; Totah, RA	1
Aslan, M; Basralı, F; Nasırcılar Ülker, S; Özcan, F; Özen, N; Şentürk, ÜK; Ülker, P	1
Chen, R; Cheng, O; Ding, S; Huang, B; Huang, J; Jiang, Q; Qiu, H; Zhang, J	1
Babapoor-Farrokhran, S; Hu, K; Kannan, S; Koehler, RC; Kulikowicz, E; Robertson, CL; Shu, S; Spicer, D; Zhang, Z	1
Cárdenas, S; Colombero, C; Costas, MA; Dakarapu, R; Falck, JR; Nowicki, S; Panelo, L	1
Lian, G; Luo, L; Wang, H; Wang, J; Wang, T; Xie, L; Xu, C	1
Cui, W; Du, Y; Feng, D; Ge, S; Guo, W; Liu, H; Luo, J; Qu, Y; Shi, Y; Wang, P; Wang, Q; Wu, X; Zheng, L	1

Reviews

1 review(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine

Article	Year
Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors. Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:9 Topics: Amidines; Angiogenesis Inhibitors; Animals; Cerebrovascular Circulation; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Myocardial Reperfusion Injury; Oligonucleotides, Antisense	2005

Article

Year

Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors.

Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:9

Topics: Amidines; Angiogenesis Inhibitors; Animals; Cerebrovascular Circulation; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Myocardial Reperfusion Injury; Oligonucleotides, Antisense

2005

Other Studies

57 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine

Article	Year
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. British journal of pharmacology, 2001, Volume: 133, Issue:3 Topics: Amidines; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microsomes; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2001
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorganic & medicinal chemistry letters, 2001, Dec-03, Volume: 11, Issue:23 Topics: Amidines; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Inhibitory Concentration 50; Kidney; Microsomes; Structure-Activity Relationship	2001
20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:4 Topics: Amidines; Animals; Carbon Dioxide; Cerebrovascular Circulation; Enzyme Inhibitors; Erythrocytes; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Male; Microscopy, Video; Partial Pressure; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Subarachnoid Hemorrhage; Time Factors	2002
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 284, Issue:5 Topics: Amidines; Animals; Antibodies; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Electric Stimulation; Endothelial Growth Factors; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Mixed Function Oxygenases; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Stroke, 2003, Volume: 34, Issue:5 Topics: Amidines; Animals; Blood; Brain Ischemia; Calcium Signaling; Cerebrospinal Fluid; Cerebrovascular Circulation; Cisterna Magna; Eicosanoic Acids; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Injections; Male; Middle Cerebral Artery; Muscle, Smooth, Vascular; Phospholipases A; Propanolamines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Subarachnoid Hemorrhage; Vascular Resistance; Vasoconstriction; Vasospasm, Intracranial	2003
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4 Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride; Triazoles	2003
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels. Circulation research, 2004, Feb-06, Volume: 94, Issue:2 Topics: 3T3 Cells; Adenoviridae; Amidines; Animals; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Genetic Vectors; Humans; Hydroxyeicosatetraenoic Acids; Lauric Acids; Male; Mice; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Organ Specificity; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Renal Artery; Transduction, Genetic; Vascular Endothelial Growth Factor A	2004
Inhibitors of cytochrome P450 4A suppress angiogenic responses. The American journal of pathology, 2005, Volume: 166, Issue:2 Topics: Amides; Amidines; Animals; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cornea; Cytochrome P-450 CYP4A; DNA, Complementary; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Hydroxyeicosatetraenoic Acids; Male; Mitogens; Neovascularization, Pathologic; Polymerase Chain Reaction; Polymers; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Umbilical Veins; Vascular Endothelial Growth Factor A	2005
Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery. Pharmacological research, 2005, Volume: 52, Issue:3 Topics: Amidines; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carotid Arteries; Carotid Artery Diseases; Diabetes Mellitus, Experimental; Hydroxyeicosatetraenoic Acids; Monomeric GTP-Binding Proteins; Organophosphonates; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Sulfonamides; Triazoles; Vascular Diseases; Vasoconstriction; Vasodilation	2005
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2 Topics: Amidines; Antineoplastic Agents; Arachidonic Acid; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP4A; DNA Fragmentation; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Glioma; Humans; Hydroxyeicosatetraenoic Acids; In Situ Nick-End Labeling; Mitogen-Activated Protein Kinase 1; Mitosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Thymidine	2005
Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9 Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Arachidonic Acid; Cell Membrane; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kinetics; Oxidation-Reduction; Rats	2005
Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11 Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Amidines; Animals; Arterioles; Calcium Signaling; Caproates; Cyclic N-Oxides; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Eye Proteins; Hydrazines; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Miconazole; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Photolysis; Proadifen; Purinergic Antagonists; Rats; Rats, Long-Evans; Retinal Vessels; Signal Transduction; Vasoconstriction; Vasodilation; Vasomotor System	2006
Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2006, Volume: 26, Issue:12 Topics: Amidines; Animals; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Male; Microsomes; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; Vasoconstriction	2006
Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 291, Issue:4 Topics: Adaptation, Physiological; Amidines; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dinoprostone; Hydroxyeicosatetraenoic Acids; Imidazoles; Indomethacin; Losartan; Male; Microcirculation; Nephrectomy; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Vasoconstriction; Vasoconstrictor Agents	2006
Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat. Journal of hypertension, 2006, Volume: 24, Issue:9 Topics: Amidines; Animals; Arginine; Blood Pressure; Bradykinin; Cyclosporine; Cytochrome P-450 Enzyme System; Endothelin-1; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microsomes; Nitric Oxide; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Triazoles	2006
Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:3 Topics: Amidines; Animals; Arachidonic Acids; Blood Pressure; Enzyme Inhibitors; Hydrostatic Pressure; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Male; Natriuresis; Rats; Triazoles	2007
Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57 Suppl 11 Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Laser-Doppler Flowmetry; Male; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation; Triazoles; Vasoconstrictor Agents; Vasodilation	2006
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:2 Topics: Amides; Amidines; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney Glomerulus; Male; Permeability; Proteins; Rats; Rats, Sprague-Dawley	2007
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Acetylcholine; Amidines; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Dihydrotestosterone; Drug Synergism; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Artery; Superoxides; Vasodilation; Vasodilator Agents	2007
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11 Topics: Amidines; Antibodies; Antiparasitic Agents; Arachidonic Acid; Benzamidines; Benzoflavones; Butyrophenones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Intestinal Mucosa; Intestines; Kinetics; Methylation; Microsomes; Oxygenases; Piperidines; Prodrugs; Recombinant Proteins; Stereoisomerism	2007
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Cerebral Cortex; Cerebrovascular Circulation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hyperemia; Indazoles; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Physical Stimulation; Rats; Rats, Wistar; Time Factors; Vasodilation; Vibrissae	2008
20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:10 Topics: Amidines; Animals; Cell Culture Techniques; Cell Proliferation; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Epithelial Cells; Hydroxyeicosatetraenoic Acids; Mice; Mice, Inbred BALB C; Polycystic Kidney Diseases	2008
Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:11 Topics: Amidines; Animals; Brain; Chemistry, Pharmaceutical; Cytochrome P-450 Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley	2008
Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion. European journal of pharmacology, 2008, Oct-31, Volume: 596, Issue:1-3 Topics: Amides; Amidines; Animals; Apoptosis; Caspase 3; Cytochrome P-450 CYP4A; Enzyme Activation; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Signal Transduction; Sulfones	2008
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6 Topics: Amidines; Animals; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Cytochrome P-450 CYP4A; Disease Models, Animal; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Infarction, Middle Cerebral Artery; Isoenzymes; Male; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Severity of Illness Index; Stroke; Time Factors; Up-Regulation	2008
Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Cyclic AMP; Cytochrome P-450 CYP4A; Disease Models, Animal; Enzyme Activation; Epoxy Compounds; Extracellular Signal-Regulated MAP Kinases; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microsomes; Organ Size; Polycystic Kidney, Autosomal Recessive; Protein Isoforms; Rats; Rats, Sprague-Dawley; RNA, Messenger	2009
Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:5 Topics: Amidines; Animals; Arterioles; Blood Substitutes; Blood Transfusion; Brain Ischemia; Endothelin A Receptor Antagonists; Endothelins; Hemoglobins; Hydroxyeicosatetraenoic Acids; Male; Models, Animal; Oligopeptides; Pia Mater; Polymers; Rats; Rats, Wistar; Regional Blood Flow; Vasodilation	2009
Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes. Autonomic & autacoid pharmacology, 2009, Volume: 29, Issue:1-2 Topics: Amidines; Angiotensin II; Animals; Blood Glucose; Body Weight; Carbachol; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Endothelin-1; Enzyme Inhibitors; Histamine; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mesenteric Arteries; Microsomes; Nitroprusside; Norepinephrine; Perfusion; Rats; Rats, Wistar; Renal Artery; Triazoles; Vasoconstriction; Vasodilation	2009
Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury. Autonomic & autacoid pharmacology, 2009, Volume: 29, Issue:1-2 Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Coronary Circulation; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Epoxide Hydrolases; Glyburide; Heart; Hydroxyeicosatetraenoic Acids; Male; Microsomes; Myocardium; Rats; Rats, Wistar; Reperfusion Injury; Urea; Vascular Resistance; Ventricular Dysfunction, Left	2009
The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. Journal of hypertension, 2009, Volume: 27, Issue:8 Topics: Adrenocorticotropic Hormone; Amidines; Animals; Body Weight; Dexamethasone; F2-Isoprostanes; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Systole	2009
Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer research, 2009, Volume: 29, Issue:10 Topics: Amidines; Animals; Arachidonic Acid; Carcinoma, Renal Cell; Cell Growth Processes; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Down-Regulation; Humans; Hydroxyeicosatetraenoic Acids; Kidney Neoplasms; Mice; Mice, Nude; RNA, Messenger; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays	2009
The role of 20-hydroxyeicosatetraenoic acid in cerebral arteriolar constriction and the inhibitory effect of propofol. Anesthesia and analgesia, 2009, Volume: 109, Issue:6 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Amidines; Anesthetics, Intravenous; Animals; Arterioles; Cell-Free System; Cerebral Arteries; Electric Stimulation; Enzyme Inhibitors; Free Radical Scavengers; Glycoproteins; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Microscopy, Video; NADPH Oxidases; Onium Compounds; Propofol; Rats; Rats, Wistar; Sodium Channel Blockers; Superoxides; Tetrodotoxin; Time Factors; Vasoconstriction	2009
Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction. Pharmacology, 2010, Volume: 86, Issue:3 Topics: Amidines; Animals; Arachidonic Acids; Blood Pressure; Carbachol; Cardiovascular Physiological Phenomena; Carotid Arteries; Endothelial Cells; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Urea; Vascular Diseases; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2010
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:5 Topics: Amidines; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Lentivirus; Lisinopril; Losartan; Mass Spectrometry; Oligonucleotide Array Sequence Analysis; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Time Factors	2010
20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4 Topics: Adult; Aged; Amidines; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Platelets; Calcium Channels; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelin-1; Humans; Hydroxyeicosatetraenoic Acids; Imidazoles; Ionophores; Irbesartan; Male; Middle Aged; Neutrophils; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Tetrazoles; Young Adult	2011
20-Hydroxyeicosatetraenoic acid induces apoptosis in neonatal rat cardiomyocytes through mitochondrial-dependent pathways. Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:3 Topics: Amidines; Animals; Animals, Newborn; Apoptosis; Arachidonic Acid; bcl-2-Associated X Protein; Benzimidazoles; Carbocyanines; Caspase 3; Cell Survival; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluorescent Dyes; Genes, bcl-2; Hydroxyeicosatetraenoic Acids; Hydroxylation; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction; Staining and Labeling	2011
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 300, Issue:6 Topics: Amidines; Animals; Arachidonic Acids; Blood Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyeicosatetraenoic Acids; Hypertension, Renovascular; Kidney; Male; Rats; Regional Blood Flow; Sodium	2011
Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamics. Experimental eye research, 2011, Volume: 93, Issue:1 Topics: Amidines; Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Erythrocytes; Hydroxyeicosatetraenoic Acids; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Regional Blood Flow; Retinal Vessels	2011
Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. American journal of physiology. Heart and circulatory physiology, 2012, Mar-15, Volume: 302, Issue:6 Topics: Amidines; Animals; Animals, Newborn; Caspase 3; Cell Death; Cell Hypoxia; Cytoprotection; Glucose; Hippocampus; Hydroxyeicosatetraenoic Acids; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Tissue Culture Techniques	2012
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. Journal of neurochemistry, 2012, Volume: 121, Issue:1 Topics: Amidines; Animals; Animals, Newborn; Brain Ischemia; Hydroxyeicosatetraenoic Acids; Infusions, Intraventricular; Male; Swine	2012
Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2). European journal of pharmacology, 2012, May-15, Volume: 683, Issue:1-3 Topics: Amidines; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Doxorubicin; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Kidney Tubules; Osmolar Concentration; Protective Agents; RNA, Messenger	2012
Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. European journal of pharmacology, 2012, Jul-05, Volume: 686, Issue:1-3 Topics: Amidines; Animals; Cytochrome P-450 CYP4A; Dopamine; Glomerular Filtration Rate; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Liver; Male; Natriuretic Agents; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Triazoles	2012
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Molecular endocrinology (Baltimore, Md.), 2012, Volume: 26, Issue:11 Topics: Amidines; Animals; Blood Glucose; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Glucose Transporter Type 1; Glycogen Phosphorylase; Hydroxyeicosatetraenoic Acids; Hyperglycemia; Hypertension; Insulin Receptor Substrate Proteins; Isoquinolines; Liver; Male; Mice; Mice, Transgenic; Phosphorylase Kinase; Phosphorylation; Signal Transduction; Sulfonamides	2012
Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. British journal of pharmacology, 2013, Volume: 168, Issue:8 Topics: Amidines; Animals; Blood Pressure; Cells, Cultured; Cerebrovascular Disorders; Cytochrome P-450 Enzyme System; Cytokines; Hydroxyeicosatetraenoic Acids; Male; Middle Cerebral Artery; NF-kappa B; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Vasomotor System	2013
20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:1 Topics: Amidines; Angioplasty, Balloon, Coronary; Animals; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Cell Movement; Cell Proliferation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hyperplasia; Male; Muscle, Smooth, Vascular; Neointima; Rats; Rats, Sprague-Dawley; Triazoles; Tunica Intima	2013
Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets. Developmental neuroscience, 2015, Volume: 37, Issue:4-5 Topics: Amidines; Animals; Animals, Newborn; Cytochrome P-450 CYP4A; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Swine	2015
20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:11 Topics: Amidines; Animals; Asphyxia Neonatorum; Body Water; Brain Chemistry; Brain Edema; Cerebral Cortex; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Eicosanoids; Heart Arrest; Hydroxyeicosatetraenoic Acids; Male; Neurodegenerative Diseases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Treatment Outcome	2015
Shexiang Baoxin pills promotes angiogenesis in myocardial infarction rats via up-regulation of 20-HETE-mediated endothelial progenitor cells mobilization. Atherosclerosis, 2017, Volume: 263 Topics: Amidines; Angiogenesis Inducing Agents; Animals; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Drugs, Chinese Herbal; Endothelial Progenitor Cells; Hydroxyeicosatetraenoic Acids; Male; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Rats, Sprague-Dawley; Signal Transduction; Vascular Endothelial Growth Factor A	2017
Hyperbaric oxygenation and 20-hydroxyeicosatetreanoic acid inhibition reduce stroke volume in female diabetic Sprague-Dawley rats. Experimental physiology, 2017, 12-01, Volume: 102, Issue:12 Topics: Amidines; Animals; Aryl Hydrocarbon Hydroxylases; Brain; Combined Modality Therapy; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Cytochrome P450 Family 4; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Epoxide Hydrolases; Female; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hyperbaric Oxygenation; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Nitric Oxide Synthase Type III; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Time Factors	2017
Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia. Prostaglandins & other lipid mediators, 2018, Volume: 134 Topics: Amidines; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Hydroxyeicosatetraenoic Acids; Pre-Eclampsia; Pregnancy; Rats	2018
Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:12 Topics: Amidines; Breast Neoplasms; Cytochrome P450 Family 4; Disease Progression; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Interleukin-1 Receptor-Associated Kinases; Lauric Acids; Mass Spectrometry; Microsomes, Liver; Molecular Docking Simulation; Oxidation-Reduction; Recombinant Proteins; Saccharomyces cerevisiae	2017
Effect of 20-HETE inhibition on L-NAME-induced hypertension in rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:3 Topics: Amidines; Animals; Blood Pressure; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Tissue Culture Techniques; Vascular Resistance; Vasoconstriction; Vasodilation	2018
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions. Experimental cell research, 2019, 09-01, Volume: 382, Issue:1 Topics: Amidines; Anilides; Animals; Cell Line; Cytochrome P-450 CYP4A; Diabetic Nephropathies; Down-Regulation; Epithelial Cells; Gene Expression Regulation; Glucose; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Tubules; Male; Mice; PPAR alpha; PPAR gamma; PPAR-beta; Rats; Sulfones; Thiophenes	2019
Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury. Developmental neuroscience, 2019, Volume: 41, Issue:3-4 Topics: Amidines; Animals; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Inflammation; Male; Rats, Sprague-Dawley; Reperfusion Injury	2019
GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:2 Topics: Amidines; Androgens; Cell Movement; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; Hydroxyeicosatetraenoic Acids; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Male; Matrix Metalloproteinase 2; PC-3 Cells; Prostatic Neoplasms; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction	2020
Role of 20-hydroxyeicosatetraenoic acid in pulmonary hypertension and proliferation of pulmonary arterial smooth muscle cells. Pulmonary pharmacology & therapeutics, 2020, Volume: 64 Topics: Amidines; Animals; Cell Proliferation; Chromatography, Liquid; Hydroxyeicosatetraenoic Acids; Hypertension, Pulmonary; Hypoxia; Male; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2020
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study. Cell proliferation, 2021, Volume: 54, Issue:2 Topics: Amidines; Animals; Apoptosis; Brain Injuries, Traumatic; Dynamins; Female; Humans; Hydroxyeicosatetraenoic Acids; Logistic Models; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mitochondria; Mitochondrial Dynamics; Neurons; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Signal Transduction; Sirtuin 1	2021