Page last updated: 2024-09-03

20-hydroxy-5,8,11,14-eicosatetraenoic acid and miconazole

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with miconazole in 9 studies

Compound Research Comparison

Studies
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Trials
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Recent Studies (post-2010)
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Studies
(miconazole)
Trials
(miconazole)
Recent Studies (post-2010) (miconazole)
640132332,309238476

Protein Interaction Comparison

ProteinTaxonomy20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50)miconazole (IC50)
Metabotropic glutamate receptor 6Homo sapiens (human)6.5
AcetylcholinesteraseElectrophorus electricus (electric eel)2.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)5.314
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Mus musculus (house mouse)4.55
Cytochrome P450 1A2 Rattus norvegicus (Norway rat)4.55
Cytochrome P450 1A2Homo sapiens (human)4.55
Tyrosine-protein kinase FynHomo sapiens (human)4.16
Heme oxygenase 1 Rattus norvegicus (Norway rat)5.8
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.939
Muscarinic acetylcholine receptor M2Homo sapiens (human)4.336
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.197
ATP-dependent translocase ABCB1Homo sapiens (human)3
Cytochrome P450 3A4Homo sapiens (human)0.4938
Alpha-2A adrenergic receptorHomo sapiens (human)3.966
Adenosine receptor A3Homo sapiens (human)2.811
Cytochrome P450 2D6Homo sapiens (human)1.32
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.971
AromataseHomo sapiens (human)0.6
Cytochrome P450 2C9 Homo sapiens (human)0.2
Beta-3 adrenergic receptorHomo sapiens (human)5.482
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)3.7
Androgen receptorRattus norvegicus (Norway rat)7.089
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)2.811
Alpha-2B adrenergic receptorHomo sapiens (human)3.598
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.154
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.8
Substance-K receptorHomo sapiens (human)4.839
D(1A) dopamine receptorHomo sapiens (human)6.247
Heme oxygenase 2Rattus norvegicus (Norway rat)5.8
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.939
Thromboxane-A synthase Homo sapiens (human)0.263
Histamine H2 receptorHomo sapiens (human)6.75
Alpha-1D adrenergic receptorHomo sapiens (human)3.046
Substance-P receptorHomo sapiens (human)6.813
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.907
5-hydroxytryptamine receptor 2CHomo sapiens (human)5.314
Sodium-dependent serotonin transporterHomo sapiens (human)0.778
Cytochrome P450 2C19Homo sapiens (human)0.008
Mu-type opioid receptorHomo sapiens (human)6.059
D(3) dopamine receptorHomo sapiens (human)3.199
Delta-type opioid receptorHomo sapiens (human)3.387
Kappa-type opioid receptorHomo sapiens (human)6.594
5-hydroxytryptamine receptor 2BHomo sapiens (human)5.545
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)2.811
CholinesteraseEquus caballus (horse)5.55
Sodium-dependent dopamine transporter Homo sapiens (human)1.701
Lanosterol 14-alpha demethylaseHomo sapiens (human)0.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)6.7

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's5 (55.56)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Imig, JD; Kaldunski, M; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP1
Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP1
Benzoni, D; Bernard, N; Messer-Létienne, I; Roman, RJ; Sassard, J1
Oyekan, AO1
Abe, M; Arima, S; Chiba, Y; Endo, Y; Ito, O; Ito, S; Kohagura, K; Omata, K1
Campbell, WB; Endsley, MP; Falck, JR; Gross, ER; Gross, GJ; Isbell, MA; Moore, JM; Nithipatikom, K1
Caron, N; Declèves, AE; El Hajjam, A; Falck, JR; Joly, E; Kramp, R1
Metea, MR; Newman, EA1
Bolognesi, M; Gaiani, S; Gatta, A; Jiang, H; McGiff, JC; Sacerdoti, D1

Other Studies

9 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and miconazole

ArticleYear
Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow.
    The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2

    Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Homeostasis; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Miconazole; Microcirculation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Circulation

1994
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Miconazole; Microsomes; Muscle, Smooth, Vascular; Oxazines; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation

1994
20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats.
    European journal of pharmacology, 1999, Aug-13, Volume: 378, Issue:3

    Topics: Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Heptanoic Acids; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Kidney; Male; Miconazole; Organ Size; Oxygenases; Rats; Receptors, Thromboxane; Renal Circulation; Systole; Vascular Resistance; Vasodilation

1999
Cytochrome p450-dependent metabolites of arachidonic acid and renal function in the rat.
    Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:8

    Topics: Animals; Antifungal Agents; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Homeostasis; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Function Tests; Male; Miconazole; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Urodynamics

2000
Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Male; Miconazole; Norepinephrine; Rabbits; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents

2001
Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway.
    Circulation research, 2004, Oct-15, Volume: 95, Issue:8

    Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Fatty Acids, Unsaturated; Female; Hydroxyeicosatetraenoic Acids; Isoenzymes; Male; Miconazole; Microsomes; Mixed Function Oxygenases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sulfones

2004
Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases.
    Clinical and experimental pharmacology & physiology, 2004, Volume: 31, Issue:10

    Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hemodynamics; Hydroxyeicosatetraenoic Acids; Indomethacin; Kidney; Male; Miconazole; Rats; Rats, Wistar; Renal Circulation; Vasodilation

2004
Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Amidines; Animals; Arterioles; Calcium Signaling; Caproates; Cyclic N-Oxides; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Eye Proteins; Hydrazines; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Miconazole; Neuroglia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Photolysis; Proadifen; Purinergic Antagonists; Rats; Rats, Long-Evans; Retinal Vessels; Signal Transduction; Vasoconstriction; Vasodilation; Vasomotor System

2006
11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.
    Prostaglandins & other lipid mediators, 2011, Volume: 96, Issue:1-4

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Endothelin-1; Hepatic Veins; Hydroxyeicosatetraenoic Acids; Hypertension, Portal; Infusion Pumps; Liver; Liver Cirrhosis, Experimental; Male; Miconazole; Organ Culture Techniques; Oxidoreductases; Phenylephrine; Portal Pressure; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction; Vasodilation

2011