20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with losartan in 5 studies
| Studies (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Trials (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Recent Studies (post-2010) (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Studies (losartan) | Trials (losartan) | Recent Studies (post-2010) (losartan) |
|---|---|---|---|---|---|
| 640 | 13 | 233 | 7,231 | 1,245 | 2,118 |
| Protein | Taxonomy | 20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50) | losartan (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 9.01 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2.882 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.019 | |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | 0.0018 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.019 | |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0247 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0234 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.0032 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.047 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.025 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0118 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.019 | |
| Platelet glycoprotein VI | Homo sapiens (human) | 4 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.1481 | |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | 0.018 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.2884 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Escalante, B; López-Sánchez, P; Martínez-Ayala, S; Rios, A; Sánchez-Mendoza, A; Vázquez-Cruz, B | 1 |
| Carroll, MA; Croft, KD; McGiff, JC; Sanchez-Mendoza, A | 1 |
| Caron, N; Flamion, B; Imig, JD; Joly, E; Kramp, R; Michel, A; Seqqat, R | 1 |
| Abraham, NG; Cheng, J; Falck, JR; Goli, M; Gotlinger, K; Inoue, K; Schwartzman, ML; Sodhi, K; Wu, CC | 1 |
| Bradford, C; Falck, JR; Gotlinger, KH; Gupte, SA; Hunter, I; Hutcheson, B; Hutcheson, R; Joseph, G; Joshi, SR; Maniyar, R; Proctor, S; Rocic, P; Schwartzman, ML; Soler, A; Yang, J; Zhang, FF | 1 |
5 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and losartan
| Article | Year |
|---|---|
Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites.
Topics: Adrenalectomy; Angiotensin II; Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Indomethacin; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Ouabain; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes | 2000 |
Angiotensin II releases 20-HETE from rat renal microvessels.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arachidonic Acids; Arterioles; Capillaries; Cytochrome P-450 Enzyme System; Estrenes; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Imidazoles; Kidney; Losartan; Male; NADP; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Type C Phospholipases | 2000 |
Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE.
Topics: Adaptation, Physiological; Amidines; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dinoprostone; Hydroxyeicosatetraenoic Acids; Imidazoles; Indomethacin; Losartan; Male; Microcirculation; Nephrectomy; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Vasoconstriction; Vasoconstrictor Agents | 2006 |
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
Topics: Amidines; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Lentivirus; Lisinopril; Losartan; Mass Spectrometry; Oligonucleotide Array Sequence Analysis; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2010 |
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Topics: Animals; Blood Pressure; Collagen Type I; Collagen Type III; Compliance; Cytochrome P-450 CYP4A; Cytochrome P450 Family 4; Diastole; Elastin; Enzyme Activation; Hydroxyeicosatetraenoic Acids; Hypertension; Losartan; Male; Matrix Metalloproteinase 12; Metabolic Syndrome; Proteolysis; Rats, Sprague-Dawley; RNA, Small Interfering; Vascular Stiffness | 2018 |