Compounds > 20-hydroxy-5,8,11,14-eicosatetraenoic acid

Page last updated: 2024-09-03

20-hydroxy-5,8,11,14-eicosatetraenoic acid and dihydrotestosterone

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with dihydrotestosterone in 11 studies

Compound Research Comparison

Studies (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Trials (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Recent Studies (post-2010) (20-hydroxy-5,8,11,14-eicosatetraenoic acid)	Studies (dihydrotestosterone)	Trials (dihydrotestosterone)	Recent Studies (post-2010) (dihydrotestosterone)
640	13	233	9,325	307	1,517

Protein Interaction Comparison

Protein	Taxonomy	20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50)	dihydrotestosterone (IC50)
Plasma kallikrein	Homo sapiens (human)		0.0031
Glucocorticoid receptor	Homo sapiens (human)		0.54
Sex hormone-binding globulin	Homo sapiens (human)		0.0038
Progesterone receptor	Oryctolagus cuniculus (rabbit)		0.44
Progesterone receptor	Homo sapiens (human)		7.3
Mineralocorticoid receptor	Homo sapiens (human)		0.36
Sex hormone-binding globulin	Rattus norvegicus (Norway rat)		0.023
Androgen receptor	Homo sapiens (human)		0.0048
Androgen receptor	Rattus norvegicus (Norway rat)		0.4041
Androgen receptor	Mus musculus (house mouse)		0.001
Mineralocorticoid receptor	Rattus norvegicus (Norway rat)		2.1
Testosterone 17-beta-dehydrogenase 3	Homo sapiens (human)		0.0026

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (45.45)	29.6817
2010's	6 (54.55)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adas, F; Breyer, MD; Capdevila, JH; Falck, JR; Holla, VR; Imig, JD; Keeney, DS; Kovacs, WJ; Magnuson, MA; Olsen, N; Price, E; Waterman, MR; Zhao, X	1
Capdevila, JH; Marji, JS; Nakagawa, K; Schwartzman, ML; Waterman, MR	1
Skott, O	1
Lombard, JH; Roman, RJ	1
Cheng, J; Deng, H; Ishizuka, T; Kemp, R; Nasjletti, A; Schwartzman, ML; Singh, H	1
Cheng, J; Falck, JR; Gotlinger, KH; Jat, JL; Kelkar, M; Schwartzman, ML; Wu, CC; Zhang, FF; Zhang, Y	1
Capdevila, JH; Cheng, J; Ding, Y; Falck, JR; Garcia, V; Gotlinger, K; Manthati, VL; Mei, S; Schwartzman, ML; Weidenhammer, A; Wu, CC; Zhang, F	1
Capdevila, JH; Dimitrova, I; Ding, Y; Falck, JR; Garcia, V; Joseph, G; Manthati, VL; Schwartzman, ML; Weidenhammer, A; Wu, CC; Zhang, F	1
Bernstein, KE; Capdevila, JH; Dakarapu, R; Ding, Y; Falck, JR; Garcia, V; Gotlinger, K; Joseph, G; Schwartzman, ML; Shkolnik, B; Zhang, FF	1
Dalmasso, C; Maranon, R; Moulana, M; Patil, C; Reckelhoff, JF; Romero, DG	1
Alvarez, E; Colombero, C; Mormandi, E; Nowicki, S; Papademetrio, D; Sacca, P	1

Reviews

1 review(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and dihydrotestosterone

Article	Year
Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Animals; Cardiovascular Diseases; Dihydrotestosterone; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Oxidative Stress; Risk Factors; Sex Characteristics	2007

Other Studies

10 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and dihydrotestosterone

Article	Year
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9 Topics: Androgens; Animals; Arachidonic Acid; Blood Pressure; Castration; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Enzyme Induction; Female; Gene Deletion; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Knockout; Microsomes; Mixed Function Oxygenases; Renal Circulation; RNA, Messenger; Sex Characteristics; Testosterone; Vascular Resistance	2001
Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:4 Topics: Animals; Blood Pressure; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Characteristics; Testosterone	2003
Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:4 Topics: Animals; Blood Pressure; Dihydrotestosterone; Female; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Male; Rats; Sex Characteristics	2003
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Acetylcholine; Amidines; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Dihydrotestosterone; Drug Synergism; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Artery; Superoxides; Vasodilation; Vasodilator Agents	2007
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Androgens; Animals; Blood Pressure; Dihydrotestosterone; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; I-kappa B Kinase; Rats; Rats, Sprague-Dawley; Renal Artery; Sesquiterpenes; Vasoconstriction	2011
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:8 Topics: Androgens; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dihydrotestosterone; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Up-Regulation	2013
20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. American journal of physiology. Renal physiology, 2013, Sep-01, Volume: 305, Issue:5 Topics: Animals; Blood Pressure; Dihydrotestosterone; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice; Rats; Rats, Sprague-Dawley; Renal Artery; Reserpine	2013
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Jul-01, Volume: 309, Issue:1 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice, Transgenic; Microvessels; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Time Factors; Vascular Remodeling	2015
20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. American journal of physiology. Renal physiology, 2016, 07-01, Volume: 311, Issue:1 Topics: Androgens; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Female; Gene Deletion; Gene Knockout Techniques; Hydroxyeicosatetraenoic Acids; Hyperandrogenism; Hypertension; Microcirculation; Rats; Rats, Inbred Dahl; Renal Circulation; Steroids	2016
Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells. Hormones & cancer, 2017, Volume: 8, Issue:4 Topics: Androgens; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochrome P450 Family 4; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Hydroxyeicosatetraenoic Acids; Male; Prostatic Neoplasms; Receptors, Androgen	2017