20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with arachidonic acid in 160 studies
| Studies (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Trials (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Recent Studies (post-2010) (20-hydroxy-5,8,11,14-eicosatetraenoic acid) | Studies (arachidonic acid) | Trials (arachidonic acid) | Recent Studies (post-2010) (arachidonic acid) |
|---|---|---|---|---|---|
| 640 | 13 | 233 | 19,295 | 486 | 3,040 |
| Protein | Taxonomy | 20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50) | arachidonic acid (IC50) |
|---|---|---|---|
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | 2.75 | |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| 60 kDa chaperonin | Escherichia coli | 7.3 | |
| 10 kDa chaperonin | Escherichia coli | 7.3 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.0715 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.6026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 45 (28.13) | 18.2507 |
| 2000's | 72 (45.00) | 29.6817 |
| 2010's | 38 (23.75) | 24.3611 |
| 2020's | 5 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, X; Koop, DR; Laethem, CL; Laethem, RM | 1 |
| Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC | 1 |
| Carroll, MA; McGiff, JC | 2 |
| Abraham, NG; Falck, JR; Feldman, E; Lutton, JD; Schwartzman, ML | 1 |
| Abraham, NG; Bhatt, RK; Falck, JR; Lin, FM; Omata, K; Schwartzman, ML | 1 |
| Oliw, EH | 1 |
| Harder, DR; Roman, RJ | 2 |
| Erlij, D; Escalante, B; Falck, JR; McGiff, JC | 1 |
| Andersson, K; Bäckström, K; DePierre, JW; Sohlenius, AK; Wigren, J | 1 |
| Balazy, M; McGiff, JC; Schieber, EB; Zhu, Y | 1 |
| Falck, JR; Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP | 1 |
| Ma, YH; Roman, RJ; Schwartzman, ML | 1 |
| Imig, JD; Kaldunski, M; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP | 1 |
| Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP | 1 |
| Campbell, WB; Falck, JR; Gebremedhin, D; Harder, DR; Jefcoat, C; Narayanan, J; Roman, R | 1 |
| Clark, JE; Falck, JR; Gebremedhin, D; Harder, DR; Ma, YH; Masters, BS; Roman, RJ; Schwartzman, ML | 1 |
| Frohlich, B; Ma, YH; Markham, B; Roman, RJ | 1 |
| Escalante, B; Falck, JR; Lee, SG; Omata, K; Schwartzman, ML; Sessa, W | 1 |
| Lu, M; Wang, W | 1 |
| Abe, K; Arima, S; Ito, S; Omata, K; Tsunoda, K | 1 |
| Jacob, HJ; Krieger, JE; Roman, RJ; Stec, DE; Trolliet, MR | 1 |
| Falck, JR; Harder, DR; Imig, JD; Roman, RJ; Stec, DE; Zou, AP | 1 |
| Falck, JR; Fleming, JT; Gebremedhin, D; Harder, DR; Jacobs, ER; Roman, RJ; Zou, AP | 1 |
| Amlal, H; Bichara, M; Legoff, C; Paillard, M; Vernimmen, C | 1 |
| Abraham, NG; da Silva, JL; Lin, F; Nishimura, M; Schwartzman, ML | 1 |
| Balazy, M; Mastyugin, V; Roman, RJ; Schwartzman, ML; Stec, DE; Wang, MH; Yang, CS | 1 |
| Alonso-Galicia, M; Drummond, HA; Falck, JR; Reddy, KK; Roman, RJ | 1 |
| Falcone, JC; Grider, JS; Jackson, BA; Kilpatrick, EL; Ott, CE | 1 |
| Alonso-Galicia, M; Roman, RJ; Wilson, TW | 1 |
| Birks, EK; Bousamra, M; Effros, RM; Jacobs, ER; Marsh, JA; Presberg, K | 1 |
| Grillo, MP; Huse, LM; Kroetz, DL; Thuresson, A | 1 |
| Aperia, A; Eklöf, AC; Greengard, P; Holtbäck, U; Nowicki, S; Sundelöf, M | 1 |
| Aebly, MR; Gebremedhin, D; Harder, DR; Jacobs, ER; Lange, AR; Narayanan, J | 1 |
| Amlal, H; Bichara, M; LeGoff, C; Paillard, M; Soleimani, M; Vernimmen, C | 1 |
| Jin, R; Lasker, JM; Powell, PK; Wolf, I | 1 |
| Effros, RM; Harder, DR; Jacobs, ER; Roman, RJ; Zhu, D | 1 |
| Funae, Y; Imaoka, S | 1 |
| Benter, IF; Fatima, S; Harper, J; Karzoun, N; Malik, KU; Muthalif, MM; Uddin, MR | 1 |
| McAward, K; McGiff, JC; Oyekan, AO | 1 |
| Campbell, WB; Effros, RM; Falck, JR; Jacobs, ER; Reddy, KM; Zhu, D | 1 |
| Conetta, J; McAward, K; McGiff, JC; Oyekan, AO; Rosenfeld, L | 1 |
| Falck, JR; Nguyen, X; Reddy, KM; Schwartzman, ML; Wang, MH | 1 |
| Ito, O; Roman, RJ | 1 |
| Fulton, D; McGiff, JC; Oyekan, AO; Quilley, J; Youseff, T | 1 |
| Barac-Nieto, M; Silverstein, DM; Spitzer, A | 1 |
| Bloswick, BP; Chen, WB; Lasker, JM; Powell, PK; Wilson, PD; Wolf, I | 1 |
| Hercule, HC; Oyekan, AO | 1 |
| Escalante, B; López-Sánchez, P; Martínez-Ayala, S; Rios, A; Sánchez-Mendoza, A; Vázquez-Cruz, B | 1 |
| Baum, M; Falck, JR; Griener, JC; Quigley, R; Reddy, KM | 1 |
| Oyekan, AO | 1 |
| Alonso-Galicia, M; Falck, JR; Henderson, L; Maier, KG; Narayanan, J; Roman, RJ | 1 |
| Erdmann, B; Gross, V; Honeck, H; Kärgel, E; Luft, FC; Milia, AF; Neunaber, R; Schneider, W; Schunck, WH | 1 |
| Hoagland, KM; Ito, O; Ito, S; Omata, K; Roman, RJ | 1 |
| Bend, JR; McCormack, DG; Mehta, S; Scott, JA; Webb, CD; Yaghi, A | 1 |
| Campbell, WB; DiCamelli, RF; Falck, JR; Gross, GJ; Gumina, RJ; Kohler, S; Nithipatikom, K | 1 |
| Adas, F; Breyer, MD; Capdevila, JH; Falck, JR; Holla, VR; Imig, JD; Keeney, DS; Kovacs, WJ; Magnuson, MA; Olsen, N; Price, E; Waterman, MR; Zhao, X | 1 |
| Doi, M; Ishimoto, T; Kameo, K; Kametani, S; Miyata, N; Sato, M; Sato-Watanabe, M; Seki, T; Taniguchi, K; Tomishima, Y; Ueki, T; Yasuda, Y | 1 |
| Falck, JR; Frisbee, JC; Lombard, JH; Murali Krishna, U; Roman, RJ | 1 |
| Abe, M; Arima, S; Chiba, Y; Endo, Y; Ito, O; Ito, S; Kohagura, K; Omata, K | 1 |
| Falck, JR; Frisbee, JC; Krishna, UM; Lombard, JH | 1 |
| Fleming, I | 2 |
| Escalante, BA; McGiff, JC; Oyekan, AO | 1 |
| Roman, RJ | 1 |
| Campbell, WB; Ge, ZD; Li, PL; Zhang, DX | 1 |
| Kroetz, DL; Zeldin, DC | 1 |
| Qian, JQ; Wang, DW; Zhang, F | 1 |
| Laniado-Schwartzman, M; Marji, JS; Wang, MH | 1 |
| Alonso-Galicia, M; Cowley, AW; Greene, AS; Maier, KG; Roman, RJ | 1 |
| Jacobs, ER; Medhora, M; Zhang, C; Zhu, D | 1 |
| Bełtowski, J; Górny, D; Marciniak, A; Wójcicka, G | 1 |
| Hercule, H; Oyekan, A | 1 |
| Gu, RM; Wang, WH | 1 |
| Falck, JR; Gopal, VR; Kaide, J; Laniado-Schwartzman, M; Nasjletti, A; Wang, JS; Wang, MH; Zhang, F | 1 |
| Amaral, SL; Greene, AS; Maier, KG; Roman, RJ; Schippers, DN | 1 |
| Carroll, MA; Escalante, BA; Ferreri, NR; McGiff, JC; Oyekan, AO | 1 |
| Flasch, AK; Hoagland, KM; Roman, RJ | 1 |
| Chen, YJ; Quilley, J | 1 |
| Falck, JR; Kroetz, DL; Ortiz de Montellano, PR; Xu, F | 1 |
| Dahly-Vernon, AJ; dos Santos, EA; Flasch, AK; Hoagland, KM; Knepper, MA; Roman, RJ | 1 |
| Dahly-Vernon, AJ; Dos Santos, EA; Hoagland, KM; Roman, RJ | 1 |
| Imig, JD | 2 |
| Frye, RF; Poloyac, SM; Przychodzin, DI; Reynolds, RB; Tortorici, MA; Xie, W; Zemaitis, MA | 1 |
| Abraham, NG; Jiang, M; Laniado-Schwartzman, M; Nasjletti, A; Wang, JS; Wang, MH; Zand, BA; Zhang, F | 1 |
| Attwell, D; Peppiatt, C | 1 |
| MacVicar, BA; Mulligan, SJ | 1 |
| Caron, N; Declèves, AE; El Hajjam, A; Falck, JR; Joly, E; Kramp, R | 1 |
| Deng, H; Falck, JR; Gopal, VR; Kemp, R; Laniado-Schwartzman, M; Nasjletti, A; Singh, H; Zhang, F | 1 |
| Bellamine, A; Brown, NJ; Capdevila, JH; Cupples, LA; Dawson, EP; Demissie, S; Gainer, JV; Grant, SW; Guo, CY; O'Donnell, CJ; Wang, Y; Waterman, MR; Womble, KE | 1 |
| Kamata, K | 1 |
| Estes, AM; Jafari, N; Malik, KU; Parmentier, JH; Schaefer, SA; Yaghini, FA; Zhang, C | 1 |
| Kerr, ME; Poloyac, SM; Reynolds, RB; Yonas, H | 1 |
| Bohman, QC; Harder, DR; Miyata, N; Renic, M; Roman, RJ; Takeuchi, K | 1 |
| Falck, JR; Gross, ER; Gross, GJ; Isbell, M; Moore, J; Nithipatikom, K | 1 |
| Cowley, AW; Ito, O; Ito, S; Kohzuki, M; Mori, T; Roman, RJ; Sarkis, A; Verbalis, J | 1 |
| Edwards, PA; Falck, JR; Guo, M; Roman, RJ; Scicli, AG | 1 |
| Laniado-Schwartzman, M; Miyata, N; Seki, T; Wang, MH | 1 |
| Campbell, WB; Endsley, MP; Falck, JR; Gross, GJ; Isbell, MA; Moore, JM; Nithipatikom, K | 1 |
| Falck, JR; Gross, GJ; Isbell, MA; Moore, JM; Nithipatikom, K | 1 |
| Cowpland, C; Croft, KD; Murray, M; Puddey, IB; Su, GM | 1 |
| Falck, JR; Fang, X; Harmon, SD; Hu, S; Kaduce, TL; Raj Gopal, V; Spector, AA | 1 |
| Dunn, KM; Hacein-Bey, L; Renic, M; Roman, RJ; Takeuchi, K | 1 |
| Badzyńska, B; Kompanowska-Jezierska, E; Kuczeriszka, M | 1 |
| Flasch, A; Rieder, MJ; Roman, RJ; Stec, DE | 1 |
| Anjaiahh, S; Falck, JR; Roman, RJ; Sharma, M; Williams, JM | 1 |
| Capdevila, JH | 1 |
| Bridges, AS; Hall, JE; Kornbluth, S; Paine, MF; Tidwell, RR; Wang, MZ; Wu, JQ; Zeldin, DC | 1 |
| Chen, YJ; Li, J; Quilley, J | 1 |
| Fava, C; Jiang, H; Lechi, A; McGiff, JC; Minuz, P; Morganti, A; Patrignani, P; Ricci, M; Tacconelli, S; Turolo, L | 1 |
| Arbab, AS; Edwards, PA; Falck, JR; Guo, AM; Lehman, NL; Roman, RJ; Scicli, AG; Scicli, GM; Sheng, J | 1 |
| Kompanowska-Jezierska, E; Kuczeriszka, M | 1 |
| Benter, IF; Roman, RJ; Yousif, MH | 1 |
| Gu, F; Gu, RM; Kong, S; Liu, L; Wang, L; Wang, M; Wang, WH; Wu, P; Yang, L; Zhai, Y; Zhang, C; Zhang, J; Zhang, Y | 1 |
| Aboutabl, ME; Anwar-Mohamed, A; El-Kadi, AO; Zordoky, BN | 2 |
| Alexanian, A; Flasch, A; Miller, B; Roman, RJ; Rufanova, VA; Sorokin, A | 1 |
| Crago, EA; Donnelly, MK; Horowitz, MB; Miller, TM; Poloyac, SM; Roman, DM; Sherwood, PR | 1 |
| Blogowski, W; Dolegowska, B; Domanski, L; Jakubowska, K; Olszewska, M; Safranow, K | 1 |
| Drevensek, G; Ljuca, F | 1 |
| Bardowell, SA; Parker, RS; Stec, DE | 1 |
| Burke, M; Murphy, S; Roman, RJ; Williams, JM | 1 |
| Gąsiorowska, A; Kompanowska-Jezierska, E; Kuczeriszka, M; Olszyński, KH; Sadowski, J | 1 |
| Bao, Y; Han, Y; Huo, D; Li, W; Shen, X; Sun, C; Tan, J; Wang, X; Zeng, Q | 1 |
| Barden, A; Beer, CD; Blacker, D; Croft, KD; Hankey, GJ; Mori, TA; Puddey, IB; Ward, NC | 1 |
| Schwartzman, ML; Wu, CC | 1 |
| Boonprasert, K; Na-Bangchang, K; Ruengweerayut, R; Satarug, S | 1 |
| Bolognesi, M; Gaiani, S; Gatta, A; Jiang, H; McGiff, JC; Sacerdoti, D | 1 |
| Xie, XN; Zhang, DH; Zhu, Y | 1 |
| Ahluwalia, A; Baker, MD; Bubb, KJ; Östman, J; Panayiotou, C; Priestley, JV; Wen, H | 1 |
| Althurwi, HN; Anwar-Mohamed, A; El-Kadi, AO; El-Sherbeni, A; Elshenawy, OH; Kim, SH; Zordoky, BN | 1 |
| Alsaad, AM; El-Kadi, AO; Tse, MM; Zordoky, BN | 1 |
| Anwar-Mohamed, A; El-Kadi, AO; Elshenawy, OH | 1 |
| Hammock, BD; Liu, JY; Soetaert, W; Van Bogaert, I; Yang, J; Ye, Y; Zhang, G | 1 |
| Barden, AE; Beilin, LJ; Croft, KD; Ledowski, T; Phillips, M; Puddey, IB | 1 |
| Althurwi, HN; El-Kadi, AO; Elshenawy, OH | 1 |
| Falck, JR; Fan, F; Ge, Y; Liu, R; Murphy, SR; Roman, RJ; Williams, JM | 1 |
| Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF | 1 |
| Al-Shabrawey, M; Huang, H; Wang, MH | 1 |
| Carver, KA; Gebremedhin, D; Harder, DR; Rarick, KR; Rau, N; Roman, RJ; Zhang, DX | 1 |
| Berg, RM | 1 |
| Gao, W; Guo, G; Zhou, B; Zu, L | 1 |
| Eyre, NS; Garbacz, WG; Lu, P; Mayrhofer, G; Miller, TM; Poloyac, SM; Ren, S; Xie, W; Xu, M | 1 |
| Hellhake, S; Schebb, NH; Steuck, M | 1 |
| Cho, SA; Kim, DH; Lee, SJ; Min, J; Shin, JG; Yi, M | 1 |
| Aghazadeh-Habashi, A; Asghar, W; Jamali, F | 1 |
| Achyut, BR; Angara, K; Arbab, AS; Borin, TF; Rashid, MH | 1 |
| Kim, DH; Kim, HS; Kim, WY; Lee, SJ; Min, J; Oh, KS; Shin, JG | 1 |
| Booz, GW; Fan, F; He, X; Wang, S; Yu, Q; Zhang, C | 1 |
| Hu, G; Ito, O; Kohzuki, M; Miura, T; Muroya, Y; Ogawa, Y; Rong, R; Wang, W | 1 |
| Antonazzi, F; Benati, M; Bonafini, S; Cavarzere, P; Fava, C; Gaudino, R; Giontella, A; Karber, M; Maffeis, C; Marcon, D; Minuz, P; Montagnana, M; Rothe, M; Schunck, WH; Tagetti, A | 1 |
| Barola, C; Bartolini, D; Galarini, R; Galli, F; Gioiello, A; Giusepponi, D; Libetta, C; Moretti, S; Saluti, G; Torquato, P | 1 |
| Ahmed, SA; Al-Lawati, H; Jamali, F | 1 |
| Ito, D; Ito, O; Kohzuki, M; Miura, T; Muroya, Y; Ogawa, Y; Sakuyama, A; Takahashi, J; Xu, L | 1 |
| Angioni, C; Ferreirós, N; Geisslinger, G; Hahnefeld, L; Möser, CV; Niederberger, E; Schmetzer, J; Thomas, D; Wolters, MC | 1 |
| Alaeddine, LM; Azar, NS; Dia, B; Eid, AA; El Khoury, M; Hamza, M; Harb, F; Mogharbil, N; Noureldein, MH; Sabra, R | 1 |
| Ahluwalia, A; Bubb, K; Chen, J; Colas, R; Dalli, J; Hamers, A; Khambata, RS; Kumar, NA; Masucci, M; Montalvo Moreira, SA; Primus, CP; Rathod, K; Whitear, C | 1 |
| Van Ginderachter, JA | 1 |
20 review(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and arachidonic acid
| Article | Year |
|---|---|
Cytochrome P450-dependent arachidonate metabolites, renal function and blood pressure regulation.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cells, Cultured; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1991 |
Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Drug Resistance; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Rats; Rats, Inbred Strains; Sodium Chloride | 1997 |
[The physiological role of P450-derived arachidonic acid metabolites].
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Ion Transport; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Vasoconstriction | 1998 |
Renal functional effects of endothelins: dependency on cytochrome P450-derived arachidonate metabolites.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Endothelin-1; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Tubules; Prostaglandin-Endoperoxide Synthases; Rats | 1998 |
A new class of lipid mediators: cytochrome P450 arachidonate metabolites.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Lipid Metabolism; Lung; Muscle, Smooth; Rabbits; Renal Circulation | 2000 |
Cytochrome p450 and vascular homeostasis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Cardiovascular System; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoxy Compounds; Free Radicals; Homeostasis; Humans; Hydroxyeicosatetraenoic Acids; Isoenzymes; Mixed Function Oxygenases; Muscle, Smooth, Vascular; Vasomotor System | 2001 |
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Physiological Phenomena; Cytochrome P-450 Enzyme System; Enzymes; Humans; Hydroxyeicosatetraenoic Acids | 2002 |
Cytochrome P450 pathways of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Mixed Function Oxygenases | 2002 |
Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm.
Topics: Acute Disease; Animals; Arachidonic Acid; Cerebral Arteries; Cerebrovascular Circulation; Humans; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Subarachnoid Hemorrhage; Time Factors; Vasoconstriction; Vasodilator Agents; Vasospasm, Intracranial | 2006 |
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.
Topics: Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Eicosapentaenoic Acid; Electrophysiology; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Ion Transport; Ions; Kidney; Models, Biological; Sodium Channels | 2007 |
Cytochrome P-450 metabolites in renal circulation and excretion--interaction with the nitric oxide (NO) system.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium, Dietary; Vasoconstriction | 2008 |
20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension.
Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Biological Transport; Blood Vessels; Disease Models, Animal; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Molecular Targeted Therapy; Sodium | 2010 |
The role of 20-HETE in androgen-mediated hypertension.
Topics: Acetylcholinesterase; Androgens; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Endothelial Cells; Enzyme Induction; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Natriuresis; Postmenopause; Premenopause; Rats; Renin-Angiotensin System; Rodentia; Signal Transduction | 2011 |
[Progress in research of arachidonic acid-cytochrome P450 pathway in diabetes].
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Humans; Hydroxyeicosatetraenoic Acids; Insulin Resistance | 2011 |
Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.
Topics: Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Signal Transduction | 2013 |
20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases.
Topics: Animals; Arachidonic Acid; Cardiovascular Diseases; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation | 2013 |
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Topics: Arachidonic Acid; Cytochrome P-450 Enzyme System; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Models, Biological; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Stroke; Subarachnoid Hemorrhage | 2016 |
Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function.
Topics: Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Endothelial Cells; Humans; Hydroxyeicosatetraenoic Acids | 2016 |
Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis.
Topics: Arachidonic Acid; Breast Neoplasms; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Molecular Targeted Therapy; Neoplasm Metastasis; Signal Transduction; Tumor Microenvironment | 2017 |
Conflicting roles of 20-HETE in hypertension and renal end organ damage.
Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fibrosis; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, G-Protein-Coupled; Renal Elimination; Renal Insufficiency; Renin-Angiotensin System; Sodium; Vascular Remodeling | 2018 |
1 trial(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and arachidonic acid
| Article | Year |
|---|---|
Acute effects of red wine on cytochrome P450 eicosanoids and blood pressure in men.
Topics: Alcohol Drinking; Arachidonic Acid; Binge Drinking; Blood Pressure; Cytochrome P-450 Enzyme System; Drinking Water; Ethanol; Heart Rate; Humans; Hydroxyeicosatetraenoic Acids; Male; Time Factors; Vasodilation; Vasodilator Agents; Wine | 2013 |
139 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and arachidonic acid
| Article | Year |
|---|---|
P-450-dependent arachidonic acid metabolism in rabbit olfactory microsomes.
Topics: Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Immunoblotting; Male; Microsomes; Olfactory Mucosa; Rabbits | 1992 |
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance | 1992 |
Modulation of erythropoiesis by novel human bone marrow cytochrome P450-dependent metabolites of arachidonic acid.
Topics: Arachidonic Acid; Arachidonic Acids; Bone Marrow; Cell Adhesion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythropoiesis; Humans; Hydroxyeicosatetraenoic Acids; NADP; Prostaglandin-Endoperoxide Synthases | 1991 |
Detection of 20-hydroxyeicosatetraenoic acid in rat urine.
Topics: Animals; Arachidonic Acid; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1991 |
Biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) and 12 (S)-HETE by renal cortical microsomes of the cynomolgus monkey.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Kidney Medulla; Macaca fascicularis; Microsomes; NADP | 1990 |
Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle.
Topics: Animals; Arachidonic Acid; Biomechanical Phenomena; Dogs; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Ion Channels; Muscle, Smooth, Vascular; Rats; Renal Artery; Signal Transduction; Type C Phospholipases | 1993 |
Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cobalt; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; Loop of Henle; Rabbits | 1993 |
Synergistic induction of acyl-CoA oxidase activity, an indicator of peroxisome proliferation, by arachidonic acid and retinoic acid in Morris hepatoma 7800C1 cells.
Topics: Acyl-CoA Oxidase; Animals; Arachidonic Acid; Caprylates; Carnitine O-Acetyltransferase; Catalase; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorocarbons; Hydroxyeicosatetraenoic Acids; Immunoblotting; Liver Neoplasms, Experimental; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; Rats, Wistar; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1995 |
Identification of arachidonate P-450 metabolites in human platelet phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Blood Platelets; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Phospholipids | 1995 |
Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Feedback; Furosemide; Hydroxyeicosatetraenoic Acids; Kidney Glomerulus; Kidney Tubules; Male; Meclofenamic Acid; Mixed Function Oxygenases; Osmolar Concentration; Perfusion; Pressure; Rats; Rats, Sprague-Dawley | 1994 |
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sodium Chloride | 1994 |
Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Homeostasis; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Miconazole; Microcirculation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Circulation | 1994 |
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Miconazole; Microsomes; Muscle, Smooth, Vascular; Oxazines; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation | 1994 |
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.
Topics: Animals; Arachidonic Acid; Cats; Cerebrovascular Circulation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Female; Ferric Compounds; Hydroxyeicosatetraenoic Acids; Male; Membrane Potentials; Microcirculation; Mixed Function Oxygenases; Muscle, Smooth, Vascular; Potassium Channels | 1994 |
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Topics: Animals; Arachidonic Acid; Calcium; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Hydroxyeicosatetraenoic Acids; Kidney; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pregnancy; Rabbits; Renal Artery; Vasoconstrictor Agents | 1993 |
Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats.
Topics: Animals; Arachidonic Acid; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Lipids; Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Sodium Chloride | 1993 |
20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Carotid Arteries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Mesenteric Arteries; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Artery; Vasoconstriction; Vasoconstrictor Agents | 1993 |
Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Female; Hydroxyeicosatetraenoic Acids; Ion Channel Gating; Ion Transport; Loop of Henle; Male; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley | 1995 |
20-HETE requires increased vascular tone to constrict rabbit afferent arterioles.
Topics: Animals; Arachidonic Acid; Arterioles; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rabbits; Vascular Resistance | 1996 |
Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats.
Topics: Animals; Arachidonic Acid; Base Sequence; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Lod Score; Male; Mixed Function Oxygenases; Molecular Sequence Data; Phenotype; Rats; Rats, Inbred BN; Rats, Inbred SHR; Rats, Inbred WKY; Sodium, Dietary; Species Specificity | 1996 |
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.
Topics: Animals; Arachidonic Acid; Arterioles; Base Sequence; Blood Vessels; Hydroxyeicosatetraenoic Acids; Isomerism; Male; Microcirculation; Molecular Probes; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetraethylammonium; Tetraethylammonium Compounds; Vasoconstriction | 1996 |
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.
Topics: Animals; Arachidonic Acid; Arterioles; Calcium; Cytochrome P-450 Enzyme System; Electric Conductivity; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Renal Circulation; Vasoconstriction | 1996 |
Na(+)-K+(NH4+)-2Cl- cotransport in medullary thick ascending limb: control by PKA, PKC, and 20-HETE.
Topics: Ammonia; Animals; Arachidonic Acid; Carrier Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Hydroxyeicosatetraenoic Acids; Kidney Medulla; Loop of Henle; Male; Membrane Proteins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters | 1996 |
Cytochrome P450 4A expression and arachidonic acid omega-hydroxylation in the kidney of the spontaneously hypertensive rat.
Topics: Aging; Animals; Arachidonic Acid; Blotting, Northern; Blotting, Southern; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hypertension; Immunoblotting; Kidney; Male; Mixed Function Oxygenases; Nephrons; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Rats, Inbred SHR | 1996 |
Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Baculoviridae; Capillaries; Catalysis; Cell Line; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA, Complementary; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hydroxylation; Kidney; Lauric Acids; Microsomes; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Spodoptera | 1996 |
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arterioles; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Male; Microsomes; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley; Renal Circulation; Steroid Hydroxylases; Vasodilation | 1997 |
P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Bradykinin; Calcium; Cyclic GMP; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney Tubules, Distal; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1997 |
Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue.
Topics: Animals; Arachidonic Acid; Cats; Cattle; Dose-Response Relationship, Drug; Eicosanoids; Female; Ferrets; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Lung; Male; Middle Aged; Pulmonary Artery; Rabbits; Rats; Vasodilation | 1997 |
Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney.
Topics: Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypertension, Renal; Kidney; Lauric Acids; Male; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ribonucleases; RNA, Messenger | 1997 |
The renal dopamine system.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Catechol O-Methyltransferase; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Tubules; Natriuresis; Nerve Tissue Proteins; Phospholipases A; Phospholipases A2; Phosphoproteins; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 1998 |
Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cats; Cerebral Arteries; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Primers; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Membrane Potentials; Mixed Function Oxygenases; Molecular Sequence Data; Muscle, Smooth, Vascular; Nifedipine; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Vasoconstriction; Vasoconstrictor Agents | 1998 |
ANG II controls Na(+)-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb.
Topics: Angiotensin II; Animals; Arachidonic Acid; Carrier Proteins; Hydroxyeicosatetraenoic Acids; Kidney Medulla; Loop of Henle; Male; Osmolar Concentration; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters | 1998 |
Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.
Topics: Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Kidney; Microsomes, Liver; Mixed Function Oxygenases | 1998 |
Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Lung; Macrophages, Alveolar; Male; Microsomes; Mixed Function Oxygenases; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Pulmonary Artery; Rabbits | 1998 |
20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Activation; Epidermal Growth Factor; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Male; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Rabbits | 1998 |
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator.
Topics: Animals; Arachidonic Acid; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Male; Microsomes; Prostaglandin-Endoperoxide Synthases; Rabbits | 1999 |
Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension.
Topics: Animals; Arachidonic Acid; Blood Pressure; Body Weight; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Endothelin-1; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Myocardium; Organ Size; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1999 |
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Catalysis; Cell Line; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids; Female; Hydroxyeicosatetraenoic Acids; Hydroxylation; Insecta; Kinetics; Male; Mixed Function Oxygenases; Oxidation-Reduction; Protein Isoforms; Rats; Recombinant Proteins | 1999 |
Regulation of P-450 4A activity in the glomerulus of the rat.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Diet, Sodium-Restricted; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney Glomerulus; Male; Mixed Function Oxygenases; NADP; Nitric Oxide Donors; Rats; Rats, Inbred Lew | 1999 |
Renal cytochrome P450 omega-hydroxylase and epoxygenase activity are differentially modified by nitric oxide and sodium chloride.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mixed Function Oxygenases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Nitroprusside; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1999 |
Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Transport; Cell Line; Electrolytes; Hydroxyeicosatetraenoic Acids; Ion Transport; Kidney Cortex; Kidney Tubules, Proximal; Opossums; Oxazines; Phosphates; Renin; Sodium | 1999 |
Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11.
Topics: Antibodies; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Immunohistochemistry; Kidney; Kidney Tubules; Kinetics; Liver; Microsomes; Vasoconstrictor Agents | 2000 |
Cytochrome P450 omega/omega-1 hydroxylase-derived eicosanoids contribute to endothelin(A) and endothelin(B) receptor-mediated vasoconstriction to endothelin-1 in the rat preglomerular arteriole.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dansyl Compounds; Endothelin-1; Hydroxyeicosatetraenoic Acids; Kidney; Male; Mixed Function Oxygenases; Oligopeptides; Piperidines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction | 2000 |
Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites.
Topics: Adrenalectomy; Angiotensin II; Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Indomethacin; Ion Transport; Kidney Tubules, Proximal; Losartan; Male; Ouabain; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes | 2000 |
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport.
Topics: Amides; Animals; Arachidonic Acid; Biological Transport, Active; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney Tubules, Proximal; Mixed Function Oxygenases; Perfusion; Rabbits; Sodium-Potassium-Exchanging ATPase; Sulfones | 2000 |
Cytochrome p450-dependent metabolites of arachidonic acid and renal function in the rat.
Topics: Animals; Antifungal Agents; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Homeostasis; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Function Tests; Male; Miconazole; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Urodynamics | 2000 |
Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid.
Topics: Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Indicators and Reagents; Kidney Cortex; Microsomes; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Triazoles | 2000 |
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.
Topics: Animals; Arachidonic Acid; Bezafibrate; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypolipidemic Agents; In Situ Hybridization; Kidney; Lovastatin; Male; Mice; Mice, Inbred Strains; Microsomes; Mixed Function Oxygenases; NADP; Nephrectomy; RNA, Messenger; Sodium Chloride | 2000 |
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Enalapril; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Spironolactone; Tetrazoles | 2001 |
Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia.
Topics: Animals; Arachidonic Acid; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Heme Oxygenase (Decyclizing); Hydroxyeicosatetraenoic Acids; Isoenzymes; Lung; Male; Microsomes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Pneumonia, Bacterial; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Pseudomonas Infections; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides | 2001 |
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Coronary Vessels; Cytochrome P-450 Enzyme System; Dogs; Eicosanoids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Ischemia; Reference Standards; Reperfusion | 2001 |
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Topics: Androgens; Animals; Arachidonic Acid; Blood Pressure; Castration; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Enzyme Induction; Female; Gene Deletion; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Knockout; Microsomes; Mixed Function Oxygenases; Renal Circulation; RNA, Messenger; Sex Characteristics; Testosterone; Vascular Resistance | 2001 |
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme.
Topics: Amidines; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Kidney; Male; Microsomes; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2001 |
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats.
Topics: Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Hypertension; Hypoxia; In Vitro Techniques; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Dahl; Vascular Resistance; Vasodilation | 2001 |
Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Male; Miconazole; Norepinephrine; Rabbits; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries.
Topics: Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Male; Microscopy, Video; Muscle, Skeletal; Muscle, Smooth; Oxygen; Partial Pressure; Potassium Channel Blockers; Prostaglandins; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction | 2001 |
Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule.
Topics: Animals; Arachidonic Acid; Biological Transport; Cytochrome P-450 Enzyme System; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Rubidium Radioisotopes; Signal Transduction | 2002 |
Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate Ribose; Animals; Arachidonic Acid; Arterioles; Cattle; Coronary Vessels; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Nitroprusside; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Vasodilation | 2002 |
Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure.
Topics: Animals; Arachidonic Acid; Blood Pressure; Cloning, Molecular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; DNA, Antisense; Eukaryotic Cells; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Monophenol Monooxygenase; Rats; RNA, Messenger; Transfection | 2002 |
Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Kidney Glomerulus; Male; Microcirculation; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Sprague-Dawley; Renal Artery; Vasoconstriction | 2002 |
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II.
Topics: Amides; Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfones; Triazoles; Vasoconstriction; Vasoconstrictor Agents | 2002 |
CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bronchi; Cattle; Cells, Cultured; Cloning, Molecular; Cryopreservation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; In Situ Hybridization; Lung; Male; Microsomes; Mixed Function Oxygenases; Oligodeoxyribonucleotides, Antisense; Protein Biosynthesis; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Fixation | 2002 |
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Cortex; Kidney Medulla; Male; Okadaic Acid; Phosphodiesterase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2002 |
Renal cytochrome p450 oxygenases and preglomerular vascular response to arachidonic acid and endothelin-1 following ischemia/reperfusion.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Endothelin-1; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Glomerulus; Kinetics; Male; Microsomes; Mixed Function Oxygenases; Models, Animal; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 2002 |
Arachidonic acid inhibits K channels in basolateral membrane of the thick ascending limb.
Topics: Amides; Animals; Arachidonic Acid; Cell Membrane; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Hydroxyeicosatetraenoic Acids; Indomethacin; Loop of Henle; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Sulfones | 2002 |
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries.
Topics: Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; DNA, Complementary; Gene Expression; Hydroxyeicosatetraenoic Acids; Microcirculation; Phenylephrine; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Sulfones; Transfection; Vasoconstrictor Agents | 2003 |
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis.
Topics: Amidines; Animals; Antibodies; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Electric Stimulation; Endothelial Growth Factors; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Mixed Function Oxygenases; Muscle, Skeletal; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Cytochrome P450 arachidonic acid metabolites modulate renal tubular function.
Topics: Angiotensin II; Animals; Arachidonic Acid; Calcium; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney Tubules; Rats | 2003 |
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats.
Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride; Triazoles | 2003 |
Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney.
Topics: Animals; Arachidonic Acid; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Hydroxyeicosatetraenoic Acids; Isoenzymes; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents | 2003 |
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
Topics: Animals; Arachidonic Acid; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids; Hydroxyeicosatetraenoic Acids; Hydroxylation; Isoenzymes; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2004 |
Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys.
Topics: Animals; Animals, Genetically Modified; Arachidonic Acid; Blood Pressure; Chromosomes; Cytochrome P-450 CYP4A; Diet, Sodium-Restricted; Genetic Predisposition to Disease; Hydroxyeicosatetraenoic Acids; Hypertension; Ion Transport; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Natriuresis; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Solute Carrier Family 12, Member 1 | 2004 |
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blotting, Western; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme Inhibitors; Eicosanoids; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Immunohistochemistry; Kidney; Kidney Cortex; Male; Natriuresis; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Triazoles | 2004 |
20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis?
Topics: Animals; Arachidonic Acid; Blood Pressure; Carrier Proteins; Cytochrome P-450 Enzyme System; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Kidney Tubules, Proximal; Natriuresis | 2004 |
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Topics: Animals; Arachidonic Acid; Blotting, Western; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP4A; Dichloroethylenes; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hydroxylation; Isoniazid; Kidney; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley | 2004 |
Transfection and functional expression of CYP4A1 and CYP4A2 using bicistronic vectors in vascular cells and tissues.
Topics: Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arteries; Blotting, Western; Chlorocebus aethiops; COS Cells; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Fluorescent Antibody Technique; Genetic Vectors; Green Fluorescent Proteins; Hydroxyeicosatetraenoic Acids; Isometric Contraction; Lauric Acids; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Sprague-Dawley; Renal Circulation; Transfection | 2004 |
Neurobiology: feeding the brain.
Topics: Animals; Arachidonic Acid; Arterioles; Astrocytes; Brain; Calcium; Cerebrovascular Circulation; Energy Metabolism; Hydroxyeicosatetraenoic Acids; Mice; Phospholipases A; Rats; Vasoconstriction | 2004 |
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions.
Topics: Animals; Arachidonic Acid; Arterioles; Astrocytes; Brain; Calcium Signaling; Cerebrovascular Circulation; Egtazic Acid; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Mice; Mice, Transgenic; Norepinephrine; Patch-Clamp Techniques; Phospholipases A; Photolysis; Photons; Rats; Vasoconstriction | 2004 |
Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hemodynamics; Hydroxyeicosatetraenoic Acids; Indomethacin; Kidney; Male; Miconazole; Rats; Rats, Wistar; Renal Circulation; Vasodilation | 2004 |
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats.
Topics: Amides; Animals; Arachidonic Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasopressins | 2005 |
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Arachidonic Acid; Black People; Blood Pressure; Codon; Cohort Studies; Comorbidity; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Introns; Kidney; Lauric Acids; Male; Middle Aged; Multifactorial Inheritance; Mutagenesis, Insertional; Mutation, Missense; Point Mutation; Sequence Deletion; Tennessee; United States; White People | 2005 |
Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension.
Topics: Amino Acid Substitution; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Lauric Acids; Male; Mice; Mixed Function Oxygenases; Mutation, Missense; Point Mutation; Polymorphism, Genetic; Rats; Sequence Homology, Nucleic Acid; Sex Factors; Signal Transduction; Vasoconstriction | 2005 |
Pathophysiological role of 20-HETE a cytochrome P450 metabolite of arachidonic acid.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Kidney | 2005 |
Contribution of arachidonic acid metabolites derived via cytochrome P4504A to angiotensin II-induced neointimal growth.
Topics: Angiotensin II; Animals; Arachidonic Acid; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Hydroxyeicosatetraenoic Acids; Leukocyte Common Antigens; Male; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Tunica Intima | 2005 |
Identification and quantification of the hydroxyeicosatetraenoic acids, 20-HETE and 12-HETE, in the cerebrospinal fluid after subarachnoid hemorrhage.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Aged; Arachidonic Acid; Brain Ischemia; Cerebral Arteries; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Humans; Hydroxyeicosatetraenoic Acids; Mass Spectrometry; Middle Aged; Neurochemistry; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2005 |
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE.
Topics: Animals; Anterior Cerebral Artery; Arachidonic Acid; Basilar Artery; Cerebrovascular Circulation; Cisterna Magna; Formamides; Hydroxyeicosatetraenoic Acids; Injections; Laser-Doppler Flowmetry; Male; Middle Cerebral Artery; Morpholines; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2005 |
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Prostaglandins; Signal Transduction | 2005 |
Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Dehydration; Diabetes Insipidus; Hydroxyeicosatetraenoic Acids; Kidney; Male; Oxytocin; Rats; Rats, Inbred BB; Rats, Long-Evans; Triazoles | 2005 |
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.
Topics: Amidines; Antineoplastic Agents; Arachidonic Acid; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP4A; DNA Fragmentation; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Glioma; Humans; Hydroxyeicosatetraenoic Acids; In Situ Nick-End Labeling; Mitogen-Activated Protein Kinase 1; Mitosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Thymidine | 2005 |
Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis.
Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Arachidonic Acid; Cell Membrane; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Kinetics; Oxidation-Reduction; Rats | 2005 |
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
Topics: Amides; Animals; Arachidonic Acid; Cardiotonic Agents; Coronary Circulation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Hemodynamics; Hydroxyeicosatetraenoic Acids; Ischemic Preconditioning, Myocardial; Male; Mixed Function Oxygenases; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sulfones | 2006 |
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cardiotonic Agents; Coronary Circulation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Hemodynamics; Hydroxyeicosatetraenoic Acids; Mixed Function Oxygenases; Myocardial Ischemia; Myocardial Reperfusion Injury; Spectrometry, Mass, Electrospray Ionization; Sulfones | 2006 |
Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blotting, Western; Body Weight; Central Nervous System Depressants; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Ethanol; Flavonoids; Hydroxyeicosatetraenoic Acids; Isoprostanes; Kidney; Liver; Male; Microsomes; Phenols; Polyphenols; Rats; Rats, Sprague-Dawley; Wine | 2006 |
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.
Topics: Adenoviridae; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Models, Biological; Rats; Transduction, Genetic | 2006 |
Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
Topics: Animals; Arachidonic Acid; Chlorocebus aethiops; Chromatography, High Pressure Liquid; COS Cells; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Humans; Hydroxyeicosatetraenoic Acids; Lipid Metabolism; Mass Spectrometry; Oxidation-Reduction; Oxygen; Recombinant Proteins | 2006 |
Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats.
Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Kidney Cortex; Kidney Medulla; Laser-Doppler Flowmetry; Male; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation; Triazoles; Vasoconstrictor Agents; Vasodilation | 2006 |
Functional polymorphism in human CYP4F2 decreases 20-HETE production.
Topics: Animals; Arachidonic Acid; Base Sequence; Black or African American; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Gene Expression; Gene Frequency; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Linkage Disequilibrium; Mass Spectrometry; Microsomes, Liver; Polymorphism, Single Nucleotide; Spodoptera; White People | 2007 |
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.
Topics: Amides; Amidines; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Kidney Glomerulus; Male; Permeability; Proteins; Rats; Rats, Sprague-Dawley | 2007 |
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Topics: Amidines; Antibodies; Antiparasitic Agents; Arachidonic Acid; Benzamidines; Benzoflavones; Butyrophenones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Intestinal Mucosa; Intestines; Kinetics; Methylation; Microsomes; Oxygenases; Piperidines; Prodrugs; Recombinant Proteins; Stereoisomerism | 2007 |
Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.
Topics: Aldehyde Reductase; Animals; Antioxidants; Arachidonic Acid; Benzothiazoles; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Enzyme Induction; Enzyme Inhibitors; Fenofibrate; Hydroxyeicosatetraenoic Acids; Hypoglycemic Agents; Indomethacin; Insulin; Kidney; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Perfusion; Phthalazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Spin Labels; Tyrosine | 2008 |
Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Arachidonic Acids; Case-Control Studies; Creatinine; Cross-Sectional Studies; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Hypertension, Renovascular; Male; Middle Aged; Renal Artery Obstruction | 2008 |
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
Topics: Arachidonic Acid; Cell Adhesion; Cell Cycle; Cell Proliferation; Cytochrome P-450 CYP4A; Extracellular Signal-Regulated MAP Kinases; Glioma; Humans; Hydroxyeicosatetraenoic Acids; Magnetic Resonance Imaging; Neoplastic Stem Cells; Oxidative Stress; Phenotype; Signal Transduction; Vascular Endothelial Growth Factor A | 2008 |
Cytochrome P450 metabolites of arachidonic acid play a role in the enhanced cardiac dysfunction in diabetic rats following ischaemic reperfusion injury.
Topics: 8,11,14-Eicosatrienoic Acid; Amidines; Animals; Arachidonic Acid; Blood Glucose; Body Weight; Coronary Circulation; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Epoxide Hydrolases; Glyburide; Heart; Hydroxyeicosatetraenoic Acids; Male; Microsomes; Myocardium; Rats; Rats, Wistar; Reperfusion Injury; Urea; Vascular Resistance; Ventricular Dysfunction, Left | 2009 |
CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb.
Topics: Animals; Arachidonic Acid; Chloride Channels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydroxyeicosatetraenoic Acids; Hydroxylation; In Vitro Techniques; Indomethacin; Ion Channel Gating; Loop of Henle; Male; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors | 2009 |
Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats.
Topics: Animals; Antibiotics, Antineoplastic; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 Enzyme System; Doxorubicin; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart Diseases; Hydroxyeicosatetraenoic Acids; Isoenzymes; L-Lactate Dehydrogenase; Male; Microsomes; Myocardium; Rats; Rats, Sprague-Dawley | 2010 |
Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.
Topics: Amidines; Animals; Arachidonic Acid; Carcinoma, Renal Cell; Cell Growth Processes; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Down-Regulation; Humans; Hydroxyeicosatetraenoic Acids; Kidney Neoplasms; Mice; Mice, Nude; RNA, Messenger; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2009 |
Rapid, simultaneous quantitation of mono and dioxygenated metabolites of arachidonic acid in human CSF and rat brain.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Chromatography, Liquid; Humans; Hydroxyeicosatetraenoic Acids; Male; Rats; Rats, Sprague-Dawley; Reference Standards; Subarachnoid Hemorrhage; Tandem Mass Spectrometry; Vasospasm, Intracranial | 2009 |
Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation.
Topics: Animals; Arachidonic Acid; Blotting, Western; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA, Complementary; Heart; Hydroxyeicosatetraenoic Acids; Inflammation; Kidney; Lipopolysaccharides; Liver; Male; Microsomes; Myocardium; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spectrometry, Mass, Electrospray Ionization | 2010 |
Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function?
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Arachidonic Acid; Biomarkers; Female; Graft Survival; Humans; Hydroxyeicosatetraenoic Acids; Kidney Transplantation; Lipoxygenase; Male; Middle Aged; Perioperative Period; Retrospective Studies; Time Factors; Transplantation, Homologous | 2010 |
Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome p-450 arachidonic acid metabolites.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Endothelin-1; Enzyme Inhibitors; Flavanones; Hydroxyeicosatetraenoic Acids; Indomethacin; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Rats; Receptors, Phospholipase A2; Thymidine | 2010 |
Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity.
Topics: alpha-Tocopherol; Arachidonic Acid; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Gas Chromatography-Mass Spectrometry; Genetic Association Studies; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Kinetics; Polymorphism, Single Nucleotide; Recombinant Proteins; Substrate Specificity; Tocopherols; Tocotrienols; Vitamin E | 2010 |
Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake.
Topics: Animals; Arachidonic Acid; Blood Pressure; Citrulline; Cytochrome P-450 Enzyme System; Hemodynamics; Hydroxyeicosatetraenoic Acids; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sodium, Dietary; Thiourea | 2011 |
20-Hydroxyeicosatetraenoic acid induces apoptosis in neonatal rat cardiomyocytes through mitochondrial-dependent pathways.
Topics: Amidines; Animals; Animals, Newborn; Apoptosis; Arachidonic Acid; bcl-2-Associated X Protein; Benzimidazoles; Carbocyanines; Caspase 3; Cell Survival; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluorescent Dyes; Genes, bcl-2; Hydroxyeicosatetraenoic Acids; Hydroxylation; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction; Staining and Labeling | 2011 |
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Case-Control Studies; Cytochrome P-450 Enzyme System; F2-Isoprostanes; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Oxidative Stress; Stroke | 2011 |
Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution.
Topics: Adult; Arachidonic Acid; Cadmium; Cytochrome P-450 Enzyme System; Endemic Diseases; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Epidemiological Monitoring; Female; Heme Oxygenase-1; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Diseases; Kidney Function Tests; Malaria; Male; Middle Aged; Polymorphism, Genetic; Smoking; Thailand | 2011 |
11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Endothelin-1; Hepatic Veins; Hydroxyeicosatetraenoic Acids; Hypertension, Portal; Infusion Pumps; Liver; Liver Cirrhosis, Experimental; Male; Miconazole; Organ Culture Techniques; Oxidoreductases; Phenylephrine; Portal Pressure; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction; Vasodilation | 2011 |
20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel.
Topics: Animals; Arachidonic Acid; Capsaicin; Female; Ganglia, Spinal; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurons; Patch-Clamp Techniques; Serine; TRPV Cation Channels | 2012 |
Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice.
Topics: Animals; Arachidonic Acid; Arsenic; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL | 2013 |
Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola.
Topics: Animals; Arachidonic Acid; Ascomycota; Cytochrome P-450 Enzyme System; Gene Knockout Techniques; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hydroxysteroid Dehydrogenases; Mice; Neovascularization, Physiologic; Oxidation-Reduction | 2013 |
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley | 2014 |
Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats.
Topics: Adenosine; Afferent Pathways; Animals; Arachidonic Acid; Arterioles; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Microvessels; Muscle Development; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Regional Blood Flow; Transforming Growth Factors; Vasoconstriction | 2014 |
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes.
Topics: Animals; Arachidonic Acid; Astrocytes; Brain; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Rats; Receptors, Metabotropic Glutamate | 2016 |
Myogenic and metabolic feedback in cerebral autoregulation: Putative involvement of arachidonic acid-dependent pathways.
Topics: Animals; Arachidonic Acid; Astrocytes; Brain; Calcium; Cerebrovascular Circulation; Endothelial Cells; Feedback, Physiological; Homeostasis; Humans; Hydroxyeicosatetraenoic Acids; Models, Biological; Models, Theoretical; Muscle Development; Muscle, Smooth, Vascular; Oxygen; Potassium; Signal Transduction | 2016 |
Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Arachidonic Acid; Biomarkers; Case-Control Studies; Female; Follow-Up Studies; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Prognosis; Retrospective Studies; ROC Curve | 2016 |
Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance.
Topics: Animals; Arachidonic Acid; CD36 Antigens; Diet, High-Fat; Fasting; Fatty Liver; Glycogen; Homeostasis; Hydroxyeicosatetraenoic Acids; Hypoglycemia; Insulin Resistance; Liver; Mice, Transgenic; Oxygen Consumption; Prostaglandins | 2016 |
Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade.
Topics: Apigenin; Arachidonic Acid; Cytochrome P450 Family 4; Food-Drug Interactions; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Inhibitory Concentration 50; Kidney; Liver; Microsomes; Polyphenols; Vasoconstrictor Agents | 2016 |
Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis.
Topics: Amino Acid Substitution; Arachidonic Acid; Cytochrome P450 Family 4; Erythromycin; Exome; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Mutation, Missense; Recombinant Proteins | 2017 |
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Celecoxib; Cytochrome P-450 Enzyme System; Heart; Hydroxyeicosatetraenoic Acids; Inflammation; Kidney; Lactones; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Sulfones; Thiazines; Thiazoles | 2018 |
Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
Topics: Adult; Aged; Arachidonic Acid; Asian People; Cytochrome P450 Family 4; Gene Frequency; Haplotypes; Humans; Hydroxyeicosatetraenoic Acids; Linkage Disequilibrium; Middle Aged; Polymorphism, Single Nucleotide | 2018 |
Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor.
Topics: Angiotensin II; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Protein Isoforms; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles | 2018 |
Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children.
Topics: 8,11,14-Eicosatrienoic Acid; Adolescent; Anthropometry; Arachidonic Acid; Blood Pressure; Carotid Intima-Media Thickness; Child; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 Enzyme System; Erythrocytes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Hemodynamics; Humans; Hydroxyeicosatetraenoic Acids; Male; Pediatric Obesity | 2018 |
LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum.
Topics: Adult; Arachidonic Acid; Case-Control Studies; Chromatography, Liquid; Eicosanoids; Fatty Acids, Unsaturated; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Middle Aged; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Vitamin E | 2019 |
Dose-dependency of the cardiovascular risks of non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Cardiovascular Diseases; Diclofenac; Hydroxyeicosatetraenoic Acids; Male; Rats; Rats, Sprague-Dawley; Risk Factors | 2019 |
Exercise training delays renal disorders with decreasing oxidative stress and increasing production of 20-hydroxyeicosatetraenoic acid in Dahl salt-sensitive rats.
Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Blood Pressure; Fibrosis; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Kidney Diseases; Male; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Thiobarbituric Acid Reactive Substances | 2020 |
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Arachidonic Acid; Biological Variation, Population; Blood Pressure; Cross-Over Studies; Dinoprostone; Exercise; Female; Healthy Volunteers; Heart Rate; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Lipid Metabolism; Male; Pilot Projects; Post-Exercise Hypotension; Thromboxanes | 2020 |
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomyopathies; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hydroxyeicosatetraenoic Acids; Male; NADPH Oxidase 4; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin | 2021 |
20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin.
Topics: Animals; Arachidonic Acid; Blister; Cantharidin; Edema; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Lipopolysaccharides; Mice; Neurogenic Inflammation; TRPV Cation Channels | 2022 |
The Heat Is On: 20-HETE Instructs an Immunosuppressive Phenotype in Cancer-Associated Fibroblasts.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Cancer-Associated Fibroblasts; Carcinoma, Non-Small-Cell Lung; Catalysis; Fibroblasts; Hot Temperature; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lung Neoplasms; Phenotype; Stromal Cells; Tumor Microenvironment | 2022 |