Page last updated: 2024-09-03

20-hydroxy-5,8,11,14-eicosatetraenoic acid and adenosine

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with adenosine in 8 studies

Compound Research Comparison

Studies
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Trials
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Recent Studies (post-2010)
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Studies
(adenosine)
Trials
(adenosine)
Recent Studies (post-2010) (adenosine)
6401323332,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomy20-hydroxy-5,8,11,14-eicosatetraenoic acid (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Faraci, FM; Sobey, CG1
Alonso-Galicia, M; Harder, DR; Hudetz, AG; Roman, RJ; Shen, H1
Li, D; Wang, WH; Wei, Y1
Carroll, MA; Falck, JR; Ferreri, NR; Liclican, EL; McGiff, JC; Pedraza, PL1
Boegehold, MA; Falck, JR; Mustafa, SJ; Nayeem, MA; Ponnoth, DS; Zeldin, DC1
Dick, GM; Kunduri, SS; Mustafa, SJ; Nayeem, MA; Ponnoth, DS1
Falck, JR; Fan, F; Ge, Y; Liu, R; Murphy, SR; Roman, RJ; Williams, JM1
Giedraitiene, A; Jakstas, V; Kupstyte, N; Lesauskaite, V; Skipskis, V; Tatarunas, V; Zvikas, V1

Other Studies

8 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and adenosine

ArticleYear
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
    Brain research, 1999, Mar-13, Volume: 821, Issue:2

    Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents

1999
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
    Stroke, 1999, Volume: 30, Issue:12

    Topics: Adenosine; Alkaloids; Amides; Animals; Basilar Artery; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydroxyeicosatetraenoic Acids; Indoles; Male; Microcirculation; Middle Cerebral Artery; Mixed Function Oxygenases; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfones; Vasodilation; Vasodilator Agents

1999
Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb.
    American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:5

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenylyl Cyclase Inhibitors; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Isoquinolines; Kidney; Membrane Potentials; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Potassium, Dietary; Rats; Rats, Sprague-Dawley; Sulfonamides

2004
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids.
    American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:2

    Topics: 2-Chloroadenosine; 8,11,14-Eicosatrienoic Acid; Adenosine; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Perfusion; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Renal Circulation; Sodium, Dietary; Vasodilation

2005
High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:3

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Aorta, Abdominal; Aorta, Thoracic; Blotting, Western; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Mice; Mice, Inbred C57BL; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Phenethylamines; Receptor, Adenosine A2A; Sodium, Dietary; Vasodilator Agents

2009
Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
    Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blotting, Western; Carbazoles; Cytochrome P-450 CYP4A; Enzyme Inhibitors; Female; Flavonoids; Hydroxyeicosatetraenoic Acids; Isometric Contraction; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C-alpha; Receptor, Adenosine A1

2013
Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats.
    American journal of physiology. Renal physiology, 2014, Sep-01, Volume: 307, Issue:5

    Topics: Adenosine; Afferent Pathways; Animals; Arachidonic Acid; Arterioles; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Microvessels; Muscle Development; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Regional Blood Flow; Transforming Growth Factors; Vasoconstriction

2014
The impact of CYP2C19*2, CYP4F2*3, and clinical factors on platelet aggregation, CYP4F2 enzyme activity, and 20-hydroxyeicosatetraenoic acid concentration in patients treated with dual antiplatelet therapy.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2017, Volume: 28, Issue:8

    Topics: Adenosine; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine

2017