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20-hydroxy-5,8,11,14-eicosatetraenoic acid and 19-hydroxy-5,8,11,14-eicosatetraenoic acid

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with 19-hydroxy-5,8,11,14-eicosatetraenoic acid in 22 studies

Compound Research Comparison

Studies
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Trials
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Recent Studies (post-2010)
(20-hydroxy-5,8,11,14-eicosatetraenoic acid)
Studies
(19-hydroxy-5,8,11,14-eicosatetraenoic acid)
Trials
(19-hydroxy-5,8,11,14-eicosatetraenoic acid)
Recent Studies (post-2010) (19-hydroxy-5,8,11,14-eicosatetraenoic acid)
640132333408

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.09)18.7374
1990's8 (36.36)18.2507
2000's9 (40.91)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Escalante, B; Falck, JR; Schwartzman, ML; Sessa, WC; Yadagiri, P2
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC1
Abraham, NG; Falck, JR; Feldman, E; Lutton, JD; Schwartzman, ML1
Escalante, B; Falck, JR; Laniado-Schwartzman, M; Sun, LM; Yadagiri, P1
Abraham, NG; Da Silva, JL; Escalante, B; Levere, RD; Park, E; Schwartzman, ML; Tiefenthaler, M1
Clark, JE; Falck, JR; Gebremedhin, D; Harder, DR; Ma, YH; Masters, BS; Roman, RJ; Schwartzman, ML1
Lu, M; Wang, W1
Balazy, M; Falck, JR; Mao, K; McGiff, JC; Reddy, KK1
Barac-Nieto, M; Silverstein, DM; Spitzer, A1
Baum, M; Falck, JR; Griener, JC; Quigley, R; Reddy, KM1
Carroll, MA; Croft, KD; McGiff, JC; Sanchez-Mendoza, A1
Erdmann, B; Gross, V; Honeck, H; Kärgel, E; Luft, FC; Milia, AF; Neunaber, R; Schneider, W; Schunck, WH1
Amad, M; Chuang, SS; Collop, AH; Helvig, C; Jones, G; Korczak, B; Petkovich, M; Ramshaw, HA; Taimi, M; White, JA1
Frye, RF; Poloyac, SM; Przychodzin, DI; Reynolds, RB; Tortorici, MA; Xie, W; Zemaitis, MA1
Deng, H; Falck, JR; Gopal, VR; Kemp, R; Laniado-Schwartzman, M; Nasjletti, A; Singh, H; Zhang, F1
Fleming, I1
Cheng, J; Falck, JR; Narsimhaswamy, D; Ou, JS; Pritchard, KA; Schwartzman, ML; Singh, H1
Basnet, A; Bradshaw, HB; Rimmerman, N; Tan, B; Walker, JM; Widlanski, TS1
Allorge, D; Broly, F; Cauffiez, C; Chevalier, D; Devos, A; Engels, A; Glowacki, F; Lino Cardenas, CL; Lo-Guidice, JM1
Hammock, BD; Liu, JY; Soetaert, W; Van Bogaert, I; Yang, J; Ye, Y; Zhang, G1
Gao, W; Guo, G; Zhou, B; Zu, L1

Other Studies

22 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and 19-hydroxy-5,8,11,14-eicosatetraenoic acid

ArticleYear
Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:3

    Topics: Analysis of Variance; Animals; Aorta, Thoracic; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Potassium; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase

1990
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance

1992
Modulation of erythropoiesis by novel human bone marrow cytochrome P450-dependent metabolites of arachidonic acid.
    Blood, 1991, Sep-15, Volume: 78, Issue:6

    Topics: Arachidonic Acid; Arachidonic Acids; Bone Marrow; Cell Adhesion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythropoiesis; Humans; Hydroxyeicosatetraenoic Acids; NADP; Prostaglandin-Endoperoxide Synthases

1991
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction

1989
19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.
    Biochemical and biophysical research communications, 1988, May-16, Volume: 152, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; Kidney Cortex; Microsomes; Ouabain; Rabbits; Rats; Sodium-Potassium-Exchanging ATPase

1988
Tin-mediated heme oxygenase gene activation and cytochrome P450 arachidonate hydroxylase inhibition in spontaneously hypertensive rats.
    The American journal of the medical sciences, 1994, Volume: 307, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tin; Transcriptional Activation

1994
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
    Circulation research, 1993, Volume: 72, Issue:1

    Topics: Animals; Arachidonic Acid; Calcium; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Hydroxyeicosatetraenoic Acids; Kidney; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pregnancy; Rabbits; Renal Artery; Vasoconstrictor Agents

1993
Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney.
    The Journal of general physiology, 1995, Volume: 106, Issue:4

    Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Female; Hydroxyeicosatetraenoic Acids; Ion Channel Gating; Ion Transport; Loop of Henle; Male; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley

1995
New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE).
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Animals; Diglycerides; Fatty Acids; Hydroxyeicosatetraenoic Acids; Kidney; Phospholipids; Rats

1997
Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Transport; Cell Line; Electrolytes; Hydroxyeicosatetraenoic Acids; Ion Transport; Kidney Cortex; Kidney Tubules, Proximal; Opossums; Oxazines; Phosphates; Renin; Sodium

1999
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport.
    American journal of physiology. Renal physiology, 2000, Volume: 278, Issue:6

    Topics: Amides; Animals; Arachidonic Acid; Biological Transport, Active; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney Tubules, Proximal; Mixed Function Oxygenases; Perfusion; Rabbits; Sodium-Potassium-Exchanging ATPase; Sulfones

2000
Angiotensin II releases 20-HETE from rat renal microvessels.
    American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:3

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Arachidonic Acids; Arterioles; Capillaries; Cytochrome P-450 Enzyme System; Estrenes; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Imidazoles; Kidney; Losartan; Male; NADP; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Type C Phospholipases

2000
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:4

    Topics: Animals; Arachidonic Acid; Bezafibrate; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypolipidemic Agents; In Situ Hybridization; Kidney; Lovastatin; Male; Mice; Mice, Inbred Strains; Microsomes; Mixed Function Oxygenases; NADP; Nephrectomy; RNA, Messenger; Sodium Chloride

2000
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: alpha-Linolenic Acid; Amino Acid Sequence; Animals; Arachidonic Acids; Baculoviridae; Base Sequence; Blotting, Western; Brain; Catalysis; Cell Line; Chromatography, Liquid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA, Complementary; Expressed Sequence Tags; Fatty Acids; Humans; Hydroxyeicosatetraenoic Acids; Immunoblotting; Insecta; Mass Spectrometry; Microsomes; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Signal Transduction; Substrate Specificity; Thymus Gland; Time Factors; Tissue Distribution

2004
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:7

    Topics: Animals; Arachidonic Acid; Blotting, Western; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP4A; Dichloroethylenes; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hydroxylation; Isoniazid; Kidney; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley

2004
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:1

    Topics: Amides; Animals; Arachidonic Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasopressins

2005
Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension.
    Circulation, 2005, Jan-04, Volume: 111, Issue:1

    Topics: Amino Acid Substitution; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Lauric Acids; Male; Mice; Mixed Function Oxygenases; Mutation, Missense; Point Mutation; Polymorphism, Genetic; Rats; Sequence Homology, Nucleic Acid; Sex Factors; Signal Transduction; Vasoconstriction

2005
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Cytochrome P-450 CYP4A; Endothelial Cells; Endothelium, Vascular; Heat-Shock Proteins; Hydroxyeicosatetraenoic Acids; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Superoxides; Vasodilation

2008
Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors.
    Prostaglandins & other lipid mediators, 2009, Volume: 88, Issue:1-2

    Topics: Animals; Arachidonic Acids; Cytochrome P-450 Enzyme System; Dopamine; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Mass Spectrometry; Microsomes, Liver; Rats; Recombinant Proteins; TRPV Cation Channels

2009
Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation.
    Prostaglandins, leukotrienes, and essential fatty acids, 2010, Volume: 83, Issue:2

    Topics: Brain; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Female; France; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Lung; Male; Mutation; Polymorphism, Genetic; Thymus Gland

2010
Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola.
    Journal of lipid research, 2013, Volume: 54, Issue:11

    Topics: Animals; Arachidonic Acid; Ascomycota; Cytochrome P-450 Enzyme System; Gene Knockout Techniques; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hydroxysteroid Dehydrogenases; Mice; Neovascularization, Physiologic; Oxidation-Reduction

2013
Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome.
    Thrombosis research, 2016, Volume: 144

    Topics: Acute Coronary Syndrome; Aged; Arachidonic Acid; Biomarkers; Case-Control Studies; Female; Follow-Up Studies; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Prognosis; Retrospective Studies; ROC Curve

2016