2-propanoyl-3-(4-tolyl)tropane has been researched along with cocaine in 12 studies
| Studies (2-propanoyl-3-(4-tolyl)tropane) | Trials (2-propanoyl-3-(4-tolyl)tropane) | Recent Studies (post-2010) (2-propanoyl-3-(4-tolyl)tropane) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 12 | 0 | 0 | 32,461 | 1,096 | 9,400 |
| Protein | Taxonomy | 2-propanoyl-3-(4-tolyl)tropane (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, HM; Porrino, LJ; Williams-Hemby, L | 1 |
| Co, C; Davies, HM; Dworkin, SI; Hemby, SE; Reboussin, D; Smith, JE | 1 |
| Childers, SR; Davies, HM; Porrino, LJ | 1 |
| Childers, SR; Davies, HM; Migliarese, K; Porrino, LJ; Saikali, E | 1 |
| Childers, SR; Davies, HM; Grant, KA; Mach, RH; Nader, MA | 1 |
| Birmingham, AM; Davies, HM; Grant, KA; Nader, MA; Nader, SH | 1 |
| Childers, SR; Davies, HM; Letchworth, SR; Porrino, LJ; Sexton, T; Vaughan, RA; Vrana, KE | 1 |
| Bennett, BA; Childers, SR; Davies, HM; Letchworth, SR; Porrino, LJ; Sexton, T; Smith, HR | 1 |
| Daunais, JB; Davies, HM; Freedland, CS; Hart, SL; Porrino, LJ; Smith, HR | 1 |
| Lile, JA; Morgan, D; Nader, MA | 1 |
| Birmingham, AM; Davies, HM; Lile, JA; Morgan, D; Nader, MA; Wang, Z; Woolverton, WL | 1 |
| Davies, HM; Martin, TJ; Sizemore, GM; Smith, JE | 1 |
1 review(s) available for 2-propanoyl-3-(4-tolyl)tropane and cocaine
| Article | Year |
|---|---|
Metabolic mapping methods for the identification of the neural substrates of the effects of novel tropane analogs.
Topics: Animals; Brain; Cocaine; Deoxyglucose; Glucose; Humans; Neuropharmacology; Tropanes | 1994 |
11 other study(ies) available for 2-propanoyl-3-(4-tolyl)tropane and cocaine
| Article | Year |
|---|---|
Comparison of a novel tropane analog of cocaine, 2 beta-propanoyl-3 beta-(4-tolyl) tropane with cocaine HCl in rats: nucleus accumbens extracellular dopamine concentration and motor activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cocaine; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred F344 | 1995 |
Behavioral and local cerebral metabolic effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-tolyl)-tropane.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Dose-Response Relationship, Drug; Glucose; Male; Motor Activity; Rats; Rats, Inbred F344; Stereoisomerism; Tropanes | 1995 |
Behavioral effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-toluyl)-tropane (PTT).
Topics: Analysis of Variance; Animals; Cocaine; Dose-Response Relationship, Drug; Male; Molecular Structure; Motor Activity; Rats; Rats, Inbred F344; Stereotyped Behavior; Time Factors; Tropanes | 1994 |
The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys.
Topics: Animals; Cocaine; Discrimination Learning; Female; Injections, Intravenous; Macaca mulatta; Male; Reinforcement, Psychology; Self Administration; Substance-Related Disorders; Time Factors | 1997 |
Further evaluation of the reinforcing effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) in rhesus monkeys.
Topics: Animals; Cocaine; Conditioning, Operant; Macaca mulatta; Male; Self Administration | 1998 |
Regulation of rat dopamine transporter mRNA and protein by chronic cocaine administration.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Gene Expression Regulation; In Situ Hybridization; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substantia Nigra; Tritium; Ventral Tegmental Area | 1999 |
Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Carrier Proteins; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Iodine Radioisotopes; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Oxidopamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sympatholytics | 2000 |
A comparison of the behavioral effects of the repeated administration of PTT, 2beta-propanoyl-3beta-(4-tolyl)tropane and cocaine.
Topics: Animals; Behavior, Animal; Brain; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins | 2000 |
First- versus last-session substitution: an evaluation of the reinforcing effects of cocaine and the cocaine analogue 2beta-propanoyl-3beta-(4-tolyl)-tropane.
Topics: Animals; Cocaine; Conditioning, Operant; Cues; Dopamine Uptake Inhibitors; Food; Macaca mulatta; Reinforcement Schedule; Reinforcement, Psychology | 2000 |
The reinforcing efficacy of the dopamine reuptake inhibitor 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) as measured by a progressive-ratio schedule and a choice procedure in rhesus monkeys.
Topics: Animals; Blood Pressure; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology | 2002 |
Effects of 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) on the self-administration of cocaine, heroin, and cocaine/heroin combinations in rats.
Topics: Analysis of Variance; Animals; Cocaine; Dopamine Uptake Inhibitors; Heroin; Male; Rats; Rats, Inbred F344; Reinforcement, Psychology; Self Administration; Substance-Related Disorders | 2004 |