2-propanol has been researched along with dinoprost in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (14.75) | 18.7374 |
| 1990's | 25 (40.98) | 18.2507 |
| 2000's | 25 (40.98) | 29.6817 |
| 2010's | 2 (3.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Håkanson, R; Wang, ZY | 1 |
| Okamura, T; Toda, N; Wang, Y | 1 |
| Crawford, KS; Kaufman, PL | 1 |
| Abdel-Latif, AA; Tachado, SD; Yousufzai, SY | 1 |
| Bhattacherjee, P; Csukas, S; Paterson, CA | 1 |
| Cheng-Bennett, A; Poyer, J; Weinkam, RJ; Woodward, DF | 1 |
| Abdel-Latif, AA; Carter, KD; Tachado, SD; Yousufzai, SY | 1 |
| Burke, JA; Chen, J; Palmer, BP; Ruiz, G; Wheeler, LA; Williams, LS; Woldemussie, E; Woodward, DF | 1 |
| Azuma, I; Goh, Y; Hayaishi, O; Nakajima, M | 1 |
| Candia, OA; Chu, TC; Iizuka, S | 1 |
| Fujimoto, N; Goh, Y; Hayaishi, O; Urade, Y | 1 |
| Mitchell, MD; Weaver, D; Weinreb, RN | 1 |
| Boeynaems, JM; Demolle, D; Preud'homme, Y | 1 |
| Kobayashi, S; Suzuki, R | 1 |
| Chiou, GC; Watanabe, K | 1 |
| Resul, B; Selén, G; Sjöquist, B; Stjernschantz, J | 1 |
| Hacksell, U; Liljebris, C; Resul, B; Selén, G; Stjernschantz, J | 1 |
| Martin, XD | 1 |
| Bhattacherjee, P; Paterson, CA | 1 |
| Kitamura, S; Mishima, HK; Moriishi, M; Nikaido, H; Tatsumi, K | 1 |
| Abdel-Latif, AA; Tachado, SD; Zhang, Y | 1 |
| Bhattacherjee, P; Csukas, S; Paterson, CA; Rhodes, L | 1 |
| Andley, UP; Becker, B; Fritz, C; Morrison, AR | 1 |
| Fujimoto, N; Shichi, H | 1 |
| Abdel-Latif, AA; Ye, Z; Yousufzai, SY | 1 |
| Burke, JA; Chan, MF; Chen, G; Cheng-Bennett, A; Kharlamb, A; Lai, RK; Shan, T; Wheeler, LA; Woodward, DF | 1 |
| Resul, B; Selén, G; Stjernschantz, J | 1 |
| Basu, S; Stjernschantz, J | 1 |
| Kitazawa, Y; Yamamoto, T | 1 |
| Araie, M; Tamaki, Y; Tomidokoro, A; Tomita, K | 1 |
| Abdel-Latif, AA; Yousufzai, SY | 1 |
| Camras, CB; Eisenberg, DL | 1 |
| Bhattacherjee, P; Mukhopadhyay, P; Paterson, CA; Williams, BS | 1 |
| Iizuka, Y; Kashiwagi, K; Tsukahara, S | 1 |
| Hu, DN; McCormick, SA; Stjernschantz, J | 1 |
| Abdel-Latif, AA; Gao, G; Yousufzai, SY | 1 |
| Babiole, M; Schoch, C; Wilhelm, F | 1 |
| Angert, M; Lindsey, JD; Wang, N; Weinreb, RN | 1 |
| Gabelt, BT; Gaton, DD; Kaufman, PL; Lindsey, JD; Sagara, T; Weinreb, RN | 1 |
| Abdel-Latif, AA; Ansari, HR; Husain, S | 1 |
| Awe, SO; Harris, LC; LeDay, AM; Ohia, SE; Opere, CA | 1 |
| Bhattacherjee, P; Paterson, CA; Percicot, C | 1 |
| Iizuka, Y; Kanai, N; Kashiwagi, K; Suzuki, M; Tanaka, Y; Tsuchida, T; Tsukahara, S | 1 |
| Albert, DM; Drago, F; Hu, DN; Stjernschantz, JW; Wistrand, PJ | 1 |
| Husain, S; Jafri, F | 1 |
| Abran, D; Chemtob, S; Davies, SS; Ju, WK; Neufeld, AH; Roberts, LJ | 1 |
| Burk, RM; Chan, MF; Chen, J; Krauss, AH; Protzmann, CE; Williams, LS; Woodward, DF | 1 |
| Evinger, AJ; Guzman, VM; Krauss, AH; Li, C; Liang, Y; Protzman, CE; Woodward, DF | 1 |
| Dean, TR; Graff, G; Haggard, K; Hellberg, MR; Ke, TL; Klimko, PG | 1 |
| Abdel-Latif, AA; Ansari, HR; Davis, AM; Kaddour-Djebbar, I | 1 |
| Camras, CB; Meza, JL; Toris, CB; Zhan, GL | 1 |
| Goto, W; Hara, H; Kageyama, M; Matsugi, T; Matsumura, Y; Mori, N; Nakajima, T | 1 |
| Abdel-Latif, AA; Ansari, HR; Kaddour-Djebbar, I | 1 |
| Kane, FE; Kapik, BM; McCarey, BE | 1 |
| Abdel-Latif, AA; Akhtar, RA; Ansari, HR; Kaddour-Djebbar, I | 1 |
| Chen, J; Krauss, AH; Nieves, AL; Protzman, CE; Sachs, G; Scott, DF; Spada, CS; Wheeler, LA; Woodward, DF | 1 |
| Hasegawa, Y; Hirano, K; Ishibashi, T; Kanaide, H; Niiro, N; Nishimura, J | 1 |
| Burk, RM; Donde, Y; Krauss, AH; Landsverk, K; Liang, Y; Nieves, AL; Protzman, CE; Struble, C; Wang, JW; Woodward, DF | 1 |
| Cornell, CL; Fliri, HG; Garst, ME; Kharlamb, AB; Landsverk, KJ; Martos, JL; Pettit, SN; Stamer, WD; Struble, CS; Wan, Z; Wang, JW; Wheeler, LA; Woodward, DF | 1 |
| Borghi, V; Carreiro, ST; Chiroli, V; Chong, WK; Gale, DC; Impagnatiello, F; Krauss, AH; Ongini, E; Prasanna, G; Toris, CB | 1 |
3 review(s) available for 2-propanol and dinoprost
| Article | Year |
|---|---|
Studies on prostanoid receptors in ocular tissues.
Topics: Adenylyl Cyclases; Animals; Cats; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Iris; Phosphoric Diester Hydrolases; Rabbits; Receptors, Prostaglandin; Receptors, Prostaglandin E; Signal Transduction | 1994 |
A preliminary risk-benefit assessment of latanoprost and unoprostone in open-angle glaucoma and ocular hypertension.
Topics: Dinoprost; Drug Administration Schedule; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Iris; Latanoprost; Ocular Hypertension; Pigment Epithelium of Eye; Prostaglandins F, Synthetic; Risk Assessment | 1999 |
Mechanism and clinical significance of prostaglandin-induced iris pigmentation.
Topics: Amides; Animals; Antihypertensive Agents; Bimatoprost; Cloprostenol; Dinoprost; Eye Color; Gene Expression Regulation; Humans; Iris; Iris Diseases; Latanoprost; Lipids; Melanocytes; Monophenol Monooxygenase; Pigmentation Disorders; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Travoprost; Up-Regulation | 2002 |
1 trial(s) available for 2-propanol and dinoprost
| Article | Year |
|---|---|
Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Betaxolol; Dinoprost; Double-Blind Method; Eye Color; Eyelashes; Female; Glaucoma, Open-Angle; Hair Color; Humans; Hyperpigmentation; Incidence; Intraocular Pressure; Iris; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Photography; Timolol | 2004 |
57 other study(ies) available for 2-propanol and dinoprost
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
(+/-)-CP-96,345, a selective tachykinin NK1 receptor antagonist, has non-specific actions on neurotransmission.
Topics: Animals; Biphenyl Compounds; Carbachol; Dinoprost; Electric Stimulation; Female; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Synaptic Transmission; Tachykinins; Vas Deferens | 1992 |
Local generation and action of angiotensin II in dog iris sphincter muscle.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Dinoprost; Dogs; Dose-Response Relationship, Drug; Female; Iris; Male; Muscle Contraction; Muscle, Smooth; Peptidyl-Dipeptidase A | 1992 |
Dose-related effects of prostaglandin F2 alpha isopropylester on intraocular pressure, refraction, and pupil diameter in monkeys.
Topics: Accommodation, Ocular; Animals; Dinoprost; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Iris; Macaca fascicularis; Pupil; Refraction, Ocular | 1991 |
Species differences in the effects of leukotriene D4 on inositol trisphosphate accumulation, cyclic AMP formation and contraction in iris sphincter of the mammalian eye.
Topics: Animals; Cats; Cattle; Cyclic AMP; Dinoprost; Humans; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Rabbits; Radioimmunoassay; Species Specificity; SRS-A; Swine | 1990 |
Prostaglandin E2 binding sites in bovine iris-ciliary body.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Dinoprostone; Iris; Kidney Medulla; Kinetics; Radioligand Assay; Rats; Receptors, Prostaglandin; Receptors, Prostaglandin E | 1990 |
Lack of prostaglandin F2 alpha metabolism by human ocular tissues.
Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Dinoprost; Eye; Female; Humans; In Vitro Techniques; Iris; Lung; Rabbits; Sclera | 1990 |
Short-term desensitization of prostaglandin F2 alpha receptors increases cyclic AMP formation and reduces inositol phosphates accumulation and contraction in the bovine iris sphincter.
Topics: Animals; Cattle; Cyclic AMP; Diglycerides; Dinoprost; In Vitro Techniques; Indomethacin; Inositol Phosphates; Iris; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Phosphatidic Acids; Phosphoproteins; Phosphorylation; Receptors, Prostaglandin | 1989 |
Prostaglandin F2 alpha effects on intraocular pressure negatively correlate with FP-receptor stimulation.
Topics: Administration, Topical; Animals; Cats; Dinoprost; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Iris; Male; Pupil; Rabbits; Receptors, Prostaglandin; Time Factors; Tonometry, Ocular | 1989 |
Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits.
Topics: Administration, Topical; Animals; Aqueous Humor; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Hyperemia; Intraocular Pressure; Iris; Prostaglandin D2; Rabbits; Reflex, Pupillary; Time Factors; Tonometry, Ocular | 1988 |
Effects of forskolin, prostaglandin F2 alpha, and Ba2+ on the short-circuit current of the isolated rabbit iris-ciliary body.
Topics: Animals; Barium; Ciliary Body; Colforsin; Dinoprost; Electric Conductivity; Electrophysiology; Female; In Vitro Techniques; Intraocular Pressure; Iris; Prostaglandins F; Rabbits | 1986 |
Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system.
Topics: Animals; Ciliary Body; Dinoprost; Dinoprostone; Eye; Glutathione; Hydroxyprostaglandin Dehydrogenases; Iris; Male; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Retina; Sclera; Tissue Distribution | 1987 |
Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris.
Topics: Animals; Aqueous Humor; Dinoprost; Dinoprostone; Female; Iris; Laser Therapy; Lasers; Male; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rabbits | 1985 |
Metabolism of arachidonic acid in rabbit iris and retina.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprost; Dinoprostone; Hydroxyeicosatetraenoic Acids; Iris; Prostaglandins E; Prostaglandins F; Rabbits; Retina; Thromboxane B2 | 1985 |
Response of bovine intra-ocular muscles to transmural stimulation in the presence of various prostaglandins.
Topics: Action Potentials; Alprostadil; Animals; Cattle; Ciliary Body; Dinoprost; Dinoprostone; Electric Stimulation; In Vitro Techniques; Indomethacin; Iris; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Neuromuscular Junction; Parasympathomimetics; Prostaglandins; Prostaglandins E; Prostaglandins F; Sympathomimetics; Synaptic Transmission | 1983 |
Action mechanism of timolol to lower the intraocular pressure in rabbits.
Topics: Animals; Aqueous Humor; Catecholamines; Ciliary Body; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Intraocular Pressure; Iris; Prostaglandins E; Prostaglandins F; Rabbits; Regional Blood Flow; Retinal Vessels; Sodium-Potassium-Exchanging ATPase; Timolol | 1983 |
Preclinical pharmacology of latanoprost, a phenyl-substituted PGF2 alpha analogue.
Topics: Administration, Topical; Animals; Aqueous Humor; Blood Platelets; Cats; Cattle; Cornea; Coronary Vessels; Corpus Luteum; Dinoprost; Female; Guinea Pigs; Ileum; In Vitro Techniques; Iris; Latanoprost; Macaca fascicularis; Male; Muscle, Smooth; Organ Specificity; Prostaglandins F, Synthetic; Rabbits; Regional Blood Flow; Swine; Vas Deferens | 1995 |
Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester: potential antiglaucoma agents.
Topics: Animals; Capillary Permeability; Cats; Dinoprost; Glaucoma; Haplorhini; Humans; Intraocular Pressure; Iris; Muscle Contraction; Rabbits; Structure-Activity Relationship | 1995 |
Treatment of pigment dispersion syndrome.
Topics: Dinoprost; Epinephrine; Exfoliation Syndrome; Humans; Iris; Laser Therapy; Miotics; Retinal Detachment | 1994 |
15-Ketoprostaglandin delta 13-reductase activity in bovine ocular tissues.
Topics: 15-Oxoprostaglandin 13-Reductase; Ammonium Sulfate; Animals; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Ciliary Body; Cytosol; Dinoprost; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Eye; Iris; Molecular Weight; NADP; Oxidation-Reduction; Substrate Specificity | 1993 |
Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cattle; Chromatography, Ion Exchange; Cyclic AMP; Dinoprost; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Phorbol Esters; Protein Kinase C; Radioimmunoassay; Receptors, Prostaglandin; Staurosporine | 1993 |
Prostaglandin E2 and F2 alpha binding sites in the bovine iris ciliary body.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Dinoprostone; Iris; Kinetics; Ligands; Muscles; Radioligand Assay; Receptors, Prostaglandin; Receptors, Prostaglandin E | 1993 |
The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cataract; Ciliary Body; Conjunctiva; Cornea; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Indomethacin; Iris; Lens Cortex, Crystalline; Misoprostol; Ophthalmic Solutions; Oxytocics; Potassium; Rabbits; Radiation Injuries, Experimental; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Ultraviolet Rays | 1996 |
Effect of prostaglandins on cultured porcine iris sphincter muscle cells.
Topics: Animals; Carbachol; Cells, Cultured; Cyclic AMP; Dinoprost; Dinoprostone; Iris; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Receptors, Prostaglandin E; Swine | 1996 |
Prostaglandin F2 alpha and its analogs induce release of endogenous prostaglandins in iris and ciliary muscles isolated from cat and other mammalian species.
Topics: Animals; Cats; Cattle; Ciliary Body; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Humans; Indomethacin; Iris; Latanoprost; Macaca mulatta; Muscles; Prostaglandins; Prostaglandins F, Synthetic; Rabbits | 1996 |
In-vivo activity and enzymatic hydrolysis of novel prostaglandin F2 alpha prodrugs in ocular tissues.
Topics: Animals; Antihypertensive Agents; Ciliary Body; Conjunctiva; Cornea; Culture Techniques; Dinoprost; Dogs; Dose-Response Relationship, Drug; Esters; Eye; Female; Humans; Hydrolysis; Hyperemia; Intraocular Pressure; Iris; Macaca fascicularis; Male; Prodrugs; Pupil | 1996 |
Prostaglandin-induced iridial pigmentation in primates.
Topics: Administration, Topical; Animals; Dinoprost; Dinoprostone; Eye Color; Iris; Iris Diseases; Latanoprost; Macaca fascicularis; Melanosis; Ophthalmic Solutions; Pigment Epithelium of Eye; Prostaglandins; Prostaglandins F, Synthetic; Sympathectomy | 1997 |
Delta13-reductase dependent metabolism of prostaglandins in the mammalian brain and eye.
Topics: Animals; Brain; Cattle; Ciliary Body; Cornea; Cytosol; Dinoprost; Eye; Haplorhini; Hydroxyprostaglandin Dehydrogenases; Iris; NAD; Prostaglandins; Rabbits; Swine; Tritium | 1997 |
Iris-color change developed after topical isopropyl unoprostone treatment.
Topics: Administration, Topical; Dinoprost; Eye Color; Follow-Up Studies; Glaucoma; Humans; Iris; Iris Diseases; Male; Middle Aged; Ophthalmic Solutions | 1997 |
In vivo measurement of iridial circulation using laser speckle phenomenon.
Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Circulation; Blood Flow Velocity; Dinoprost; Intraocular Pressure; Iris; Lasers; Microspheres; Ophthalmic Solutions; Rabbits; Reproducibility of Results; Timolol | 1998 |
Tyrosine kinase inhibitors suppress prostaglandin F2alpha-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle.
Topics: Animals; Calcium; Carbachol; Cardiotonic Agents; Cats; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Hydrolysis; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Prostaglandins F, Synthetic; Protein-Tyrosine Kinases; Vanadates | 1998 |
Bovine iris-sphincter muscle lacks FP receptor binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Dinoprost; DNA Primers; Iris; Muscle, Smooth; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Reverse Transcriptase Polymerase Chain Reaction | 1999 |
Metabolites of isopropyl unoprostone as potential ophthalmic solutions to reduce intraocular pressure in pigmented rabbits.
Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Ciliary Body; Cornea; Dinoprost; Eye; Intraocular Pressure; Iris; Ophthalmic Solutions; Pigmentation; Rabbits; Retina; Tissue Distribution; Tritium | 1999 |
Effect of prostaglandins A(2), E(1), F(2 alpha)and latanoprost on cultured human iridal melanocytes.
Topics: Alprostadil; Cell Differentiation; Cell Division; Cells, Cultured; Dendrites; Dinoprost; Dose-Response Relationship, Drug; Humans; Iris; Melanins; Melanocytes; Microscopy, Phase-Contrast; Prostaglandins; Prostaglandins A | 2000 |
Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle.
Topics: Animals; Carbachol; Cats; Dinoprost; Enzyme Inhibitors; Flavonoids; Imidazoles; Iris; Miotics; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxytocics; Phosphorylation; Pyridines | 2000 |
In vitro corneal permeation of unoprostone isopropyl (UI) and its metabolism in the isolated pig eye.
Topics: Acetylcholinesterase; Animals; Antihypertensive Agents; Aqueous Humor; Butyrylcholinesterase; Carbonic Anhydrases; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Dinoprost; Hydrolysis; Iris; Naphthols; Permeability; Prodrugs; Substrate Specificity; Swine; Trabecular Meshwork | 2001 |
Latanoprost and matrix metalloproteinase-1 in human choroid organ cultures.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Choroid; Ciliary Body; Dinoprost; DNA Primers; DNA Probes; Humans; Immunoblotting; Iris; Latanoprost; Matrix Metalloproteinase 1; Middle Aged; Organ Culture Techniques; Polymerase Chain Reaction; Prostaglandins F, Synthetic; RNA, Messenger | 2001 |
Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment.
Topics: Administration, Topical; Animals; Anterior Eye Segment; Ciliary Body; Dinoprost; Immunoenzyme Techniques; Intraocular Pressure; Iris; Macaca fascicularis; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Muscle, Smooth; Ophthalmic Solutions; Sclera; Uvea | 2001 |
Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Benzylamines; Blotting, Western; Calcium-Transporting ATPases; Cats; Densitometry; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Ionomycin; Ionophores; Iris; Isoproterenol; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle, Smooth; Sulfonamides; Thapsigargin | 2001 |
Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Dinoprost; Dinoprostone; Electric Stimulation; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; Iris; Isomerism; Isoprostanes; Norepinephrine; Receptors, Thromboxane; Sympathetic Nervous System; Synaptic Transmission; Thromboxane-A Synthase; Vasoconstrictor Agents | 2001 |
Studies on receptor binding and signal transduction pathways of unoprostone isopropyl.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Binding, Competitive; Calcium; Cattle; Ciliary Body; Corpus Luteum; Cyclic AMP; Dinoprost; Female; Iris; Ligands; Muscle, Smooth; Rabbits; Receptors, Prostaglandin; Signal Transduction | 2001 |
Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism.
Topics: Adult; Animals; Antihypertensive Agents; Antiporters; Aqueous Humor; Cattle; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; DNA-Binding Proteins; HeLa Cells; Humans; Indomethacin; Iris; Latanoprost; Organic Anion Transporters; Prostaglandins F, Synthetic | 2002 |
Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1.
Topics: Animals; Blotting, Western; Cats; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genistein; Iris; Isoenzymes; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Binding; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine; Tyrphostins | 2002 |
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro.
Topics: Amides; Animals; Bimatoprost; Ciliary Body; Cloprostenol; Cornea; Dinoprost; Eye; Humans; Hydrolysis; In Vitro Techniques; Iris; Kinetics; Lipid Metabolism; Lipids; Prodrugs; Sclera; Swine; Time Factors | 2003 |
Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Antihypertensive Agents; Calcium Signaling; Cats; Dinoprost; Iris; Mice; Muscle, Smooth; Ocular Hypertension | 2002 |
Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression.
Topics: Alprostadil; Amides; Animals; Bimatoprost; Cats; Cell Line; Cells, Cultured; Ciliary Body; Cloprostenol; Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Dinoprost; Gene Expression; Glaucoma; Humans; Immediate-Early Proteins; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Iris; Kinetics; Lipids; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Trabecular Meshwork; Up-Regulation | 2003 |
The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.
Topics: Amides; Animals; Bimatoprost; Chromatography, High Pressure Liquid; Ciliary Body; Cloprostenol; Cornea; Dinoprost; Humans; Hydrolysis; In Vitro Techniques; Iris; Lipid Metabolism; Lipids; Rabbits; Sclera | 2003 |
Effects of prostaglandin F2alpha and latanoprost on phosphoinositide turnover, myosin light chain phosphorylation and contraction in cat iris sphincter.
Topics: Animals; Antihypertensive Agents; Cats; Dinoprost; Dose-Response Relationship, Drug; In Vitro Techniques; Intraocular Pressure; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphatidylinositols; Phosphorylation; Prostaglandins F, Synthetic | 2003 |
Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.
Topics: Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Cyclooxygenase Inhibitors; Dinoprost; Esters; Eye Color; Eye Proteins; Flurbiprofen; Iris; Melanins; Moxisylyte; Pigmentation; Premedication; Rabbits; Superior Cervical Ganglion; Sympathectomy | 2003 |
New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents.
Topics: Administration, Topical; Animals; Cats; Cell Line, Tumor; Dinoprost; Drug Evaluation, Preclinical; Forecasting; Intraocular Pressure; Iris; Latanoprost; Macaca fascicularis; Melanins; Mice; Miosis; Prostaglandins F; Prostaglandins F, Synthetic; Receptors, Prostaglandin | 2003 |
Effects of prostaglandin F2alpha, latanoprost and carbachol on phosphoinositide turnover, MAP kinases, myosin light chain phosphorylation and contraction and functional existence and expression of FP receptors in bovine iris sphincter.
Topics: Animals; Antihypertensive Agents; Carbachol; Cattle; Culture Techniques; Dinoprost; Dose-Response Relationship, Drug; Inositol Phosphates; Iris; Latanoprost; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphatidylinositols; Phosphorylation; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Signal Transduction | 2004 |
Species differences in the effects of prostanoids on MAP kinase phosphorylation, myosin light chain phosphorylation and contraction in bovine and cat iris sphincter smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cats; Cattle; Dinoprost; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Prostaglandins; Prostaglandins F, Synthetic; Species Specificity | 2005 |
Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells.
Topics: Amides; Animals; Bimatoprost; Calcium; Calcium Signaling; Carbachol; Cats; Cells, Cultured; Cholinergic Agonists; Cloprostenol; Dinoprost; Humans; Intraocular Pressure; Iris; Lipids; Microscopy, Confocal; Muscle Contraction | 2005 |
Prostaglandin F2alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle.
Topics: Animals; Antihypertensive Agents; Calcium; Carbachol; Dinoprost; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Prostaglandins F, Synthetic; Protein Serine-Threonine Kinases; rho-Associated Kinases; Swine; Type C Phospholipases | 2006 |
Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Iris; Oxazoles; Receptors, Prostaglandin; Recombinant Proteins | 2007 |
Bimatoprost, prostamide activity, and conventional drainage.
Topics: Aged; Aged, 80 and over; Amides; Animals; Antihypertensive Agents; Aqueous Humor; Bimatoprost; Calcium; Calcium Signaling; Cats; Cell Culture Techniques; Cloprostenol; Dinoprost; Dinoprostone; Female; Humans; Intraocular Pressure; Iris; Lipids; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Oxazoles; Receptors, Thromboxane; Recombinant Proteins; Trabecular Meshwork | 2007 |
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Aqueous Humor; Cell Line; Ciliary Body; Cyclic GMP; Dinoprost; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Glaucoma; Guanylate Cyclase; Intraocular Pressure; Iris; Latanoprost; Macaca fascicularis; Male; Nitric Oxide; Nitric Oxide Donors; Ocular Hypertension; Prostaglandins F, Synthetic; Rabbits; Rats; Tonometry, Ocular | 2011 |