2-propanol and dinoprost

2-propanol has been researched along with dinoprost in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19909 (14.75)18.7374
1990's25 (40.98)18.2507
2000's25 (40.98)29.6817
2010's2 (3.28)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Håkanson, R; Wang, ZY1
Okamura, T; Toda, N; Wang, Y1
Crawford, KS; Kaufman, PL1
Abdel-Latif, AA; Tachado, SD; Yousufzai, SY1
Bhattacherjee, P; Csukas, S; Paterson, CA1
Cheng-Bennett, A; Poyer, J; Weinkam, RJ; Woodward, DF1
Abdel-Latif, AA; Carter, KD; Tachado, SD; Yousufzai, SY1
Burke, JA; Chen, J; Palmer, BP; Ruiz, G; Wheeler, LA; Williams, LS; Woldemussie, E; Woodward, DF1
Azuma, I; Goh, Y; Hayaishi, O; Nakajima, M1
Candia, OA; Chu, TC; Iizuka, S1
Fujimoto, N; Goh, Y; Hayaishi, O; Urade, Y1
Mitchell, MD; Weaver, D; Weinreb, RN1
Boeynaems, JM; Demolle, D; Preud'homme, Y1
Kobayashi, S; Suzuki, R1
Chiou, GC; Watanabe, K1
Resul, B; Selén, G; Sjöquist, B; Stjernschantz, J1
Hacksell, U; Liljebris, C; Resul, B; Selén, G; Stjernschantz, J1
Martin, XD1
Bhattacherjee, P; Paterson, CA1
Kitamura, S; Mishima, HK; Moriishi, M; Nikaido, H; Tatsumi, K1
Abdel-Latif, AA; Tachado, SD; Zhang, Y1
Bhattacherjee, P; Csukas, S; Paterson, CA; Rhodes, L1
Andley, UP; Becker, B; Fritz, C; Morrison, AR1
Fujimoto, N; Shichi, H1
Abdel-Latif, AA; Ye, Z; Yousufzai, SY1
Burke, JA; Chan, MF; Chen, G; Cheng-Bennett, A; Kharlamb, A; Lai, RK; Shan, T; Wheeler, LA; Woodward, DF1
Resul, B; Selén, G; Stjernschantz, J1
Basu, S; Stjernschantz, J1
Kitazawa, Y; Yamamoto, T1
Araie, M; Tamaki, Y; Tomidokoro, A; Tomita, K1
Abdel-Latif, AA; Yousufzai, SY1
Camras, CB; Eisenberg, DL1
Bhattacherjee, P; Mukhopadhyay, P; Paterson, CA; Williams, BS1
Iizuka, Y; Kashiwagi, K; Tsukahara, S1
Hu, DN; McCormick, SA; Stjernschantz, J1
Abdel-Latif, AA; Gao, G; Yousufzai, SY1
Babiole, M; Schoch, C; Wilhelm, F1
Angert, M; Lindsey, JD; Wang, N; Weinreb, RN1
Gabelt, BT; Gaton, DD; Kaufman, PL; Lindsey, JD; Sagara, T; Weinreb, RN1
Abdel-Latif, AA; Ansari, HR; Husain, S1
Awe, SO; Harris, LC; LeDay, AM; Ohia, SE; Opere, CA1
Bhattacherjee, P; Paterson, CA; Percicot, C1
Iizuka, Y; Kanai, N; Kashiwagi, K; Suzuki, M; Tanaka, Y; Tsuchida, T; Tsukahara, S1
Albert, DM; Drago, F; Hu, DN; Stjernschantz, JW; Wistrand, PJ1
Husain, S; Jafri, F1
Abran, D; Chemtob, S; Davies, SS; Ju, WK; Neufeld, AH; Roberts, LJ1
Burk, RM; Chan, MF; Chen, J; Krauss, AH; Protzmann, CE; Williams, LS; Woodward, DF1
Evinger, AJ; Guzman, VM; Krauss, AH; Li, C; Liang, Y; Protzman, CE; Woodward, DF1
Dean, TR; Graff, G; Haggard, K; Hellberg, MR; Ke, TL; Klimko, PG1
Abdel-Latif, AA; Ansari, HR; Davis, AM; Kaddour-Djebbar, I1
Camras, CB; Meza, JL; Toris, CB; Zhan, GL1
Goto, W; Hara, H; Kageyama, M; Matsugi, T; Matsumura, Y; Mori, N; Nakajima, T1
Abdel-Latif, AA; Ansari, HR; Kaddour-Djebbar, I1
Kane, FE; Kapik, BM; McCarey, BE1
Abdel-Latif, AA; Akhtar, RA; Ansari, HR; Kaddour-Djebbar, I1
Chen, J; Krauss, AH; Nieves, AL; Protzman, CE; Sachs, G; Scott, DF; Spada, CS; Wheeler, LA; Woodward, DF1
Hasegawa, Y; Hirano, K; Ishibashi, T; Kanaide, H; Niiro, N; Nishimura, J1
Burk, RM; Donde, Y; Krauss, AH; Landsverk, K; Liang, Y; Nieves, AL; Protzman, CE; Struble, C; Wang, JW; Woodward, DF1
Cornell, CL; Fliri, HG; Garst, ME; Kharlamb, AB; Landsverk, KJ; Martos, JL; Pettit, SN; Stamer, WD; Struble, CS; Wan, Z; Wang, JW; Wheeler, LA; Woodward, DF1
Borghi, V; Carreiro, ST; Chiroli, V; Chong, WK; Gale, DC; Impagnatiello, F; Krauss, AH; Ongini, E; Prasanna, G; Toris, CB1

Reviews

3 review(s) available for 2-propanol and dinoprost

ArticleYear
Studies on prostanoid receptors in ocular tissues.
    Journal of ocular pharmacology, 1994,Spring, Volume: 10, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cats; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Iris; Phosphoric Diester Hydrolases; Rabbits; Receptors, Prostaglandin; Receptors, Prostaglandin E; Signal Transduction

1994
A preliminary risk-benefit assessment of latanoprost and unoprostone in open-angle glaucoma and ocular hypertension.
    Drug safety, 1999, Volume: 20, Issue:6

    Topics: Dinoprost; Drug Administration Schedule; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Iris; Latanoprost; Ocular Hypertension; Pigment Epithelium of Eye; Prostaglandins F, Synthetic; Risk Assessment

1999
Mechanism and clinical significance of prostaglandin-induced iris pigmentation.
    Survey of ophthalmology, 2002, Volume: 47 Suppl 1

    Topics: Amides; Animals; Antihypertensive Agents; Bimatoprost; Cloprostenol; Dinoprost; Eye Color; Gene Expression Regulation; Humans; Iris; Iris Diseases; Latanoprost; Lipids; Melanocytes; Monophenol Monooxygenase; Pigmentation Disorders; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Travoprost; Up-Regulation

2002

Trials

1 trial(s) available for 2-propanol and dinoprost

ArticleYear
Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%.
    Ophthalmology, 2004, Volume: 111, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Betaxolol; Dinoprost; Double-Blind Method; Eye Color; Eyelashes; Female; Glaucoma, Open-Angle; Hair Color; Humans; Hyperpigmentation; Incidence; Intraocular Pressure; Iris; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Photography; Timolol

2004

Other Studies

57 other study(ies) available for 2-propanol and dinoprost

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
(+/-)-CP-96,345, a selective tachykinin NK1 receptor antagonist, has non-specific actions on neurotransmission.
    British journal of pharmacology, 1992, Volume: 107, Issue:3

    Topics: Animals; Biphenyl Compounds; Carbachol; Dinoprost; Electric Stimulation; Female; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rabbits; Receptors, Neurotransmitter; Receptors, Tachykinin; Synaptic Transmission; Tachykinins; Vas Deferens

1992
Local generation and action of angiotensin II in dog iris sphincter muscle.
    Experimental eye research, 1992, Volume: 55, Issue:4

    Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Dinoprost; Dogs; Dose-Response Relationship, Drug; Female; Iris; Male; Muscle Contraction; Muscle, Smooth; Peptidyl-Dipeptidase A

1992
Dose-related effects of prostaglandin F2 alpha isopropylester on intraocular pressure, refraction, and pupil diameter in monkeys.
    Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:3

    Topics: Accommodation, Ocular; Animals; Dinoprost; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Iris; Macaca fascicularis; Pupil; Refraction, Ocular

1991
Species differences in the effects of leukotriene D4 on inositol trisphosphate accumulation, cyclic AMP formation and contraction in iris sphincter of the mammalian eye.
    Prostaglandins, 1990, Volume: 39, Issue:3

    Topics: Animals; Cats; Cattle; Cyclic AMP; Dinoprost; Humans; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Rabbits; Radioimmunoassay; Species Specificity; SRS-A; Swine

1990
Prostaglandin E2 binding sites in bovine iris-ciliary body.
    Investigative ophthalmology & visual science, 1990, Volume: 31, Issue:6

    Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Dinoprostone; Iris; Kidney Medulla; Kinetics; Radioligand Assay; Rats; Receptors, Prostaglandin; Receptors, Prostaglandin E

1990
Lack of prostaglandin F2 alpha metabolism by human ocular tissues.
    Investigative ophthalmology & visual science, 1990, Volume: 31, Issue:7

    Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Dinoprost; Eye; Female; Humans; In Vitro Techniques; Iris; Lung; Rabbits; Sclera

1990
Short-term desensitization of prostaglandin F2 alpha receptors increases cyclic AMP formation and reduces inositol phosphates accumulation and contraction in the bovine iris sphincter.
    Current eye research, 1989, Volume: 8, Issue:11

    Topics: Animals; Cattle; Cyclic AMP; Diglycerides; Dinoprost; In Vitro Techniques; Indomethacin; Inositol Phosphates; Iris; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Phosphatidic Acids; Phosphoproteins; Phosphorylation; Receptors, Prostaglandin

1989
Prostaglandin F2 alpha effects on intraocular pressure negatively correlate with FP-receptor stimulation.
    Investigative ophthalmology & visual science, 1989, Volume: 30, Issue:8

    Topics: Administration, Topical; Animals; Cats; Dinoprost; Dose-Response Relationship, Drug; Female; Intraocular Pressure; Iris; Male; Pupil; Rabbits; Receptors, Prostaglandin; Time Factors; Tonometry, Ocular

1989
Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits.
    Japanese journal of ophthalmology, 1988, Volume: 32, Issue:4

    Topics: Administration, Topical; Animals; Aqueous Humor; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Hyperemia; Intraocular Pressure; Iris; Prostaglandin D2; Rabbits; Reflex, Pupillary; Time Factors; Tonometry, Ocular

1988
Effects of forskolin, prostaglandin F2 alpha, and Ba2+ on the short-circuit current of the isolated rabbit iris-ciliary body.
    Current eye research, 1986, Volume: 5, Issue:7

    Topics: Animals; Barium; Ciliary Body; Colforsin; Dinoprost; Electric Conductivity; Electrophysiology; Female; In Vitro Techniques; Intraocular Pressure; Iris; Prostaglandins F; Rabbits

1986
Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system.
    Biochimica et biophysica acta, 1987, Sep-25, Volume: 921, Issue:2

    Topics: Animals; Ciliary Body; Dinoprost; Dinoprostone; Eye; Glutathione; Hydroxyprostaglandin Dehydrogenases; Iris; Male; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Retina; Sclera; Tissue Distribution

1987
Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris.
    Investigative ophthalmology & visual science, 1985, Volume: 26, Issue:8

    Topics: Animals; Aqueous Humor; Dinoprost; Dinoprostone; Female; Iris; Laser Therapy; Lasers; Male; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rabbits

1985
Metabolism of arachidonic acid in rabbit iris and retina.
    Investigative ophthalmology & visual science, 1985, Volume: 26, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprost; Dinoprostone; Hydroxyeicosatetraenoic Acids; Iris; Prostaglandins E; Prostaglandins F; Rabbits; Retina; Thromboxane B2

1985
Response of bovine intra-ocular muscles to transmural stimulation in the presence of various prostaglandins.
    Experimental eye research, 1983, Volume: 36, Issue:6

    Topics: Action Potentials; Alprostadil; Animals; Cattle; Ciliary Body; Dinoprost; Dinoprostone; Electric Stimulation; In Vitro Techniques; Indomethacin; Iris; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Neuromuscular Junction; Parasympathomimetics; Prostaglandins; Prostaglandins E; Prostaglandins F; Sympathomimetics; Synaptic Transmission

1983
Action mechanism of timolol to lower the intraocular pressure in rabbits.
    Ophthalmic research, 1983, Volume: 15, Issue:3

    Topics: Animals; Aqueous Humor; Catecholamines; Ciliary Body; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Intraocular Pressure; Iris; Prostaglandins E; Prostaglandins F; Rabbits; Regional Blood Flow; Retinal Vessels; Sodium-Potassium-Exchanging ATPase; Timolol

1983
Preclinical pharmacology of latanoprost, a phenyl-substituted PGF2 alpha analogue.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Administration, Topical; Animals; Aqueous Humor; Blood Platelets; Cats; Cattle; Cornea; Coronary Vessels; Corpus Luteum; Dinoprost; Female; Guinea Pigs; Ileum; In Vitro Techniques; Iris; Latanoprost; Macaca fascicularis; Male; Muscle, Smooth; Organ Specificity; Prostaglandins F, Synthetic; Rabbits; Regional Blood Flow; Swine; Vas Deferens

1995
Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester: potential antiglaucoma agents.
    Journal of medicinal chemistry, 1995, Jan-20, Volume: 38, Issue:2

    Topics: Animals; Capillary Permeability; Cats; Dinoprost; Glaucoma; Haplorhini; Humans; Intraocular Pressure; Iris; Muscle Contraction; Rabbits; Structure-Activity Relationship

1995
Treatment of pigment dispersion syndrome.
    Ophthalmology, 1994, Volume: 101, Issue:10

    Topics: Dinoprost; Epinephrine; Exfoliation Syndrome; Humans; Iris; Laser Therapy; Miotics; Retinal Detachment

1994
15-Ketoprostaglandin delta 13-reductase activity in bovine ocular tissues.
    Current eye research, 1993, Volume: 12, Issue:1

    Topics: 15-Oxoprostaglandin 13-Reductase; Ammonium Sulfate; Animals; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Ciliary Body; Cytosol; Dinoprost; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Eye; Iris; Molecular Weight; NADP; Oxidation-Reduction; Substrate Specificity

1993
Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.
    Investigative ophthalmology & visual science, 1993, Volume: 34, Issue:6

    Topics: Adenylyl Cyclases; Alkaloids; Animals; Cattle; Chromatography, Ion Exchange; Cyclic AMP; Dinoprost; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Iris; Muscle Contraction; Phorbol Esters; Protein Kinase C; Radioimmunoassay; Receptors, Prostaglandin; Staurosporine

1993
Prostaglandin E2 and F2 alpha binding sites in the bovine iris ciliary body.
    Investigative ophthalmology & visual science, 1993, Volume: 34, Issue:7

    Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliary Body; Dinoprost; Dinoprostone; Iris; Kinetics; Ligands; Muscles; Radioligand Assay; Receptors, Prostaglandin; Receptors, Prostaglandin E

1993
The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cataract; Ciliary Body; Conjunctiva; Cornea; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Indomethacin; Iris; Lens Cortex, Crystalline; Misoprostol; Ophthalmic Solutions; Oxytocics; Potassium; Rabbits; Radiation Injuries, Experimental; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Ultraviolet Rays

1996
Effect of prostaglandins on cultured porcine iris sphincter muscle cells.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1996,Fall, Volume: 12, Issue:3

    Topics: Animals; Carbachol; Cells, Cultured; Cyclic AMP; Dinoprost; Dinoprostone; Iris; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Receptors, Prostaglandin E; Swine

1996
Prostaglandin F2 alpha and its analogs induce release of endogenous prostaglandins in iris and ciliary muscles isolated from cat and other mammalian species.
    Experimental eye research, 1996, Volume: 63, Issue:3

    Topics: Animals; Cats; Cattle; Ciliary Body; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Humans; Indomethacin; Iris; Latanoprost; Macaca mulatta; Muscles; Prostaglandins; Prostaglandins F, Synthetic; Rabbits

1996
In-vivo activity and enzymatic hydrolysis of novel prostaglandin F2 alpha prodrugs in ocular tissues.
    Experimental eye research, 1996, Volume: 63, Issue:4

    Topics: Animals; Antihypertensive Agents; Ciliary Body; Conjunctiva; Cornea; Culture Techniques; Dinoprost; Dogs; Dose-Response Relationship, Drug; Esters; Eye; Female; Humans; Hydrolysis; Hyperemia; Intraocular Pressure; Iris; Macaca fascicularis; Male; Prodrugs; Pupil

1996
Prostaglandin-induced iridial pigmentation in primates.
    Survey of ophthalmology, 1997, Volume: 41 Suppl 2

    Topics: Administration, Topical; Animals; Dinoprost; Dinoprostone; Eye Color; Iris; Iris Diseases; Latanoprost; Macaca fascicularis; Melanosis; Ophthalmic Solutions; Pigment Epithelium of Eye; Prostaglandins; Prostaglandins F, Synthetic; Sympathectomy

1997
Delta13-reductase dependent metabolism of prostaglandins in the mammalian brain and eye.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:3

    Topics: Animals; Brain; Cattle; Ciliary Body; Cornea; Cytosol; Dinoprost; Eye; Haplorhini; Hydroxyprostaglandin Dehydrogenases; Iris; NAD; Prostaglandins; Rabbits; Swine; Tritium

1997
Iris-color change developed after topical isopropyl unoprostone treatment.
    Journal of glaucoma, 1997, Volume: 6, Issue:6

    Topics: Administration, Topical; Dinoprost; Eye Color; Follow-Up Studies; Glaucoma; Humans; Iris; Iris Diseases; Male; Middle Aged; Ophthalmic Solutions

1997
In vivo measurement of iridial circulation using laser speckle phenomenon.
    Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Circulation; Blood Flow Velocity; Dinoprost; Intraocular Pressure; Iris; Lasers; Microspheres; Ophthalmic Solutions; Rabbits; Reproducibility of Results; Timolol

1998
Tyrosine kinase inhibitors suppress prostaglandin F2alpha-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle.
    European journal of pharmacology, 1998, Nov-06, Volume: 360, Issue:2-3

    Topics: Animals; Calcium; Carbachol; Cardiotonic Agents; Cats; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Hydrolysis; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Prostaglandins F, Synthetic; Protein-Tyrosine Kinases; Vanadates

1998
Bovine iris-sphincter muscle lacks FP receptor binding sites.
    Ocular immunology and inflammation, 1999, Volume: 7, Issue:1

    Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Dinoprost; DNA Primers; Iris; Muscle, Smooth; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Reverse Transcriptase Polymerase Chain Reaction

1999
Metabolites of isopropyl unoprostone as potential ophthalmic solutions to reduce intraocular pressure in pigmented rabbits.
    Japanese journal of pharmacology, 1999, Volume: 81, Issue:1

    Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Ciliary Body; Cornea; Dinoprost; Eye; Intraocular Pressure; Iris; Ophthalmic Solutions; Pigmentation; Rabbits; Retina; Tissue Distribution; Tritium

1999
Effect of prostaglandins A(2), E(1), F(2 alpha)and latanoprost on cultured human iridal melanocytes.
    Experimental eye research, 2000, Volume: 70, Issue:1

    Topics: Alprostadil; Cell Differentiation; Cell Division; Cells, Cultured; Dendrites; Dinoprost; Dose-Response Relationship, Drug; Humans; Iris; Melanins; Melanocytes; Microscopy, Phase-Contrast; Prostaglandins; Prostaglandins A

2000
Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle.
    European journal of pharmacology, 2000, Oct-27, Volume: 407, Issue:1-2

    Topics: Animals; Carbachol; Cats; Dinoprost; Enzyme Inhibitors; Flavonoids; Imidazoles; Iris; Miotics; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxytocics; Phosphorylation; Pyridines

2000
In vitro corneal permeation of unoprostone isopropyl (UI) and its metabolism in the isolated pig eye.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:2

    Topics: Acetylcholinesterase; Animals; Antihypertensive Agents; Aqueous Humor; Butyrylcholinesterase; Carbonic Anhydrases; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Dinoprost; Hydrolysis; Iris; Naphthols; Permeability; Prodrugs; Substrate Specificity; Swine; Trabecular Meshwork

2001
Latanoprost and matrix metalloproteinase-1 in human choroid organ cultures.
    Current eye research, 2001, Volume: 22, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Choroid; Ciliary Body; Dinoprost; DNA Primers; DNA Probes; Humans; Immunoblotting; Iris; Latanoprost; Matrix Metalloproteinase 1; Middle Aged; Organ Culture Techniques; Polymerase Chain Reaction; Prostaglandins F, Synthetic; RNA, Messenger

2001
Increased matrix metalloproteinases 1, 2, and 3 in the monkey uveoscleral outflow pathway after topical prostaglandin F(2 alpha)-isopropyl ester treatment.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2001, Volume: 119, Issue:8

    Topics: Administration, Topical; Animals; Anterior Eye Segment; Ciliary Body; Dinoprost; Immunoenzyme Techniques; Intraocular Pressure; Iris; Macaca fascicularis; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Muscle, Smooth; Ophthalmic Solutions; Sclera; Uvea

2001
Activation of p42/p44 mitogen-activated protein kinase and contraction by prostaglandin F2alpha, ionomycin, and thapsigargin in cat iris sphincter smooth muscle: inhibition by PD98059, KN-93, and isoproterenol.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Benzylamines; Blotting, Western; Calcium-Transporting ATPases; Cats; Densitometry; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Flavonoids; In Vitro Techniques; Ionomycin; Ionophores; Iris; Isoproterenol; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle, Smooth; Sulfonamides; Thapsigargin

2001
Potentiation of sympathetic neurotransmission in bovine isolated irides by isoprostanes.
    Free radical research, 2001, Volume: 35, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Dinoprost; Dinoprostone; Electric Stimulation; F2-Isoprostanes; Fatty Acids, Unsaturated; Hydrazines; Hydrogen Peroxide; Iris; Isomerism; Isoprostanes; Norepinephrine; Receptors, Thromboxane; Sympathetic Nervous System; Synaptic Transmission; Thromboxane-A Synthase; Vasoconstrictor Agents

2001
Studies on receptor binding and signal transduction pathways of unoprostone isopropyl.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:5

    Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Binding, Competitive; Calcium; Cattle; Ciliary Body; Corpus Luteum; Cyclic AMP; Dinoprost; Female; Iris; Ligands; Muscle, Smooth; Rabbits; Receptors, Prostaglandin; Signal Transduction

2001
Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism.
    Experimental eye research, 2002, Volume: 74, Issue:1

    Topics: Adult; Animals; Antihypertensive Agents; Antiporters; Aqueous Humor; Cattle; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; DNA-Binding Proteins; HeLa Cells; Humans; Indomethacin; Iris; Latanoprost; Organic Anion Transporters; Prostaglandins F, Synthetic

2002
Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1.
    Biochemical and biophysical research communications, 2002, Oct-11, Volume: 297, Issue:5

    Topics: Animals; Blotting, Western; Cats; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genistein; Iris; Isoenzymes; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Binding; Signal Transduction; Time Factors; Type C Phospholipases; Tyrosine; Tyrphostins

2002
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:1

    Topics: Amides; Animals; Bimatoprost; Ciliary Body; Cloprostenol; Cornea; Dinoprost; Eye; Humans; Hydrolysis; In Vitro Techniques; Iris; Kinetics; Lipid Metabolism; Lipids; Prodrugs; Sclera; Swine; Time Factors

2003
Ocular hypotensive activity of prostaglandin F2 alpha (PGF2 alpha) analogs with neutral substituents at position 1 is predicted by the isolated cat iris sphincter smooth muscle preparation but not Ca+ signalling in Swiss 3T3 cells.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: 3T3 Cells; Animals; Antihypertensive Agents; Calcium Signaling; Cats; Dinoprost; Iris; Mice; Muscle, Smooth; Ocular Hypertension

2002
Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression.
    The Journal of biological chemistry, 2003, Jul-18, Volume: 278, Issue:29

    Topics: Alprostadil; Amides; Animals; Bimatoprost; Cats; Cell Line; Cells, Cultured; Ciliary Body; Cloprostenol; Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Dinoprost; Gene Expression; Glaucoma; Humans; Immediate-Early Proteins; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Iris; Kinetics; Lipids; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Trabecular Meshwork; Up-Regulation

2003
The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:2

    Topics: Amides; Animals; Bimatoprost; Chromatography, High Pressure Liquid; Ciliary Body; Cloprostenol; Cornea; Dinoprost; Humans; Hydrolysis; In Vitro Techniques; Iris; Lipid Metabolism; Lipids; Rabbits; Sclera

2003
Effects of prostaglandin F2alpha and latanoprost on phosphoinositide turnover, myosin light chain phosphorylation and contraction in cat iris sphincter.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:3

    Topics: Animals; Antihypertensive Agents; Cats; Dinoprost; Dose-Response Relationship, Drug; In Vitro Techniques; Intraocular Pressure; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphatidylinositols; Phosphorylation; Prostaglandins F, Synthetic

2003
Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.
    Journal of glaucoma, 2003, Volume: 12, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Cyclooxygenase Inhibitors; Dinoprost; Esters; Eye Color; Eye Proteins; Flurbiprofen; Iris; Melanins; Moxisylyte; Pigmentation; Premedication; Rabbits; Superior Cervical Ganglion; Sympathectomy

2003
New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:12

    Topics: Administration, Topical; Animals; Cats; Cell Line, Tumor; Dinoprost; Drug Evaluation, Preclinical; Forecasting; Intraocular Pressure; Iris; Latanoprost; Macaca fascicularis; Melanins; Mice; Miosis; Prostaglandins F; Prostaglandins F, Synthetic; Receptors, Prostaglandin

2003
Effects of prostaglandin F2alpha, latanoprost and carbachol on phosphoinositide turnover, MAP kinases, myosin light chain phosphorylation and contraction and functional existence and expression of FP receptors in bovine iris sphincter.
    Experimental eye research, 2004, Volume: 78, Issue:2

    Topics: Animals; Antihypertensive Agents; Carbachol; Cattle; Culture Techniques; Dinoprost; Dose-Response Relationship, Drug; Inositol Phosphates; Iris; Latanoprost; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphatidylinositols; Phosphorylation; Prostaglandins F, Synthetic; Receptors, Prostaglandin; Signal Transduction

2004
Species differences in the effects of prostanoids on MAP kinase phosphorylation, myosin light chain phosphorylation and contraction in bovine and cat iris sphincter smooth muscle.
    Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 72, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cats; Cattle; Dinoprost; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Prostaglandins; Prostaglandins F, Synthetic; Species Specificity

2005
Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells.
    Experimental eye research, 2005, Volume: 80, Issue:1

    Topics: Amides; Animals; Bimatoprost; Calcium; Calcium Signaling; Carbachol; Cats; Cells, Cultured; Cholinergic Agonists; Cloprostenol; Dinoprost; Humans; Intraocular Pressure; Iris; Lipids; Microscopy, Confocal; Muscle Contraction

2005
Prostaglandin F2alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:11

    Topics: Animals; Antihypertensive Agents; Calcium; Carbachol; Dinoprost; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Iris; Latanoprost; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Prostaglandins F, Synthetic; Protein Serine-Threonine Kinases; rho-Associated Kinases; Swine; Type C Phospholipases

2006
Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris.
    British journal of pharmacology, 2007, Volume: 150, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Iris; Oxazoles; Receptors, Prostaglandin; Recombinant Proteins

2007
Bimatoprost, prostamide activity, and conventional drainage.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:9

    Topics: Aged; Aged, 80 and over; Amides; Animals; Antihypertensive Agents; Aqueous Humor; Bimatoprost; Calcium; Calcium Signaling; Cats; Cell Culture Techniques; Cloprostenol; Dinoprost; Dinoprostone; Female; Humans; Intraocular Pressure; Iris; Lipids; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Oxazoles; Receptors, Thromboxane; Recombinant Proteins; Trabecular Meshwork

2007
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
    Experimental eye research, 2011, Volume: 93, Issue:3

    Topics: Administration, Topical; Animals; Antihypertensive Agents; Aqueous Humor; Cell Line; Ciliary Body; Cyclic GMP; Dinoprost; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Glaucoma; Guanylate Cyclase; Intraocular Pressure; Iris; Latanoprost; Macaca fascicularis; Male; Nitric Oxide; Nitric Oxide Donors; Ocular Hypertension; Prostaglandins F, Synthetic; Rabbits; Rats; Tonometry, Ocular

2011