2-piperidone and pyrroles

Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dogs; Electrocardiography; Female; Heart Conduction System; Male; Nicardipine; Piperidones; Potassium Channels; Pyrans; Pyrroles; Thiophenes; Vasodilator Agents

Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Atmosphere Exposure Chambers; Benzopyrans; Blood Pressure; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Male; Methacholine Chloride; Nebulizers and Vaporizers; Piperidones; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Administration, Oral; Aerosols; Airway Resistance; Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Duodenum; Guinea Pigs; Histamine; Histamine Antagonists; Injections, Intravenous; Intubation, Gastrointestinal; Lung Compliance; Male; Methacholine Compounds; Piperidones; Pyrroles; Rats; Rats, Sprague-Dawley

Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Endothelins; Female; Femoral Artery; In Vitro Techniques; Male; Nicardipine; Nitroprusside; Piperidones; Potassium Channels; Pyrans; Pyrroles; Saphenous Vein; Thiophenes; Vasodilation; Vasodilator Agents

Topics: Animals; Benzamides; Benzopyrans; Binding Sites; Brain; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypothermia; In Situ Hybridization; Indoles; Mice; Mice, Transgenic; Motor Activity; Piperidones; Propylamines; Pyridines; Pyrimidines; Pyrroles; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombination, Genetic; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium

Topics: Amino Acid Sequence; Animals; Antibodies, Blocking; Antibody Specificity; Dopamine; In Vitro Techniques; Male; Mice; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; Neostriatum; Neuropeptides; Oligopeptides; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Synaptosomes

Topics: Animals; Brain; Electrophysiology; Kinetics; Male; Piperazines; Piperidones; Prosencephalon; Pyridines; Pyrroles; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds

Topics: Animals; Biphenyl Compounds; Decerebrate State; Male; Norepinephrine; Oxadiazoles; Piperazines; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Sumatriptan; Sympathomimetics; Tachycardia

Topics: Aged; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain; Dipeptides; Drug Interactions; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Oxadiazoles; Piperazines; Piperidones; Postmortem Changes; Protein Binding; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfur Isotopes

Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; HeLa Cells; Humans; Mice; Mice, Nude; Mice, SCID; Minichromosome Maintenance Complex Component 2; Molecular Structure; Nuclear Proteins; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Small Molecule Libraries; Structure-Activity Relationship; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA; DNA Replication; Humans; Minichromosome Maintenance Complex Component 2; Nuclear Proteins; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Xenograft Model Antitumor Assays

Topics: Aggression; Analysis of Variance; Animals; Behavior, Animal; Bites and Stings; Dose-Response Relationship, Drug; Grooming; Male; Mice; Photomicrography; Piperazines; Piperidones; Prefrontal Cortex; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Walking

Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hexamethonium; Infusions, Intravenous; Male; Methoxamine; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Sodium Chloride; Spinal Cord; Spiro Compounds; Time Factors; Vasoconstrictor Agents

Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; CD40 Ligand; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase 9; DNA Replication; Gene Expression Regulation, Leukemic; Humans; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Myeloid Cell Leukemia Sequence 1 Protein; NIH 3T3 Cells; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; RNA Polymerase II; Signal Transduction

Topics: Benzamides; Chemistry, Pharmaceutical; Computer Simulation; Crystallography, X-Ray; Cytokines; Drug Design; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Models, Chemical; Molecular Chaperones; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Tumor Necrosis Factor-alpha

Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Cell Line, Transformed; Disease Models, Animal; DNA-Binding Proteins; Enzyme Inhibitors; Frontal Lobe; Gene Expression Regulation; Humans; Movement; Mutation; Neurodegenerative Diseases; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; RNA, Small Interfering; Serine; TDP-43 Proteinopathies; Transfection

Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Indoles; Inhibitory Concentration 50; Models, Molecular; Oxindoles; Piperidones; Pyrroles; Spiro Compounds

Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Cycle Proteins; Checkpoint Kinase 1; Chromatography, High Pressure Liquid; DNA Replication; HEK293 Cells; HeLa Cells; Humans; Hydroxyurea; Mass Spectrometry; Minichromosome Maintenance Complex Component 2; Molecular Sequence Data; Phosphopeptides; Phosphorylation; Piperidones; Protein Interaction Maps; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; RNA Interference; RNA, Small Interfering; Substrate Specificity

Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Male; Neurons; Piperidones; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Somatosensory Cortex; Spiro Compounds

Topics: Animals; Cell Cycle Proteins; CHO Cells; Chromatin; Cricetinae; Cricetulus; DNA Replication; Enzyme Inhibitors; Etoposide; Ovum; Phosphorylation; Piperidones; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyrroles; S Phase Cell Cycle Checkpoints; Xenopus; Xenopus Proteins

Topics: Apoptosis; Biological Availability; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; Humans; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 9; Female; Fluorouracil; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; Xenograft Model Antitumor Assays

Topics: Adenocarcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cohort Studies; DNA Replication; G1 Phase Cell Cycle Checkpoints; Humans; Molecular Targeted Therapy; Pancreatic Neoplasms; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; Transfection

Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Resistance, Viral; Gene Expression Regulation, Viral; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Microbial Sensitivity Tests; Piperidones; Pyrroles; Viral Proteins; Virus Replication

Topics: Adenosine Triphosphate; Binding, Competitive; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Replication; Female; Humans; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles

Topics: Antioxidants; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Drug Repositioning; Hep G2 Cells; Humans; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Piperidones; Protein Serine-Threonine Kinases; Pyrroles; Reactive Oxygen Species; Signal Transduction

Topics: Cell Cycle Proteins; Cell Line; Dimethyl Sulfoxide; DNA Repair Enzymes; DNA Replication; DNA, Single-Stranded; Etoposide; Exodeoxyribonucleases; Humans; Mitosis; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Signal Transduction

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Arachidonic Acids; Cyproheptadine; Drug Interactions; Eating; gamma-Aminobutyric Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Piperazines; Piperidines; Piperidones; Pyrazoles; Pyridines; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium

Topics: 3' Flanking Region; 5' Flanking Region; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Indolizines; Myeloid Cells; Phenylenediamines; Piperazines; Piperidines; Piperidones; Protein Kinase Inhibitors; Pyridines; Pyridinium Compounds; Pyrimidines; Pyrroles; RNA Polymerase II; Translocation, Genetic

Topics: Animals; Antiviral Agents; Cell Line; DNA, Viral; Dogs; Piperidones; Pyrroles; Varicellovirus; Virus Replication

Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cell Cycle Proteins; Cells, Cultured; Cerebellum; Cyclin-Dependent Kinase 9; DNA-Binding Proteins; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Piperidones; Protein Aggregation, Pathological; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles