2-piperidone has been researched along with pyrimidinones in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonte, D; Melcher, K; Sasi, NK; Soon, FF; Tiwari, K; Wang, T; Weinreich, M; Xu, HE | 1 |
| Gaboriau, D; Quachthithu, H; Rainey, MD; Santocanale, C | 1 |
| Coquel, F; Lin, YL; MacKeigan, JP; Pasero, P; Sasi, NK; Weinreich, M | 1 |
| Anderson, AA; Becker, PS; Erba, HP; Flesher, DL; Grunwald, MR; Henary, HA; Rasmussen, E; Shami, PJ; Wang, ES; Zhu, M | 1 |
| Flaherty, KT; Henary, HA; Johnson, DB; Lewis, KD; Long, GV; Moschos, SJ; Puzanov, I; Sandhu, S; Sullivan, RJ; Upreti, VV; Wong, H | 1 |
2 trial(s) available for 2-piperidone and pyrimidinones
| Article | Year |
|---|---|
Phase 1b study of the MDM2 inhibitor AMG 232 with or without trametinib in relapsed/refractory acute myeloid leukemia.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Targeted Therapy; Piperidones; Proto-Oncogene Proteins c-mdm2; Pyridones; Pyrimidinones; Recurrence; Treatment Outcome | 2019 |
Targeting wild-type TP53 using AMG 232 in combination with MAPK inhibition in Metastatic Melanoma; a phase 1 study.
Topics: Acetates; Antineoplastic Combined Chemotherapy Protocols; Humans; Melanoma; Nausea; Piperidones; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Tumor Suppressor Protein p53 | 2022 |
3 other study(ies) available for 2-piperidone and pyrimidinones
| Article | Year |
|---|---|
The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.
Topics: Apoptosis; Biological Availability; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; Humans; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles | 2014 |
DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.
Topics: Adenosine Triphosphate; Binding, Competitive; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Replication; Female; Humans; Phosphorylation; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles | 2017 |
DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.
Topics: Cell Cycle Proteins; Cell Line; Dimethyl Sulfoxide; DNA Repair Enzymes; DNA Replication; DNA, Single-Stranded; Etoposide; Exodeoxyribonucleases; Humans; Mitosis; Piperidones; Protein Serine-Threonine Kinases; Pyrimidinones; Pyrroles; Signal Transduction | 2018 |