Compounds > 2-piperidone
Page last updated: 2024-08-21

2-piperidone and piplartine

2-piperidone has been researched along with piplartine in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (18.60)29.6817
2010's28 (65.12)24.3611
2020's7 (16.28)2.80

Authors

AuthorsStudies
Alves, AP; Bezerra, DP; Castro, FO; Costa-Lotufo, LV; Elmiro, FJ; Lima, MA; Moraes, MO; Pessoa, C; Silveira, ER1
Bezerra, DP; Costa-Lotufo, LV; de Castro, FO; de Moraes, MO; Elmiro, FJ; Lima, MA; Militão, GC; Pessoa, C; Silveira, ER1
Alexandre Silveira, J; Cícero Bezerra Felipe, F; de Barros Viana, GS; de Oliveira Souza, LE; Deusdênia Loiola Pessoa, O; Esdras de Andrade Uchoa, D; Rocha Silveira, E; Trajano Sousa Filho, J1
Alves, AP; Bezerra, DP; Costa-Lotufo, LV; de Alencar, NM; de Castro, FO; de Moraes, MO; Elmiro, FJ; Lima, MA; Lima, MW; Mesquita, RO; Pessoa, C; Silveira, ER1
Bezerra, DP; Costa-Lotufo, LV; de Moraes, MO; de Vasconcellos, MC; e Silva, AC; Henriques, JA; Lima, MA; Moura, DJ; Rosa, RM; Saffi, J; Silveira, ER1
Ahn, SC; Chang, JH; Cho, HJ; Kim, KY; Kim, YJ; Kong, EH; Yu, SN1
Bezerra Felipe, CF; Felix, FH; Fontenele, JB; Leal, LK; Silveira, ER; Viana, GS1
Jyothi, D; Madhusudana Rao, J; Mangala Gowri, P; Rama Subba Rao, V; Sreedhar, AS; Vanathi, P1
Crotti, AE; Iamamoto, Y; Kato, MJ; Lopes, NP; Lotufo, LV; Schaab, EH1
Kato, MJ; Kawano, T; Lopes, PO; Moraes, Jd; Nakano, E; Nascimento, C; Yamaguchi, LF1
de Moraes, J; Kato, MJ; Nakano, E; Nascimento, C; Yamaguchi, LF1
Bemquerer, MP; Bittencourt, CR; de Moraes, J; Ingram, K; Kato, MJ; Keiser, J; Leite, JR; Nakano, E; Nascimento, C; Yamaguchi, LF1
Akileshwari, C; Babu, KH; Babu, KS; Chandra Kumar, RS; Muthenna, P; Petrash, JM; Prasad, KR; Rao, JM; Rao, VR; Reddy, GB; Shankaraiah, G; Suresh, G; Yadav, PA1
Bezerra, DP; Costa-Lotufo, LV; de Moraes, MO; Pessoa, C; Saker-Neto, N; Silveira, ER1
Baggio, CH; Burci, LM; da Silva, LM; Facundo, VA; Marques, MC; Militão, JS; Pereira, IT; Rodrigues, RV; Santos, AR; Werner, MF1
Babu, KS; Kumar, JU; Kumar, RS; Pitke, VV; Poornima, B; Rao, GT; Shankaraiah, G; Sreedhar, AS1
Borrely, SI; Fokoue, HH; Kato, MJ; Lopes, PO; Marques, JV; Nakano, E; Ohlweiler, FP; Pereira, CA; Pinheiro, Ade S; Rapado, LN; Scotti, MT; Yamaguchi, LF1
da Silva, EA; de Oliveira, AR; Gouvea, DR; Kato, MJ; Lopes, NP; Marques, LM; Pupo, MT; Vessecchi, R1
Ferreira, B; Guimarães, A; Kato, M; Maleck, M; Mallet, J1
Fofaria, NM; Srivastava, SK1
Bezerra, DP; Chammas, R; de Aquino, NC; Ferreira, PM; Machado, CM; Pessoa, C; Silveira, ER1
Fang, J; Meng, X; Peng, S; Yao, J; Zhang, B1
Fofaria, NM; Liu, X; Qhattal, HS; Srivastava, SK1
Huang, W; Li, J; Liu, H; Wang, J; Wang, Y; Xie, D; Zhang, Y; Zhu, P; Zuo, J1
Meegan, MJ; Nathwani, S; O'Boyle, NM; Twamley, B; Zisterer, DM1
Arcanjo, DDR; Campelo, YDM; de Moraes, J; de Souza de Almeida Leite, JR; Eaton, P; Guimarães, MA; Kato, MJ; Lima, DF; Mafud, AC; Mascarenhas, YP; Mendonça, RZ; Pinto, PLS; Silva, MPN; Véras, LMC; Yamaguchi, LF1
Ayala, AP; Ellena, J; Joshi, BD; Karthick, T; Mishra, R; Srivastava, A; Tandon, P1
da Silva-Junior, EA; Furtado, NAJC; Gouvea, DR; Kato, MJ; Lopes, NP; Paludo, CR; Pupo, MT; Vessecchi, R1
Araújo, MSS; de Oliveira, ARM; Dias-Baruffi, M; Lopes, NP; Moreira, FL; Moreira, ML; Pilon, AC; Riul, TB1
Barboza, JN; da Nóbrega, FR; de Sousa, DP; Nascimento Sousa, SCS; Ozdemir, O; Turkez, H1
Gunia-Krzyżak, A; Koczurkiewicz, P; Pękala, E; Piska, K; Wójcik-Pszczoła, K1
Carvalho, VFM; Costa-Lotufo, LV; Giacone, DV; Lopes, LB; Silveira, ER1
Bezerra, DP; Caruso, ÍP; Cornélio, ML; de Alcântara-Contessoto, NS; Filho, JMB1
Chen, M; Fan, X; Ji, J; Lu, C; Song, J; Tu, J; Weng, Q; Wu, F; Xu, M; Zhang, D; Zhao, Z; Zheng, L1
Carvalho, VFM; Chorilli, M; Costa-Fernandez, S; Costa-Lotufo, LV; de Araujo, GLB; de Matos, JKR; Lopes, LB; Salata, GC; Silveira, ER; Steiner, AA1
Almeida, RN; Bezerra Filho, CDSM; Nóbrega, FRD; Ozdemir, O; Perez-Castillo, Y; Sousa, DP; Tejera, E; Turkez, H1
Antar, GM; Cogo, RM; Lago, JHG; Mazloum, SF; Mendonça, PS; Mengarda, AC; Moraes, J; Morais, CS; Morais, TR; Salvadori, MC; Teixeira, FS1
Cheng, X; Tian, P; Yan, X; Zheng, W1
Costa-Lotufo, LV; Dartora, VFMC; de Matos, JKR; de Oliveira, EA; Giacone, DV; Lopes, LB; Maria-Engler, SS; Miranda, DAG; Passos, JS; Silveira, ER1
Barbosa-Filho, JM; Bezerra, DP; Contessoto, NSA; Cornélio, ML; da Silveira, NJF; Girol, AP; Henrique, T; Oliani, SM; Silveira, ER; Stefanini, ACB; Tajara, EH; Zanon, CF1
Braga, CB; Ferreira-Silva, GA; Grigolo, TA; Ionta, M; Ornelas, C; Pilli, RA; Russowsky, D1
Branco, PC; Costa-Lotufo, LV; Dartora, VFC; Lopes, LB; Passos, JS; Salata, GC; Silveira, E; Steiner, AA1
da Fonseca, ACC; de Sousa, DP; Machado, TQ; Perez-Castillo, Y; Robbs, BK; Silva, RHN; Tejera, E1

Reviews

2 review(s) available for 2-piperidone and piplartine

ArticleYear
Overview of the therapeutic potential of piplartine (piperlongumine).
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013, Feb-14, Volume: 48, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Drugs, Investigational; Fruit; Humans; Medicine, Ayurvedic; Neoplasms; Patents as Topic; Piper; Piperidones

2013
Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chemistry Techniques, Synthetic; Dioxolanes; Drug Discovery; Humans; Neoplasms; Piper; Piperidones; Structure-Activity Relationship

2018

Other Studies

41 other study(ies) available for 2-piperidone and piplartine

ArticleYear
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2006, Volume: 39, Issue:6

    Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Proliferation; Disease Models, Animal; Female; Kidney; Liver; Mice; Neoplasm Transplantation; Piper; Piperidines; Piperidones; Plant Extracts; Plant Roots; Polyunsaturated Alkamides; Sarcoma 180; Spleen

2006
Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways.
    Toxicology in vitro : an international journal published in association with BIBRA, 2007, Volume: 21, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; In Vitro Techniques; K562 Cells; Leukemia; Leukemia, T-Cell; Microscopy, Fluorescence; Monocytes; Necrosis; Nucleic Acid Conformation; Piper; Piperidones; Signal Transduction

2007
Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2007, Volume: 14, Issue:9

    Topics: Alkaloids; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Mice; Pentylenetetrazole; Phytotherapy; Piper; Piperidones; Plant Extracts; Plant Roots; Seizures

2007
In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:2

    Topics: Alanine Transaminase; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Benzodioxoles; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fluorouracil; HL-60 Cells; Humans; Inhibitory Concentration 50; Kidney; Leukopenia; Liver; Mice; Piperidines; Piperidones; Polyunsaturated Alkamides; Sarcoma 180; Urea

2008
Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells.
    Mutation research, 2008, Apr-30, Volume: 652, Issue:2

    Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Dose-Response Relationship, Drug; Membrane Potential, Mitochondrial; Mutagenicity Tests; Piper; Piperidones; Saccharomyces cerevisiae

2008
Piplartine induces caspase-mediated apoptosis in PC-3 human prostate cancer cells.
    Oncology reports, 2008, Volume: 20, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; DNA Fragmentation; G2 Phase; Humans; Male; Piperidones; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2

2008
Antiplatelet effects of piplartine, an alkamide isolated from Piper tuberculatum: possible involvement of cyclooxygenase blockade and antioxidant activity.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:4

    Topics: Adenosine Diphosphate; Antioxidants; Arachidonic Acid; Collagen; Cyclooxygenase Inhibitors; Drug Interactions; Humans; In Vitro Techniques; Piperaceae; Piperidones; Plant Roots; Platelet Aggregation; Platelet-Rich Plasma; Thrombin

2009
Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.
    Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; HSP70 Heat-Shock Proteins; Humans; Mice; Piper; Piperidones; Plant Roots; Rats; Stereoisomerism

2009
Biomimetic oxidation of piperine and piplartine catalyzed by iron(III) and manganese(III) porphyrins.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:5

    Topics: Alkaloids; Benzodioxoles; Biological Products; Biomimetics; Catalysis; Cytochrome P-450 Enzyme System; Ferric Compounds; Inactivation, Metabolic; Iodobenzenes; Iron; Manganese; Oxidation-Reduction; Piperidines; Piperidones; Polyunsaturated Alkamides; Porphyrins; Singlet Oxygen; Spectrometry, Mass, Electrospray Ionization

2010
Schistosoma mansoni: In vitro schistosomicidal activity of piplartine.
    Experimental parasitology, 2011, Volume: 127, Issue:2

    Topics: Animals; Biomphalaria; Cell Survival; Chlorocebus aethiops; Cricetinae; Female; Male; Mesocricetus; Microscopy, Confocal; Piper; Piperidones; Plant Extracts; Schistosoma mansoni; Vero Cells

2011
Schistosoma mansoni: in vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula.
    Experimental parasitology, 2012, Volume: 132, Issue:2

    Topics: Animals; Biomphalaria; Cricetinae; Larva; Mesocricetus; Microscopy, Confocal; Piper; Piperidones; Plant Extracts; Praziquantel; Schistosoma mansoni; Schistosomicides; Time Factors

2012
In vitro synergistic interaction between amide piplartine and antimicrobial peptide dermaseptin against Schistosoma mansoni schistosomula and adult worms.
    Current medicinal chemistry, 2013, Volume: 20, Issue:2

    Topics: Amino Acid Sequence; Amphibian Proteins; Animals; Antimicrobial Cationic Peptides; Antiparasitic Agents; Drug Combinations; Drug Synergism; Microscopy, Confocal; Molecular Sequence Data; Molecular Structure; Oviposition; Piperidones; Reproduction; Schistosoma mansoni; Schistosomiasis mansoni

2013
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs).
    European journal of medicinal chemistry, 2012, Volume: 57

    Topics: Aldehyde Reductase; Biological Transport; Drug Design; Enzyme Assays; Enzyme Inhibitors; Erythrocytes; Humans; Hypoglycemic Agents; Indoles; Molecular Docking Simulation; Piper; Piperidones; Plant Extracts; Plant Roots; Recombinant Proteins; Sorbitol; Structure-Activity Relationship

2012
Antiulcer and gastric antisecretory effects of dichloromethane fraction and piplartine obtained from fruits of Piper tuberculatum Jacq. in rats.
    Journal of ethnopharmacology, 2013, Jun-21, Volume: 148, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Fruit; Gastric Acid; Gastric Mucosa; Glutathione; H(+)-K(+)-Exchanging ATPase; Methylene Chloride; Mice; Mucus; Phytotherapy; Piper; Piperidones; Plant Extracts; Rabbits; Rats; Rats, Wistar; Solvents; Stomach Ulcer

2013
Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition.
    Journal of Asian natural products research, 2013, Volume: 15, Issue:6

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Cell Cycle; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Piper; Piperidones; Pseudomonas aeruginosa; Staphylococcus aureus

2013
Schistosomiasis control using piplartine against Biomphalaria glabrata at different developmental stages.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:6

    Topics: Animals; Antiparasitic Agents; Biological Assay; Biomphalaria; Magnetic Resonance Spectroscopy; Piper; Piperidones; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Survival Analysis

2013
In vitro metabolism of the alkaloid piplartine by rat liver microsomes.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 95

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Male; Microsomes, Liver; Piperidones; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
Cytotoxicity of piperamides towards Aedes aegypti (Diptera: Culicidae).
    Journal of medical entomology, 2014, Volume: 51, Issue:2

    Topics: Aedes; Animals; Dioxolanes; Insecticides; Larva; Lethal Dose 50; Piper; Piperidones; Plant Extracts

2014
Critical role of STAT3 in melanoma metastasis through anoikis resistance.
    Oncotarget, 2014, Aug-30, Volume: 5, Issue:16

    Topics: Animals; Anoikis; Cell Line, Tumor; Gene Knockdown Techniques; Heterografts; Humans; Male; Melanoma; Mice; Mice, SCID; Phosphorylation; Piperidones; Signal Transduction; STAT3 Transcription Factor; Transfection; Tyrphostins

2014
Antitumour efficacy of Piper tuberculatum and piplartine based on the hollow fiber assay.
    Planta medica, 2015, Volume: 81, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Piper; Piperidones; Plant Extracts; Plant Roots; Polyvinyls

2015
Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents.
    Journal of medicinal chemistry, 2015, Jul-09, Volume: 58, Issue:13

    Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Cinnamates; Coumaric Acids; Cytoprotection; Dioxolanes; Hydrogen Peroxide; Molecular Structure; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Piperidones; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship

2015
Nanoemulsion formulations for anti-cancer agent piplartine--Characterization, toxicological, pharmacokinetics and efficacy studies.
    International journal of pharmaceutics, 2016, Feb-10, Volume: 498, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Caco-2 Cells; Chemistry, Pharmaceutical; Emulsions; Female; Humans; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Piperidones; Treatment Outcome; Xenograft Model Antitumor Assays

2016
Design, Synthesis and Pharmacological Evaluation of Novel Piperlongumine derivatives as Potential Antiplatelet Aggregation Candidate.
    Chemical biology & drug design, 2016, Volume: 87, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Dioxolanes; Drug Evaluation, Preclinical; Humans; Piperidones; Platelet Aggregation; Platelet Aggregation Inhibitors

2016
Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Dioxolanes; Female; Humans; MCF-7 Cells; Microtubules; Models, Molecular; Piperidones; Reactive Oxygen Species; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2017
Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Cell Shape; Chlorocebus aethiops; Cricetinae; Dogs; Drug Synergism; Drug Therapy, Combination; Imidazoles; Madin Darby Canine Kidney Cells; Male; Mice; Microscopy, Confocal; Piperidones; Praziquantel; Schistosoma mansoni; Vero Cells

2017
Spectroscopic (far or terahertz, mid-infrared and Raman) investigation, thermal analysis and biological activity of piplartine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2017, Sep-05, Volume: 184

    Topics: Biomarkers; Hydrogen Bonding; Molecular Docking Simulation; Piperidones; Proteins; Spectrum Analysis, Raman; Static Electricity; Terahertz Imaging; Thermodynamics; Thermogravimetry; Vibration

2017
Gas-phase fragmentation of protonated piplartine and its fungal metabolites using tandem mass spectrometry and computational chemistry.
    Journal of mass spectrometry : JMS, 2017, Volume: 52, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Ascomycota; Biotransformation; Gases; Hydrogenation; Metabolomics; Molecular Dynamics Simulation; Molecular Structure; Piperidones; Tandem Mass Spectrometry

2017
Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites.
    Planta medica, 2018, Volume: 84, Issue:15

    Topics: Animals; Anthelmintics; Antiprotozoal Agents; Biomimetics; Dioxolanes; Female; Inhibitory Concentration 50; Leishmania infantum; Liver; Macrophages, Peritoneal; Metalloporphyrins; Mice, Inbred BALB C; Microsomes; Piperaceae; Piperidones; Rats

2018
Piplartine Analogues and Cytotoxic Evaluation against Glioblastoma.
    Molecules (Basel, Switzerland), 2018, Jun-08, Volume: 23, Issue:6

    Topics: Apoptosis; Biological Availability; Brain Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Piperidones; Plant Extracts

2018
Development of a method for quantitative determination of the cytotoxic agent piplartine (piperlongumine) in multiple skin layers.
    Biomedical chromatography : BMC, 2019, Volume: 33, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Chromatography, High Pressure Liquid; Dioxolanes; Linear Models; Piperidones; Reproducibility of Results; Sensitivity and Specificity; Skin; Skin Absorption; Swine

2019
An investigation into the interaction between piplartine (piperlongumine) and human serum albumin.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2019, Sep-05, Volume: 220

    Topics: Binding Sites; Computer Simulation; Humans; Molecular Docking Simulation; Piperidones; Serum Albumin, Human; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics

2019
Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/β-catenin pathway inactivation through ICAT.
    Cancer letters, 2019, Sep-28, Volume: 460

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Mice, Nude; Neoplasm Invasiveness; Piperidones; RNA, Long Noncoding; Tumor Burden; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2019
Optimization of composition and obtainment parameters of biocompatible nanoemulsions intended for intraductal administration of piplartine (piperlongumine) and mammary tissue targeting.
    International journal of pharmaceutics, 2019, Aug-15, Volume: 567

    Topics: Adhesiveness; Animals; Antineoplastic Agents, Phytogenic; Chickens; Chitosan; Chorioallantoic Membrane; Dioxolanes; Drug Administration Routes; Emulsions; Female; Glycerol; Hyaluronic Acid; Mammary Glands, Animal; Nanoparticles; Phosphatidylcholines; Piperidones; Polysorbates; Rats, Wistar; Skin; Swine

2019
NFBTA: A Potent Cytotoxic Agent against Glioblastoma.
    Molecules (Basel, Switzerland), 2019, Jun-29, Volume: 24, Issue:13

    Topics: Acrylamides; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dioxolanes; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Molecular Docking Simulation; Piperidones

2019
Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis.
    Acta tropica, 2020, Volume: 205

    Topics: Animals; Disease Models, Animal; Female; Mice; Piper; Piperidones; Schistosomiasis mansoni; Schistosomicides

2020
Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression.
    Cancer medicine, 2020, Volume: 9, Issue:12

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Piperidones; RNA, Circular; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models.
    International journal of biological macromolecules, 2020, Dec-15, Volume: 165, Issue:Pt A

    Topics: Alginates; Cell Proliferation; Chitosan; Cytotoxins; Emulsions; Humans; Melanocytes; Melanoma; Nanoparticles; Piperidones; Skin Neoplasms

2020
Biological and physical approaches on the role of piplartine (piperlongumine) in cancer.
    Scientific reports, 2020, 12-17, Volume: 10, Issue:1

    Topics: Alkaloids; Annexin A1; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CCL2; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Neoplasm Invasiveness; Neoplasms; Piper; Piperidones; Tumor Microenvironment

2020
Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents.
    Bioorganic chemistry, 2021, Volume: 116

    Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperidones; Pyrones; Structure-Activity Relationship; Triazoles

2021
Hyaluronic acid nanoemulsions improve piplartine cytotoxicity in 2D and 3D breast cancer models and reduce tumor development after intraductal administration.
    International journal of biological macromolecules, 2022, Oct-31, Volume: 219

    Topics: Breast Neoplasms; Chitosan; Female; Humans; Hyaluronic Acid; Nanoparticles; Piperidones

2022
Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma.
    Molecules (Basel, Switzerland), 2023, Feb-09, Volume: 28, Issue:4

    Topics: Cell Line, Tumor; Humans; Mouth Neoplasms; Piperidones; Quality of Life; Squamous Cell Carcinoma of Head and Neck

2023