2-piperidone has been researched along with piperidines in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 111 (74.50) | 18.7374 |
| 1990's | 7 (4.70) | 18.2507 |
| 2000's | 17 (11.41) | 29.6817 |
| 2010's | 13 (8.72) | 24.3611 |
| 2020's | 1 (0.67) | 2.80 |
| Authors | Studies |
|---|---|
| Maddocks, JL; Nicholls, PJ; Smithers, JL | 1 |
| Peinhardt, G | 1 |
| Ishida, N; Saito, N; Suzuki, F | 1 |
| Sheldon, AT; Zeiger, E | 1 |
| Ishida, N; Suzuki, F; Umenai, T | 1 |
| Chobanova, I; Mikhaĭlova, D; Ognianova, V | 1 |
| Jindal, MN; Patel, NB; Patel, VK | 2 |
| Milushev, A; Stoichkov, I; Todorov, D | 1 |
| Fell, V; Pollitt, RJ | 1 |
| Briddon, A; Oberholzer, VG | 1 |
| Daleva, L; Ognianova, V | 1 |
| Fukumoto, K; Kametani, T; Nemoto, H; Seto, H | 1 |
| Blaszczyk, B; Gieldanowski, J | 1 |
| Scheurer, S; Steinegger, E | 1 |
| Haller, R; Kohlmorgen, R | 1 |
| Fickentscher, K | 1 |
| Ishida, N; Saito, N; Sasaki, K; Suzuki, F | 1 |
| Cook, WL; Gerald, MC; Gupta, TK; Witiak, DT | 1 |
| Chambers, WH; Davis, AL; Fell, DA; Gage, LD; Haynes, JR; Hulme, KL; Kelley, DH; McCord, TJ | 1 |
| Paál, T | 1 |
| Lijinsky, W; Taylor, HW | 1 |
| Möhrle, H; Specks, F | 1 |
| Koch, H; Pischek, G | 2 |
| Nanchev, N; Saev, S; Stoĭkova, N; Tenev, K; Vulchev, P | 1 |
| Ishida, N; Kitame, F; Saito, N; Suzuki, F | 1 |
| Daleva, L; Nikolov, R; Nikolova, M | 1 |
| Akhrem, AA; Budaĭ, SI; Khlebnikova, TS; Lakhvich, FA; Shcherbakova, TN | 1 |
| Green, S | 1 |
| Michalska, D | 1 |
| Wang, H; Xu, W; Yuan, Y | 2 |
| Hara, H; Hashimoto, K; Kakegawa, T; Koga, T; Shintomi, Y; Tanaka, M; Tsuda, H | 1 |
| Tsuda, H | 1 |
| Goehring, RR; Greenwood, TD; Nwokogu, GC; Pisipati, JS; Rogers, TG; Wolfe, JF | 1 |
| Arblaster, CI; Cameron, DW; Lavi, Y; Laycock, GM; Shulman, A | 2 |
| Isono, K; Osada, H; Sonoda, T; Uramoto, M; Uzawa, J | 1 |
| Isono, K; Kusakabe, H; Osada, H; Sonoda, T | 1 |
| Crisma, M; Johnson, RL; Toniolo, C; Valle, G; Yu, KL | 1 |
| Koo, A; Lin, YC; Long, KH; Xu, SB | 1 |
| Holmquist, B; Neels, H; Scharpé, S; van Sande, M | 1 |
| Hendry, LB; Muldoon, TG | 1 |
| Eriguchi, N; Hara, H; Ikeda, I; Inoue, S; Nakayama, T; Nishida, H; Ohishi, K; Tsuda, H; Yoshida, H | 1 |
| Ho, IK; Kamiyama, H; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I | 1 |
| Baldauf, J; Büch, HP; Knabe, J; Wahl, S | 1 |
| Ashraf, AQ; Burzynski, SR; Kampalath, BN; Liau, MC | 1 |
| Burzynski, B; Burzynski, SR; Kampalath, BN; Liau, MC | 1 |
| Burzynski, B; Burzynski, SR; Liau, MC; Szopa, M | 1 |
| Burzynski, SR; Copland, JA; Hendry, LB; Lehner, AF; Muldoon, TG | 1 |
| Copland, JA; Hendry, LB; Lehner, AF; Muldoon, TG | 1 |
| Corradi, F; Cristina, T; de Meglio, PG; Gentili, P; Ravenna, F; Riva, M; Tempra-Gabbiati, G | 1 |
| Boadle-Biber, MC; Phan, TH | 1 |
| Alphin, RS; Day, PA; Hall, IH; Maguire, JH; Murthy, AR | 1 |
| Jindal, MN; Patel, NB; Patel, VK; Venkatakrishna-Bhatt, H | 2 |
| Johnston, GA; Nicholson, GM; Spence, I | 1 |
| Akiyama, S; Fujii, T; Ohba, M | 1 |
| Baro, F; Dom, R; Van Lommel, R | 2 |
| Kyogoku, Y; Yu, NT | 1 |
| Georgiev, V; Petkova, B | 1 |
| Brustad, T | 1 |
| Cohn, G; Cupp, J; Keith, A; Snipes, W | 1 |
| Christova, K; Daleva, L; Dantschev, D; Mutaftschieva, V | 1 |
| Ariëns, EJ; Beld, AJ | 1 |
| Nikolova, M; Stéphanova, D; Tchavdarov, D | 1 |
| Velichkova, S | 1 |
| Bardier, B; Cadenat, H; Fabie, M | 1 |
| Koch, H; Köhler, F | 1 |
| Brustad, T; Wold, E | 1 |
| Inch, WR; Olive, PL; Sutherland, RM | 1 |
| Ariëns, EJ; Soudijn, W; van Wijngaarden, I | 1 |
| Gutkowska, B | 1 |
| Marsboom, R; Symoens, J; Temmerman, R | 1 |
| Nakano, NI; Schowen, RL; Smissman, EE | 1 |
| Geerts, H; Symoens, J; Van Gestel, J | 1 |
| Haller, R; Hänsel, W; Kohlmorgen, R | 1 |
| Nitzsche, HJ; Nuhn, P; Wagner, G | 1 |
| Arimura, K; Nakanishi, M | 1 |
| Martin, CF; Moon, BH | 1 |
| Bignardi, G; Mosti, L; Schenone, P | 1 |
| Awaji, T; Itami, T; Takauchi, K; Tsukatani, H | 1 |
| Brugmans, J; Demoen, P; Janssen, PA; Lenaerts, FM; Niemegeers, CJ; Schellekens, KH; Van Nueten, JM; Van Wijngaarden, I | 1 |
| Callery, PS; Geelhaar, LA | 1 |
| Büch, HP; Knabe, J; Reischig, D | 1 |
| Powers, NR; Sauers, LJ | 1 |
| Guliamov, MG | 1 |
| Baker, S; Bitter, SM; Caroon, JM; Clark, RD; Kluge, AF; Okada, MD; Repke, DB; Roszkowski, AP; Strosberg, AM | 1 |
| Daleva, L; Stefanova, D | 1 |
| Ishida, N; Ohashi, Y; Shimomura, T | 1 |
| Foley, C; Rotschafer, JC; Zaske, D | 1 |
| Chen, G; Kern, JT; Kerwin, SM; Thomas, PW | 1 |
| Itoh, T; Kibayashi, C; Yamazaki, N | 1 |
| Chaudhary, AG; Doss, GA; Franklin, RB; Hop, CE; Kumar, S; Stearns, RA; Yin, W | 1 |
| Cussac, D; Marini, L; Millan, MJ; Newman-Tancredi, A; Touzard, M | 1 |
| Faul, MM; Kobierski, ME; Kopach, ME | 1 |
| MALLARD, BG; WILSON, CO | 2 |
| KIRISAWA, M; SUGASAWA, S | 1 |
| JALLING, O | 1 |
| STEWART, JS | 1 |
| GROSS, F; TURRIAN, H | 1 |
| MERTES, MP; WILSON, CO | 1 |
| LINDBLAD, CG | 1 |
| GISVOLD, O; MERTES, MP | 1 |
| HARRIS, R; VELARDE, NN | 1 |
| HOFFMANN, K; KEBERLE, H; RIESS, W | 1 |
| LIEBMAN, AA; RATTO, PA | 1 |
| FRATTA, I; SIGG, EB; WUEST, HM | 1 |
| KEMP, RT; KRAUTH, CA; MONTGOMERY, JA; SCHAEFFER, HJ; SHEALY, YF; STRUCK, RF | 1 |
| ROBINSON, JB; THOMAS, J | 1 |
| DAVIES, D; NICHOLLS, PJ | 1 |
| LOUGHLIN, EH; MULLIN, WG; SCHWIMMER, J; SCHWIMMER, M | 1 |
| BRANDMAN, O; CONIARIS, J; KELLER, HE | 1 |
| MULLER, P; ROHRER, F | 1 |
| JURGENS, R; PELLMONT, B; STUDER, A | 1 |
| HORSTMANN, W | 1 |
| BENICA, WS; WILSON, CO | 1 |
| Boot, JR; Broadmore, RJ; Cooper, J; Eyre, TA; Mitchell, SN; Pullar, IA; Sanger, GJ; Wedley, S | 1 |
| Chang, NC; Chen, BF; Cheng, CC; Tsai, MR | 1 |
| Guo, ZQ; Huang, PQ; Ruan, YP | 1 |
| Alves, AP; Bezerra, DP; Castro, FO; Costa-Lotufo, LV; Elmiro, FJ; Lima, MA; Moraes, MO; Pessoa, C; Silveira, ER | 1 |
| Mani, NS; Morrill, C | 1 |
| Backes, BJ; Ballaron, SJ; Beno, DW; Kempf-Grote, AJ; Lai, C; Li, X; Longenecker, K; Lubben, TH; Pei, Z; Pireh, D; Sham, HL; Stewart, KD; Trevillyan, JM; von Geldern, TW | 1 |
| Davies, SG; Roberts, PM; Smith, AD | 1 |
| Amat, M; Bosch, J; Escolano, C; Lozano, O; Molins, E | 1 |
| Alves, AP; Bezerra, DP; Costa-Lotufo, LV; de Alencar, NM; de Castro, FO; de Moraes, MO; Elmiro, FJ; Lima, MA; Lima, MW; Mesquita, RO; Pessoa, C; Silveira, ER | 1 |
| Fan, GJ; Wee, AG | 1 |
| McELVAIN, SM; RORIG, K | 1 |
| Amirthaganesan, S; Aridoss, G; Jeong, YT; Kabilan, S; Kim, JT; Kumar, NA; Lim, KT | 1 |
| Chen, L; Li, X; Salinas, GD | 1 |
| Gopalakrishnan, M; Kanagarajan, V; Nagini, S; Thanusu, J | 1 |
| Banerjee, A; Schepmann, D; Wünsch, B | 1 |
| Crotti, AE; Iamamoto, Y; Kato, MJ; Lopes, NP; Lotufo, LV; Schaab, EH | 1 |
| McELVAIN, SM; STORK, G | 2 |
| Hakala-Yatkin, M; Tyystjärvi, E | 1 |
| Erdogdu, Y; Rajarajan, G; Saleem, H; Subashchandrabose, S; Thanikachalam, V | 1 |
| Deák, Z; Hakala-Yatkin, M; Hideg, E; Karonen, M; Krieger-Liszkay, A; Rutherford, AW; Tyystjärvi, E; Vass, I | 1 |
| Athyros, VG; Elisaf, MS; Filippatos, TD | 1 |
| Bracha, S; Chappell, PE; Goodall, CP; Marley, K; Stang, B; Viall, AK | 1 |
| Du, ZT; Huang, W; Lin, GQ; Si, CM; Wei, BG | 1 |
| Haq, W; Tiwari, VS; Yadav, SR | 1 |
| Anbuselvan, C; Arockia Doss, M; Rajarajan, G; Savithiri, S; Thanikachalam, V | 1 |
| Cruz-Martínez, AM; Escartín-Pérez, RE; Florán-Garduño, B; López-Alonso, VE; Mancilla-Díaz, JM; Tejas-Juárez, JG | 1 |
| Acharya, P; Hiebert, SW; Liu, Q; Sampathi, S; Savona, MR; Stengel, KR; Wang, J; Zhao, Y | 1 |
| Egorov, MP; Elinson, MN; Goloveshkin, AS; Hansford, KA; Karpenko, KA; Minaeva, AP; Vereshchagin, AN | 1 |
2 review(s) available for 2-piperidone and piperidines
| Article | Year |
|---|---|
'Antineoplastons'. An unproved cancer therapy.
Topics: Benzeneacetamides; Humans; Neoplasms; Peptides; Piperidines; Piperidones | 1992 |
The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors [corrected].
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Humans; Linagliptin; Nitriles; Piperidines; Piperidones; Purines; Pyrazines; Pyrazoles; Pyrimidines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Thiazolidines; Triazoles; Uracil; Vildagliptin | 2014 |
3 trial(s) available for 2-piperidone and piperidines
| Article | Year |
|---|---|
Dexetimide: an effective drug for the control of extrapyramidal symptoms induced by pipothiazine palmitate.
Topics: Administration, Oral; Adult; Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Benzyl Compounds; Delayed-Action Preparations; Drug Evaluation; Humans; Injections, Intramuscular; Male; Middle Aged; Palmitic Acids; Phenothiazines; Piperidines; Piperidones; Placebos; Psychotic Disorders; Remission, Spontaneous; Sulfonamides | 1973 |
A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.
Topics: Administration, Oral; Adult; Antiparkinson Agents; Basal Ganglia Diseases; Benztropine; Benzyl Compounds; Clinical Trials as Topic; Delayed-Action Preparations; Evaluation Studies as Topic; Haloperidol; Humans; Injections, Intramuscular; Intraocular Pressure; Male; Middle Aged; Movement Disorders; Parasympatholytics; Piperidines; Piperidones; Placebos; Psychotic Disorders; Tropanes | 1971 |
[Experience with the use of new Bulgarian psychotropic drugs].
Topics: Adolescent; Adult; Aminopyrine; Aminoquinolines; Child; Clinical Trials as Topic; Depression; Dipyrone; Drug Combinations; Epilepsy; Female; Humans; Male; Mental Disorders; Middle Aged; Phenobarbital; Piperidines; Piperidones; Procyclidine; Psychotropic Drugs; Pyrrolidines; Substance Withdrawal Syndrome; Syndrome | 1982 |
144 other study(ies) available for 2-piperidone and piperidines
| Article | Year |
|---|---|
Proceedings: Studies of experimental chronic renal failure I, Increased permeability of the rat's blood-brain barrier to phenglutarimide hydrochloride.
Topics: Animals; Blood-Brain Barrier; Kidney Failure, Chronic; Male; Permeability; Piperidines; Piperidones; Rats | 1975 |
[Acidity and acidimetric titration of medically used glutaric acid imide].
Topics: Hydrogen-Ion Concentration; Methods; Piperidines; Piperidones; Potentiometry | 1977 |
Effect of an interferon inducer, 9-methylstreptimidone, on influenza virus infection in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Influenza A virus; Interferon Inducers; Male; Mice; Orthomyxoviridae Infections; Piperidines; Piperidones | 1977 |
The mutagenicity of N-nitrosopiperidines for Salmonella typhimurium.
Topics: Dimethyl Sulfoxide; DNA Repair; DNA, Bacterial; Isonipecotic Acids; Mutagens; Mutation; Nitroso Compounds; Pipecolic Acids; Piperidines; Piperidones; Salmonella typhimurium | 1978 |
Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice.
Topics: Animals; Candida albicans; Candidiasis; Female; Interferon Inducers; Interferons; Mice; Piperidines; Piperidones; Time Factors | 1978 |
[Pharmacokinetics of the original Bulgarian preparation, tempidon, in experimental animals].
Topics: Absorption; Administration, Oral; Animals; Dose-Response Relationship, Drug; Injections, Intravenous; Kinetics; Male; Piperidines; Piperidones; Rats; Time Factors; Tissue Distribution; Tosyl Compounds; Triacetoneamine-N-Oxyl | 1979 |
Ganglionic action of some newly synthesized glutarimide compounds.
Topics: Animals; Blood Pressure; Cats; Female; Ganglia; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Piperidones; Sympathomimetics; Urinary Bladder | 1978 |
[Experiment to potentiate the effect of cyclophosphamide combined with tempidon and caffeine in leukemia L1210 and Lewis hepatic carcinoma].
Topics: Animals; Caffeine; Carcinoma; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Liver Neoplasms; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Piperidines; Piperidones; Psychotropic Drugs; Tosyl Compounds; Triacetoneamine-N-Oxyl | 1978 |
3-Aminopiperid-2-one, an unusual metabolite in the urine of a patient with hyperammonaemia, hyperornithinaemia and homocitrullinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Chromatography, Gas; Chromatography, Ion Exchange; Citrulline; Electrophoresis; Humans; Mass Spectrometry; Ornithine; Piperidines; Piperidones | 1978 |
3-Amino-2-piperidone in the urine of patients with hyperornithinemia.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Electrophoresis; Female; Humans; Infant; Ornithine; Piperidines; Piperidones | 1978 |
[Determination of the plasma level and excretion to tempidon in man after oral use].
Topics: Administration, Oral; Biopharmaceutics; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Piperidines; Piperidones; Time Factors; Triacetoneamine-N-Oxyl | 1978 |
Study of some newly synthesized glutarimide compounds on skeletal muscle.
Topics: Animals; Anura; Cats; In Vitro Techniques; Muscle Contraction; Muscles; Neuromuscular Junction; Piperidines; Piperidones; Rats | 1977 |
[Studies on the syntheses of heterocyclic compounds. DCCXII. Attempts to the ring-closure of piperidone derivatives by Grewe cyclization (author's transl)].
Topics: Cyclization; Piperidines; Piperidones | 1977 |
Pharmacologic studies on anti-inflammatory activity of di- and triketopiperidine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Antibody-Producing Cells; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Guinea Pigs; Hyperemia; Immunosuppressive Agents; Lethal Dose 50; Mice; Piperidines; Piperidones; Rats; Tuberculin Test | 1976 |
[The question of the occurrence of di- and triacetonamines in plants. Genista hystrix Lange. 30. Legume alkaloids].
Topics: Piperidines; Piperidones; Plants; Triacetoneamine-N-Oxyl | 1976 |
[Synthesis and structure of substituted N-benzylpiperidone carboxylates].
Topics: Benzyl Compounds; Magnetic Resonance Spectroscopy; Molecular Conformation; Piperidines; Piperidones | 1976 |
[N-(3,4,5,6-Tetrahydrophthalyl)glutamic acid imide].
Topics: Phthalimides; Piperidines; Piperidones | 1976 |
Antiviral and interferon-inducing activity of a new glutarimide antibiotic, 9-methylstreptimidone.
Topics: Animals; Anti-Bacterial Agents; Antiviral Agents; Female; Interferon Inducers; Lung; Male; Mice; Mice, Inbred Strains; Orthomyxoviridae Infections; Piperidines; Piperidones | 1976 |
Para-substituted N-acetyl-L(S)- and -D(R)-alpha-amino-N-phenylglutarimides. A structure-activity study of substituent effects on steroselective anticonvulsant activity.
Topics: Animals; Anticonvulsants; Ethosuximide; Male; Mice; Phenytoin; Piperidines; Piperidones; Seizures; Stereoisomerism; Structure-Activity Relationship; Trimethadione | 1976 |
Synthesis and antibacterial activities of some chloro analogs of 3 amino-3,4-dihydro-1-hydroxycarbostyril.
Topics: Anti-Bacterial Agents; Escherichia coli; Hydroxyquinolines; Lactobacillus; Leuconostoc; Microbial Sensitivity Tests; Piperidines; Piperidones | 1975 |
[Study of the buffer effect in the qualitative analysis of drugs. II].
Topics: Alkaloids; Buffers; Carboxylic Acids; Chlorobenzoates; Drug Contamination; Hydrochloric Acid; Hydrolysis; Indomethacin; Lactates; Methods; Piperidines; Piperidones; Prenylamine | 1975 |
Tumorigenesis by oxygenated nitrosopiperidines in rats.
Topics: Animals; Esophageal Neoplasms; Liver Neoplasms; Neoplasms, Experimental; Nitroso Compounds; Nose Neoplasms; Piperidines; Piperidones; Rats; Sex Factors | 1975 |
[1,8-Naphthyridine-derivatives from dehydrogenative cyclization (author's transl)].
Topics: Cyclization; Magnetic Resonance Spectroscopy; Mass Spectrometry; Naphthyridines; Oxidation-Reduction; Piperidines; Piperidones | 1975 |
[The biologic half-life of the thalidomide-like compound K-2004 (author's transl)].
Topics: Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Half-Life; Hypnotics and Sedatives; Intestinal Absorption; Male; Piperidines; Piperidones; Rats; Thalidomide | 1975 |
[Analgometric determination of the analgetic action of tempalgin in man].
Topics: Aminopyrine; Dipyrone; Drug Combinations; Drug Evaluation, Preclinical; Humans; Pain; Piperidines; Piperidones; Placebos; Skin | 1975 |
[Characteristics of 9-methylstreptimidone, a new interferon inducer].
Topics: Animals; Interferon Inducers; Mice; Piperidines; Piperidones | 1975 |
Study of development of tolerance to and barbiturate-like physical dependence on the tranquilizer tempidon.
Topics: Animals; Barbiturates; Dogs; Drug Synergism; Drug Tolerance; Humans; Mice; Piperidines; Piperidones; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Tosyl Compounds; Tranquilizing Agents; Triacetoneamine-N-Oxyl | 1975 |
[Metabolism and elimination in the rat of the thalidomide-like compound K-2004 (author's transl)].
Topics: Animals; Bridged-Ring Compounds; Half-Life; Molecular Conformation; Piperidines; Piperidones; Rats | 1976 |
[New (general) method of complete synthesis of glutarimide antibiotics and their analogs].
Topics: Anti-Bacterial Agents; Piperidines; Piperidones | 1976 |
Theoretical investigations on the structure and potential binding sites of antineoplaston A10 and experimental findings.
Topics: Antineoplastic Agents; Benzeneacetamides; Binding Sites; Mathematical Computing; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Piperidones | 1990 |
Pharmacokinetic study of radioactive antineoplaston A10 in rats and mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzeneacetamides; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Mice; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Studies of the release rate and bioavailability of antineoplaston A10 capsule.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzeneacetamides; Biological Availability; Capsules; Injections, Intravenous; Piperidines; Piperidones; Rabbits | 1990 |
The anticancer effect of antineoplaston A-10 on human breast cancer serially transplanted to athymic mice.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Piperidines; Piperidones; Transplantation, Heterologous | 1990 |
Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines. The members of Antineoplaston Study Group.
Topics: Administration, Oral; Animals; Benzeneacetamides; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Piperidines; Piperidones; Transplantation, Heterologous; Tumor Cells, Cultured | 1990 |
Synthesis and anticonvulsant activity of 2-benzylglutarimides.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Mice; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1990 |
The guinea-pig isolated atrium as a model system for the central actions of selected CNS stimulant and depressant drugs. Part 2. Mechanisms involved in the actions and interactions of the convulsant bemegride and its hypnotic homologue 3-methyl-3-n-butylg
Topics: Animals; Bemegride; Central Nervous System Depressants; Central Nervous System Stimulants; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Models, Biological; Piperidines; Piperidones; Receptors, Muscarinic | 1988 |
Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation.
Topics: Antibiotics, Antineoplastic; Epidermal Growth Factor; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Piperidines; Piperidones; Pyridones; Spectrophotometry, Ultraviolet; Spectrum Analysis | 1989 |
Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Chromatography, Gel; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Fermentation; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Piperidines; Piperidones; Pyridones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spores, Bacterial; Streptomyces | 1989 |
Structure of (3S)-3-tert-butyloxycarbonylamino-2-piperidone.
Topics: Chemical Phenomena; Chemistry, Physical; Crystallization; Crystallography; Molecular Structure; Piperidines; Piperidones | 1989 |
The guinea-pig isolated atrium as a model system for the central actions of selected CNS stimulant and depressant drugs. Part 1: 3,3-Diakylglutarimide homologues and related drugs.
Topics: Animals; Antipsychotic Agents; Central Nervous System Depressants; Central Nervous System Stimulants; Convulsants; In Vitro Techniques; Mice; Myocardial Contraction; Pentylenetetrazole; Piperidines; Piperidones; Stereoisomerism | 1987 |
[Hypotensive and vasodilator effects of triacetonamine as demonstrated by the intravital microcirculation method].
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Male; Microcirculation; Muscles; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Triacetoneamine-N-Oxyl; Vasodilation | 1987 |
Kininase II of human seminal fluid: kinetics and inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Binding, Competitive; Captopril; Chlorides; Enalapril; Humans; Kinetics; Male; Peptidyl-Dipeptidase A; Piperidines; Piperidones; Semen; Spermatozoa | 1986 |
Actions of an endogenous antitumorigenic agent on mammary tumor development and modeling analysis of its capacity for interacting with DNA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzeneacetamides; DNA, Neoplasm; Female; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Orchiectomy; Piperidines; Piperidones; Rats; Tamoxifen | 1988 |
Chemopreventive effect of antineoplaston A-10 on urethane-induced pulmonary neoplasm in mice.
Topics: Adenoma; Animals; Benzeneacetamides; Female; Lung Neoplasms; Mice; Piperidines; Piperidones; Urethane | 1988 |
Central effects of N-substituted derivatives of 2,6-dioxopiperidine in mice.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System; Convulsants; Hypnotics and Sedatives; Male; Mice; Piperidines; Piperidones; Sleep; Structure-Activity Relationship | 1988 |
[2,6-Piperidinediones, 6. The anticholinergic activities of enantiomers of 2,6-piperidinediones with a basic side chain].
Topics: Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Stereoisomerism | 1988 |
Pharmacokinetic study of radioactive antineoplaston A10 following oral administration in rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzeneacetamides; Feces; Kinetics; Male; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Tissue Distribution | 1987 |
Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia.
Topics: Adenoma; Animals; Antineoplastic Agents; Benzeneacetamides; Benzo(a)pyrene; Body Weight; Female; Lung Neoplasms; Mice; Mice, Inbred A; Piperidines; Piperidones | 1987 |
Chemo-surveillance: a novel concept of the natural defence mechanism against cancer.
Topics: Antineoplastic Agents; Benzeneacetamides; Humans; Neoplasms; Peptides; Piperidines; Piperidones | 1987 |
Stereochemical modelling studies of the interaction of antineoplaston A10 with DNA.
Topics: Antineoplastic Agents; Benzeneacetamides; Chemical Phenomena; Chemistry, Physical; DNA; Humans; Models, Chemical; Molecular Conformation; Piperidines; Piperidones | 1987 |
Inhibition of spontaneous mouse mammary tumour development by antineoplaston A10.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; Female; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Orchiectomy; Piperidines; Piperidones | 1987 |
[Pyrrolidone and piperidone derivatives with antihistaminic and antianaphylactic activities. Synthesis and pharmacological study].
Topics: Anaphylaxis; Animals; Barbiturates; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine Antagonists; Male; Mice; Mice, Inbred Strains; Piperidines; Piperidones; Pyrrolidinones; Rats; Sleep | 1987 |
AGN 2979 [3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4, 4-dimethylpiperidine-2,6-dione]. An inhibitor of the activation of tryptophan hydroxylase.
Topics: Animals; Brain Stem; Calmodulin; Enzyme Activation; Gallic Acid; Haloperidol; Male; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Tryptophan Hydroxylase; Xanthines | 1986 |
Hypolipidemic activity of 3- and 4-phenyl-piperidine-2,6-diones and selected N-substituted derivatives.
Topics: Animals; Cholesterol; Indicators and Reagents; Lipid Metabolism; Lipoproteins; Male; Mice; Mice, Inbred Strains; Organ Specificity; Phospholipids; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triglycerides | 1986 |
Pharmacology of new glutarimide compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Diethylamines; Drug Evaluation, Preclinical; Female; Male; Mice; Morpholines; Piperidines; Piperidones; Structure-Activity Relationship | 1985 |
Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat.
Topics: Amino Acids; Animals; Bemegride; Central Nervous System Depressants; Convulsants; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neurons; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Spinal Cord | 1985 |
Lactams. XXIV. Alkaline hydrolysis of 1-benzyl-2-piperidone derivatives: application to cis-trans isomerization of the 5-ethyl-2-oxo-4-piperidineacetic acid system.
Topics: Benzyl Compounds; Chemical Phenomena; Chemistry; Hydrolysis; Isomerism; Lactams; Piperidines; Piperidones | 1985 |
Specific H-bonding of glutarimides and hydantoins to derivatives of RNA bases in chloroform solution.
Topics: Bemegride; Chemical Phenomena; Chemistry; Chloroform; Cycloheximide; Ethosuximide; Glutethimide; Hydantoins; Pemoline; Phenobarbital; Phenytoin; Piperidines; Piperidones; Primidone; RNA; Spectrophotometry, Infrared; Thalidomide | 1973 |
Pharmacological studies of some central effects of tempidon.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Male; Mice; Pentylenetetrazole; Piperidines; Piperidones; Receptors, Cholinergic; Strychnine; Tosyl Compounds; Triacetoneamine-N-Oxyl | 1974 |
Radiosensitization of anoxic cells of E. coli K-12 by organic nitroxyl free radicals.
Topics: Cell Survival; Cyclic N-Oxides; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Electrons; Escherichia coli; Free Radicals; Methods; Oxygen; Piperidines; Piperidones; Radiation Effects; Radiation-Sensitizing Agents; Time Factors; Tritium | 1972 |
Electron spinal resonance analysis of the nitroxide spin label 2,2,6,6-tetramethylpipidone-N-oxyl (Tempone) in single crystals of the reduced Tempone matrix.
Topics: Crystallization; Crystallography; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Mathematics; Microwaves; Molecular Conformation; Oxidation-Reduction; Piperidines; Piperidones; Spin Labels | 1974 |
[1-Azgomethine derivatives from 3.3-diethyl-5-methyl-2.4-piperidinedione].
Topics: Central Nervous System; Chemical Phenomena; Chemistry; Hydrazines; Hydrazones; Lethal Dose 50; Piperidines; Piperidones; Spectrophotometry, Infrared | 1972 |
Stereospecific binding as a tool in attempts to localize and isolate muscarinic receptors. Part II. Binding of (plus)-benzetimide, (minus)-benzetimide and atropine to a fraction from bovine tracheal smooth muscle and to bovine caudate nucleus.
Topics: Animals; Atropine; Benzyl Compounds; Binding Sites; Cattle; Caudate Nucleus; Digitonin; Dose-Response Relationship, Drug; Freeze Drying; In Vitro Techniques; Indicators and Reagents; Methacholine Compounds; Microsomes; Muscle, Smooth; Piperidines; Piperidones; Receptors, Cholinergic; Stereoisomerism; Tartrates; Trachea; Tritium | 1974 |
[The effect of tempidon on the EEG of cats in acute and chronic experiments].
Topics: Animals; Cats; Cerebral Cortex; Depression, Chemical; Electric Stimulation; Electroencephalography; Hypothalamus; Mesencephalon; Muscle Tonus; Piperidines; Piperidones; Red Nucleus; Reticular Formation; Time Factors; Tosyl Compounds; Tranquilizing Agents | 1974 |
[The effect of tempidon on oxidative phosphorylation in liver and brain mitochondria].
Topics: Animals; Brain; Female; In Vitro Techniques; Ketoglutaric Acids; Male; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Piperidines; Piperidones; Rats; Tosyl Compounds; Triacetoneamine-N-Oxyl | 1974 |
[A new antispasmodic analgesic in dentistry].
Topics: Adolescent; Adult; Aged; Aminopyrine; Analgesics; Benzophenones; Dipyrone; Drug Evaluation; Face; Female; Humans; Male; Middle Aged; Mouth; Parasympatholytics; Piperidines; Piperidones | 1974 |
[Teratological study on the thalidomide-like compounds K-2004 and K-2604 in the mouse and rat].
Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Drug Evaluation, Preclinical; Female; Fetus; Hypnotics and Sedatives; Imides; Injections, Intraperitoneal; Mice; Piperidines; Piperidones; Pregnancy; Rats; Teratogens; Thalidomide | 1974 |
Reactions between nitroxyl free radicals and radiation-induced transients in nucleosides.
Topics: Adenosine; Alkaloids; Cyclic N-Oxides; Cytidine; Deoxyribose; Free Radicals; Guanosine; Nucleosides; Oxygen; Piperidines; Piperidones; Radiation Effects; Radiation-Sensitizing Agents; Spectrum Analysis; Spin Labels; Thymidine | 1973 |
The effect of triacetoneamine-N-oxyl on oxygenation and radiocurability of a mouse mammary carcinoma.
Topics: Animals; Body Temperature; Cyclic N-Oxides; Diffusion; Dose-Response Relationship, Drug; Free Radicals; Heart Rate; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Mice; Neoplasm Recurrence, Local; Oxygen; Piperidines; Piperidones; Radiation Dosage; Radiation-Sensitizing Agents; Respiration; Time Factors | 1972 |
Dexetimide, a useful tool in acetylcholine-receptor localization.
Topics: Acetamides; Animals; Atropine; Benzyl Compounds; Binding Sites; Caudate Nucleus; Cell Membrane; Centrifugation, Density Gradient; Dialysis; Drug Interactions; Glutethimide; In Vitro Techniques; Ligands; Male; Methacholine Compounds; Parasympatholytics; Piperidines; Piperidones; Rats; Receptors, Cholinergic; Stereoisomerism; Sucrose; Tritium | 1973 |
[Synthesis of 1-butyl-3,5-bis-(pyridinemethyl)-piperidone-4 and 1-butyl-3,5-bis-(4-pyridinemethyl)-piperidone-4].
Topics: Piperidines; Piperidones; Pyridines; Spectrophotometry, Infrared | 1973 |
The effect of benzetimide on intestinal motility in pigs.
Topics: Administration, Oral; Animals; Defecation; Depression, Chemical; Gastrointestinal Motility; Injections, Intramuscular; Parasympatholytics; Piperidines; Piperidones; Swine | 1973 |
Nucleophilic and bifunctional catalysis. Mechanism, reactivity, and transition-state structure in the hydrolysis of 2-chloro-4-isopropylamino-6-cyclopropylamino-s-triazine by N-hydroxysuccinimide and 1-hydroxy-2-piperidone.
Topics: Catalysis; Cyclopropanes; Herbicides; Hydrolysis; Piperidines; Piperidones; Propylamines; Succinimides; Triazines | 1973 |
Benzetimide in the treatment of diarrhoea in newborn calves and adult cattle.
Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents; Benzyl Compounds; Cattle; Cattle Diseases; Chloramphenicol; Diarrhea; Drug Therapy, Combination; Gastrointestinal Motility; Neomycin; Parasympatholytics; Piperidines; Piperidones; Time Factors | 1974 |
[The structure of 1,2,6-triphenylpiperidone derivatives (author's transl)].
Topics: Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Piperidines; Piperidones; Polycyclic Compounds; Spectrophotometry, Infrared | 1974 |
[Thionation of various piperidindiones and succinimides].
Topics: Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Piperidines; Piperidones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Succinimides; Sulfides; Thiones | 1974 |
[Studies on piperidine derivatives. 3. Studies on the synthesis of 3-oxo-1-thia-4,8-diazaspiro [4,5] decane derivatives. (1)].
Topics: Amines; Chemical Phenomena; Chemistry; Piperidines; Piperidones; Spiro Compounds; Sulfhydryl Compounds; Thiazoles | 1971 |
3-aminopiperidones. V. 2-ethoxy and 2-carbethoxy derivatives of 2-p-methoxyphenylglutarimide.
Topics: Anticonvulsants; Benzyl Compounds; Chemical Phenomena; Chemistry; Glutarates; Imides; Infrared Rays; Piperidines; Piperidones; Spectrum Analysis; Structure-Activity Relationship | 1971 |
[Derivatives of 1-substituted 2,3-dihydro-3-hydroxymethylene-4-quinolones and of 1-benzyl-3-hydroxymethylene-4-piperidone].
Topics: Amines; Benzyl Compounds; Ketones; Piperidines; Piperidones; Pyrazoles; Quinolines | 1971 |
Isolation of 2,2,6,6-tetramethylpiperidone-(4) from pronase lysate of ox brain as a hypotensive principle.
Topics: Animals; Antihypertensive Agents; Brain Chemistry; Cats; Infrared Rays; Magnetic Resonance Spectroscopy; Peptide Hydrolases; Piperidines; Piperidones; Pronase; Spectrum Analysis | 1971 |
Benzetimide and its optical isomers.
Topics: Animals; Atropine; Benzyl Compounds; Carbon Isotopes; Diarrhea; Dogs; Female; Guinea Pigs; Ileum; In Vitro Techniques; Isomerism; Lethal Dose 50; Male; Methacholine Compounds; Mice; Muscle Contraction; Parasympatholytics; Pilocarpine; Piperidines; Piperidones; Pupil; Rats; Salivation; Tremorine | 1971 |
Biosynthesis of 5-aminopentanoic acid and 2-piperidone from cadaverine and 1-piperideine in mouse.
Topics: Amine Oxidase (Copper-Containing); Amino Acids; Amino Acids, Neutral; Animals; Cadaverine; Diamines; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Liver; Male; Mice; Mice, Inbred ICR; Piperidines; Piperidones; Pyridines | 1984 |
Piperidinediones, III. Structure-activity relationships of the enantiomers of a series of 2,6-piperidinedione derivatives.
Topics: Anesthetics; Animals; Piperidines; Piperidones; Rats; Stereoisomerism; Structure-Activity Relationship | 1984 |
N-(N-octyl)-glutarimide and proprietary compound (CHR8). A comparison of the mutagenic responses in the Ames assay and Drosophila sex-linked recessive lethal assay.
Topics: Animals; Genes, Lethal; Genes, Recessive; Genetic Linkage; Insect Repellents; Mutagenicity Tests; Organic Chemicals; Piperidines; Piperidones; Sex Chromosomes | 1983 |
Reduction of barbiturate anaesthesia by new glutarimide compounds in mice.
Topics: Animals; Mice; Pentobarbital; Piperidines; Piperidones; Sleep; Structure-Activity Relationship; Time Factors | 1980 |
Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.
Topics: Animals; Hypertension; Male; Oxazines; Piperidines; Piperidones; Rats; Spiro Compounds; Structure-Activity Relationship; Systole | 1983 |
[Experimental models of anxiety as a method of predicting the tranquilizing effect of psychotropic drugs].
Topics: Animals; Anxiety; Behavior, Animal; Female; Humans; Male; Methaqualone; Models, Psychological; Piperidines; Piperidones; Prognosis; Rats; Rats, Inbred Strains; Triacetoneamine-N-Oxyl | 1982 |
[Antiviral effect of 9-methylstreptimidone in plants (author's transl)].
Topics: Anti-Bacterial Agents; Antiviral Agents; Nicotiana; Piperidines; Piperidones; Plant Diseases; Plants, Toxic; Tobacco Mosaic Virus | 1980 |
Glutethimide overdose--clinical and kinetic observations of glutethimide and a metabolite.
Topics: Adult; Glutethimide; Half-Life; Humans; Male; Piperidines; Piperidones | 1980 |
Perylene diimide G-quadruplex DNA binding selectivity is mediated by ligand aggregation.
Topics: Anthracenes; DNA; Fluorescent Dyes; Hydrogen Bonding; Hydrogen-Ion Concentration; Light; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Perylene; Piperidines; Piperidones; Scattering, Radiation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2002 |
Asymmetric synthesis of (-)-adaline.
Topics: Alkaloids; Animals; Bridged-Ring Compounds; Coleoptera; Piperidines; Piperidones; Stereoisomerism | 2002 |
A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.
Topics: Biotransformation; Catalysis; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Piperidines; Piperidones; Pyrrolidines; Triacetoneamine-N-Oxyl | 2003 |
h5-HT(1B) receptor-mediated constitutive Galphai3-protein activation in stably transfected Chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-HT.
Topics: Animals; Benzopyrans; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dioxins; GTP-Binding Protein gamma Subunits; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Methiothepin; Piperazines; Piperidines; Piperidones; Propylamines; Pyrimidines; Radionuclide Imaging; Receptor, Serotonin, 5-HT1B; Serotonin; Spiro Compounds; Sulfur Radioisotopes | 2003 |
Green chemistry approach to the synthesis of N-substituted piperidones.
Topics: Environmental Pollution; Heterocyclic Compounds, 4 or More Rings; Piperidines; Piperidones | 2003 |
Glutarimides. III. N-Alkyl and N-aryl-3,3-diethylglutarimides.
Topics: Piperidines; Piperidones | 1954 |
Oxidation of 3-substituted 1-alkylpyridinium salt. III. Preparation of 1-methyl-3-ethyl-6-pyridone and -piperidone.
Topics: Benzimidazoles; Piperidines; Piperidones; Pyridines; Pyridones | 1955 |
Effect of betabeta-methylethyl glutarimide and amytal on rat-liver mitochondrial respiration.
Topics: Amobarbital; Animals; Barbiturates; Cell Respiration; Liver; Mitochondria; Piperidines; Piperidones; Rats | 1956 |
Clinical trial of methyprylone, a piperidine hypnotic.
Topics: Barbiturates; Humans; Hypnotics and Sedatives; Piperidines; Piperidones | 1956 |
Glutarimides. IV. N-alkyl and N-aryl derivatives of 3-phenylglutarimide and 3-phenyl-2-methylglutarimide.
Topics: Glutethimide; Humans; Imides; Piperidines; Piperidones | 1957 |
[Anticholinergic properties of hypnotic and anticonvulsive glutarimides].
Topics: Cholinergic Antagonists; Hypnotics and Sedatives; Parasympatholytics; Piperidines; Piperidones | 1958 |
Glutarimides. V. Synthesis of 2-allyl-2-phenylglutarimide.
Topics: Glutethimide; Piperidines; Piperidones | 1958 |
[Something on glutarimides].
Topics: Piperidines; Piperidones | 1960 |
Ketals and hemithioketals of 1-methyl-4-piperidone and tropinone.
Topics: Ethers; Heterocyclic Compounds; Piperidines; Piperidones; Tropanes | 1961 |
The effect of methyprylon on the sleep of residents of an old age institution: a double-blind study.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Humans; Piperidines; Piperidones; Sleep | 1960 |
[On the stereospecific metabolism of the optical antipodes of alpha-phenyl-alpha-ethyl-glutarimide (Doriden)].
Topics: Glucuronates; Glutethimide; Piperidines; Piperidones | 1963 |
SYNTHESIS OF SOME SUBSTITUTED PIPERIDONES.
Topics: Amides; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Chemistry, Pharmaceutical; Cyanides; Pharmacy; Piperidines; Piperidones; Pyridines; Research | 1964 |
PHARMACOLOGICAL PROPERTIES AND TERATOGENIC ACTION OF 2-(HEXAHYDROPHTHALIMIDO) GLUTARIMIDE AND 2-PHTHALIMIDO-N-METHYLGLUTARIMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Mice; Piperidines; Piperidones; Pregnancy; Pregnancy, Animal; Rabbits; Research; Thalidomide; Toxicology | 1964 |
SYNTHESIS OF POTENTIAL ANTINEOPLASTIC AGENTS. 33. BETA-DIKETONE ANALOGS OF THE GLUTARIMIDE ANTIBIOTICS.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chemistry, Pharmaceutical; Ketones; Leukemia L1210; Neoplasms, Experimental; Pharmacology; Piperidines; Piperidones; Research; Sarcoma 180 | 1964 |
THE PREPARATION OF N-T-BUTYL-4-PIPERIDONE.
Topics: Chemistry, Pharmaceutical; Ketones; Pharmacy; Piperidines; Piperidones; Research | 1965 |
RF VALUES OF SOME GLUTARIMIDES.
Topics: Bemegride; Chromatography; Glutethimide; Imides; Piperidines; Piperidones; Research | 1965 |
Clinical studies on toxicity and on hypnotic and sedative effects of RO 1-6463*, noludar (3,3-diethyl-2,4-dioxo-5-methylpiperidine).
Topics: Biomedical Research; Humans; Hypnotics and Sedatives; Piperidines; Piperidones | 1955 |
A new, mild sedative-hypnotic, a piperidine derivative (noludar).
Topics: Anti-Allergic Agents; Hypnotics and Sedatives; Piperidines; Piperidones | 1955 |
[Clinical experience with glutethimid, a glutarimide, as soporific].
Topics: Anticonvulsants; Piperidines; Piperidones; Sleep Wake Disorders | 1955 |
[Noludar, a new soporific of the piperidine series].
Topics: Hypnotics and Sedatives; Piperidines; Piperidones | 1955 |
[Experiences with a barbiturate-free hypnotic and sedative in small children. Clinical and electroencephalographic research on 2,4-dioxo-3,3-diethyl-5-methylpiperidine (Noludar)].
Topics: Barbiturates; Hypnotics and Sedatives; Piperidines; Piperidones | 1962 |
Glutarimides I. 3-alkyl-3-methylglutarimides.
Topics: Imides; Piperidines; Piperidones | 1950 |
The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig.
Topics: Animals; Autoreceptors; Cerebral Cortex; Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Guinea Pigs; Hypothalamus; Indoles; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Piperidines; Piperidones; Pyrimidines; Rats; Rats, Inbred Strains; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Presynaptic; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Spiro Compounds; Subcellular Fractions; Triazoles; Tritium; United Kingdom | 2004 |
A novel and highly regioselective approach to 5-methoxy-6-substituted-3-sulfonyl-delta-enlactams from 5-methoxy-3-sulfonyl glutarimide: synthesis of cis-2-substituted-3-piperidinols.
Topics: Lactams; Molecular Structure; Piperidines; Piperidones; Stereoisomerism | 2005 |
A versatile approach for the asymmetric syntheses of (1R,9aR)-epiquinamide and (1R,9aR)-homopumiliotoxin 223G.
Topics: Alkaloids; Catalysis; Indolizines; Molecular Structure; Piperidines; Piperidones; Quinolizines; Stereoisomerism | 2006 |
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Proliferation; Disease Models, Animal; Female; Kidney; Liver; Mice; Neoplasm Transplantation; Piper; Piperidines; Piperidones; Plant Extracts; Plant Roots; Polyunsaturated Alkamides; Sarcoma 180; Spleen | 2006 |
Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling.
Topics: Benzyl Compounds; Bromides; Cross-Linking Reagents; Molecular Structure; Piperidines; Piperidones; Silanes | 2007 |
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
Topics: Adenosine Deaminase Inhibitors; Animals; Biological Availability; Crystallography, X-Ray; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glycoproteins; Humans; Molecular Conformation; Phenethylamines; Piperidines; Piperidones; Rats; Stereoisomerism; Structure-Activity Relationship | 2007 |
Asymmetric three- and [2 + 1]-component conjugate addition reactions for the stereoselective synthesis of polysubstituted piperidinones.
Topics: Crystallography, X-Ray; Esters; Lithium; Oxazolidinones; Piperidines; Piperidones; Stereoisomerism; Temperature | 2007 |
Enantioselective synthesis of 3,3-disubstituted piperidine derivatives by enolate dialkylation of phenylglycinol-derived oxazolopiperidone lactams.
Topics: Alkylation; Ethanolamines; Glycine; Indole Alkaloids; Lactams; Oxazoles; Piperidines; Piperidones; Stereoisomerism | 2007 |
In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.
Topics: Alanine Transaminase; Alkaloids; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Benzodioxoles; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fluorouracil; HL-60 Cells; Humans; Inhibitory Concentration 50; Kidney; Leukopenia; Liver; Mice; Piperidines; Piperidones; Polyunsaturated Alkamides; Sarcoma 180; Urea | 2008 |
Asymmetric synthesis of (+)-isofebrifugine and (-)-sedacryptine from a common chiral nonracemic building block.
Topics: Alkaloids; Piperidines; Piperidones; Quinazolines; Stereoisomerism | 2008 |
Piperidine derivatives; the condensation of aromatic aldehydes with l-methyl-4-piperidone.
Topics: Aldehydes; Piperidines; Piperidones | 1948 |
A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Drug Resistance, Microbial; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Chemical; Models, Molecular; Piperidines; Piperidones; Pyridines; Rifampin | 2008 |
Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds | 2009 |
Chemopreventive potential of 3-[2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino]-2-thioxoimidazolidin-4-one on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Anticarcinogenic Agents; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Dose-Response Relationship, Drug; Drug Design; gamma-Glutamyltransferase; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Male; Mesocricetus; Molecular Structure; Mouth Mucosa; Mouth Neoplasms; Piperidines; Piperidones; Random Allocation; Thiohydantoins; Tumor Burden | 2010 |
Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.
Topics: Alcohols; Amines; Analgesics; Binding Sites; Dioxolanes; Halogenation; Humans; Piperidines; Piperidones; Protein Binding; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2010 |
Biomimetic oxidation of piperine and piplartine catalyzed by iron(III) and manganese(III) porphyrins.
Topics: Alkaloids; Benzodioxoles; Biological Products; Biomimetics; Catalysis; Cytochrome P-450 Enzyme System; Ferric Compounds; Inactivation, Metabolic; Iodobenzenes; Iron; Manganese; Oxidation-Reduction; Piperidines; Piperidones; Polyunsaturated Alkamides; Porphyrins; Singlet Oxygen; Spectrometry, Mass, Electrospray Ionization | 2010 |
Piperidine derivatives; the preparation of l-benzoyl-3-carbethoxy-4-piperidone; a synthesis of guvacine.
Topics: Nicotinic Acids; Piperidines; Piperidones | 1946 |
Piperidine derivatives; C-alkylation of l-benzoyl-3-carbethoxy-4-piperidone; synthesis of ethyl 3-ethyl-4-piperidylacetate (d1-ethyl cincholoiponate).
Topics: Alkylation; Piperidines; Piperidones | 1946 |
Inhibition of Photosystem II by the singlet oxygen sensor compounds TEMP and TEMPD.
Topics: Cyclic N-Oxides; Electron Transport; Oxidation-Reduction; Oxygen; Oxygen Compounds; Photosystem II Protein Complex; Piperidines; Piperidones; Singlet Oxygen | 2011 |
FT-Raman, FT-IR spectra and total energy distribution of 3-pentyl-2,6-diphenylpiperidin-4-one: DFT method.
Topics: Alkaloids; Carbon; Computer Simulation; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen; Normal Distribution; Oximes; Oxygen; Piperidines; Piperidones; Scattering, Radiation; Software; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; X-Ray Diffraction | 2011 |
Pure forms of the singlet oxygen sensors TEMP and TEMPD do not inhibit Photosystem II.
Topics: Light; Photosystem II Protein Complex; Piperidines; Piperidones; Singlet Oxygen; Spin Labels; Spinacia oleracea; Thylakoids | 2011 |
Antagonism of serotonin receptor 1B decreases viability and promotes apoptosis in the COS canine osteosarcoma cell line.
Topics: Animals; Apoptosis; Cell Survival; Cyclic AMP Response Element-Binding Protein; Dog Diseases; Dogs; Extracellular Signal-Regulated MAP Kinases; Osteosarcoma; Piperidines; Piperidones; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Signal Transduction; Spiro Compounds; Taurine; Thiadiazines | 2016 |
Diastereoconvergent synthesis of trans-5-hydroxy-6-substituted-2-piperidinones by addition-cyclization-deprotection process.
Topics: Cyclization; Molecular Structure; Piperidines; Piperidones; Stereoisomerism | 2014 |
Stereoselective Synthesis of (R)-3-Methylthalidomide by Piperidin-2-one Ring Assembly Approach.
Topics: Chemistry Techniques, Synthetic; Hydrogen-Ion Concentration; Piperidines; Piperidones; Stereoisomerism; Thalidomide | 2015 |
Synthesis, electronic structure investigation of 3-pentyl-2,6-di(furan-2-yl)piperidin-4-one by FT-IR, FT-Raman and UV-Visible spectral studies and ab initio/DFT calculations.
Topics: Chemistry Techniques, Synthetic; Entropy; Furans; Hydrogen; Models, Molecular; Oxygen; Piperidines; Piperidones; Quantum Theory; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics | 2015 |
CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Arachidonic Acids; Cyproheptadine; Drug Interactions; Eating; gamma-Aminobutyric Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Piperazines; Piperidines; Piperidones; Pyrazoles; Pyridines; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium | 2018 |
The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.
Topics: 3' Flanking Region; 5' Flanking Region; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation, Leukemic; Humans; Indolizines; Myeloid Cells; Phenylenediamines; Piperazines; Piperidines; Piperidones; Protein Kinase Inhibitors; Pyridines; Pyridinium Compounds; Pyrimidines; Pyrroles; RNA Polymerase II; Translocation, Genetic | 2019 |
One-pot five-component high diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates and ammonium acetate.
Topics: Acetates; Acinetobacter baumannii; Aldehydes; Catalysis; Malonates; Nitriles; Piperidines; Piperidones; Staphylococcus aureus; Stereoisomerism | 2020 |