2-piperidone has been researched along with phenyl acetate in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 14 (77.78) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Basavaiah, D; Reddy, RJ | 1 |
| Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chow, D; Deignan, J; Fox, BM; Gonzalez-Lopez De Turiso, F; Gustin, D; Huang, X; Jiang, M; Jiao, X; Jin, L; Kayser, F; Kopecky, DJ; Li, Y; Lo, MC; Long, AM; Medina, JC; Michelsen, K; Oliner, JD; Olson, SH; Osgood, T; Ragains, M; Rew, Y; Saiki, AY; Schneider, S; Sun, D; Toteva, M; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J | 1 |
| Bernard, D; Wang, S; Zhao, Y | 1 |
| Cheung, E; Fisher, B; Lucas, BS; McGee, LR; Medina, JC; Olson, SH | 1 |
| Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chen, X; Chow, D; Deignan, J; Duquette, J; Eksterowicz, J; Fisher, B; Fox, BM; Fu, J; Gonzalez, AZ; Gonzalez-Lopez De Turiso, F; Gribble, M; Houze, JB; Huang, X; Jiang, M; Jin, L; Kayser, F; Li, Z; Liu, JJ; Lo, MC; Long, AM; Lucas, B; McGee, LR; McIntosh, J; Medina, JC; Mihalic, J; Oliner, JD; Olson, SH; Osgood, T; Peterson, ML; Rew, Y; Roveto, P; Saiki, AY; Shaffer, P; Sun, D; Toteva, M; Wang, Y; Wang, YC; Wortman, S; Yakowec, P; Yan, X; Ye, Q; Yu, D; Yu, M; Zhao, X; Zhou, J; Zhu, J | 1 |
| Beck, HP; Canon, J; Chen, A; Chow, D; Duquette, J; Eksterowicz, J; Fox, BM; Fu, J; Gonzalez, AZ; Houze, J; Huang, X; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; Medina, JC; Oliner, JD; Olson, SH; Osgood, T; Rew, Y; Saiki, AY; Shaffer, P; Sun, D; Wortman, S; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J | 1 |
| Rew, Y; Sun, D | 1 |
| Chen, A; Chen, X; Deignan, J; Huang, X; Kayser, F; Liu, JJ; Lo, MC; Long, AM; McGee, LR; Medina, JC; Mihalic, J; Oliner, JD; Olson, SH; Sun, D; Wang, Y; Yakowec, P; Ye, Q; Yu, M; Zhou, J; Zhu, J | 1 |
| Canon, J; Chen, A; Cordover, D; Coxon, A; Eksterowicz, J; Jin, L; Kaufman, S; Kendall, R; Oliner, JD; Olson, SH; Osgood, T; Radinsky, R; Robertson, R; Saiki, AY; Ye, Q; Yu, D; Zhou, J | 1 |
| Huang, WT; Jiang, M; Jin, L; Ling, Y; Olson, SH; Sun, D; Wong, BK; Xu, G; Yan, X; Ye, Q | 1 |
| Armstrong, EA; Canon, J; Francis, DM; Harari, PM; Huang, S; Iyer, G; Li, C; Ma, F; Werner, LR | 1 |
| Bakulina, O; Chizhova, M; Dar'in, D; Garabadzhiu, AV; Grigoreva, T; Gureyev, MA; Ivanov, G; Krasavin, M; Lepikhina, A; Novikova, D; Tribulovich, VG; Zhumagalieva, A | 1 |
| Cho, HJ; Han, S; Her, NG; Lee, Y; Nam, DH; Oh, JW; Oh, YJ; Ryu, GH | 1 |
| Bio, MM; Caille, S; Cochran, BM; Corbett, MT; Correll, TL; Fang, YQ; Flick, TG; Jones, SC; Silva Elipe, MV; Smith, AG; Tucker, JL; Vounatsos, F; Walker, SD; Wells, G; Yeung, D | 1 |
| Anderson, AA; Becker, PS; Erba, HP; Flesher, DL; Grunwald, MR; Henary, HA; Rasmussen, E; Shami, PJ; Wang, ES; Zhu, M | 1 |
| Blay, JY; Cassier, PA; Chawla, S; De Vos, F; de Weger, V; Eskens, F; Frank, R; Gluck, WL; Gounder, MM; Henary, HA; Rasmussen, E; Siegel, D; Soria, JC; Wagner, AJ | 1 |
| Egorov, MP; Elinson, MN; Goloveshkin, AS; Hansford, KA; Karpenko, KA; Minaeva, AP; Vereshchagin, AN | 1 |
| Flaherty, KT; Henary, HA; Johnson, DB; Lewis, KD; Long, GV; Moschos, SJ; Puzanov, I; Sandhu, S; Sullivan, RJ; Upreti, VV; Wong, H | 1 |
1 review(s) available for 2-piperidone and phenyl acetate
| Article | Year |
|---|---|
Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer.
Topics: Acetates; Animals; Antineoplastic Agents; Binding Sites; Humans; Models, Molecular; Piperidones; Protein Binding; Protein Conformation; Proto-Oncogene Proteins c-mdm2; Structure-Activity Relationship | 2014 |
3 trial(s) available for 2-piperidone and phenyl acetate
| Article | Year |
|---|---|
Phase 1b study of the MDM2 inhibitor AMG 232 with or without trametinib in relapsed/refractory acute myeloid leukemia.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Targeted Therapy; Piperidones; Proto-Oncogene Proteins c-mdm2; Pyridones; Pyrimidinones; Recurrence; Treatment Outcome | 2019 |
Phase 1 study of the MDM2 inhibitor AMG 232 in patients with advanced P53 wild-type solid tumors or multiple myeloma.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Piperidones; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2020 |
Targeting wild-type TP53 using AMG 232 in combination with MAPK inhibition in Metastatic Melanoma; a phase 1 study.
Topics: Acetates; Antineoplastic Combined Chemotherapy Protocols; Humans; Melanoma; Nausea; Piperidones; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Tumor Suppressor Protein p53 | 2022 |
14 other study(ies) available for 2-piperidone and phenyl acetate
| Article | Year |
|---|---|
Simple and facile synthesis of tetralone-spiro-glutarimides and spiro-bisglutarimides from Baylis-Hillman acetates.
Topics: Acetates; Models, Molecular; Molecular Structure; Piperidones; Spiro Compounds; Tetralones | 2008 |
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
Topics: Acetates; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Hepatocytes; Humans; Macaca fascicularis; Mice; Mice, Nude; Models, Molecular; Molecular Conformation; Neoplasm Transplantation; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Rats; rho GTP-Binding Proteins; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2012 |
AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development.
Topics: Acetates; Animals; Antineoplastic Agents; Humans; Piperidones; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2012 |
An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.
Topics: Acetates; Amino Alcohols; Antineoplastic Agents; Cyclization; Humans; Lactones; Models, Molecular; Oxazoles; Piperidones; Proto-Oncogene Proteins c-mdm2; Stereoisomerism; Tumor Suppressor Protein p53 | 2012 |
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
Topics: Acetates; Administration, Oral; Antineoplastic Agents; Biological Availability; Crystallography, X-Ray; Drug Discovery; Humans; Piperidones; Protein Conformation; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2014 |
Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
Topics: Acetates; Animals; Antineoplastic Agents; Bone Neoplasms; Carboxylic Acids; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Drug Design; Female; Humans; Hydrogen Bonding; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Myocytes, Smooth Muscle; Osteosarcoma; Piperidones; Protein Binding; Protein Interaction Domains and Motifs; Proto-Oncogene Proteins c-mdm2; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Topics: Acetates; Animals; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Conformation; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Rats; Structure-Activity Relationship; Sulfonamides; Tumor Suppressor Protein p53 | 2014 |
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.
Topics: Acetates; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Female; HCT116 Cells; HT29 Cells; Humans; MCF-7 Cells; Mice; Mice, Nude; Piperidones; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2015 |
Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation.
Topics: Acetates; Administration, Intravenous; Administration, Oral; Animals; Bile; Biological Availability; Biotransformation; Dogs; Glucuronides; Haplorhini; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Piperidones; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Species Specificity | 2015 |
Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors.
Topics: Acetates; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Disease Models, Animal; Humans; Mice; Neoplasms; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Radiation, Ionizing; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2015 |
Design, in silico prioritization and biological profiling of apoptosis-inducing lactams amenable by the Castagnoli-Cushman reaction.
Topics: Acetates; Antineoplastic Agents; Apoptosis; Chemistry Techniques, Synthetic; Drug Design; Green Fluorescent Proteins; HCT116 Cells; High-Throughput Screening Assays; Humans; Imidazoles; Indoles; Lactams; Molecular Docking Simulation; Piperazines; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Small Molecule Libraries; Spiro Compounds; Tumor Suppressor Protein p53 | 2018 |
Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells.
Topics: Acetates; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Glioblastoma; Humans; Imidazolines; Mutation; Nestin; Piperidones; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53; Zinc Finger E-box-Binding Homeobox 1 | 2018 |
Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis-Pinnick Tandem Transformation.
Topics: Acetates; Molecular Structure; Ozone; Piperidones | 2019 |
One-pot five-component high diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates and ammonium acetate.
Topics: Acetates; Acinetobacter baumannii; Aldehydes; Catalysis; Malonates; Nitriles; Piperidines; Piperidones; Staphylococcus aureus; Stereoisomerism | 2020 |