Page last updated: 2024-08-21

2-piperidone and migrastatin

2-piperidone has been researched along with migrastatin in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	17 (56.67)	29.6817
2010's	12 (40.00)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Hamada, M; Homma, Y; Imoto, M; Nakae, K; Sawa, T; Takeuchi, T; Yoshimoto, Y	1
Imoto, M; Naganawa, H; Nakae, K; Sawa, T; Takahashi, Y; Takeuchi, T; Ueda, M; Yoshimoto, Y	1
Imoto, M; Kawatani, M; Naganawa, H; Nakae, K; Takahashi, Y; Takemoto, Y	1
Arslanian, R; Cadapan, L; Carney, JR; Licari, P; Starks, CM; Woo, EJ; Zavala, S	1
Imoto, M; Kitahara, T; Matsumura, K; Naganawa, H; Nakae, K; Nakamura, H; Shiro, M; Takahashi, Y; Watanabe, H	1
Danishefsky, SJ; Gaul, C; Njardarson, JT	1
Danishefsky, SJ; Gaul, C; Huang, XY; Njardarson, JT; Shan, D	1
Danishefsky, SJ; Dorn, DC; Gaul, C; Huang, XY; Moore, MA; Njardarson, JT; Shan, D; Tong, WP; Wu, KD	1
Jiang, H; Ju, J; Lim, SK; Shen, B	1
Chen, L; Danishefsky, SJ; Gaul, C; Huang, XY; Ma, X; Njardarson, JT; Shan, D	1
Imoto, M; Takemoto, Y; Tashiro, E	1
Her, Y; Jiang, H; Ju, J; Lim, SK; Seo, JW; Shen, B	1
Akamatsu, Y; Nakae, K; Nishimura, Y; Ohba, S	1
Baker, HL; Bewley, CA; Chen, L; Huang, XY; Metaferia, BB	1
Anquetin, G; McMahon, K; Murphy, EP; Murphy, PV; Rawe, SL	1
Hoffmann, FM; Ju, J; Lim, SK; Peters, NR; Rajski, SR; Seo, JW; Shen, B	1
Chen, Y; Farnet, CM; Feng, Z; Jiang, H; Ju, J; Lim, SK; Rajski, SR; Seo, JW; Shen, B; Zazopoulos, E	1
Danishefsky, SJ; Krauss, IJ; Mandal, M; Massagué, J; Moore, MA; Nagorny, P; Oskarsson, T; Ouerfelli, O; Perez, L; Xiao, D; Yang, G	1
Danishefsky, S	1
Chen, L; Huang, XY; Jakoncic, J; Yang, S; Zhang, JJ	1
Andricopulo, AD; Dias, LC; Guido, RV; Oliva, G; Santos, RN	1
Danishefsky, SJ; Downey, R; Lecomte, N; Moore, MA; Nagorny, P; Njardarson, JT; Ouerfelli, O; Yang, G	1
Bulkowska, M; Gajewska, M; Homa, A; Król, M; Lo Re, D; Majchrzak, K; Motyl, T; Murphy, PV; Pawłowski, K	1
Anderson, KI; Lo Re, D; Murphy, PV; Nobis, M; Zhou, Y	1
Jones, LF; Krol, M; Leahy, L; Lo Re, D; Mucha, J; Murphy, PV; Santocanale, C; Zhou, Y	2
Giralt, E; Lo Re, D	1
Heisenberg, CP; Tavano, S	1
Airan, Y; Prasad, KR	1
Alburquerque-González, B; Bernabé-García, Á; Bernabé-García, M; Cayuela, ML; Conesa-Zamora, P; López-Calderón, FF; Luque, I; Montoro-García, S; Nicolas, FJ; Pérez-Sánchez, H; Rodrigues, PC; Ruiz Sanz, J; Salo, T	1

Reviews

3 review(s) available for 2-piperidone and migrastatin

Article	Year
On the potential of natural products in the discovery of pharma leads: a case for reassessment. Natural product reports, 2010, Volume: 27, Issue:8 Topics: Animals; Biological Products; Drug Discovery; Epothilones; Macrolides; Mice; Molecular Structure; Myxococcales; Piperidones; Streptomyces	2010
The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer. Molecules (Basel, Switzerland), 2017, Feb-09, Volume: 22, Issue:2 Topics: Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Cell Movement; Drug Evaluation, Preclinical; Humans; Macrolides; Neoplasm Metastasis; Neoplasms; Piperidones	2017
Migrasomes take center stage. Nature cell biology, 2019, Volume: 21, Issue:8 Topics: Animals; Cell Movement; Cholesterol; Extracellular Vesicles; Humans; Macrolides; Piperidones; Tetraspanins; Zebrafish	2019

Other Studies

27 other study(ies) available for 2-piperidone and migrastatin

Article	Year
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. The Journal of antibiotics, 2000, Volume: 53, Issue:10 Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Cell Survival; Chemotaxis; DNA; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Fermentation; Humans; Lactones; Macrolides; Melanoma, Experimental; Mice; Neoplasms; Piperidones; Protein Biosynthesis; RNA; Streptomyces; Tumor Cells, Cultured; Wound Healing	2000
Migrastatin, a novel 14-membered lactone from Streptomyces sp. MK929-43F1. The Journal of antibiotics, 2000, Volume: 53, Issue:10 Topics: Antibiotics, Antineoplastic; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Piperidones; Streptomyces	2000
Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. The Journal of antibiotics, 2001, Volume: 54, Issue:12 Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Small Cell; Humans; Lactones; Lung Neoplasms; Macrolides; Mice; Piperidones; Rats; Tumor Cells, Cultured	2001
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis. The Journal of antibiotics, 2002, Volume: 55, Issue:2 Topics: Antibiotics, Antineoplastic; Fermentation; Lactones; Macrolides; Molecular Structure; Piperidones	2002
Absolute configuration of migrastatin, a novel 14-membered ring macrolide. The Journal of antibiotics, 2002, Volume: 55, Issue:4 Topics: Antibiotics, Antineoplastic; Crystallography, X-Ray; Lactones; Macrolides; Molecular Conformation; Molecular Structure; Piperidones	2002
The total synthesis of (+)-migrastatin. Journal of the American Chemical Society, 2003, May-21, Volume: 125, Issue:20 Topics: Antineoplastic Agents; Lactones; Macrolides; Piperidones; Stereoisomerism; Streptomyces	2003
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. Journal of the American Chemical Society, 2004, Feb-04, Volume: 126, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Movement; Drug Design; Endothelium, Vascular; Humans; Lactones; Macrolides; Mice; Piperidones; Structure-Activity Relationship	2004
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. Journal of the American Chemical Society, 2004, Sep-15, Volume: 126, Issue:36 Topics: Alcohols; Animals; Cell Movement; Endothelium, Vascular; Humans; Ketones; Lactones; Macrolides; Mammary Neoplasms, Experimental; Mice; Piperidones; Structure-Activity Relationship	2004
Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. Journal of the American Chemical Society, 2005, Feb-16, Volume: 127, Issue:6 Topics: Chromatography, High Pressure Liquid; Lactones; Macrolides; Piperidones; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Streptomyces	2005
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-08, Volume: 102, Issue:10 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Lactones; Lung Neoplasms; Macrolides; Mice; Neoplasm Metastasis; Piperidones; rac GTP-Binding Proteins	2005
Suppression of multidrug resistance by migrastatin. The Journal of antibiotics, 2006, Volume: 59, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Lactones; Macrolides; Mice; Paclitaxel; Piperidones; Vinblastine; Vincristine	2006
Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Organic letters, 2006, Dec-07, Volume: 8, Issue:25 Topics: Chromatography, High Pressure Liquid; Hot Temperature; Isomerism; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperidones; Stereoisomerism	2006
Migrastatin acts as a muscarinic acetylcholine receptor antagonist. The Journal of antibiotics, 2006, Volume: 59, Issue:11 Topics: Animals; Calcium; Carbachol; Cell Line, Tumor; Cells, Cultured; Cyclic AMP; Drinking; Female; Humans; Lactones; Macrolides; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Piperidones; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder	2006
Synthetic macrolides that inhibit breast cancer cell migration in vitro. Journal of the American Chemical Society, 2007, Mar-07, Volume: 129, Issue:9 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Movement; Female; Humans; Lactones; Macrolides; Models, Chemical; Piperidones; Quinic Acid; Tumor Cells, Cultured	2007
Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal. Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:5 Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Calcium Gluconate; Cell Line, Tumor; Lactones; Macrolides; Models, Chemical; Piperidones; Stereoisomerism; Structure-Activity Relationship; Synovial Membrane	2008
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorganic & medicinal chemistry letters, 2008, Nov-15, Volume: 18, Issue:22 Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Drug Design; Female; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship	2008
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. The Journal of biological chemistry, 2009, Oct-23, Volume: 284, Issue:43 Topics: Base Sequence; Gene Deletion; Genome, Bacterial; Macrolides; Molecular Sequence Data; Multigene Family; Open Reading Frames; Piperidones; Polyketide Synthases; Streptomyces	2009
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society, 2010, Mar-10, Volume: 132, Issue:9 Topics: Animals; Antineoplastic Agents; Biological Products; Breast Neoplasms; Cell Movement; Drug Screening Assays, Antitumor; Ethers; Female; Humans; Macrolides; Mice; Molecular Conformation; Neoplasm Metastasis; Piperidones; Stereoisomerism	2010
Migrastatin analogues target fascin to block tumour metastasis. Nature, 2010, Apr-15, Volume: 464, Issue:7291 Topics: Actins; Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Movement; Crystallography, X-Ray; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Macrolides; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Microfilament Proteins; Models, Molecular; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Piperidones; Protein Conformation	2010
Quantitative structure-activity studies on a series of migrastatin analogs as inhibitors of cancer cell metastasis. Medicinal chemistry (Shariqah (United Arab Emirates)), 2011, Volume: 7, Issue:3 Topics: Cell Movement; Databases, Factual; Macrolides; Models, Molecular; Molecular Conformation; Neoplasm Invasiveness; Neoplasm Metastasis; Piperidones; Quantitative Structure-Activity Relationship; Stereoisomerism	2011
Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-13, Volume: 108, Issue:37 Topics: Animals; Cell Line, Tumor; Cell Movement; Ethers; Humans; Lung Neoplasms; Macrolides; Male; Mice; Neoplasm Metastasis; Piperidones; Small Cell Lung Carcinoma; Xenograft Model Antitumor Assays	2011
Migrastatin analogues inhibit canine mammary cancer cell migration and invasion. PloS one, 2013, Volume: 8, Issue:10 Topics: Actins; Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Collagen; Cytoskeleton; Dogs; Dose-Response Relationship, Drug; Drug Combinations; Humans; Laminin; Macrolides; Mammary Neoplasms, Animal; Microfilament Proteins; Microscopy, Confocal; Models, Chemical; Molecular Structure; Neoplasm Invasiveness; Piperidones; Proteoglycans	2013
Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics. Chembiochem : a European journal of chemical biology, 2014, Jul-07, Volume: 15, Issue:10 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cadherins; Cell Adhesion; Cell Movement; Fluorescence Recovery After Photobleaching; Humans; Macrolides; Mice, Nude; Pancreatic Neoplasms; Piperidones; Tumor Cells, Cultured	2014
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring. Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Dec-07, Volume: 21, Issue:50 Topics: Alkenes; Cell Line, Tumor; Cell Movement; Female; Glucuronides; Humans; Macrocyclic Compounds; Macrolides; Pancreatic Neoplasms; Piperidones; Structure-Activity Relationship	2015
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring. Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Dec-07, Volume: 21, Issue:50 Topics: Cell Line, Tumor; Cell Movement; Humans; Macrocyclic Compounds; Macrolides; Molecular Structure; Piperidones; Structure-Activity Relationship	2015
Furan Oxidation Strategy for the Synthesis of the Macrolactone Analogue of Migrastatin. The Journal of organic chemistry, 2019, 11-15, Volume: 84, Issue:22 Topics: Furans; Macrolides; Molecular Structure; Oxidation-Reduction; Piperidones	2019
New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Experimental & molecular medicine, 2020, Volume: 52, Issue:2 Topics: Animals; Antidepressive Agents; Carrier Proteins; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Imipramine; Macrolides; Microfilament Proteins; Neoplasm Invasiveness; Piperidones; Zebrafish	2020