2-piperidone has been researched along with isomigrastatin in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arslanian, R; Cadapan, L; Carney, JR; Licari, P; Starks, CM; Woo, EJ; Zavala, S | 1 |
| Jiang, H; Ju, J; Lim, SK; Shen, B | 1 |
| Jiang, H; Ju, J; Lim, SK; Seo, JW; Shen, B | 1 |
| Her, Y; Jiang, H; Ju, J; Lim, SK; Seo, JW; Shen, B | 1 |
| Danishefsky, SJ; Krauss, IJ; Mandal, M | 1 |
| Coeffet-LeGal, MF; Feng, Z; Rajski, SR; Shen, B; Wang, L; Xu, Z | 1 |
| Hoffmann, FM; Ju, J; Lim, SK; Peters, NR; Rajski, SR; Seo, JW; Shen, B | 1 |
| Chen, Y; Farnet, CM; Feng, Z; Jiang, H; Ju, J; Lim, SK; Rajski, SR; Seo, JW; Shen, B; Zazopoulos, E | 1 |
| Feng, Z; Huang, L; Shen, B; Wu, X; Xu, Z; Yang, D; Zhu, X | 1 |
| Ju, J; Kwong, T; Lim, SK; Lohman, JR; Ma, M; Shen, B | 1 |
| Fürstner, A; Lam, MH; Llaveria, J; Loganzo, F; Maderna, A; Micoine, K; Persich, P | 1 |
| Cleveland, J; Farnet, CM; Jiang, H; Ju, J; Kwong, T; Lim, SK; Lohman, JR; Ma, M; Seo, JW; Shen, B; Yang, C; Zazopoulos, E | 1 |
| Jones, LF; Krol, M; Leahy, L; Lo Re, D; Mucha, J; Murphy, PV; Santocanale, C; Zhou, Y | 1 |
| Ma, M; Pan, G; Shen, B; Teng, Q; Xu, Z; Zhang, B | 1 |
| Adhikari, A; Shen, B; Teijaro, CN | 1 |
1 review(s) available for 2-piperidone and isomigrastatin
| Article | Year |
|---|---|
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.
Topics: Adamantane; Aminobenzoates; Aminoglycosides; Aminophenols; Anilides; Bacterial Proteins; Biological Products; Biosynthetic Pathways; Drug Discovery; Enediynes; Gene Expression Regulation, Bacterial; Genes, Bacterial; Lactams; Macrolides; Metabolic Engineering; Multigene Family; Piperidones; Polycyclic Compounds; Protein Conformation; Sequence Analysis, DNA; Streptomyces; Thiazoles; Thiones | 2019 |
14 other study(ies) available for 2-piperidone and isomigrastatin
| Article | Year |
|---|---|
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
Topics: Antibiotics, Antineoplastic; Fermentation; Lactones; Macrolides; Molecular Structure; Piperidones | 2002 |
Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin.
Topics: Chromatography, High Pressure Liquid; Lactones; Macrolides; Piperidones; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Streptomyces | 2005 |
Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.
Topics: Antibiotics, Antineoplastic; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidones; Streptomyces | 2005 |
Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.
Topics: Chromatography, High Pressure Liquid; Hot Temperature; Isomerism; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperidones; Stereoisomerism | 2006 |
Total synthesis of (+)-isomigrastatin.
Topics: Isomerism; Lactones; Macrolides; Molecular Structure; Piperidones | 2007 |
Engineered production of iso-migrastatin in heterologous Streptomyces hosts.
Topics: Base Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromosomes, Artificial, Bacterial; Cloning, Molecular; DNA Primers; Macrolides; Mass Spectrometry; Multigene Family; Piperidones; Polymerase Chain Reaction; Streptomyces | 2009 |
Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.
Topics: Animals; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship | 2009 |
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.
Topics: Base Sequence; Gene Deletion; Genome, Bacterial; Macrolides; Molecular Sequence Data; Multigene Family; Open Reading Frames; Piperidones; Polyketide Synthases; Streptomyces | 2009 |
Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR.
Topics: Antineoplastic Agents; Biosynthetic Pathways; Gene Expression Profiling; Macrolides; Piperidones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Streptomyces lividans | 2011 |
Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity.
Topics: Biosynthetic Pathways; Macrolides; Molecular Structure; Piperidones; Polyketide Synthases; Streptomyces; Substrate Specificity | 2013 |
Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.
Topics: Anti-Bacterial Agents; Cell Movement; Female; Humans; Macrolides; Magnetic Resonance Spectroscopy; Piperidones | 2013 |
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
Topics: Antibiotics, Antineoplastic; Bacterial Proteins; Base Sequence; Bioreactors; Cell Line, Tumor; Cell Survival; Drug Design; Gene Silencing; Humans; Macrolides; Models, Biological; Molecular Sequence Data; Molecular Structure; Multigene Family; Mutant Proteins; Neoplasms; Piperidones; Polyketide Synthases; Polyketides; Protein Engineering; Recombinant Proteins; Stereoisomerism; Streptomyces; Structure-Activity Relationship | 2014 |
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.
Topics: Alkenes; Cell Line, Tumor; Cell Movement; Female; Glucuronides; Humans; Macrocyclic Compounds; Macrolides; Pancreatic Neoplasms; Piperidones; Structure-Activity Relationship | 2015 |
A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.
Topics: Catalysis; Hydro-Lyases; Macrolides; Piperidones; Polyketide Synthases; Protein Conformation; Protein Domains; Substrate Specificity; Water | 2017 |