Page last updated: 2024-08-21

2-piperidone and curcumin

2-piperidone has been researched along with curcumin in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (10.87)	29.6817
2010's	34 (73.91)	24.3611
2020's	7 (15.22)	2.80

Authors

Authors	Studies
Al-Deeb, OA; Awadalla, SA; El-Shafie, FS; El-Sherbeny, MA; Farag, HA; Youssef, KM	1
Du, Y; Fu, H; Kasinski, AL; Khuri, FR; Liotta, D; Shoji, M; Snyder, JP; Sun, A; Sun, SY; Thomas, SL; Wang, CY; Zhao, J	1
Giannakakou, P; Hamel, E; Liotta, D; Malik, S; Snyder, JP; Thomas, SL; Zhong, D; Zhou, W	1
Bratasz, A; Hideg, K; Kálai, T; Kuppusamy, ML; Kuppusamy, P; Rink, C; Rivera, BK; Selvendiran, K; Sen, CK; Tong, L	1
Jyothi, D; Madhusudana Rao, J; Mangala Gowri, P; Rama Subba Rao, V; Sreedhar, AS; Vanathi, P	1
Dayton, A; Hideg, K; Kálai, T; Kuppusamy, ML; Kuppusamy, P; Meduru, S; Rivera, BK; Selvendiran, K	1
Miranda, M; Narayan, M; Pal, R	1
Anant, S; Awasthi, V; Dozmorov, MG; Sahoo, K	1
Balog, M; Hideg, K; Kálai, T; Kuppusamy, ML; Kuppusamy, P; Rivera, BK; Selvendiran, K	1
Ahmed, S; Dayton, A; Hideg, K; Kálai, T; Kuppusamy, ML; Kuppusamy, P; Rivera, BK; Selvendiran, K	1
Brown, AP; Hu, F; Liotta, DC; Marcus, AI; Miller, AH; Moore, TW; Olivera, A; Pace, TW; Shim, H; Snyder, JP; Sun, A; Yoon, Y	1
Anant, S; Awasthi, S; Awasthi, V; Natarajan, A; Vilekar, P	1
Arrendale, RF; Chen, ZG; Culver, D; Evers, TJ; Fu, H; Howard, RB; Khuri, FR; Lin, X; Mancini, A; Moore, TW; Morii, N; Reddy, P; Shin, DM; Shoji, M; Sica, G; Snyder, JP; Sun, A; Zhang, H; Zhu, S	1
Moore, TW; Shoji, M; Snyder, JP; Sun, A; Yamaguchi, M	1
Cai, Y; Chen, X; Liang, G; Pan, Z; Tang, Q; Wang, J; Weng, B; Wu, J; Yang, S; Zhang, Y	1
Adsay, VN; Diaz, R; El-Rayes, BF; Farris, AB; Mamoru, S; Nagaraju, GP; Snyder, JP; Wen, J; Zhu, S	1
Conney, AH; Cui, XX; Ding, N; Du, ZY; Fan, YX; Verano, M; Wang, H; Zhang, K; Zhao, SQ; Zheng, X; Zhou, DY	1
Awasthi, S; Awasthi, V; King, C; Lagisetty, P; Vilekar, P	1
Chun, HS; Kim, CS; Kim, DK; Kim, HJ; Kim, JS; Kim, SG; Kim, YH; Lee, SA; Oh, JS; Park, MG; Yang, SJ; Yu, SK	1
Arrendale, RF; Chen, ZG; Culver, D; Evers, TJ; Fu, H; Howard, RB; Khuri, FR; Moore, TW; Morii, N; Reddy, P; Shin, DM; Shoji, M; Sica, G; Snyder, JP; Sun, A; Zhang, H; Zhu, S	1
Ames, MM; Buhrow, SA; Gilbert, JA; Jia, L; Reid, JM; Shoji, M; Snyder, JP	1
Ashritha, N; El-Rayes, BF; Kandimalla, R; Ko, JE; Nagaraju, GP; Shoji, M; Snyder, JP; Zhu, S	1
Bai, H; Chen, F; Huang, C; Liu, G; Peng, C; Song, E; Song, Y; Wang, H; Wu, C; Zeng, P; Zhang, B; Zhang, P	1
Cai, Z; Chen, M; He, F; Liang, G; Shi, L; Wei, X; Wu, J; Xu, RA; Ying, S; Zhang, X	1
Andrews, G; Balzarini, J; Bhullar, KS; Duffield, KM; Jha, A; Ness, MR; Ravoori, S; Rupasinghe, HP	1
Ali, I; Anthwal, A; Haque, A; Rawat, DS; Rawat, MS; Singh, K; Tyagi, AK	1
Alam, A; Belalcazar, A; El-Rayes, BF; Nagaraju, GP; Pattnaik, S; Rajitha, B; Shaib, WL; Shoji, M; Snyder, JP	1
Alam, A; Alese, OB; El-Rayes, BF; Nagaraju, GP; Pattnaik, S; Rajitha, B; Shaib, WL; Shoji, M; Snyder, JP	1
Aboussekhra, A; Al-Howail, HA; Al-Jammaz, I; Al-Khalaf, HH; Al-Mazrou, A; Al-Otaibi, B; Daghestani, MH; Hakami, HA	1
Chen, W; Chen, X; Dai, X; Feng, C; He, G; Liang, G; Qiu, C; Vinothkumar, R; Wang, Y; Wu, W; Xie, Y; Ye, Q; Zhou, H	1
Araya-Maturana, R; Martínez-Cifuentes, M; Weiss-López, B	1
Carney, PR; Depke, MG; Kennedy, GD; Larsen, L; McNally, J; Megna, BW; Nukaya, M; Rosengren, RJ	1
Addala, E; Bandy, B; Das, S; Das, U; Dimmock, JR; Karki, SS; Rafiei, H	1
Chen, S; Cridge, AG; Hawkins, BC; Nimick, M; Rosengren, RJ	1
Bauer, MR; Cunha, AC; Dhiman, A; Fersht, AR; Gogna, R; Gomm, JJ; Hansen, LA; Hideg, K; Holmes, M; Holmes, TR; Jones, LJ; Kiparoidze, S; Kuppusamy, ML; Kuppusamy, P; Madan, E; Nagane, M; Park, YA; Parker, TM; Pelham, CJ; Selvendiran, K; Shaik, K; Shee, K; Smith, SD; Tomás, AR	1
Anant, S; Begemann, G; Biersack, B; Padhye, S; Schmitt, F; Schobert, R; Subramaniam, D	1
Bognár, B; Hideg, K; Kálai, T; Kuppusamy, ML; Kuppusamy, P; Prabhat, AM	1
El-Manawaty, MA; Fawzy, NG; Fayad, W; Girgis, AS; Panda, SS; Srour, AM	1
Armanini, D; Barollo, S; Bertazza, L; Faccio, I; Mari, ME; Mian, C; Pezzani, R; Redaelli, M; Rubin, B; Zorzan, M	1
Aboussekhra, A; Alhabardi, S; Alomrani, A; AlQuadeib, B; Alshamsan, A; Attia, MI	1
He, Y; Li, W; Qian, Y; Yang, Y; Zhang, J; Zhou, D	1
Chen, CW; Chen, YL; Hsieh, MJ; Hsieh, YH; Ju, PC; Lin, CW; Su, CW; Yang, SF	1
A Jamal, AR; Chan, KM; Kamaluddin, NF; Lam, KW; Rajab, NF; Razali, NSC	1
Aboussekhra, A; Al-Jammaz, I; Al-Mohanna, F; Al-Mohanna, M; Al-Otaibi, B; Alhabardi, SA; Alraouji, NN	1
Choudhury, AR; Farkas, ME; Golakoti, NR; Joshi, BP; Joshi, M; Kar, S; Kumar Rokkam, S; Mas-Rosario, JA	1
Hou, G; Li, C; Li, W; Liu, Y; Yan, W	1

Other Studies

46 other study(ies) available for 2-piperidone and curcumin

Article	Year
Synthesis of curcumin analogues as potential antioxidant, cancer chemopreventive agents. Archiv der Pharmazie, 2004, Volume: 337, Issue:1 Topics: Adenosine Triphosphate; Alkadienes; Animals; Anticarcinogenic Agents; Antioxidants; Cell Survival; Cells, Cultured; Curcumin; Cycloheptanes; Cyclohexanes; Cyclopentanes; Female; Forecasting; Free Radical Scavengers; Free Radicals; Humans; Luminescent Measurements; Male; Molecular Structure; Neutrophils; Piperidones	2004
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Benzylidene Compounds; Cell Death; Cell Line, Tumor; Cell Nucleus; Curcumin; Drug Screening Assays, Antitumor; Humans; I-kappa B Kinase; Inhibitory Concentration 50; Models, Biological; NF-kappa B; Phosphorylation; Piperidones; Protein Processing, Post-Translational; Protein Transport; Signal Transduction; Tumor Necrosis Factor-alpha	2008
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:15 Topics: Antineoplastic Agents; Benzylidene Compounds; Cell Hypoxia; Curcumin; Cytoskeleton; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Epothilones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubules; Mitosis; Neoplasms; Paclitaxel; Piperidones; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein	2008
Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3 Topics: Activating Transcription Factor 2; Animals; Apoptosis; Benzylidene Compounds; Carotid Arteries; Caspase 3; Cell Cycle; Cell Proliferation; Cells, Cultured; Coronary Restenosis; Curcumin; G1 Phase; Gene Expression; Growth Inhibitors; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Molecular Structure; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Piperidones; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; RNA, Small Interfering	2009
Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba. Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; HSP70 Heat-Shock Proteins; Humans; Mice; Piper; Piperidones; Plant Roots; Rats; Stereoisomerism	2009
Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer biology & therapy, 2010, Nov-15, Volume: 10, Issue:10 Topics: Animals; Antineoplastic Agents; Curcumin; Electron Spin Resonance Spectroscopy; Female; Halogenation; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Piperidones; Rats; Rats, Wistar; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2010
Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention. Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1 Topics: Benzylidene Compounds; Carrier Proteins; Cell Line, Tumor; Curcumin; Flavonoids; Free Radical Scavengers; Green Fluorescent Proteins; Humans; Lewy Bodies; Nerve Tissue Proteins; Nitric Oxide; Parkinson Disease; Phenols; Piperidones; Polyphenols; Reactive Oxygen Species; Stress, Physiological	2011
The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress. Investigational new drugs, 2012, Volume: 30, Issue:2 Topics: Active Transport, Cell Nucleus; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; Antioxidants; Benzylidene Compounds; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Lung Neoplasms; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Piperidones; Reactive Oxygen Species; Time Factors	2012
Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity. Journal of medicinal chemistry, 2011, Aug-11, Volume: 54, Issue:15 Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Curcumin; Drug Screening Assays, Antitumor; Humans; Piperidones; Structure-Activity Relationship	2011
HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer biology & therapy, 2011, Nov-01, Volume: 12, Issue:9 Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Curcumin; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Piperidones; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays	2011
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International immunopharmacology, 2012, Volume: 12, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; DNA-Binding Proteins; I-kappa B Kinase; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Phosphorylation; Piperidones; Protein Transport; Signal Transduction; Tumor Necrosis Factor-alpha	2012
EF24 suppresses maturation and inflammatory response in dendritic cells. International immunology, 2012, Volume: 24, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Bone Marrow Cells; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Curcumin; Cytokines; Dendritic Cells; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Piperidones; Transcriptional Activation	2012
Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integrative biology : quantitative biosciences from nano to macro, 2012, Volume: 4, Issue:6 Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Survival; Curcumin; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Phosphorylation; Piperidones; Random Allocation; Signal Transduction; Solubility; Specific Pathogen-Free Organisms; Transcription Factor RelA; Xenograft Model Antitumor Assays	2012
Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition. Integrative biology : quantitative biosciences from nano to macro, 2012, Volume: 4, Issue:8 Topics: Animals; Bone and Bones; Cell Differentiation; Cell Line; Cellular Senescence; Curcumin; Dose-Response Relationship, Drug; Drug Design; Gene Expression Regulation; Luciferases; Mice; Models, Chemical; NF-kappa B; NIH 3T3 Cells; Osteoblasts; Osteoclasts; Piperidones; Pyridines; RANK Ligand; Signal Transduction; Smad4 Protein; Tumor Necrosis Factor-alpha	2012
Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents. Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Curcumin; Dose-Response Relationship, Drug; Drug Discovery; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Piperidones; Sepsis; Signal Transduction; Structure-Activity Relationship; Survival Analysis	2013
Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer. Cancer letters, 2013, Dec-01, Volume: 341, Issue:2 Topics: Animals; Blotting, Western; Cadherins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Mice; Mice, Nude; Osteonectin; Pancreatic Neoplasms; Piperidones; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays	2013
Synthesis and evaluation of curcumin-related compounds containing benzyl piperidone for their effects on human cancer cells. Chemical & pharmaceutical bulletin, 2013, Volume: 61, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Curcumin; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperidones; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship	2013
Antibacterial activity of synthetic curcumin derivatives: 3,5-bis(benzylidene)-4-piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA). Applied biochemistry and biotechnology, 2014, Volume: 172, Issue:7 Topics: Animals; Anti-Bacterial Agents; Bacteria; Cell Line; Curcumin; Dendritic Cells; Dimerization; Mice; Pentetic Acid; Phagocytosis; Piperidones	2014
Induction of apoptosis by diphenyldifluoroketone in osteogenic sarcoma cells is associated with activation of caspases. Oncology reports, 2014, Volume: 31, Issue:5 Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzylidene Compounds; BH3 Interacting Domain Death Agonist Protein; Bone Neoplasms; Caspase 3; Caspase 7; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Curcumin; Enzyme Activation; Fas-Associated Death Domain Protein; Humans; Osteosarcoma; Piperidones; Poly(ADP-ribose) Polymerases; Tumor Suppressor Protein p53	2014
Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts. Current cancer drug targets, 2014, Volume: 14, Issue:4 Topics: Animals; Antineoplastic Agents; Biological Availability; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Curcumin; Female; Half-Life; Head and Neck Neoplasms; Humans; I-kappa B Kinase; Mice, Inbred ICR; Mice, Nude; Neoplasm Proteins; Phosphorylation; Piperidones; Protein Processing, Post-Translational; Pyridines; Random Allocation; Specific Pathogen-Free Organisms; Squamous Cell Carcinoma of Head and Neck; Transcription Factor RelA; Tumor Burden; Xenograft Model Antitumor Assays	2014
Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993). Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:6 Topics: Animals; Chromatography, Liquid; Curcumin; Dogs; Humans; Male; Mass Spectrometry; Mice; Piperidones; Protein Binding; Rats	2014
Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer. Cancer letters, 2015, Feb-28, Volume: 357, Issue:2 Topics: Angiogenesis Inhibitors; Angiopoietins; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Culture Media, Conditioned; Curcumin; Female; Gene Expression; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Nude; Neovascularization, Pathologic; Neovascularization, Physiologic; Pancreatic Neoplasms; Piperidones; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2015
MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2. Toxicology letters, 2015, May-05, Volume: 234, Issue:3 Topics: Antineoplastic Agents; Benzylidene Compounds; Blotting, Western; Cell Line, Tumor; Cell Movement; Curcumin; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; HMGA2 Protein; Humans; Melanoma; MicroRNAs; Piperidones; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation	2015
Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed research international, 2015, Volume: 2015 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Curcumin; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Piperidones	2015
Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Cell Survival; Curcumin; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Piperidones; Quantitative Structure-Activity Relationship; Reactive Oxygen Species; Topoisomerase II Inhibitors	2015
Synthesis of 4-piperidone Based Curcuminoids with Anti-inflammatory and Anti-Proliferation Potential in Human Cancer Cell Lines. Anti-cancer agents in medicinal chemistry, 2016, Volume: 16, Issue:7 Topics: Curcumin; Molecular Docking Simulation; Piperidones; Spectrum Analysis	2016
Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer. Cancer letters, 2016, Apr-10, Volume: 373, Issue:2 Topics: Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Down-Regulation; Female; Humans; Mice; NF-kappa B; Piperidones; Protein Transport; Pyridines; Thymidylate Synthase	2016
Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer. Molecular carcinogenesis, 2017, Volume: 56, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Chickens; Colon; Colorectal Neoplasms; Curcumin; Female; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Piperidones; Pyridines; Rats; Rectum; Signal Transduction; Vascular Endothelial Growth Factor A	2017
PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells. BMC cancer, 2016, 07-27, Volume: 16 Topics: Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemokine CCL2; Curcumin; Drug Stability; Epithelial-Mesenchymal Transition; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Mice; Piperidones; Signal Transduction; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2016
Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Caspases; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Curcumin; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Mitochondria; Piperidones; Reactive Oxygen Species	2016
A Computational Study of Structure and Reactivity of N-Substitued-4-Piperidones Curcumin Analogues and Their Radical Anions. Molecules (Basel, Switzerland), 2016, Dec-02, Volume: 21, Issue:12 Topics: Anions; Chemistry Techniques, Analytical; Computational Biology; Curcumin; Electrons; Models, Molecular; Piperidones	2016
The aryl hydrocarbon receptor as an antitumor target of synthetic curcuminoids in colorectal cancer. The Journal of surgical research, 2017, 06-01, Volume: 213 Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Cell Survival; Colorectal Neoplasms; Curcumin; HCT116 Cells; Humans; Piperidones; Pyridines; Receptors, Aryl Hydrocarbon	2017
3,5-Bis(3-dimethylaminomethyl-4-hydroxybenzylidene)-4-piperidone and related compounds induce glutathione oxidation and mitochondria-mediated cell death in HCT-116 colon cancer cells. Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16 Topics: Apoptosis; Cell Line; Colonic Neoplasms; Curcumin; Glutathione; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Piperidones; Reactive Oxygen Species; Superoxides	2017
Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International journal of oncology, 2018, Volume: 52, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Curcumin; Humans; Male; Piperidones; Prostatic Neoplasms, Castration-Resistant; Pyridines	2018
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. The Journal of biological chemistry, 2018, 03-23, Volume: 293, Issue:12 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Curcumin; Female; Humans; Mice; Mice, Nude; Mutant Proteins; Mutation; Neoplasms; Piperidones; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2018
Halogenated Bis(methoxybenzylidene)-4-piperidone Curcuminoids with Improved Anticancer Activity. ChemMedChem, 2018, 06-06, Volume: 13, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; G1 Phase Cell Cycle Checkpoints; Halogenation; Humans; Male; Mice, Nude; Molecular Structure; Piperidones; Reactive Oxygen Species; Structure-Activity Relationship; Xenograft Model Antitumor Assays; Zebrafish	2018
Antiproliferative Effect of a Novel 4,4'-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells. Cell biochemistry and biophysics, 2019, Volume: 77, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Colonic Neoplasms; Curcumin; Electron Spin Resonance Spectroscopy; HCT116 Cells; Humans; Phosphorylation; Piperidones; Reactive Oxygen Species; STAT3 Transcription Factor; Tumor Suppressor Protein p53	2019
Novel Curcumin Inspired Antineoplastic 1-Sulfonyl-4-Piperidones: Design, Synthesis and Molecular Modeling Studies. Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:8 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperidones; Structure-Activity Relationship	2019
Biological Effects of EF24, a Curcumin Derivative, Alone or Combined with Mitotane in Adrenocortical Tumor Cell Lines. Molecules (Basel, Switzerland), 2019, Jun-12, Volume: 24, Issue:12 Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Curcumin; Drug Evaluation, Preclinical; Drug Synergism; Humans; Mice; Mitotane; Molecular Structure; Piperidones; Reactive Oxygen Species	2019
A validated RP-HPLC method for the determination of piperidone analogue of curcumin. Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:2 Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Curcumin; Piperidones; Reproducibility of Results	2020
The Curcumin Analog EF24 is Highly Active Against Chemotherapy- Resistant Melanoma Cells. Current cancer drug targets, 2021, Volume: 21, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Curcumin; Humans; Melanoma; Piperidones	2021
Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells. Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:8 Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Curcumin; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Piperidones; Squamous Cell Carcinoma of Head and Neck	2022
Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Scientific reports, 2022, 07-30, Volume: 12, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Curcumin; Glioblastoma; Humans; Piperidones	2022
The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects. Scientific reports, 2023, 03-14, Volume: 13, Issue:1 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Humans; Mice; Piperidones; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; TOR Serine-Threonine Kinases	2023
Diarylidene-N-Methyl-4-Piperidones and Spirobibenzopyrans as Antioxidant and Anti-Inflammatory Agents. Chemistry & biodiversity, 2023, Volume: 20, Issue:9 Topics: Anti-Inflammatory Agents; Antioxidants; Curcumin; Humans; Inflammation; Nitric Oxide; Piperidones	2023
Treatment of rheumatoid arthritis with curcumin analog 3,5-bis(arylidene)-4-piperidone. Future medicinal chemistry, 2023, Volume: 15, Issue:22 Topics: Animals; Arthritis, Rheumatoid; Curcumin; Inflammation; Molecular Docking Simulation; NF-kappa B; Piperidones; Rats	2023