Page last updated: 2024-08-21

2-piperidone and cc-122

2-piperidone has been researched along with cc-122 in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (30.77)24.3611
2020's9 (69.23)2.80

Authors

AuthorsStudies
Czarnik, AW; DeWitt, SH; Jacques, V; Judge, TM; Van der Ploeg, LH1
Amantangelo, MD; Barnes, L; Bjorklund, C; Breider, M; Cai, T; Chiu, H; Chopra, R; Couto, S; Daniel, TO; Fontanillo, C; Gandhi, AK; Hagner, PR; Havens, CG; Kang, J; Khambatta, G; Klippel, A; Kosek, J; Lopez-Girona, A; Lu, G; Man, HW; Narla, RK; Pourdehnad, M; Raymon, H; Rychak, E; Schafer, PH; Thakurta, A; Trotter, M; Waldman, M; Wang, M1
Chopra, R; DiMartino, J; Gandhi, AK; Hagner, PR; Hege, K; Li, Y; Papadopoulos, KP; Pourdehnad, M; Rasco, DW; Shih, K; Wei, X1
Carayannopoulos, LN; Chen, J; Li, Y; Liu, L; MacGorman, K; Ogasawara, K; Palmisano, M; Zhou, S1
Chen, J; Hoffmann, M; Li, Y; Liu, L; MacGorman, K; Palmisano, M; Zhou, S1
Bouabdallah, R; Buchholz, TJ; Carpio, C; Carrancio, S; Cordoba, R; Couto, S; Damian, S; Gandhi, AK; Gharibo, M; Hagner, PR; Hege, K; Lopez-Martin, JA; Martin, A; Panizo, C; Pinto, A; Pourdehnad, M; Rasco, D; Ribrag, V; RisueƱo, A; Salar, A; Salles, G; Sancho, JM; Santoro, A; Schmitz, F; Trotter, MWB; Van den Neste, E; Verhoef, G; Wang, M; Wang, X; Wei, X; Weng, A; Ysebaert, L1
Bijou, F; Bouabdallah, R; Chen, T; Chiappella, A; Doorduijn, JK; Hagner, PR; Hege, K; Kersten, MJ; Klein, C; Mendez, C; Michot, JM; Mosulen, S; Nikolova, Z; Pourdehnad, M; Ribrag, V; Salles, G; Sarmiento, R; Uttamsingh, S; Vitolo, U; Zinzani, PL1
Luminari, S1
Amini, RM; Apollonio, B; Awan, FT; Chiu, H; Fanous, M; Gandhi, AK; Hagner, PR; Ioannou, N; Janardhanan, P; Jones, J; Kay, NE; Lopez-Girona, A; Papazoglou, D; Patten, PEM; Ramsay, AG; Rosenquist, R; Shanafelt, TD; Stamatopoulos, K; Stokes, M; Sutton, LA; Tallman, MS; Vardi, A1
Chou, T; Doi, T; Fujimoto, H; Hagner, PR; Hatake, K; Hirose, T; Kato, H; Ogaki, Y; Pourdehnad, M; Seo, S; Terui, Y; Yamamoto, K1
Baughman, JM; Fontanillo, C; Jang, IS; Khater, M; Lu, G; Mizukoshi, R; Mo, Z; Namiranian, S; Rolfe, M; Silva-Torres, A; Slade, M; Wang, K; Weng, S; Wood, S1
Abbiati, RA; Carrancio, S; Kasibhatla, S; Loos, R; McConnell, M; Pierce, DW; Pourdehnad, M; Ratushny, AV; Santini, CC; Trotter, MWB1
Hartmann, MD; Heim, C1

Trials

5 trial(s) available for 2-piperidone and cc-122

ArticleYear
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
    Blood, 2015, Aug-06, Volume: 126, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Ikaros Transcription Factor; Interferon Regulatory Factor-7; Interferons; Lenalidomide; Lentivirus; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, SCID; Molecular Mimicry; Peptide Hydrolases; Piperidones; Proteolysis; Quinazolinones; RNA, Small Interfering; Signal Transduction; T-Lymphocytes; Thalidomide; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2015
A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 01-01, Volume: 25, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lymphoma, Non-Hodgkin; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Piperidones; Quinazolinones; Ubiquitin-Protein Ligases

2019
Single-Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC-122) in Subjects With Mild, Moderate, or Severe Renal Impairment.
    Clinical pharmacology in drug development, 2020, Volume: 9, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Genetic Pleiotropy; Glioblastoma; Hematologic Neoplasms; Humans; Liver Neoplasms; Male; Middle Aged; Piperidones; Quinazolinones; Renal Insufficiency; Safety; Severity of Illness Index; Ubiquitin-Protein Ligases

2020
Avadomide plus obinutuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (CC-122-NHL-001): a multicentre, dose escalation and expansion phase 1 study.
    The Lancet. Haematology, 2020, Volume: 7, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Half-Life; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Neutropenia; Piperidones; Quinazolinones; Recurrence; Severity of Illness Index; Thrombocytopenia; Treatment Outcome

2020
Phase I, multicenter, dose-escalation study of avadomide in adult Japanese patients with advanced malignancies.
    Cancer science, 2021, Volume: 112, Issue:1

    Topics: Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Esophageal Neoplasms; Female; Humans; Japan; Lymphoma, Non-Hodgkin; Male; Maximum Tolerated Dose; Middle Aged; Piperidones; Quinazolinones

2021

Other Studies

8 other study(ies) available for 2-piperidone and cc-122

ArticleYear
Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Mar-24, Volume: 112, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Female; Humans; Inflammation; Leukocytes, Mononuclear; Mice; Mice, SCID; Models, Chemical; Neoplasm Transplantation; Neoplasms; Piperidones; Quinazolinones; Stereoisomerism; Thalidomide; Tumor Necrosis Factor-alpha

2015
Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.
    Journal of clinical pharmacology, 2019, Volume: 59, Issue:12

    Topics: Adult; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Middle Aged; Piperidones; Quinazolinones; Rifampin; Young Adult

2019
Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier.
    Blood, 2020, 03-26, Volume: 135, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers; Drug Resistance, Neoplasm; Female; Humans; Immunophenotyping; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Middle Aged; Neoplasm Staging; Odds Ratio; Piperidones; Prognosis; Quinazolinones; Recurrence; Retreatment; T-Lymphocytes; Treatment Outcome

2020
New IMiD on the block.
    The Lancet. Haematology, 2020, Volume: 7, Issue:9

    Topics: Antibodies, Monoclonal, Humanized; B-Lymphocytes; Humans; Lymphoma, Non-Hodgkin; Piperidones; Quinazolinones

2020
Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy.
    Blood, 2021, 01-14, Volume: 137, Issue:2

    Topics: Animals; Antineoplastic Agents; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Interferons; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Activation; Mice; Piperidones; Quinazolinones; Signal Transduction; T-Lymphocytes; Tumor Microenvironment; Xenograft Model Antitumor Assays

2021
Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen.
    Blood advances, 2021, 04-13, Volume: 5, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Clustered Regularly Interspaced Short Palindromic Repeats; Humans; Lymphoma, Large B-Cell, Diffuse; Piperidones; Potassium Channels; Quinazolinones; Ubiquitin-Protein Ligases

2021
Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies.
    The AAPS journal, 2021, 08-27, Volume: 23, Issue:5

    Topics: Antineoplastic Agents; Biological Variation, Population; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Models, Biological; Network Pharmacology; Neutropenia; Neutrophils; Piperidones; Quinazolinones

2021
High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system.
    Acta crystallographica. Section D, Structural biology, 2022, Mar-01, Volume: 78, Issue:Pt 3

    Topics: Morpholines; Phthalimides; Piperidones; Quinazolinones

2022