Page last updated: 2024-08-21

2-piperidone and 3,5-bis(2-fluorobenzylidene)piperidin-4-one

2-piperidone has been researched along with 3,5-bis(2-fluorobenzylidene)piperidin-4-one in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (10.64)	29.6817
2010's	38 (80.85)	24.3611
2020's	4 (8.51)	2.80

Authors

Authors	Studies
Bratasz, A; Hideg, K; Kuppusamy, P; Kutala, VK; Selvendiran, K; Tong, L; Trigg, NJ; Vishwanath, S	1
Anant, S; Dieckgraefe, BK; George, R; Hideg, K; Houchen, CW; Kuppusamy, P; Lee, KB; May, R; Ramanujam, RP; Subramaniam, D; Sureban, SM	1
Alizadeh, AR; Kisiel, W; Liotta, DC; Lu, YJ; McCarey, BE; Mosley, CA; Nichols, C; Parker, ET; Pohl, J; Shim, H; Shoji, M; Snyder, JP; Sun, A	1
Du, Y; Fu, H; Kasinski, AL; Khuri, FR; Liotta, D; Shoji, M; Snyder, JP; Sun, A; Sun, SY; Thomas, SL; Wang, CY; Zhao, J	1
Giannakakou, P; Hamel, E; Liotta, D; Malik, S; Snyder, JP; Thomas, SL; Zhong, D; Zhou, W	1
Du, Y; Fu, H; Khuri, FR; Li, Z; Liotta, D; Lou, B; Purcell, J; Snyder, JP; Thomas, SL; Zhao, J	1
Horowitz, IR; Huang, RP; Liotta, DC; Mancini, A; Sidell, N; Tan, X; Taylor, RN; Wieser, F	1
Miranda, M; Narayan, M; Pal, R	1
Hou, L; Jiang, H; Liang, Y; Liu, L; Lu, Z; Meng, X; Pan, S; Song, X; Wang, J; Yin, D; Zheng, T	1
Anant, S; Awasthi, V; Lagisetty, P; Sahoo, K; Subramaniam, D	1
Brown, AP; Hu, F; Liotta, DC; Marcus, AI; Miller, AH; Moore, TW; Olivera, A; Pace, TW; Shim, H; Snyder, JP; Sun, A; Yoon, Y	1
Anant, S; Awasthi, S; Awasthi, V; Natarajan, A; Vilekar, P	1
Han, T; Liang, Y; Liu, H; Liu, L; Pan, S; Song, R; Tian, L; Wang, L	1
Fang, X; Jiang, H; Liang, Y; Liu, H; Liu, J; Liu, L; Meng, X; Song, R; Tian, L; Wang, J; Wang, L; Yin, D; Zheng, T	1
Pfeffer, LM; Sims, M; Yang, CH; Yue, J	1
Aravindan, N; Aravindan, S; Awasthi, V; Herman, TS; Natarajan, M	1
Awasthi, V; Roberts, PR; Sahoo, K; Yadav, VR	1
Ben, W; Dong, L; Guan, Y; Huang, Y; Lu, M; Ning, N; Wang, Y; Yang, Y; Yuan, J; Zhang, D	1
Kabiraj, P; Pal, R; Roy, D	1
Chun, HS; Kim, CS; Kim, DK; Kim, HJ; Kim, JS; Kim, SG; Kim, YH; Lee, SA; Oh, JS; Park, MG; Yang, SJ; Yu, SK	1
Awasthi, S; Awasthi, V; Vilekar, P; Yadav, VR	1
Awasthi, V; Hussain, A; Sahoo, K; Yadav, VR	1
Awasthi, V; Hussain, A; Kosanke, S; Xie, J; Yadav, VR	1
Bai, H; Chen, F; Huang, C; Liu, G; Peng, C; Song, E; Song, Y; Wang, H; Wu, C; Zeng, P; Zhang, B; Zhang, P	1
Awasthi, V; Hedrick, A; Rao, G; Xie, J	1
Chen, T; Chen, W; Chen, X; Feng, Z; Liang, G; Qiu, C; Wang, Z; Xia, Y; Yang, S; Ye, Q; Ying, S; Zou, P	1
Bendas, G; Bisht, S; Brossart, P; Feldmann, G; Holdenrieder, S; Nolting, J; Rupp, A; Schlesinger, M; Schubert, R; Wenzel, J	1
Jiang, HC; Liang, YJ; Liu, JR; Liu, LX; Pan, SH; Qu, LD; Song, RP; Sun, BS; Wang, JB; Yin, DL; Zheng, TS	1
Chen, W; Chen, X; Cui, R; Fan, X; Ji, J; Liang, G; Vinothkumar, R; Wu, F; Zhang, Q; Zhao, Z; Zou, P	1
Chen, W; Chen, X; Dai, X; Feng, C; He, G; Liang, G; Qiu, C; Vinothkumar, R; Wang, Y; Wu, W; Xie, Y; Ye, Q; Zhou, H	1
Huang, L; Li, W; Liang, G; Qiu, P; Ren, J; Shi, L; Wang, J; Wu, J; Wu, S; Wu, X; Yao, S; Yun, D; Zhang, S	1
Jin, X; Jin, Y; Li, X; Tin, L; Wu, Y; Zhang, F; Zhang, Y; Zhao, R	1
Chen, W; Chen, X; Dai, X; Feng, C; Liang, G; Qiu, C; Rajamanickam, V; Ye, Q; Zhang, X; Zhuge, W; Zou, P	1
Aoki, I; Bakalova, R; Higashi, T; Nikolova, B; Shibata, S; Zhelev, Z	1
Dolezel, P; Mlejnek, P; Ruzickova, E; Skoupa, N	1
Bai, E; Chen, Q; Du, X; Fu, W; Jiang, C; Jin, R; Li, W; Liang, G; Qiu, P; Wang, J; Wang, L; Wei, T; Wu, J; Xu, H; Yao, S	1
Barollo, S; Bertazza, L; Casal Ide, E; Cavedon, E; Censi, S; Iacobone, M; Manso, J; Mian, C; Pezzani, R; Sensi, F; Vianello, F; Watutantrige-Fernando, S	1
Awasthi, V; Houson, H; Nkepang, G; Rao, G; Teng, C; Yari, H	1
Millay, MH; Monroe, JD; Patty, BG; Smith, ME	1
He, Y; Li, W; Zhang, R; Zheng, G; Zhou, D	1
Chen, L; Jiang, C; Li, Q; Lin, X; Wu, J; Wu, X; Xie, J; Xu, H; Zhang, H; Zheng, Z	1
Armanini, D; Barollo, S; Bertazza, L; Faccio, I; Mari, ME; Mian, C; Pezzani, R; Redaelli, M; Rubin, B; Zorzan, M	1
Hodzic, D; Millay, MH; Monroe, JD; Patty, BG; Smith, ME	1
Awasthi, S; Awasthi, V; Rao, G; Vilekar, P	1
Chen, X; Deng, Z; Huang, L; Jin, D; Li, F; Li, Q; Lin, H; Lin, S; Song, Y; Yang, T; Zhang, C	1
Cassidy, H; Ibáñez Gaspar, V; McCaul, J; McMorrow, T; Slattery, C	1
Chen, HL; Duan, Y; Ling, M; Lv, XA; Ma, FX; Zhang, HC; Zhang, S	1

Other Studies

47 other study(ies) available for 2-piperidone and 3,5-bis(2-fluorobenzylidene)piperidin-4-one

Article	Year
EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Caspase Inhibitors; Caspases; Cell Division; Cell Survival; Cisplatin; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Fas Ligand Protein; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Phosphorylation; Piperidones; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; PTEN Phosphohydrolase; RNA, Small Interfering; Time Factors; Tumor Suppressor Protein p53; Ubiquitin; Up-Regulation; Xenograft Model Antitumor Assays	2007
Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity. Cancer research, 2008, Mar-15, Volume: 68, Issue:6 Topics: Adenocarcinoma; Animals; Apoptosis; Benzylidene Compounds; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; HCT116 Cells; HT29 Cells; Humans; Interleukin-8; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Neovascularization, Pathologic; Piperidones; Stomach Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2008
Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of drug targeting, 2008, Volume: 16, Issue:3 Topics: Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Endocytosis; Factor VIIa; Humans; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Piperidones; Rabbits; Thromboplastin; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2008
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Benzylidene Compounds; Cell Death; Cell Line, Tumor; Cell Nucleus; Curcumin; Drug Screening Assays, Antitumor; Humans; I-kappa B Kinase; Inhibitory Concentration 50; Models, Biological; NF-kappa B; Phosphorylation; Piperidones; Protein Processing, Post-Translational; Protein Transport; Signal Transduction; Tumor Necrosis Factor-alpha	2008
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:15 Topics: Antineoplastic Agents; Benzylidene Compounds; Cell Hypoxia; Curcumin; Cytoskeleton; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Epothilones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubules; Mitosis; Neoplasms; Paclitaxel; Piperidones; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein	2008
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical pharmacology, 2010, Nov-01, Volume: 80, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Piperidones; Pyridines	2010
Multiple anticancer activities of EF24, a novel curcumin analog, on human ovarian carcinoma cells. Reproductive sciences (Thousand Oaks, Calif.), 2010, Volume: 17, Issue:10 Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Female; Humans; Ovarian Neoplasms; Piperidones; Reverse Transcriptase Polymerase Chain Reaction; RNA; Vascular Endothelial Growth Factor A	2010
Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention. Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1 Topics: Benzylidene Compounds; Carrier Proteins; Cell Line, Tumor; Curcumin; Flavonoids; Free Radical Scavengers; Green Fluorescent Proteins; Humans; Lewy Bodies; Nerve Tissue Proteins; Nitric Oxide; Parkinson Disease; Phenols; Piperidones; Polyphenols; Reactive Oxygen Species; Stress, Physiological	2011
Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma. PloS one, 2011, Volume: 6, Issue:8 Topics: Animals; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Cyclooxygenase 2; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Piperidones; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Xenograft Model Antitumor Assays	2011
Anticancer activity of an imageable curcuminoid 1-[2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH). Chemical biology & drug design, 2012, Volume: 79, Issue:2 Topics: Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Humans; Hydrazines; Isotope Labeling; Mice; Mice, Nude; Piperidones; Radiopharmaceuticals; Rats; Technetium; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Transplantation, Heterologous	2012
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International immunopharmacology, 2012, Volume: 12, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; DNA-Binding Proteins; I-kappa B Kinase; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Phosphorylation; Piperidones; Protein Transport; Signal Transduction; Tumor Necrosis Factor-alpha	2012
EF24 suppresses maturation and inflammatory response in dendritic cells. International immunology, 2012, Volume: 24, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Bone Marrow Cells; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Curcumin; Cytokines; Dendritic Cells; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Piperidones; Transcriptional Activation	2012
In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS one, 2012, Volume: 7, Issue:10 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Liver Neoplasms, Experimental; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Piperidones; Tumor Burden; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays	2012
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Niacinamide; Phenylurea Compounds; Piperidones; Sorafenib; Treatment Outcome; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays	2013
The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PloS one, 2013, Volume: 8, Issue:8 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; MicroRNAs; Piperidones; Prostatic Neoplasms; RNA Interference; Signal Transduction; Transcription Factor RelA; Xenograft Model Antitumor Assays	2013
Novel synthetic monoketone transmute radiation-triggered NFκB-dependent TNFα cross-signaling feedback maintained NFκB and favors neuroblastoma regression. PloS one, 2013, Volume: 8, Issue:8 Topics: Benzylidene Compounds; Cell Line, Tumor; Cell Survival; Clone Cells; Extracellular Space; Feedback, Physiological; Humans; Neuroblastoma; NF-kappa B; Piperidones; Recurrence; Signal Transduction; Telomerase; Transcriptional Activation; Tumor Necrosis Factor-alpha	2013
Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 347, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Heme Oxygenase (Decyclizing); Hypovolemia; Lung; Male; Nitric Oxide Synthase Type II; Piperidones; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Survival Analysis; Transcription Factor RelA	2013
Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells. Cancer science, 2013, Volume: 104, Issue:12 Topics: Animals; Benzylidene Compounds; Biological Transport; Cell Line, Tumor; Cell Movement; Cell Proliferation; Energy Metabolism; Female; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; Peritoneal Neoplasms; Piperidones	2013
EF24 prevents rotenone-induced estrogenic status alteration in breast cancer. Cell biology international, 2014, Volume: 38, Issue:4 Topics: Benzylidene Compounds; Breast Neoplasms; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; HEK293 Cells; HeLa Cells; Humans; MCF-7 Cells; Microscopy, Confocal; Oxidative Stress; Piperidones; Protein Disulfide-Isomerases; Reactive Oxygen Species; Rotenone; Up-Regulation	2014
Induction of apoptosis by diphenyldifluoroketone in osteogenic sarcoma cells is associated with activation of caspases. Oncology reports, 2014, Volume: 31, Issue:5 Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzylidene Compounds; BH3 Interacting Domain Death Agonist Protein; Bone Neoplasms; Caspase 3; Caspase 7; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Curcumin; Enzyme Activation; Fas-Associated Death Domain Protein; Humans; Osteosarcoma; Piperidones; Poly(ADP-ribose) Polymerases; Tumor Suppressor Protein p53	2014
Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock. Artificial organs, 2014, Volume: 38, Issue:8 Topics: Animals; Benzylidene Compounds; Disease Models, Animal; Lung; Male; NF-kappa B; Piperidones; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Shock, Hemorrhagic; Signal Transduction; Toll-Like Receptor 4	2014
Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones EF24 and CLEFMA. The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:2 Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzylidene Compounds; Epithelial Cells; Ileum; Intestinal Mucosa; Male; Permeability; Peroxidase; Piperidones; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Shock, Hemorrhagic; Tight Junction Proteins	2014
The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model. Scandinavian journal of trauma, resuscitation and emergency medicine, 2015, Feb-03, Volume: 23 Topics: Animals; Benzylidene Compounds; Disease Models, Animal; Immunoblotting; Immunohistochemistry; Liver; Piperidones; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic	2015
MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2. Toxicology letters, 2015, May-05, Volume: 234, Issue:3 Topics: Antineoplastic Agents; Benzylidene Compounds; Blotting, Western; Cell Line, Tumor; Cell Movement; Curcumin; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; HMGA2 Protein; Humans; Melanoma; MicroRNAs; Piperidones; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation	2015
Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model. Neuropharmacology, 2015, Volume: 99 Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Energy Metabolism; Male; Mitochondria; NAD; Nerve Growth Factor; Neuroprotective Agents; Phosphocreatine; Piperidones; Pyruvic Acid; Rats, Sprague-Dawley; Shock, Hemorrhagic	2015
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells. Oncotarget, 2016, Apr-05, Volume: 7, Issue:14 Topics: Animals; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Piperidones; Reactive Oxygen Species; Stomach Neoplasms; Thioredoxin Reductase 1; Xenograft Model Antitumor Assays	2016
A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies. Journal of nanobiotechnology, 2016, Jul-11, Volume: 14, Issue:1 Topics: Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Line, Tumor; Cell Survival; Deoxycytidine; Disease Progression; Drug Compounding; Drug Therapy, Combination; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Injections, Subcutaneous; Liposomes; Mice; NF-kappa B; Pancreatic Neoplasms; Phosphorylation; Piperidones; Signal Transduction; Xenograft Model Antitumor Assays	2016
EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma. Scientific reports, 2016, 08-30, Volume: 6 Topics: Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Cell Movement; Cholangiocarcinoma; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasm Metastasis; Neoplasm Proteins; NF-kappa B; Piperidones; Signal Transduction	2016
Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer. Redox biology, 2016, Volume: 10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzylidene Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Piperidones; Reactive Oxygen Species; Sirolimus; Stomach Neoplasms; Xenograft Model Antitumor Assays	2016
Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Caspases; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Curcumin; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Mitochondria; Piperidones; Reactive Oxygen Species	2016
Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer. European journal of medicinal chemistry, 2017, Jan-05, Volume: 125 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Drug Design; Humans; Lung; Lung Neoplasms; Mitochondria; NF-kappa B; Piperidones; Reactive Oxygen Species; Signal Transduction	2017
EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells BioMed research international, 2016, Volume: 2016 Topics: Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Movement; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Phosphorylation; Piperidones; Proto-Oncogene Proteins pp60(c-src)	2016
Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer. British journal of pharmacology, 2017, Volume: 174, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endoplasmic Reticulum Stress; Heterocyclic Compounds, 3-Ring; Humans; Mitochondria; Oncogene Protein v-akt; Phosphorylation; Piperidones; Reactive Oxygen Species; Stomach Neoplasms; Structure-Activity Relationship	2017
Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic" Anticancer research, 2017, Volume: 37, Issue:10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzylidene Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Hydrogen Peroxide; Irinotecan; Magnetic Resonance Imaging; Male; Melatonin; Mice, Inbred BALB C; Mice, Nude; Oncogenes; Oxidative Stress; Piperidones; Reactive Oxygen Species; Signal Transduction; Superoxides; Time Factors; Tumor Burden	2017
Apoptosis Induced by the Curcumin Analogue EF-24 Is Neither Mediated by Oxidative Stress-Related Mechanisms nor Affected by Expression of Main Drug Transporters ABCB1 and ABCG2 in Human Leukemia Cells. International journal of molecular sciences, 2017, Oct-31, Volume: 18, Issue:11 Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzylidene Compounds; Cell Line, Tumor; Glutathione; Humans; Leukemia; Neoplasm Proteins; Oxidative Stress; Piperidones; Reactive Oxygen Species	2017
Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors. European journal of medicinal chemistry, 2018, Jan-20, Volume: 144 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; Humans; I-kappa B Kinase; Mice, Nude; Molecular Docking Simulation; Neoplasms; NF-kappa B; Phosphorylation; Piperidones; Signal Transduction	2018
EF24 (a Curcumin Analog) and ZSTK474 Emphasize the Effect of Cabozantinib in Medullary Thyroid Cancer. Endocrinology, 2018, 06-01, Volume: 159, Issue:6 Topics: Aged; Anilides; Antineoplastic Agents; Benzylidene Compounds; Carcinoma, Neuroendocrine; Cell Proliferation; Drug Synergism; Female; Humans; Male; Middle Aged; Piperidones; Pyridines; Thyroid Neoplasms; Triazines; Tumor Cells, Cultured	2018
Induction of gut proteasome activity in hemorrhagic shock and its recovery by treatment with diphenyldihaloketones CLEFMA and EF24. American journal of physiology. Gastrointestinal and liver physiology, 2018, 08-01, Volume: 315, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Intestinal Mucosa; Intestine, Small; Multiple Organ Failure; Piperidones; Proteasome Endopeptidase Complex; Rats; Shock, Hemorrhagic; Systemic Inflammatory Response Syndrome; Treatment Outcome	2018
The curcuminoid, EF-24, reduces cisplatin-mediated reactive oxygen species in zebrafish inner ear auditory and vestibular tissues. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2018, Volume: 57 Topics: Animals; Antineoplastic Agents; Benzylidene Compounds; Cisplatin; Drug Antagonism; Hair Cells, Auditory; Hair Cells, Vestibular; Piperidones; Reactive Oxygen Species; Zebrafish	2018
The curcumin analog EF24 is a novel senolytic agent. Aging, 2019, 01-28, Volume: 11, Issue:2 Topics: Benzylidene Compounds; Cell Line; Cell Survival; Cellular Senescence; Epithelial Cells; Fibroblasts; Humans; Piperidones; Reactive Oxygen Species	2019
Design and optimize N-substituted EF24 as effective and low toxicity NF-κB inhibitor for lung cancer therapy via apoptosis-to-pyroptosis switch. Chemical biology & drug design, 2019, Volume: 94, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Cell Survival; Drug Design; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Nitrogen; Piperidones; Pyroptosis; Xenograft Model Antitumor Assays	2019
Biological Effects of EF24, a Curcumin Derivative, Alone or Combined with Mitotane in Adrenocortical Tumor Cell Lines. Molecules (Basel, Switzerland), 2019, Jun-12, Volume: 24, Issue:12 Topics: Adrenal Cortex Neoplasms; Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Curcumin; Drug Evaluation, Preclinical; Drug Synergism; Humans; Mice; Mitotane; Molecular Structure; Piperidones; Reactive Oxygen Species	2019
Anti-Cancer and Ototoxicity Characteristics of the Curcuminoids, CLEFMA and EF24, in Combination with Cisplatin. Molecules (Basel, Switzerland), 2019, Oct-29, Volume: 24, Issue:21 Topics: A549 Cells; Animals; Antineoplastic Agents; Benzylidene Compounds; Caspases; Cell Death; Cisplatin; Diarylheptanoids; Evoked Potentials, Auditory; Humans; Inhibitory Concentration 50; Ototoxicity; Piperidones; Proto-Oncogene Mas; Zebrafish	2019
Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells. Immunobiology, 2020, Volume: 225, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Cell Line; Dendritic Cells; Inflammation Mediators; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Piperidones; Proteasome Endopeptidase Complex; Receptors, Interleukin-1; Sp1 Transcription Factor; Up-Regulation	2020
EF24 induces ferroptosis in osteosarcoma cells through HMOX1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 136 Topics: Antineoplastic Agents; Benzylidene Compounds; Bone Neoplasms; Cell Line, Tumor; Ferroptosis; Gene Expression Regulation, Neoplastic; Heme Oxygenase-1; Humans; Iron; Malondialdehyde; Osteosarcoma; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperidones; Reactive Oxygen Species; Signal Transduction	2021
Effects of Curcumin Analogues DMC and EF24 in Combination with the Cytokine TRAIL against Kidney Cancer. Molecules (Basel, Switzerland), 2021, Oct-18, Volume: 26, Issue:20 Topics: Apoptosis; Benzylidene Compounds; Carcinoma, Renal Cell; Cell Movement; Diarylheptanoids; Drug Therapy, Combination; Humans; Kidney Neoplasms; Piperidones; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured	2021
The Curcumin Analog EF24 Inhibits Proliferation and Invasion of Triple-Negative Breast Cancer Cells by Targeting the Long Noncoding RNA HCG11/Sp1 Axis. Molecular and cellular biology, 2022, 01-20, Volume: 42, Issue:1 Topics: Animals; Benzylidene Compounds; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Mice; MicroRNAs; Piperidones; RNA, Long Noncoding; Sp1 Transcription Factor; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2022