2-phenylquinazoline and benzotriazole

2-phenylquinazoline has been researched along with benzotriazole* in 1 studies

Other Studies

1 other study(ies) available for 2-phenylquinazoline and benzotriazole

Article	Year
Benzotriazole Substituted 2-Phenylquinazolines as Anticancer Agents: Synthesis, Screening, Antiproliferative and Tubulin Polymerization Inhibition Activity. Current cancer drug targets, 2023, Volume: 23, Issue:4 Development of anticancer agents targeting tubulin protein.. Tubulin protein is being explored as an important target for anticancer drug development. Ligands binding to the colchicine binding site of the tubulin protein act as tubulin polymerization inhibitors and arrest the cell cycle in the G2/M phase.. Synthesis and screening of benzotriazole-substituted 2-phenyl quinazolines as potential anticancer agents.. A series of benzotriazole-substituted quinazoline derivatives have been synthesized and evaluated against human MCF-7 (breast), HeLa (cervical) and HT-29 (colon) cancer cell lines using standard MTT assays.. ARV-2 with IC. The benzotriazole-substituted 2-phenyl quinazolines have the potential to be developed as potent anticancer agents. Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Molecular Docking Simulation; Polymerization; Quinazolines; Structure-Activity Relationship; Tubulin	2023

Article

Year

Benzotriazole Substituted 2-Phenylquinazolines as Anticancer Agents: Synthesis, Screening, Antiproliferative and Tubulin Polymerization Inhibition Activity.

Current cancer drug targets, 2023, Volume: 23, Issue:4

Development of anticancer agents targeting tubulin protein.. Tubulin protein is being explored as an important target for anticancer drug development. Ligands binding to the colchicine binding site of the tubulin protein act as tubulin polymerization inhibitors and arrest the cell cycle in the G2/M phase.. Synthesis and screening of benzotriazole-substituted 2-phenyl quinazolines as potential anticancer agents.. A series of benzotriazole-substituted quinazoline derivatives have been synthesized and evaluated against human MCF-7 (breast), HeLa (cervical) and HT-29 (colon) cancer cell lines using standard MTT assays.. ARV-2 with IC. The benzotriazole-substituted 2-phenyl quinazolines have the potential to be developed as potent anticancer agents.

Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Molecular Docking Simulation; Polymerization; Quinazolines; Structure-Activity Relationship; Tubulin

2023