2-oxothiazolidine-4-carboxylic acid has been researched along with thiazoles in 170 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (25.88) | 18.7374 |
| 1990's | 89 (52.35) | 18.2507 |
| 2000's | 37 (21.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morita, I; Murota, S; Ochi, H | 1 |
| Huang, HS; Jurima-Romet, M | 1 |
| Bauman, PF; Bray, TM; Sikorski, B; Taylor, CG | 1 |
| Banks, MF; Coloso, RM; Garcia, RA; Stipanuk, MH | 1 |
| Meredith, MJ | 1 |
| Ravindranath, V; Shivakumar, BR | 1 |
| Khoury, MD; Pereira, MA | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Nakada, Y; Saito, Y; Uozumi, T; Yamada, K | 1 |
| Coloso, RM; Hirschberger, LL; Stipanuk, MH | 1 |
| Ford, JM; Hait, WN; Yang, JM | 1 |
| Fujimoto, M; Hirata, M; Ohno, K | 1 |
| Boyd, MR; Ravindranath, V | 1 |
| Aebi, S; Lauterburg, BH; Porta, P; Summer, K | 1 |
| Deguchi, T; Mataki, Y; Naya, M; Noguchi, M; Yasuda, M | 1 |
| Baker, DH; Chung, TK; Funk, MA | 1 |
| Chung, LY; Khan, L; Schmidt, RJ | 1 |
| Ferko, AP | 1 |
| Akagi, R; Taguchi, T; Ubuka, T | 1 |
| DeGraff, W; Friedman, N; Mitchell, JB; Russo, A | 1 |
| Albright, N; DeGraff, WG; Mitchell, JB; Phillips, TL; Rajpal, R; Russo, A | 1 |
| Anderson, ME; Bridges, RJ; Meister, A; Underwood, M | 1 |
| Duddy, SK; Hsia, MT | 1 |
| Cooper, JA; Merrill, WW | 1 |
| Brodeur, J; Goyal, R; Tardif, R | 1 |
| Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Robert, A | 1 |
| Asai, K; Funaki, C; Hayashi, T; Kuzuya, F; Kuzuya, M; Naito, M | 1 |
| Parthasarathy, R; Ramasubbu, N | 1 |
| Allen, RG; Farmer, KJ; Newton, RK; Sohal, RS; Toy, PL | 1 |
| Devoto, MA; Puente, J; Sapag-Hagar, M | 1 |
| Ferguson, AE; Kanz, MF; Moslen, MT; Whitehead, RF | 1 |
| Anderson, ME; Meister, A | 2 |
| Chopp, M; Hetzel, FW; Mesina, JE; Page, RH | 1 |
| Abney, NL; Maatta, EA; Perchellet, EM; Perchellet, JP | 1 |
| DeGraff, WG; Mitchell, JB; Russo, A | 1 |
| Harper, BL; Moslen, MT; Roy, D | 1 |
| Phillips, PG; Tsan, MF | 1 |
| Hayes, MA; Kim, HL; Merrill, JC; Murray, CA; Safe, S | 1 |
| Fidelus, RK | 1 |
| Bauman, PF; Bray, TM; Smith, TK | 1 |
| Carmichael, J; DeGraff, W; Friedman, N; Glatstein, E; Mitchell, JB; Russo, A; Tochner, Z | 1 |
| Brodeur, J; Goyal, R | 1 |
| Fidelus, RK; Ginouves, P; Lawrence, D; Tsan, MF | 1 |
| Nishina, H; Ohta, J; Ubuka, T | 1 |
| Bracken, WM; Klaassen, CD | 1 |
| Anderson, ME; Hwang, O; Meister, A | 1 |
| Fidelus, RK; Tsan, MF | 1 |
| Kim, HL; Merrill, J; Safe, S | 1 |
| Dierickx, PJ; Vanderwielen, C | 1 |
| Boettcher, B; Meister, A | 2 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Danis, EH; Del Vecchio, PJ; Rosano, CL; Tsan, MF | 1 |
| DeGraff, WG; Finkelstein, E; Gamson, J; Mitchell, JB; Russo, A; Spiro, IJ | 1 |
| Mitchell, JB; Russo, A | 2 |
| Friedman, N; McPherson, S; Mitchell, JB; Russo, A | 1 |
| Bruggink, JE; Glazenburg, EJ; Mulder, GJ; Wolters-Keulemans, K | 1 |
| Bailie, MB; Hook, JB; Newton, JF; Smith, JH | 1 |
| Meister, A; Williamson, JM | 1 |
| Boettcher, B; Meister, A; Williamson, JM | 1 |
| Anders, MW; Stevens, JL | 1 |
| Baruchel, S; Batist, G; Farah, R; Jamali, M; Wang, T | 1 |
| Auld, PA; Frayer, WW; Jain, A; Madsen, DC; Mårtensson, J; Meister, A; Schwartz, MK | 1 |
| Bohets, HH; D'Haese, PC; De Broe, ME; Dierickx, PJ; Nouwen, EJ; Van der Biest, I; Van Landeghem, GF; Van Thielen, MN | 1 |
| Herzenberg, LA; Raju, PA; Roederer, M | 1 |
| Averill, L; Dando, S; Georges, D; Goldberg, D; Lederman, MM; Schmelzer, R | 1 |
| Huxtable, RJ; Yan, CC | 1 |
| Aschner, M; Kimelberg, HK; Lash, LH; Mullaney, KJ; Wagoner, D | 1 |
| Borum, PR; Chance, M; Emgushov, RT; Jackson, JB; Kalayjian, RC; Mayer, KH; Skowron, G; Spell, SA; Webb, LS; Yen-Lieberman, B | 1 |
| Bais, R; Baker, PW; Rofe, AM | 2 |
| Bray, TM; Taylor, CG | 1 |
| Gechman, M; Story, K; Webb, LE | 1 |
| Fisher, JE; Potturi, RB; Resnick, E; Zimmerman, EF | 1 |
| Barnidge, M; Janney, CG; Neuschwander-Tetri, BA | 1 |
| Grendell, JH; Luthen, RE | 1 |
| Ensunsa, JL; Hirschberger, LL; Stipanuk, MH | 1 |
| Breborowicz, A; Martis, L; Oreopoulos, DG; Witowski, J | 1 |
| Bray, TM; Goss, PM; Nagy, LE | 1 |
| Banks, MF; Stipanuk, MH | 1 |
| Fujiyama, J; Hirayama, K; Yasutake, A | 1 |
| Hosono, K; Kobayashi, H; Mochizuki, K | 1 |
| Moog, C; Obert, G; Simon, G | 1 |
| Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE | 1 |
| Chaudiére, J; Fougeat, S; Gerard-Monnier, D; Gourvest, JF | 1 |
| Glosson, JA; Goldberg, DI; Madsen, DC; Rowe, WB; White, RD; Wilson, DM | 1 |
| Smith, TK; Sousadias, MG | 1 |
| Forman, HJ; Hu, H; Liu, RM; Robison, TW | 1 |
| Burt, M; Harrison, LE; Hochwald, SN; Rose, DM | 1 |
| Baker, ER; Baker, H; DeAngelis, B; Frank, O; Hutner, SH; Khalil, M | 1 |
| Breborowicz, A; Martis, L; Oreopoulos, DG; Patrikarea, A | 1 |
| Ida, N; Maeda, K; Miyazaki, T; Murata, Y; Nagaya, T; Sato, M; Seo, H | 1 |
| Blair, SL; Burt, ME; Rose, DM; Sachar, S | 1 |
| Becker, MI; De Ioannes, AE; Díaz, MI; Garbarino, JA; Kalergis, AM; López, CB; Sein, J | 1 |
| Giles, KC; Gross, CL; Smith, WJ | 1 |
| Bauer, G; Chen, P; Factor, R; Markham, R; Mitchell, J; Schwartz, DH | 1 |
| Gordon, D; Leaf, C; Rice, D; Safron, J; White, R | 1 |
| Grendell, JH; Häussinger, D; Lüthen, R; Niederau, C | 1 |
| Douglas, SD; Ho, WZ; Sison, A; Starr, SE | 1 |
| Greene, JJ; Hutter, DE; Till, BG | 1 |
| Assimos, DG; Holmes, RP; Leaf, CD; Whalen, JJ | 1 |
| Arons, MM; Bernard, GR; Morris, PE; Paz, HL; Russell, JA; Wheeler, AP; Wright, PE | 1 |
| Ali-Osman, F; Srivenugopal, KS | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ | 1 |
| Breborowicz, A; Korybalska, K; Martis, L; Moberly, J; Oreopoulos, DG; Polubinska, A; Wieczorowska-Tobis, K | 1 |
| Aviram, M; Rosenblat, M | 1 |
| Dringen, R; Hamprecht, B; Kranich, O; Sandberg, M | 1 |
| Frei, B; Gokce, N; Holbrook, M; Keaney, JF; Leaf, C; Vita, JA | 1 |
| Alpert, LC; Batist, G; Chen, X; Griffith, OW; Hayward, MA; Schecter, RL | 1 |
| Harris, C; Miller, JM; Nuttall, AL; Raphael, Y; Yamasoba, T | 1 |
| Bray, TM; Levy, MA; Sikorski, B | 1 |
| Brash, DE; Chu, E; Ju, J; Liu, M; Pelling, JC | 1 |
| Barditch-Crovo, P; Borum, P; Buier, R; Goldberg, D; Kalayjian, RC; Lederman, M; Lietman, P; Noe, D; Rowe, WB; Skowron, G | 1 |
| Alghamdi, GA; Borum, PR; Jassal, SV; Logan, J; Martis, L; Moberly, JB; Moran, JE; Mupas, L; Oreopoulos, DG; Rodela, H; Story, KO; Webb, LE; Wolfson, M | 1 |
| Anderson, ME | 1 |
| Batist, G; Carystinos, GD; Chen, X | 1 |
| Batist, G; Chen, X | 1 |
| Goddard, CM; Leaf, CD; Poon, BY; Russell, JA; Walley, KR | 1 |
| Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Maes, HH; Wasserman, K | 1 |
| Gwilt, PR; Leaf, CD; Li, XY; Radick, LE; Whalen, JJ | 1 |
| Dringen, R; Hamprecht, B | 1 |
| Averill, DA; Lord-Fontaine, S | 1 |
| Brown, RH; Cudkowicz, ME; Ellis, T; Gwilt, PR; Hayden, DL; Sexton, PM; Whalen, J | 1 |
| Mochizuki, K | 1 |
| Hales, BF; Ozolins, TR | 2 |
| Breborowicz, A; Moberly, JB; Oreopoulos, DG; Wisniewska, J | 1 |
| Grzybowski, AE | 1 |
| Clayette, P; Dereuddre-Bosquet, N; Dormont, D; Fretier, P; Imbach, JL; Jaccard, P; Mialocq, P; Oiry, J; Puy, JY | 1 |
| Ajami, AM; Fukagawa, NK; Hercules, E | 1 |
| Bradford, BU; Brenner, D; Enomoto, N; Forman, D; Frey, W; Iimuro, Y; Kono, H; Nakagami, M; Rusyn, I; Thurman, RG; Yamashina, S | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Hammarqvist, F; Wernerman, J | 1 |
| Fodor, J; Gullner, G; Kömives, T; Tóbiás, I | 1 |
| Alonso-Varona, A; Bilbao, P; Calle, Y; Castro, B; del Olmo, M; Palomares, T | 1 |
| Brown, LA; Guidot, DM; Jain, L; Lois, M; Modelska, K; Moss, IM; Pittet, JF | 1 |
| Birnboim, HC; Privora, H | 1 |
| Herman, TS; Martinez, BR; Meltz, ML; Mohan, S; Natarajan, M | 1 |
| Griebel, RW; Juurlink, BH; Kamencic, H; Lyon, AW; Paterson, PG | 1 |
| An, NH; Han, MK; Jang, SI; Kim, HK; Kim, SJ; Kim, UH; Park, HJ; Park, KH; Park, KJ; Park, YR; Shin, YM | 1 |
| Bierl, C; Cap, A; Heydrick, S; Loscalzo, J; Weiss, N; Zhang, YY | 1 |
| Brown, MK; Fraley, TS; Kaetzel, RS; Reed, DJ; Will, Y | 1 |
| Alonso-Varona, A; Bilbao, J; Bilbao, P; Castro, B; del Olmo, M; Palomares, T | 1 |
| Assimos, DG; Holmes, RP; Milliner, DS; Wilson, DM | 1 |
| Chang, YC; Chou, MY; Huang, FM; Tai, KW; Yang, LC | 1 |
| James, TL; Macdonald, JM; Schmidlin, O | 1 |
| Frei, B; Hagen, T; Keaney, JF; Smith, A; Visioli, F; Zhang, W | 1 |
| Drozak, J; Winiarska, K | 1 |
| Chang, YC; Chou, MY; Hsieh, YS; Huang, FM; Lii, CK; Tai, KW | 1 |
| Chang, YC; Chou, MY; Tsai, CH | 1 |
| Gur, ES; Kahveci, N; Korfali, E; Ozgüç, H; Serdar, Z; Tokyay, R | 1 |
| Aksenov, ND; Efremova, TN; Gamaleĭ, IA; Kirpichnikova, KM | 1 |
| Harding, CO; Held, P | 1 |
| Bryła, J; Drozak, J; Jagielski, AK; Wegrzynowicz, M; Winiarska, K | 1 |
| Clayberger, C; Krensky, AM; Li, Q; Okada, S; Whitin, JC | 1 |
| Abe, K; Saito, F; Tokui, T; Yamada, M | 1 |
| Abe, K; Iijima, Y; Ishikawa, H; Watanabe, T | 1 |
| Baek, SY; Chung, BS; Kang, CD; Kim, JY; Kim, SD; Kim, SH; Park, KH; Park, SW | 1 |
| Efremova, TN; Gamaleĭ, IA; Khaĭtlina, SIu; Kirpichnikova, KM | 1 |
| Choi, IW; Im, MJ; Kim, UH; Lee, HK; Lee, KS; Lee, YC; Lim, JS; Park, HS; Park, KH; Park, SJ | 1 |
| Breborowicz, A; Oreopoulos, D; Polubinska, A; Pyda, M; Witowski, J | 1 |
| Chang, YC; Chen, YJ; Chu, SC; Hsieh, YS; Tsai, CH; Yang, SF | 1 |
| Aschner, JL; Aschner, M; Shanker, G; Syversen, T | 1 |
| Jin, SM; Kim, CY; Kim, SR; Kim, UH; Lee, KS; Lee, YC; Min, KH; Park, HS; Park, KH; Park, SJ | 1 |
| Lee, YC; Park, SJ | 1 |
| Chang, YC; Ho, YC | 1 |
| Jin, SM; Kim, SR; Lee, KS; Lee, YC; Li, L; Min, KH; Park, HS; Park, SJ | 1 |
| Breborowicz, A; Oreopoulos, DG; Podkowka, R; Styszynski, A; Wieczorowska-Tobis, K | 1 |
7 review(s) available for 2-oxothiazolidine-4-carboxylic acid and thiazoles
| Article | Year |
|---|---|
The roles of intracellular glutathione in antineoplastic chemotherapy.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition.
Topics: Animals; Antioxidants; Dietary Proteins; Glutathione; Immunity, Innate; Infections; Nutrition Disorders; Prodrugs; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Up-Regulation | 1994 |
Glutathione: an overview of biosynthesis and modulation.
Topics: Animals; Buthionine Sulfoximine; Dipeptides; Enzyme Inhibitors; Esterification; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Kinetics; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Potential for selective modulation of glutathione in cancer chemotherapy.
Topics: Animals; Buthionine Sulfoximine; Cell Communication; Drug Resistance; Enzyme Inhibitors; Female; Gap Junctions; Glutamate-Cysteine Ligase; Glutathione; Humans; Mammary Neoplasms, Experimental; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1998 |
Modulation of endogenous glutathione availability.
Topics: Acetylcysteine; Animals; Cysteine; Glutamine; Glutathione; Humans; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
[Glutathione in therapy].
Topics: Animals; Cysteine; Diabetes Mellitus; Glutathione; Humans; Infections; Neurodegenerative Diseases; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2002 |
Antioxidants as novel agents for asthma.
Topics: Acetylcysteine; Anti-Asthmatic Agents; Antioxidants; Asthma; Cysteine; Glutathione; Humans; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2006 |
8 trial(s) available for 2-oxothiazolidine-4-carboxylic acid and thiazoles
| Article | Year |
|---|---|
A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects.
Topics: Adult; Aged; beta 2-Microglobulin; CD4-Positive T-Lymphocytes; Cysteine; Female; Glutathione; HIV Seropositivity; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1994 |
The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretion.
Topics: Adult; Humans; Male; Oxalates; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.
Topics: Acetylcysteine; Adult; Antioxidants; Bilirubin; Bronchoalveolar Lavage Fluid; Cardiac Output; Cysteine; Double-Blind Method; Free Radical Scavengers; Glutathione; Humans; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiration, Artificial; Respiratory Distress Syndrome; Thiazoles; Thiazolidines; Time Factors | 1997 |
L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.
Topics: Administration, Oral; Aged; Arteriosclerosis; Blood Flow Velocity; Blood Glucose; Blood Pressure; Cholesterol; Coronary Disease; Cysteine; Double-Blind Method; Endothelium, Vascular; Female; Glutathione; Heart Rate; Humans; Hyperemia; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Triglycerides; Ultrasonography | 1998 |
A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.
Topics: Adult; Anti-HIV Agents; Cysteine; Dose-Response Relationship, Drug; Double-Blind Method; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine).
Topics: Administration, Oral; Cysteine; Double-Blind Method; Female; Glutathione; Humans; Kidney Failure, Chronic; Male; Middle Aged; Osmolar Concentration; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adult; Amyotrophic Lateral Sclerosis; Glutathione; Humans; Infusions, Intravenous; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1.
Topics: Calcium Oxalate; Calcium, Dietary; Cysteine; Female; Humans; Hyperoxaluria, Primary; Infusions, Intravenous; Male; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Treatment Outcome | 2001 |
155 other study(ies) available for 2-oxothiazolidine-4-carboxylic acid and thiazoles
| Article | Year |
|---|---|
Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
Topics: Animals; Antioxidants; Azoles; Buthionine Sulfoximine; Carotid Arteries; Cattle; Cells, Cultured; Endothelium, Vascular; Glutathione; Glutathione Peroxidase; Isoindoles; Kinetics; Leukotrienes; Lipid Peroxides; Maleates; Methionine Sulfoximine; Organoselenium Compounds; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Selenium; Sodium Selenite; Thiazoles; Thiazolidines | 1992 |
Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enalapril; Enzyme Induction; Glutathione; Inactivation, Metabolic; Liver; Liver Diseases; Male; Necrosis; Pregnenolone Carbonitrile; Protoporphyrins; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1992 |
Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats.
Topics: Administration, Oral; Animals; Body Weight; Glutathione; Lung; Magnetic Resonance Spectroscopy; Organ Size; Oxygen; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1992 |
Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes.
Topics: Animals; Cells, Cultured; Chelating Agents; Cysteine; Glutathione; Indicators and Reagents; Liver; Male; Methionine; Phenanthrolines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfates; Taurine; Thiazoles; Thiazolidines | 1992 |
Glutathione and glutathione conjugate efflux from cultured liver cells.
Topics: Animals; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Ethacrynic Acid; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; Isoxazoles; Liver; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1991 |
Selective modulation of glutathione in mouse brain regions and its effect on acrylamide-induced neurotoxicity.
Topics: Acrylamides; Animals; Brain; Buthionine Sulfoximine; Drug Interactions; Female; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Injections, Spinal; Liver; Maleates; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1992 |
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Eflornithine; Ellagic Acid; Isothiocyanates; Male; Precancerous Conditions; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfides; Thiazoles; Thiazolidines; Thiocyanates | 1991 |
Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Doxorubicin; Drug Resistance; Etoposide; Glioma; Glutathione; Kinetics; Methionine Sulfoximine; Nimustine; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Vinblastine | 1991 |
Uptake and metabolism of L-2-oxo-[35S]thiazolidine-4-carboxylate by rat cells is slower than that of L-[35S]cysteine or L-[35S]methionine.
Topics: Animals; Biological Transport; Chromatography, High Pressure Liquid; Cysteine; Glutathione; In Vitro Techniques; Intestine, Small; Kidney Tubules; Liver; Male; Methionine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Thiazoles; Thiazolidines | 1991 |
Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice.
Topics: Animals; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Flupenthixol; Glutathione; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Verapamil | 1991 |
Protective effect of prostaglandin A2 against menadione-induced cell injury in cultured porcine aorta endothelial cells.
Topics: Animals; Aorta; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Methionine; Prostaglandins A; Pyrrolidonecarboxylic Acid; Swine; Thiazoles; Thiazolidines; Time Factors; Vitamin K | 1991 |
Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran.
Topics: Alanine Transaminase; Animals; Antimetabolites; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cystine; Drug Interactions; Furans; Glutathione; Male; Maleates; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1991 |
L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human.
Topics: Adult; Cysteine; Glutathione; Humans; Lymphocytes; Male; Middle Aged; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1991 |
Effects of L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, on teratogenicity of 5-fluorouracil in mice.
Topics: Animals; Body Weight; Cystine; Drug Synergism; Female; Fluorouracil; Glutathione; Limb Deformities, Congenital; Liver; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Pregnancy; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1990 |
L-2-oxothiazolidine-4-carboxylate as a cysteine precursor: efficacy for growth and hepatic glutathione synthesis in chicks and rats.
Topics: Administration, Oral; Animals; Chickens; Cysteine; Diet; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Inbred Strains; Regression Analysis; Thiazoles; Thiazolidines; Weight Gain | 1990 |
Are free radicals and not quinones the haptenic species derived from urushiols and other contact allergenic mono- and dihydric alkylbenzenes? The significance of NADH, glutathione, and redox cycling in the skin.
Topics: Animals; Benzene; Benzene Derivatives; Catechols; Dermatitis, Contact; Free Radicals; Glutathione; Haptens; Male; Mice; NAD; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Quinones; Skin; Thiazoles; Thiazolidines | 1990 |
The interaction between ethanol and cysteine on the central depressant effects of ethanol in mice.
Topics: Animals; Cysteine; Drug Synergism; Ethanol; gamma-Aminobutyric Acid; Injections, Intraventricular; Isethionic Acid; Male; Mice; Posture; Pyrrolidonecarboxylic Acid; Reflex; Thiazoles; Thiazolidines | 1990 |
Tissue contents and urinary excretion of taurine after administration of L-cysteine and L-2-oxothiazolidine-4-carboxylate to rats.
Topics: Animals; Caseins; Cysteine; Cysteine Dioxygenase; Cystine; Dietary Proteins; Dioxygenases; Injections, Intraperitoneal; Liver; Male; Oxygenases; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Taurine; Thiazoles; Thiazolidines; Tissue Distribution | 1990 |
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.
Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin | 1986 |
Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione; Methionine Sulfoximine; Nitroimidazoles; Oxygen; Pyrrolidonecarboxylic Acid; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1989 |
Glutathione metabolism at the blood-cerebrospinal fluid barrier.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Buthionine Sulfoximine; Choroid Plexus; Cysteine; Dipeptides; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Buthionine Sulfoximine; Glutathione; Insecticides; Liver; Male; Methionine Sulfoximine; Plants; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Reference Values; Thiazoles; Thiazolidines | 1989 |
Modulation of endoperoxide product levels and cyclophosphamide-induced injury by glutathione repletion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Glutathione; Lung; Lung Injury; Male; Prostaglandin Endoperoxides; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1989 |
Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.
Topics: Acetylcysteine; Acrylonitrile; Animals; Ethylene Dibromide; Ethylene Oxide; Glutathione; Hydrocarbons, Brominated; Kidney; Liver; Male; Nitriles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors | 1989 |
Role of glutathione status in protection against ethanol-induced gastric lesions.
Topics: Acetylcysteine; Animals; Cysteamine; Ethanol; Gastric Mucosa; Glutathione; Male; Maleates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach Ulcer; Thiazoles; Thiazolidines | 1989 |
Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells.
Topics: Animals; Antimetabolites; Aorta, Thoracic; Buthionine Sulfoximine; Cattle; Cell Survival; Cells, Cultured; Endothelium, Vascular; Fetus; Glutathione; Kinetics; Lipoproteins, LDL; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1989 |
Crystal structure of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Crystallization; Hydrogen Bonding; Models, Molecular; Pyrrolidonecarboxylic Acid; Software; Thiazoles; Thiazolidines; X-Ray Diffraction | 1989 |
Effects of experimentally altered glutathione levels on life span, metabolic rate, superoxide dismutase, catalase and inorganic peroxides in the adult housefly, Musca domestica.
Topics: Animals; Buthionine Sulfoximine; Catalase; Energy Metabolism; Glutathione; Houseflies; Kinetics; Life Expectancy; Methionine Sulfoximine; Peroxides; Pyrrolidonecarboxylic Acid; Superoxide Dismutase; Thiazoles; Thiazolidines | 1985 |
Modulation of gamma-glutamyl cycle and glutathione levels in rat mammary gland explants.
Topics: Amidohydrolases; Animals; Buthionine Sulfoximine; Culture Techniques; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Mammary Glands, Animal; Methionine Sulfoximine; Peptide Synthases; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1986 |
Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1,1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Dichloroethylenes; Glutathione; Hydrocarbons, Chlorinated; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate.
Topics: Animals; Brain; Brain Stem; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cysteine; Glutathione; Hypothalamus; Male; Mice; Pons; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain.
Topics: Animals; Brain; Glutathione; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1989 |
Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate
Topics: Acetylcysteine; Animals; Cells, Cultured; Ditiocarb; Epidermis; Female; Glutathione; Glutathione Peroxidase; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1987 |
Glutathione depletion greatly reduces neocarzinostatin cytotoxicity in Chinese hamster V79 cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cysteine; Glutathione; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin | 1985 |
Effects of a cysteine precursor, L-2-oxothiazolidine-carboxylate, nutritional status, and sex on tissue glutathione and hepatic GSH-utilizing enzymes of CD-1 mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Liver; Male; Mice; Nutritional Status; Pyrrolidonecarboxylic Acid; Sex Factors; Thiazoles; Thiazolidines | 1988 |
L-2-oxothiazolidine-4-carboxylate protects cultured endothelial cells against hyperoxia-induced injury.
Topics: Cells, Cultured; Endothelium, Vascular; Glutathione; Oxygen; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1988 |
Intracellular delivery of cysteine.
Topics: Animals; Biological Transport; Cysteine; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Radioisotope Dilution Technique; Sulfur Radioisotopes; Thiazoles; Thiazolidines; Tissue Distribution | 1987 |
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Topics: Acetylcysteine; Animals; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1988 |
The generation of oxygen radicals: a positive signal for lymphocyte activation.
Topics: Animals; Cell Line; Free Radicals; Glutathione; Lymphocyte Activation; Mercaptoethanol; Mice; Oxygen; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; Thymoma; Tumor Cells, Cultured | 1988 |
Effect of dietary protein deficiency and L-2-oxothiazolidine-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Circadian Rhythm; Cysteine; Diet; Glutathione; Liver; Male; Protein Deficiency; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors | 1988 |
Effect of a cysteine prodrug (L-2-oxothiazolidine-4-carboxylic acid) on the metabolism and toxicity of bromobenzene: a repeated exposure study.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Glutathione; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1987 |
Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation.
Topics: Acridine Orange; Animals; Buthionine Sulfoximine; Cell Cycle; Concanavalin A; Flow Cytometry; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymidine | 1987 |
Effect of L-2-oxothiazolidine-4-carboxylate administration on glutathione and cysteine concentrations in guinea pig liver and kidney.
Topics: Animals; Cysteine; Glutathione; Guinea Pigs; Kidney; Kinetics; Liver; Male; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1987 |
Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction.
Topics: Animals; Cells, Cultured; Dexamethasone; Ethanol; Liver; Metallothionein; Metals; Potassium; Protein Biosynthesis; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Urethane | 1987 |
Intracellular cysteine and glutathione delivery systems.
Topics: Acetaminophen; Animals; Biological Transport, Active; Cysteine; Dipeptides; Glutathione; Intracellular Fluid; Kidney; Liver; Mice; Models, Biological; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Sulfur; Thiazoles; Thiazolidines | 1986 |
Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen.
Topics: Animals; Buthionine Sulfoximine; Glutathione; Lymphocyte Activation; Lymphocytes; Mercaptoethanol; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mitogens; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Helenalin: mechanism of toxic action.
Topics: Animals; Drug Interactions; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1986 |
Glutathione-dependent toxicity of the algicide 1-chloro-2,4-dinitrobenzene to Daphnia magna Straus.
Topics: Animals; Daphnia; Dinitrochlorobenzene; Glutathione; Pesticides; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1986 |
Synthesis of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Indicators and Reagents; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Radioisotope Dilution Technique; Sulfur Radioisotopes; Thiazoles; Thiazolidines | 1985 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
Enhancement of intracellular glutathione protects endothelial cells against oxidant damage.
Topics: Animals; Buthionine Sulfoximine; Cattle; Endothelium; Glucose Oxidase; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
The effects of cellular glutathione elevation on the oxygen enhancement ratio.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Glutathione; In Vitro Techniques; Oxygen; Pyrrolidonecarboxylic Acid; Stimulation, Chemical; Thiazoles; Thiazolidines | 1985 |
Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Free Radicals; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1985 |
Alteration of bleomycin cytotoxicity by glutathione depletion or elevation.
Topics: Animals; Bleomycin; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1984 |
Radiation response of Chinese hamster cells after elevation of intracellular glutathione levels.
Topics: Aerobiosis; Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cobalt; Cricetinae; Cricetulus; Cysteamine; Dose-Response Relationship, Radiation; Glutathione; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1984 |
Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor.
Topics: Animals; Cysteine; Glutathione; In Vitro Techniques; Kinetics; Liver; Male; Perfusion; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines | 1984 |
Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys.
Topics: Animals; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Diseases; Male; Microsomes; p-Aminohippuric Acid; Phenobarbital; Phosgene; Pyrrolidonecarboxylic Acid; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds; Thiazoles; Thiazolidines | 1984 |
Synthesis of L-2-oxothiazolidine-4-carboxylic acid.
Topics: Chlorobenzoates; Glutathione; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1984 |
Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.
Topics: Amidohydrolases; Animals; Glutathione; Kidney; Kinetics; Liver; Mice; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1981 |
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Topics: Acetaminophen; Animals; Cysteine; Glutathione; Glutathione Synthase; Inactivation, Metabolic; Liver; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1982 |
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.
Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes | 1981 |
In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Kidney; Liver; Mammary Neoplasms, Experimental; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1995 |
L-2-oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet.
Topics: Amino Acids, Sulfur; Animals; Bronchoalveolar Lavage Fluid; Diet; Glutathione; Growth; Liver; Lung; Lymphocytes; Male; Pyrrolidonecarboxylic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines; Weight Gain | 1995 |
Cytotoxicity of mercury compounds in LLC-PK1, MDCK and human proximal tubular cells.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Dogs; Drug Interactions; Glutathione; Humans; Kidney; Kidney Tubules, Proximal; LLC-PK1 Cells; Mercury Compounds; Methionine Sulfoximine; Pyrrolidonecarboxylic Acid; Spectrophotometry, Atomic; Swine; Thiazoles; Thiazolidines | 1995 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Antiviral Agents; Buthionine Sulfoximine; Cells, Cultured; Free Radical Scavengers; Gene Expression Regulation, Viral; Genes, Reporter; Glutathione; HIV Long Terminal Repeat; HIV-1; Humans; Leukocytes, Mononuclear; Methionine Sulfoximine; Monocytes; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; NF-kappa B; Phytohemagglutinins; Promoter Regions, Genetic; Protein Binding; Pyrrolidonecarboxylic Acid; Receptors, Interleukin-2; T-Lymphocytes; Thiazoles; Thiazolidines; Virus Replication | 1995 |
Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Bile; Buthionine Sulfoximine; Ethylene Chlorohydrin; Glutathione; Liver; Male; Maleates; Methionine Sulfoximine; Monocrotaline; Perfusion; Pyrroles; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1995 |
Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Methionine Sulfoximine; Methylmercury Compounds; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Taurine; Thiazoles; Thiazolidines; Tritium | 1994 |
The efficacy of (L)-2-oxothiazolidine-4-carboxylate (OTC) and (L)-cysteine in reducing urinary oxalate excretion.
Topics: Animals; Calcium Oxalate; Cysteine; Male; Metabolism; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors | 1994 |
Determination of L-2-oxothiazolidine-4-carboxylic acid (Procysteine) in human plasma by high-performance liquid chromatography.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; HIV Infections; Humans; Indicators and Reagents; Injections, Intravenous; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Respiratory Distress Syndrome; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidines | 1994 |
Role of oxygen free radicals in cocaine-induced vascular disruption in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Aorta; Blood Vessels; Cocaine; Cyclic N-Oxides; Female; Fetal Diseases; Fetal Heart; Gestational Age; Hemorrhage; Lipid Peroxidation; Maternal-Fetal Exchange; Mice; Mice, Inbred ICR; Nervous System; Nervous System Malformations; Neural Tube Defects; Nitrogen Oxides; Pregnancy; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Vasodilation; Yolk Sac | 1994 |
Cerulein-induced pancreatic cysteine depletion: prevention does not diminish acute pancreatitis in the mouse.
Topics: Animals; Ceruletide; Cysteine; Dose-Response Relationship, Drug; Female; Glutathione; Mice; Mice, Inbred Strains; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1994 |
Thiol metabolism and acute pancreatitis: trying to make the pieces fit.
Topics: Acute Disease; Animals; Ceruletide; Cysteine; Glutathione; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1994 |
Catabolism of cysteine, cystine, cysteinesulfinate, and OTC by isolated perfused rat hindquarter.
Topics: Adenine Nucleotides; Animals; Cysteine; Cystine; Hindlimb; In Vitro Techniques; Lactates; Male; Muscles; Neurotransmitter Agents; Perfusion; Phosphocreatine; Pyrrolidonecarboxylic Acid; Pyruvates; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Sulfates; Sulfur Radioisotopes; Taurine; Thiazoles; Thiazolidines | 1993 |
Enhancement of viability of human peritoneal mesothelial cells with glutathione precursor: L-2-oxothiazolidine-4-carboxylate.
Topics: Amino Acids; Cell Division; Cell Survival; Cells, Cultured; Epithelial Cells; Epithelium; Free Radicals; Glutathione; Humans; L-Lactate Dehydrogenase; Peritoneum; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymidine | 1993 |
Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats.
Topics: Amino Acids; Animals; Cells, Cultured; Cyclic AMP; Cysteine; Glutathione; Homeostasis; Liver; Male; Methionine; Oxygen; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1994 |
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine.
Topics: Acetylcysteine; Animals; Cells, Cultured; Culture Media; Cysteine; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Selenium Radioisotopes; Thiazoles; Thiazolidines | 1994 |
Mechanism of methylmercury efflux from cultured astrocytes.
Topics: Animals; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Cysteine; Glutathione; Methionine Sulfoximine; Methylmercury Compounds; Probenecid; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1994 |
Purification and some properties of a novel racemase, which racemizes 2-oxothiazolidine-4-carboxylic acid and 5-oxoproline, from Flectobacillus sp. strain B-1.
Topics: Bacillus; Hydrogen-Ion Concentration; Kinetics; Pyrrolidonecarboxylic Acid; Racemases and Epimerases; Substrate Specificity; Temperature; Thiazoles; Thiazolidines | 1994 |
Effects of glutathione precursors on human immunodeficiency virus replication.
Topics: Acetylcysteine; beta-Galactosidase; Cell Line; Colorimetry; Gene Expression Regulation, Viral; Glutathione; Granulocyte-Macrophage Colony-Stimulating Factor; HIV; HIV Long Terminal Repeat; Homocysteine; Humans; Interleukin-6; Prodrugs; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Virus Replication | 1994 |
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.
Topics: Acetylcysteine; Animals; Arteries; Drug Tolerance; Female; Nitrates; Nitroglycerin; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Veins | 1994 |
Partial prevention of glutathione depletion in rats following acute intoxication with diethylmaleate.
Topics: Animals; Brain; Cysteine; Glutathione; Heart; Kidney; Liver; Male; Maleates; Myocardium; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Toxicity evaluations of L-cysteine and Procysteine, a cysteine prodrug, given once intravenously to neonatal rats.
Topics: Animals; Animals, Newborn; Body Weight; Cysteine; Injections, Intravenous; Organ Size; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Toxicity and growth-promoting potential of spermine when fed to chicks.
Topics: Adenosylmethionine Decarboxylase; Animal Feed; Animals; Chickens; Cysteine; Diet; Dose-Response Relationship, Drug; Eating; Glutathione; Kidney; Liver; Male; Muscle, Skeletal; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Pyrrolidonecarboxylic Acid; Spermine; Thiazoles; Thiazolidines | 1995 |
Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.
Topics: Animals; Antioxidants; Benzoquinones; Cell Line; Drug Resistance; Epithelium; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutathione; Hydroquinones; Lung; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines | 1996 |
Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat.
Topics: Administration, Oral; Animals; Glutathione; Kidney; Male; Oxidation-Reduction; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines; Tissue Distribution | 1996 |
Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system.
Topics: Antioxidants; Buthionine Sulfoximine; Cysteine; Escherichia coli; Eukaryota; Free Radicals; Glutathione; Homocysteine; Methionine Sulfoximine; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Vitamin K; Vitamin K 3 | 1996 |
L-2-Oxothiazolidine-4-carboxylate and N-acetylcysteine as precursors of intracellular glutathione in human peritoneal mesothelial cells.
Topics: Acetylcysteine; Cells, Cultured; Epithelial Cells; Epithelium; Free Radical Scavengers; Free Radicals; Glutathione; Humans; Peritoneum; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1996 |
Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.
Topics: Acetylcysteine; Antioxidants; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Collagenases; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Interleukin-8; NF-kappa B; Pyrrolidonecarboxylic Acid; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidines; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Oral L-2-oxo-4-thiazolidine reduces bacterial translocation after radiation in the Fischer rat.
Topics: Administration, Oral; Animals; Bacteria; Bacterial Translocation; Body Weight; Buthionine Sulfoximine; Cells, Cultured; Eating; Glutathione; Jejunum; Liver; Lymph Nodes; Mesentery; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1996 |
Modulation of fatty acid oxidation alters contact hypersensitivity to urushiols: role of aliphatic chain beta-oxidation in processing and activation of urushiols.
Topics: Allergens; Animals; Carnitine O-Palmitoyltransferase; Catechols; Clofibrate; Dermatitis, Contact; Epoxy Compounds; Fatty Acids; Hypoglycemic Agents; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Plant Extracts; Plants, Toxic; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors | 1997 |
L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity.
Topics: Antidotes; Cell Separation; Cell Survival; Drug Administration Schedule; Free Radical Scavengers; Glutathione; Humans; Lymphocytes; Mustard Gas; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Toxicity Tests | 1997 |
N-acetyl-cysteine and L-2-oxothiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice.
Topics: Acetylcysteine; Animals; Anti-HIV Agents; CD2 Antigens; Cell Division; Cells, Cultured; Coculture Techniques; Down-Regulation; Female; HIV-1; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Male; Mice; Mice, SCID; Monocytes; Peritoneal Cavity; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Replication; Zidovudine | 1997 |
Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats.
Topics: Animals; Cyclophosphamide; Cystitis; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1997 |
Beneficial effects of L-2-oxothiazolidine-4-carboxylate on cerulein pancreatitis in mice.
Topics: Amylases; Animals; Ceruletide; Disulfides; Female; Glutathione; Glutathione Disulfide; Mice; Pancreas; Pancreatitis; Pyrrolidonecarboxylic Acid; Receptors, Cholecystokinin; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 1997 |
L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.
Topics: Adult; Anti-HIV Agents; Cells, Cultured; Female; Fetal Blood; HIV Infections; HIV-1; Humans; In Vitro Techniques; Infant, Newborn; Lymphocytes; Phagocytes; Pregnancy; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Replication | 1997 |
Redox state changes in density-dependent regulation of proliferation.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Division; Cell Line; Contact Inhibition; Fibroblasts; Fibrosarcoma; Glutathione; Humans; Male; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transcription Factors; Tumor Cells, Cultured | 1997 |
Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues.
Topics: Cysteine; Humans; Neoplasms; Prodrugs; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays | 1997 |
Alterations of intraperitoneal inflammation by the addition of L-2-oxothiazolidine-carboxylate.
Topics: Albumins; Animals; Creatinine; Dialysis Solutions; Glutathione; Leukocytes; Male; Nitrites; Peritoneal Dialysis; Peritoneum; Peritonitis; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1997 |
Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Buthionine Sulfoximine; Cell Line; Glutathione; Glutathione Peroxidase; Lipoproteins, LDL; Macrophages; Macrophages, Peritoneal; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxides; Pyrrolidonecarboxylic Acid; Selenium; Superoxides; Thiazoles; Thiazolidines | 1998 |
Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine.
Topics: Animals; Astrocytes; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; Cystathionine; Cysteine; Cystine; gamma-Glutamyltransferase; Glutathione; Methionine; Nerve Tissue Proteins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1998 |
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione.
Topics: Animals; Female; Glutathione; Humans; Immunohistochemistry; Neoplasms; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Thiazoles; Thiazolidines | 1998 |
Role of glutathione in protection against noise-induced hearing loss.
Topics: Animals; Antioxidants; Auditory Threshold; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; Cochlea; Cysteine; Evoked Potentials, Auditory, Brain Stem; Female; Glutathione; Guinea Pigs; Hearing Loss, Noise-Induced; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy.
Topics: Animals; Dietary Proteins; Glutathione; Hyperoxia; Lung; Male; Protein-Energy Malnutrition; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1998 |
Antioxidant action via p53-mediated apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Dimercaprol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E | 1998 |
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi | 1998 |
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Synergism; Glutathione; Humans; Melphalan; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1998 |
L-2-Oxothiazolidine-4-carboxylic acid prevents endotoxin-induced cardiac dysfunction.
Topics: Analysis of Variance; Animals; Endotoxins; Escherichia coli; Free Radicals; Glutathione; Infusions, Intravenous; Injections, Subcutaneous; Leukocyte Count; Myocardial Contraction; Myocardium; Prodrugs; Pyrrolidonecarboxylic Acid; Rabbits; Reactive Oxygen Species; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left | 1998 |
Protection by L-2-oxothiazolidine-4-carboxylic acid of hydrogen peroxide-induced CD3zeta and CD16zeta chain down-regulation in human peripheral blood lymphocytes and lymphokine-activated killer cells.
Topics: CD3 Complex; Cytoprotection; Down-Regulation; Humans; Hydrogen Peroxide; Killer Cells, Lymphokine-Activated; Lipopolysaccharides; Lymphocytes; Monocytes; Pyrrolidonecarboxylic Acid; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Receptors, IgG; Signal Transduction; Thiazoles; Thiazolidines | 1998 |
Pharmacokinetics of 2-oxothiazolidine-4-carboxylate, a cysteine prodrug, and cysteine.
Topics: Adult; Cysteine; Glutathione; Humans; Infusions, Intravenous; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1998 |
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.
Topics: Acetylcysteine; Animals; Brain; Cells, Cultured; Cysteine; Female; Glutathione; Methionine; Neurons; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1999 |
Enhancement of cytotoxicity of hydrogen peroxide by hyperthermia in chinese hamster ovary cells: role of antioxidant defenses.
Topics: Acetylcysteine; Amitrole; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Glutathione; Hot Temperature; Hydrogen Peroxide; Intracellular Fluid; Mesna; Oxidation-Reduction; Protective Agents; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Purification and characterization of 5-oxo-L-prolinase from Paecilomyces varioti F-1, an ATP-dependent hydrolase active with L-2-oxothiazolidine-4-carboxylic acid.
Topics: Amidohydrolases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydrogen-Ion Concentration; Paecilomyces; Pyrrolidonecarboxylic Acid; Sulfhydryl Reagents; Thiazoles; Thiazolidines | 1999 |
Post-translational regulation of AP-1 transcription factor DNA-binding activity in the rat conceptus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon-Oxygen Lyases; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Embryo, Mammalian; Female; Genes, jun; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; Phosphorylation; Pregnancy; Protein Biosynthesis; Protein Kinases; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines; Transcription Factor AP-1; Tumor Cells, Cultured | 1999 |
l-2-oxothiazolidine-4-carboxylic acid modulates function of peritoneal mesothelial cells in vitro.
Topics: Cell Division; Cells, Cultured; Dialysis Solutions; Dose-Response Relationship, Drug; Epithelial Cells; Free Radicals; Glutathione; Humans; Hyaluronic Acid; Hydrogen Peroxide; In Vitro Techniques; Interleukin-6; Peritoneal Cavity; Peritoneal Dialysis; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
In vitro effect of glutathione precursors on cytotoxicity of amino acids to human mesothelial cells.
Topics: Acetylcysteine; Amino Acids; Biological Transport; Cell Membrane; Cells, Cultured; Epithelial Cells; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; Peritoneum; Potassium; Protein Precursors; Pyrrolidonecarboxylic Acid; Rubidium Radioisotopes; Thiazoles; Thiazolidines | 1999 |
Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.
Topics: Anti-HIV Agents; HIV-1; Humans; Macrophages; Monocytes; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1999 |
L-2-[(13)C]oxothiazolidine-4-carboxylic acid: a probe for precursor mobilization for glutathione synthesis.
Topics: Acetaminophen; Adult; Aged; Breath Tests; Calorimetry, Indirect; Carbon Dioxide; Cysteine; Female; Glutathione; Humans; Kinetics; Male; Middle Aged; Models, Biological; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2000 |
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ethanol; Glutathione; Intubation, Gastrointestinal; Kupffer Cells; Liver; Liver Diseases; Male; Necrosis; NF-kappa B; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; RNA, Messenger; Thiazoles; Thiazolidines; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Elevation of glutathione level and activation of glutathione-related enzymes affect virus infection in tobacco.
Topics: Ascorbate Peroxidases; Cyclohexane Monoterpenes; Glutathione; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Malondialdehyde; Monoterpenes; Nicotiana; Peroxidases; Plant Diseases; Plant Leaves; Plants, Toxic; Pyrrolidonecarboxylic Acid; Terpenes; Thiazoles; Thiazolidines; Tobacco Mosaic Virus | 1999 |
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.
Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cell Division; Cyclophosphamide; Cysteine; Disease Progression; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glutathione; Leukopenia; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2000 |
Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats.
Topics: Administration, Oral; Animals; Cations; Cell Membrane; Cells, Cultured; Drug Combinations; Epithelium; Ethanol; Glutathione; Ion Channels; Male; Permeability; Prodrugs; Pulmonary Alveoli; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2000 |
Depletion of intracellular glutathione reduces mutations by nitric oxide-donating drugs.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutathione; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 2000 |
Antioxidant compounds interfere with the 3.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Colorimetry; Coloring Agents; Culture Media; Dithiothreitol; Kinetics; Melatonin; Mercaptoethanol; Oxidation-Reduction; Pyrrolidines; Pyrrolidonecarboxylic Acid; Reagent Kits, Diagnostic; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles; Thiazolidines; Thiocarbamates; Vitamin E | 2000 |
Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.
Topics: Animals; Behavior, Animal; Glutathione; Glutathione Reductase; Male; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Thiazoles; Thiazolidines; Up-Regulation | 2001 |
Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.
Topics: Animals; Cytoprotection; DNA; Embryonic and Fetal Development; Female; Glutathione; Homeostasis; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Thiazolidines; Transcription Factor AP-1; Yolk Sac | 1999 |
Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Antioxidants; Blood Glucose; Calcium; Cell Line; Cell Separation; Cysteine; Dimerization; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Glucose; Green Fluorescent Proteins; HeLa Cells; Humans; Hypoglycemic Agents; Immunohistochemistry; Islets of Langerhans; Luminescent Proteins; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Mutagenesis, Site-Directed; Mutation; NAD+ Nucleosidase; Oligonucleotides, Antisense; Pyrrolidonecarboxylic Acid; Signal Transduction; Thiazoles; Thiazolidines; Time Factors; Transfection | 2002 |
Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice.
Topics: Animals; Bradykinin; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Liver; Mesentery; Methacholine Chloride; Mice; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Vasodilation | 2002 |
In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knocko
Topics: Acetylcysteine; Animals; Apoptosis; Ascorbic Acid; Dexamethasone; gamma-Glutamyltransferase; Glutathione; Mice; Mice, Knockout; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymus Gland | 2002 |
L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Female; Glutathione; Interleukin-2; Liver; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Time Factors; Tumor Cells, Cultured | 2002 |
Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro.
Topics: Analysis of Variance; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Free Radical Scavengers; Glutathione; Humans; Nicotine; Nicotinic Agonists; Periodontal Ligament; Protective Agents; Protein Biosynthesis; Proteins; Pyrrolidonecarboxylic Acid; Smoking; Statistics as Topic; Sulfhydryl Compounds; Superoxide Dismutase; Thiazoles; Thiazolidines | 2002 |
In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR.
Topics: Animals; Carbon Isotopes; Female; Glutathione; Glycine; Liver; Magnetic Resonance Spectroscopy; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2002 |
Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.
Topics: Antioxidants; Aorta; Ascorbic Acid; Endothelium, Vascular; Glutathione; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thioctic Acid | 2002 |
Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.
Topics: Analysis of Variance; Buthionine Sulfoximine; Cell Culture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, fos; Glutathione; Humans; Nicotine; Periodontal Ligament; Protein Precursors; Pyrrolidonecarboxylic Acid; RNA, Messenger; Signal Transduction; Smoking; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Time Factors; Transcription, Genetic | 2003 |
The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.
Topics: Arecoline; Aspirin; Buthionine Sulfoximine; Cell Culture Techniques; Cholinergic Agonists; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Glutathione; Humans; Immunohistochemistry; Isoenzymes; Matched-Pair Analysis; Membrane Proteins; Mouth Mucosa; Nitrobenzenes; Oral Submucous Fibrosis; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyrrolidonecarboxylic Acid; Sulfonamides; Thiazoles; Thiazolidines; Transcription, Genetic; Up-Regulation | 2003 |
Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.
Topics: Animals; Constriction; Hepatic Artery; Hypovolemia; Liver; Male; Models, Animal; Portal Vein; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thiazoles; Thiazolidines | 2003 |
[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].
Topics: 3T3 Cells; Acetylcysteine; Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2003 |
L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.
Topics: Animals; Body Weight; Dietary Supplements; gamma-Glutamyltransferase; Genotype; Glutathione; Growth Disorders; Liver; Mice; Mice, Knockout; Pyrrolidonecarboxylic Acid; Reproduction; Thiazoles; Thiazolidines | 2003 |
Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gluconeogenesis; Glutathione; Intracellular Membranes; Kidney Cortex; Kidney Tubules; Male; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Rabbits; Thiazoles; Thiazolidines | 2003 |
Intracellular mediators of granulysin-induced cell death.
Topics: Antigens, Differentiation, T-Lymphocyte; Apoptosis; Calcium; Cell Death; Culture Media, Conditioned; Cytotoxicity, Immunologic; Down-Regulation; Fura-2; Glutathione; Humans; Intracellular Fluid; Jurkat Cells; Mitochondria; Peptides; Potassium; Protein Transport; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Up-Regulation | 2003 |
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Carbon; Cytosol; Escherichia coli; Humans; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Mice; Nitrates; Oxygen; Pharmaceutical Preparations; Pyroglutamyl-Peptidase I; Pyrrolidonecarboxylic Acid; Rats; Substrate Specificity; Sulfur; Thiazoles; Thiazolidines; Xenobiotics | 2004 |
Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Cattle; Cloning, Molecular; Coronary Vessels; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Molecular Sequence Data; Nitrates; Pyrrolidonecarboxylic Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Thiazoles; Thiazolidines; Vasodilator Agents | 2004 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].
Topics: 3T3 Cells; Acetylcysteine; Actin Cytoskeleton; Actins; Animals; Antioxidants; Cell Line, Transformed; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Simian virus 40; Stress Fibers; Thiazoles; Thiazolidines; Time Factors | 2004 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cell Adhesion Molecules; Chemokines; Disease Models, Animal; Eosinophil Cationic Protein; Interleukins; Lung; Mice; NF-kappa B; Ovalbumin; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2004 |
L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.
Topics: Cell Division; Cells, Cultured; Cytosol; Epithelial Cells; Epithelium; Glucose; Hemodialysis Solutions; Humans; Interleukin-6; L-Lactate Dehydrogenase; Peritoneal Cavity; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2004 |
Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.
Topics: Areca; Arecoline; Buthionine Sulfoximine; Fibroblasts; Glutathione; Humans; Interleukin-6; Male; Oral Submucous Fibrosis; Polymerase Chain Reaction; Pyrrolidonecarboxylic Acid; RNA, Messenger; Thiazoles; Thiazolidines; Up-Regulation | 2004 |
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.
Topics: Animals; Animals, Newborn; Antioxidants; Astrocytes; Buthionine Sulfoximine; Cells, Cultured; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Glutathione; Indicators and Reagents; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 2005 |
A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.
Topics: Animals; Asthma; Capillary Permeability; Female; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines; Thioctic Acid; Vascular Endothelial Growth Factor A | 2005 |
Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.
Topics: Buthionine Sulfoximine; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; Lactate Dehydrogenases; Nicotine; Phosphorylation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 2006 |
An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.
Topics: Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Capillary Permeability; Female; Gene Expression; Glycoproteins; Immunohistochemistry; Mice; Mice, Inbred C57BL; Osteoprotegerin; Ovalbumin; Phosphorylation; Prodrugs; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidines; Vascular Endothelial Growth Factor A | 2006 |
Effects of glutathione supplementation during peritoneal dialysis.
Topics: Animals; Cells, Cultured; Collagen; Epithelium; Erythrocytes; Glutathione Peroxidase; Hemodialysis Solutions; Male; Peritoneal Dialysis; Peritoneum; Proteins; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Tissue Adhesions | 2006 |