2-oxindole has been researched along with isatin in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (5.66) | 29.6817 |
| 2010's | 46 (86.79) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| Madhavan, S; Shanmugam, P; Viswambharan, B | 1 |
| Cardona, A; Crumeyrolle-Arias, M; Glover, V; Medvedev, A; Tournaire, MC | 1 |
| Castaldi, MP; Porco, JA; Troast, DM | 1 |
| Chang, TW; Fettinger, JC; Franz, AK; Hanhan, NV; Sahin, AH | 1 |
| Hayashi, T; Shintani, R; Takatsu, K | 1 |
| Chen, GY; Lu, Y; Zhong, F | 2 |
| Ahmed, NA; Ismaeel, HM; Kandile, NG; Mohamed, MI; Zaky, HT | 1 |
| Jia, X; Li, C; Li, J; Liu, Y | 1 |
| Coates, JA; Deadman, JJ; Francis, CL; Jeevarajah, D; Jones, ED; Le, G; Lucent, D; Newman, J; Peat, TS; Rhodes, DI; Ryan, JH; Savage, GP; Smith, JA; Thienthong, N; Vandegraaff, N; Winfield, LJ | 1 |
| Ayyanar, A; Perumal, PT; Praveen, C | 1 |
| Gatti, FG; Lesma, G; Pilati, T; Sacchetti, A; Silvani, A; Trucchi, B | 1 |
| Chang, Y; Chen, G; Di, Y; Gao, S; Hao, X; He, H; Li, S; Lu, Y; Yang, J | 1 |
| Arevalo, GE; Badillo, JJ; Franz, AK; MacDonald, JP; Silva-García, A | 1 |
| Feng, J; Li, P; Wang, D; Wang, R; Yan, W; Zhao, D | 1 |
| Badillo, JJ; Ball-Jones, NR; Franz, AK | 1 |
| Kumar, CV; Puranik, VG; Ramana, CV | 1 |
| Ito, H; Miyaura, N; Shirai, T; Yamamoto, Y; Yohda, M | 1 |
| Dou, X; Lu, Y; Yao, W; Zhong, F | 1 |
| Shi, M; Yang, HB | 1 |
| Hu, W; Li, M; Prajapati, D; Zan, L | 1 |
| Geng, ZC; Huang, XF; Liu, ZM; Wang, XW; Wang, Y; Zhang, SY | 1 |
| Chi, YR; Lv, H; Mo, J; Tiwari, B; Xing, C | 1 |
| Jiao, W; Li, T; Liu, R; Xiao, Z; Yao, C; Yu, C | 1 |
| Mandal, AB; Shanmugam, P; Solaiselvi, R | 1 |
| Cui, HL; Tanaka, F | 1 |
| Álvarez, E; Crespo-Peña, AM; Fernández, R; Lassaletta, JM; Martín-Zamora, E; Monge, D | 1 |
| Murata, Y; Sakamoto, M; Sengoku, T; Takahashi, M; Yagishita, F; Yoda, H | 2 |
| Liu, J; Sun, H; Wang, X; Xie, Y; Yan, T | 1 |
| Cao, X; Kong, C; Ma, Q; Qu, Y; Shen, E; Shen, W; Zhang, X; Zhou, H; Zhou, J | 1 |
| Li, T; Liu, R; Wang, X; Xiao, Z; Xie, Y; Yao, C; Yu, C | 1 |
| Sang, R; Shi, M; Yang, HB; Zhao, YZ | 1 |
| Jiang, Y; Liu, Y; Shi, F; Tu, SJ; Zhang, HH; Zhang, YC | 1 |
| Guan, YQ; Jiang, Y; Li, TZ; Sha, F; Wu, XY | 1 |
| Arewång, CJ; Bergman, J; Svensson, PH | 1 |
| Chandrasekar, S; Rajeshkumar, V; Sekar, G | 1 |
| He, Z; Li, R; Liu, Y; Yang, C; Zhou, R | 1 |
| Du, F; Du, T; Ning, Y; Peng, Y | 1 |
| Ahamad, S; Gupta, AK; Gupta, E; Kant, R; Mohanan, K | 1 |
| Bharitkar, YP; Bhayye, SS; Chatterjee, S; Das, M; Hazra, A; Kumari, MP; Kumari, N; Mondal, NB; Natarajan, R; Shah, S | 1 |
| Chen, YC; Du, W; He, Q; Shi, ML; Zhan, G | 1 |
| Butt, N; He, Q; Kou, X; Wu, L; Yang, G; Zhang, W | 1 |
| Aziz, SM; Das, D; Hajra, S; Jana, B; Mahish, P | 1 |
| Huang, Y; Jiang, Y; Liu, XQ; Liu, Y; Pan, S; Xu, XH; Yang, Y; Zhang, K | 1 |
| Molleti, N; Yong Kang, J | 1 |
| Huang, YL; Liang, H; Wei, WT; Wu, Y; Ying, WW; Zhu, WM | 1 |
| Maji, T; Partridge, JJ; Ramakumar, K; Tunge, JA | 1 |
| Ambler, BR; Krische, MJ; Turnbull, BWH; Wurm, T | 1 |
| Gong, LZ; Song, J; Wen, YH; Zhang, ZJ | 1 |
| Chebolu, R; Kinthada, LK; Meena, R; Prusty, N; Ravikumar, PC | 1 |
| Angeli, A; Arifuddin, M; Sahoo, SK; Singh, P; Swain, B; T Supuran, C; Yaddanapudi, VM | 1 |
| Eckroat, TJ; Reiland, KM | 1 |
1 review(s) available for 2-oxindole and isatin
| Article | Year |
|---|---|
Strategies for the enantioselective synthesis of spirooxindoles.
Topics: Alkylation; Indoles; Isatin; Oxindoles; Spiro Compounds; Stereoisomerism | 2012 |
52 other study(ies) available for 2-oxindole and isatin
| Article | Year |
|---|---|
Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition.
Topics: Azo Compounds; Combinatorial Chemistry Techniques; Heterocyclic Compounds, 2-Ring; Indoles; Isatin; Molecular Structure; Oxindoles; Pyrrolidines; Spiro Compounds; Thiosemicarbazones | 2007 |
Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Image Processing, Computer-Assisted; Indoles; Isatin; Male; Monoamine Oxidase Inhibitors; Oxindoles; Rats; Rats, Wistar | 2007 |
Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.
Topics: Alkenes; Cyclization; Indoles; Isatin; Oxepins; Oxindoles; Propanols; Pyrans; Silanes; Spiro Compounds; Stereoisomerism | 2009 |
Catalytic asymmetric synthesis of substituted 3-hydroxy-2-oxindoles.
Topics: Catalysis; Crystallography, X-Ray; Indium; Indoles; Isatin; Molecular Conformation; Oxindoles; Scandium; Stereoisomerism | 2010 |
Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.
Topics: Boronic Acids; Catalysis; Copper; Crystallography, X-Ray; Indoles; Isatin; Ligands; Methane; Molecular Conformation; Oxindoles; Stereoisomerism | 2010 |
Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: facile creation of 3-hydroxy-2-oxindoles.
Topics: Acrylates; Catalysis; Hydroxylation; Indoles; Isatin; Molecular Structure; Oxindoles; Stereoisomerism | 2011 |
Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Dose-Response Relationship, Drug; Fungi; Indoles; Isatin; Microbial Sensitivity Tests; Molecular Structure; Oxindoles; Structure-Activity Relationship | 2012 |
Syntheses of spirocyclic oxindole-butenolides by using three-component cycloadditions of isocyanides, allenoates, and isatins.
Topics: 4-Butyrolactone; Cyanides; Cyclization; Indoles; Isatin; Molecular Structure; Naphthalenes; Oxindoles; Spiro Compounds; Stereoisomerism | 2011 |
Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design.
Topics: Alkylation; Catalytic Domain; Crystallography; Dioxoles; Drug Design; HIV Infections; HIV Integrase Inhibitors; HIV-1; Indoles; Isatin; Ligands; Magnetic Resonance Spectroscopy; Protein Binding; Structure-Activity Relationship; Surface Plasmon Resonance | 2011 |
Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones.
Topics: Animals; Anti-Infective Agents; Anticonvulsants; Candida albicans; Catalysis; Cells, Cultured; Copper; Escherichia coli; Indoles; Isatin; Mice; Molecular Structure; Phenytoin; Staphylococcus aureus | 2011 |
Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin.
Topics: Crystallography, X-Ray; Cyanides; Hydantoins; Imines; Indoles; Isatin; Molecular Structure; Nitriles; Oxindoles; Peptidomimetics; Spiro Compounds; Stereoisomerism; Trimethylsilyl Compounds | 2011 |
Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.
Topics: Alkenes; Amino Acids; Chemistry, Organic; Crystallography, X-Ray; Cyclization; Indoles; Isatin; Magnetic Resonance Spectroscopy; Oxindoles; Pyrrolidines; Spiro Compounds; Stereoisomerism | 2012 |
Catalytic stereoselective synthesis of diverse oxindoles and spirooxindoles from isatins.
Topics: Alkynes; Azides; Catalysis; Combinatorial Chemistry Techniques; Copper; Cyclization; Indoles; Isatin; Molecular Structure; Oxindoles; Spiro Compounds; Stereoisomerism | 2012 |
Synthesis of N-alkoxycarbonyl ketimines derived from isatins and their application in enantioselective synthesis of 3-aminooxindoles.
Topics: Catalysis; Imines; Indoles; Isatin; Molecular Structure; Nitriles; Oxindoles; Stereoisomerism | 2012 |
InCl3-mediated addition of indole to isatogens: an expeditious synthesis of 13-deoxy-isatisine A.
Topics: Catalysis; Indium; Indole Alkaloids; Indoles; Isatin; Molecular Structure | 2012 |
Me-BIPAM for the synthesis of optically active 3-aryl-3-hydroxy-2-oxindoles by ruthenium-catalyzed addition of arylboronic acids to isatins.
Topics: Boronic Acids; Catalysis; Indoles; Isatin; Organophosphorus Compounds; Oxindoles; Ruthenium; Stereoisomerism | 2012 |
Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins.
Topics: Catalysis; Indoles; Isatin; Keto Acids; Molecular Structure; Oxindoles; Stereoisomerism; Thiourea | 2012 |
Asymmetric allylic alkylation of isatin-derived Morita-Baylis-Hillman carbonates with nitroalkanes.
Topics: Alkanes; Alkylation; Carbonates; Catalysis; Hydroxyquinolines; Indoles; Isatin; Molecular Structure; Nitro Compounds; Oxindoles; Quinuclidines; Stereoisomerism | 2012 |
Yb(NTf2)3-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes to construct novel spiro[tetrahydro-1,2-oxazine]oxindoles.
Topics: Catalysis; Cyclization; Cycloaddition Reaction; Cyclopropanes; Indoles; Isatin; Lewis Acids; Models, Molecular; Nitrogen Oxides; Oxazines; Oxindoles; Spiro Compounds; Stereoisomerism; Ytterbium | 2012 |
Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3'-bioxindoles.
Topics: Acetamides; Azo Compounds; Catalysis; Crystallography, X-Ray; Indoles; Isatin; Models, Molecular; Oxindoles; Rhodium; Stereoisomerism | 2012 |
Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes.
Topics: Aldehydes; Alkenes; Catalysis; Cyclization; Cyclohexanes; Indoles; Isatin; Models, Molecular; Oxindoles; Spiro Compounds; Stereoisomerism | 2012 |
Highly enantioselective addition of enals to isatin-derived ketimines catalyzed by N-heterocyclic carbenes: synthesis of spirocyclic γ-lactams.
Topics: Aldehydes; Catalysis; Imines; Indoles; Isatin; Lactams; Methane; Molecular Structure; Nitriles; Oxindoles; Spiro Compounds; Stereoisomerism | 2012 |
N-Heterocyclic-carbene-catalyzed reaction of α-bromo-α,β-unsaturated aldehyde or α,β-dibromoaldehyde with isatins: an efficient synthesis of spirocyclic oxindole-dihydropyranones.
Topics: Aldehydes; Catalysis; Chemistry Techniques, Synthetic; Halogenation; Indoles; Isatin; Methane; Oxindoles; Spiro Compounds | 2013 |
Unprecedented one-pot, domino tertiary alcohol protection-Michael type addition of halides to Morita-Baylis-Hillman adduct of isatin with RCOX/K2CO3: diastereoselective synthesis of oxindole appended β-halo esters.
Topics: Catalysis; Esters; Hydrocarbons, Halogenated; Hydrochloric Acid; Indoles; Isatin; Molecular Structure; Oxindoles; Stereoisomerism | 2013 |
Catalytic enantioselective formal hetero-Diels-Alder reactions of enones with isatins to give spirooxindole tetrahydropyranones.
Topics: Amines; Catalysis; Cycloaddition Reaction; Indoles; Isatin; Ketones; Molecular Structure; Oxindoles; Pyrones; Spiro Compounds; Stereoisomerism | 2013 |
Dual organocatalytic activation of isatins and formaldehyde tert-butyl hydrazone: asymmetric synthesis of functionalized 3-hydroxy-2-oxindoles.
Topics: Catalysis; Crystallography, X-Ray; Formaldehyde; Hydrazones; Hydrogen Bonding; Indoles; Isatin; Molecular Conformation; Naphthalenes; Oxindoles; Stereoisomerism | 2013 |
Construction of spiro-fused 2-oxindole/α-methylene- γ-butyrolactone systems with extremely high enantioselectivity via indium-catalyzed amide allylation of N-methyl isatin.
Topics: 4-Butyrolactone; Amides; Catalysis; Indium; Indoles; Isatin; Molecular Structure; Organometallic Compounds; Oxindoles; Spiro Compounds; Stereoisomerism | 2013 |
Facile creation of 3-substituted-3-hydroxy-2-oxindoles by arginine-catalyzed aldol reactions of α,β-unsaturated ketones with isatins.
Topics: Arginine; Catalysis; Crystallography, X-Ray; Indoles; Isatin; Ketones; Molecular Structure; Oxindoles | 2013 |
Production of indirubin from tryptophan by recombinant Escherichia coli containing naphthalene dioxygenase genes from Comamonas sp. MQ.
Topics: Bacterial Proteins; Comamonas; Dioxygenases; Enzyme Induction; Escherichia coli; Factor Analysis, Statistical; Gene Expression; Indoles; Isatin; Isopropyl Thiogalactoside; Multienzyme Complexes; Oxindoles; Recombinant Proteins; Tryptophan | 2014 |
NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones.
Topics: Aldehydes; Catalysis; Heterocyclic Compounds; Indoles; Isatin; Methane; Molecular Structure; Oxidation-Reduction; Oxindoles; Pyrones; Spiro Compounds | 2014 |
(DHQ)2AQN-catalyzed asymmetric substitution of isatin-derived hydrazones with O-Boc-protected Morita-Baylis-Hillman adducts: A strategy for synthesizing enantioenriched azo compounds incorporating an oxindole scaffold.
Topics: Anthraquinones; Azo Compounds; Catalysis; Ethers; Hydrazones; Indoles; Isatin; Molecular Structure; Oxindoles; Stereoisomerism | 2014 |
Organocatalytic enantioselective and (Z)-selective allylation of 3-indolylmethanol via hydrogen-bond activation.
Topics: Aldehydes; Catalysis; Hydrogen; Hydrogen Bonding; Indoles; Isatin; Oxindoles; Stereoisomerism; Styrenes | 2014 |
Direct enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole-dihydropyranones.
Topics: Aldehydes; Amides; Catalysis; Cyclization; Indoles; Isatin; Oxindoles; Pyrans; Pyrazoles; Spiro Compounds; Stereoisomerism | 2014 |
Catalytic enantioselective amide allylation of isatins and its application in the synthesis of 2-oxindole derivatives spiro-fused to the α-methylene-γ-butyrolactone functionality.
Topics: 4-Butyrolactone; Amides; Catalysis; Indoles; Isatin; Models, Molecular; Molecular Structure; Oxindoles; Spiro Compounds; Stereoisomerism | 2014 |
Oxidative ring expansion of spirocyclic oxindole derivatives.
Topics: Crystallography, X-Ray; Indoles; Isatin; Molecular Structure; ortho-Aminobenzoates; Oxidation-Reduction; Oxindoles; Quinazolines; Quinazolinones; Spiro Compounds | 2014 |
An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp(3))-H oxidation and intramolecular C-N bond formation of 2'-aminoacetophenones.
Topics: Acetophenones; Catalysis; Indoles; Iodine; Isatin; Oxidation-Reduction; Oxindoles | 2014 |
Diastereoselective synthesis of functionalized spirocyclopropyl oxindoles via P(NMe2)3-mediated reductive cyclopropanation.
Topics: Alkenes; Cyclopropanes; Electrons; Indoles; Isatin; Molecular Structure; Oxindoles; Stereoisomerism | 2014 |
Organocatalytic enantioselective 1,3-dipolar cycloadditions between Seyferth-Gilbert reagent and isatylidene malononitriles: synthesis of chiral spiro-phosphonylpyrazoline-oxindoles.
Topics: Cinchona Alkaloids; Cycloaddition Reaction; Indicators and Reagents; Indoles; Isatin; Molecular Structure; Nitriles; Oxindoles; Spiro Compounds; Stereoisomerism | 2015 |
Substrate-controlled product-selectivity in the reaction of the Bestmann-Ohira reagent with N-unprotected isatin-derived olefins.
Topics: Alkenes; Cyclization; Indoles; Isatin; Molecular Structure; Organophosphonates; Oxindoles; Pyrazoles; Stereoisomerism | 2015 |
Synthesis of Bis-pyrrolizidine-Fused Dispiro-oxindole Analogues of Curcumin via One-Pot Azomethine Ylide Cycloaddition: Experimental and Computational Approach toward Regio- and Diastereoselection.
Topics: Azo Compounds; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Curcumin; Cycloaddition Reaction; Indoles; Isatin; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxindoles; Pyrrolizidine Alkaloids; Stereoisomerism; Thiosemicarbazones | 2015 |
[4 + 3] Cycloadditions with Bromo-Substituted Morita-Baylis-Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides.
Topics: Amides; Catalysis; Cycloaddition Reaction; Heterocyclic Compounds, 4 or More Rings; Hydrocarbons, Chlorinated; Indoles; Isatin; Lewis Bases; Molecular Structure; Oxindoles; Spiro Compounds | 2015 |
Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatin-Derived Ketimines.
Topics: Boronic Acids; Catalysis; Imines; Indoles; Isatin; Molecular Structure; Nitriles; Oxindoles; Palladium; Stereoisomerism | 2016 |
Synthesis of Chiral Spiro-Aziridine Oxindoles via Aza-Corey-Chaykovsky Reaction of Isatin Derived N-tert-Butanesulfinyl Ketimines.
Topics: Aziridines; Catalysis; Imines; Indoles; Isatin; Molecular Structure; Nitriles; Oxindoles; Stereoisomerism | 2016 |
Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine.
Topics: Betaine; Catalysis; Chemistry Techniques, Synthetic; Indoles; Oxindoles | 2016 |
Catalyst-free synthesis of α
Topics: Aldehydes; Catalysis; Indoles; Isatin; Organophosphonates; Oxindoles; Phosphines; Thiourea | 2016 |
Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water.
Topics: Free Radicals; Indoles; Isatin; Molecular Structure; Nitrites; Oximes; Oxindoles; Water | 2017 |
Synthesis of Spirooxindoles via the tert-Amino Effect.
Topics: Amines; Catalysis; Cyclization; Imines; Isatin; Isomerism; Molecular Structure; Oxindoles; Solvents; Spiro Compounds; Stereoisomerism | 2017 |
Thermal Hetero-Diels-Alder Reaction of Benzocyclobutenones with Isatins To Form 2-Oxindole Spirolactones.
Topics: Cycloaddition Reaction; Isatin; Oxindoles; Polycyclic Compounds; Quantum Theory; Spironolactone; Temperature | 2017 |
Kinetic Resolution of Aziridines Enabled by N-Heterocyclic Carbene/Copper Cooperative Catalysis: Carbene Dose-Controlled Chemo-Switchability.
Topics: Aziridines; Catalysis; Copper; Cycloaddition Reaction; Heterocyclic Compounds; Isatin; Kinetics; Methane; Oxindoles; Spiro Compounds; Stereoisomerism | 2021 |
Bismuth(iii)-catalyzed regioselective alkylation of tetrahydroquinolines and indolines towards the synthesis of bioactive core-biaryl oxindoles and CYP19 inhibitors.
Topics: Alkylation; Aromatase; Aromatase Inhibitors; Bismuth; Catalysis; Chemistry Techniques, Synthetic; Hydroquinones; Isatin; Oxindoles; Stereoisomerism | 2021 |
Efficient One-pot Synthesis of 3,3-di(indolyl)indolin-2-ones from Isatin and Indole Catalyzed by VOSO
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalysis; Humans; Indoles; Isatin; Molecular Structure; Oxindoles; Protein Isoforms; Structure-Activity Relationship | 2022 |
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Isatin; Molecular Docking Simulation; Structure-Activity Relationship | 2022 |