2-nitro-4-phenylenediamine and 2-5-diaminotoluene

2-nitro-4-phenylenediamine has been researched along with 2-5-diaminotoluene* in 2 studies

Other Studies

2 other study(ies) available for 2-nitro-4-phenylenediamine and 2-5-diaminotoluene

Article	Year
Hair dye-sensitized hairdressers: the cross-reaction pattern with new generation hair dyes. Contact dermatitis, 2002, Volume: 46, Issue:6 Hair dye allergies are a frequent cause of occupational skin disease among hairdressers. Conventional hair dyes contain 4-phenylenediamine (PPD), 2, 5-diaminotoluene sulfate (DTS) and 2-nitro-4-phenylenediamine (ONPPD) as allergens. In new generation hair dyes, FD & C and D & C dyes are used in the hair dye formulations. This study investigated the cross-reaction pattern of new generation hair dyes among hairdressers (n = 40) with a known allergy to PPD and/or DTS and/or ONPPD. In the 40 hairdressers no positive reactions were observed to the single FD & C and D & C dyes. In two hairdressers, doubtful reactions were observed to one or more of the hair dye formulations. The data from this study suggest that for hairdressers sensitized to PPD and/or DTS and/or ONPPD this new generation of hair dyes is a safe alternative for use in their salons. Topics: Allergens; Case-Control Studies; Cross Reactions; Dermatitis, Allergic Contact; Dermatitis, Occupational; Hair Dyes; Hand Dermatoses; Humans; Patch Tests; Phenylenediamines	2002
Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives. Toxicology letters, 1995, Volume: 81, Issue:1 The mutagenicity of p-phenylenediamine and its derivatives was tested using Ames Salmonella strains TA98 and TA100. p-Phenylenediamine was weakly mutagenic to TA98 with metabolic activation. 2-Nitro-p-phenylenediamine was directly mutagenic to both strains, while 2-methyl-p-phenylenediamine required S9 mix. All the test compounds induced a dose-related increase in chromosomal aberrations in Chinese hamster ovary (CHO) cells in the absence of the S9 mix. The mutagenicity and toxicity of these compounds did not correlate with their oxidation potentials, or any other tested physicochemical properties including the energy difference between the lowest unoccupied and the highest occupied molecular orbital, ionization potential, and dipole moment. Topics: Animals; Biotransformation; Carcinogens; CHO Cells; Chromosome Aberrations; Coloring Agents; Cricetinae; Dose-Response Relationship, Drug; Mutagenicity Tests; Phenylenediamines; Salmonella typhimurium; Structure-Activity Relationship	1995

Article

Year

Hair dye-sensitized hairdressers: the cross-reaction pattern with new generation hair dyes.

Contact dermatitis, 2002, Volume: 46, Issue:6

Hair dye allergies are a frequent cause of occupational skin disease among hairdressers. Conventional hair dyes contain 4-phenylenediamine (PPD), 2, 5-diaminotoluene sulfate (DTS) and 2-nitro-4-phenylenediamine (ONPPD) as allergens. In new generation hair dyes, FD & C and D & C dyes are used in the hair dye formulations. This study investigated the cross-reaction pattern of new generation hair dyes among hairdressers (n = 40) with a known allergy to PPD and/or DTS and/or ONPPD. In the 40 hairdressers no positive reactions were observed to the single FD & C and D & C dyes. In two hairdressers, doubtful reactions were observed to one or more of the hair dye formulations. The data from this study suggest that for hairdressers sensitized to PPD and/or DTS and/or ONPPD this new generation of hair dyes is a safe alternative for use in their salons.

Topics: Allergens; Case-Control Studies; Cross Reactions; Dermatitis, Allergic Contact; Dermatitis, Occupational; Hair Dyes; Hand Dermatoses; Humans; Patch Tests; Phenylenediamines

2002

Mutagenicity and toxicity studies of p-phenylenediamine and its derivatives.

Toxicology letters, 1995, Volume: 81, Issue:1

The mutagenicity of p-phenylenediamine and its derivatives was tested using Ames Salmonella strains TA98 and TA100. p-Phenylenediamine was weakly mutagenic to TA98 with metabolic activation. 2-Nitro-p-phenylenediamine was directly mutagenic to both strains, while 2-methyl-p-phenylenediamine required S9 mix. All the test compounds induced a dose-related increase in chromosomal aberrations in Chinese hamster ovary (CHO) cells in the absence of the S9 mix. The mutagenicity and toxicity of these compounds did not correlate with their oxidation potentials, or any other tested physicochemical properties including the energy difference between the lowest unoccupied and the highest occupied molecular orbital, ionization potential, and dipole moment.

Topics: Animals; Biotransformation; Carcinogens; CHO Cells; Chromosome Aberrations; Coloring Agents; Cricetinae; Dose-Response Relationship, Drug; Mutagenicity Tests; Phenylenediamines; Salmonella typhimurium; Structure-Activity Relationship

1995