2-naphthol has been researched along with sirtinol in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 28 (19.86) | 29.6817 |
| 2010's | 105 (74.47) | 24.3611 |
| 2020's | 8 (5.67) | 2.80 |
| Authors | Studies |
|---|---|
| Blackwell, HE; Chao, ED; Grozinger, CM; Moazed, D; Schreiber, SL | 1 |
| Blackwell, HE; Chory, J; Dai, X; Schreiber, SL; Zhao, Y | 1 |
| Cheng, Y; Dai, X; Zhao, Y | 1 |
| Kepinski, S; Leyser, O | 1 |
| Araki, T; Milbrandt, J; Sasaki, Y | 1 |
| Alcendor, RR; Imai, S; Kirshenbaum, LA; Sadoshima, J; Vatner, SF | 1 |
| Cheng, Y; Dai, X; Hayashi, K; Nozaki, H; Zhao, Y | 1 |
| Ouaissi, A; Sereno, D; Vanhille, L; Vergnes, B | 1 |
| Akishita, M; Chang, K; Eto, M; Hikasa, M; Iijima, K; Kaneki, M; Kozaki, K; Ota, H; Ouchi, Y; Tokunaga, E | 1 |
| Camilloni, G; Chiani, F; Lavu, S; Mai, A; Mariotti, FR; Massa, S; Pezzi, R; Ragno, R; Simeoni, S; Sinclair, DA | 1 |
| Bauter, M; Kode, A; Rahman, I; Seweryniak, K; Wright, J; Yang, SR | 1 |
| Kaschani, F; van der Hoorn, R | 1 |
| Binda, O; Branton, PE; Nassif, C | 1 |
| Bernard, J; Cabral, S; da Silva, AC; Lombardo, D; Mas, E; Mathieu Daude, F; Ouaissi, A; Ouaïssi, M; Sastre, B; Tavares, J | 1 |
| Abu-Baker, A; Brais, B; Catoire, H; Holbert, S; Néri, C; Parker, JA; Pasco, MY; Rouleau, GA; Tourette, C | 1 |
| Day, YJ; Lau, YT; Liou, JT; Liu, FC; Yu, HP | 1 |
| Akishita, M; Eto, M; Iijima, K; Kano, MR; Ogawa, S; Ota, H; Ouchi, Y | 1 |
| Akao, Y; Deguchi, T; Fujita, Y; Hamada, N; Ito, M; Kojima, K; Nozawa, Y; Ohhashi, R | 1 |
| Chong, ZZ; Maiese, K | 1 |
| Hatanaka, T; Ichikawa, S; Kahyo, T; Setou, M; Yamada, MK | 1 |
| Ahmad, N; Jung-Hynes, B; Nihal, M; Zhong, W | 1 |
| He, QY; Li, DD; Li, Y; Xu, R; Zhang, XM | 1 |
| Ajmo, JM; Le, L; Liang, X; Murr, MM; Peng, Y; Rogers, CQ; Shen, Z; You, M | 1 |
| Bao, YC; Dave, KR; DeFazio, RA; Della-Morte, D; Perez-Pinzon, MA; Raval, AP | 1 |
| Chang, YW; Day, YJ; Liao, CH; Liou, JT; Liu, FC | 1 |
| Day, YJ; Liao, CH; Liou, JT; Liu, FC; Mao, CC; Yu, HP | 1 |
| Fujioka, H; Fujita, N; Hayashi, S; Ishida, K; Kubo, S; Kuroda, R; Kurosaka, M; Matsumoto, T; Matsushita, T; Sasaki, K; Takayama, K; Tei, K | 1 |
| Chae, HJ; Choe, YH; Han, MK; Kim, SR; Lee, KS; Lee, YC; Min, KH; Moon, H; Park, SJ; Yoo, WH | 1 |
| Davidson, NE; Gu, Y; Li, H; Yao, Y; Zhou, Q | 1 |
| Altucci, L; Farina, F; Mai, A; Néri, C; Pasco, MY; Rotili, D; Rouleau, GA | 1 |
| Ratovitski, EA; Vorovich, E | 1 |
| Chong, ZZ; Hou, J; Maiese, K; Shang, YC | 1 |
| Chen, CY; Coombes, RC; Di Fruscia, P; Fuchter, MJ; Ho, KK; Hsiao, CD; Lam, EW; Myatt, SS; Peck, B | 1 |
| Black, JC; Boss, O; Dyson, NJ; Elson, SL; Hart, AC; Hirsch, ML; Israelian, K; Ji, JY; Jiang, K; Kadyk, LC; Li, X; Mostoslavsky, R; Mulligan, P; Näär, AM; Najafi-Shoushtari, H; Puigserver, P; Purushotham, A; Ribich, S; Rodgers, JT; Shioda, T; Smith, JJ; Thakur, JK; Walker, AK; Watts, JL; Westphal, CH; Whetstine, JR; Yang, F | 1 |
| Nakayama, H; Nishizaki, T; Yaguchi, T; Yoshiya, S | 1 |
| Badiger, J; Kalle, AM; Mallika, A; Talukdar, P | 1 |
| Ancrenaz, V; Camins, A; Folch, J; Junyent, F; Pallàs, M; Pizarro, JG; Sureda, F; Verdaguer, E | 1 |
| Akhmedov, A; Breitenstein, A; Camici, GG; Elliott, PJ; Holy, EW; Lohmann, C; Lüscher, TF; Matter, CM; Spescha, R; Stein, S; Tanner, FC; Westphal, CH | 1 |
| Boit, KD; Diéguez, C; Dopeso-Reyes, IG; López, M; Martínez, G; Nogueiras, R; Romero, A; Vázquez, MJ; Velásquez, DA; Vidal, A | 1 |
| Asaka, M; Hashimoto-Komatsu, A; Hirase, T; Node, K | 1 |
| Donato, AJ; Durrant, JR; Lawson, BR; Lesniewski, LA; Magerko, KA; Seals, DR | 1 |
| Albanesi, C; Avitabile, S; Camilloni, G; Cesarini, E; Di Felice, F; Failla, CM; Mai, A; Mauro, ML; Orecchia, A; Scarponi, C; Sirri, V; Zambruno, G | 1 |
| Chaudry, IH; Jian, B; Raju, R; Yang, S | 1 |
| Chiu, PT; Hsiao, G; Hsu, MJ; Hsu, YF; Huang, YH; Kuo, WH; Lin, CH; Ou, G; Sheu, JR; Yang, DS | 1 |
| Aikawa, A; Arima, N; Fujimoto, T; Honda, S; Kozako, T; Shimeno, H; Shirasawa, S; Shoji, T; Soeda, S; Tanaka, H; Yoshimitsu, M | 1 |
| Kang, YG; Kim, EC; Kim, SJ; Lee, SI; Lee, YM; Park, KH | 1 |
| Candinas, D; Furer, C; Keogh, A; Laemmle, A; Lechleiter, A; Portmann, S; Roh, V; Schwarz, C; Stroka, D; Tschan, MP; Vorburger, SA | 1 |
| Kim, EK; Kim, YS; Schoene, NW; Wang, TT | 1 |
| Cho, SG; Choi, BJ; Chun, YH; Kim, EC; Kim, YS; Ko, SH; Lim, HD; Yoon, IJ | 1 |
| Andriulli, A; Benegiamo, G; Mazzoccoli, G; Pazienza, V; Piepoli, A; Vinciguerra, M | 1 |
| Madsen, AS; Olsen, CA | 1 |
| Bang, JB; Jung, YM; Kim, EC; Kim, YS; Lee, SI; Lee, YM; Park, YD | 1 |
| Ahn, MY; Choi, WS; Jung, JH; Kim, HS; Kim, TH; Lee, BM; Lee, J; Wang, J; Yoon, KS; Yoon, S | 1 |
| Hou, Q; Meng, AM; Shi, J | 1 |
| Cheong, SA; Hyun, SH; Jeon, Y; Kwak, SS; Yoon, JD | 1 |
| Kanasaki, K; Kitada, M; Koya, D; Takeda-Watanabe, A | 1 |
| Cai, AL; Li, L; Sheline, CT; Sheline, PJ; Shi, C; Takata, T; Zhang, W; Zhu, J | 1 |
| Bhattacharya, S; Chaum, E; Johnson, DA; Johnson, LR | 1 |
| Faller, DV; Moore, RL | 1 |
| Kim, EJ; Lee, SH; Um, SJ | 2 |
| Ciarlo, E; dos Santos, I; Grandmaison, G; Le Roy, D; Lugrin, J; Roger, T; Santos, A | 1 |
| Liu, FC; Tsai, YF; Yu, HP | 1 |
| Ballesteros, I; Camarero, G; Cuartero, MI; Hernández-Jiménez, M; Hurtado, O; Lizasoain, I; Moraga, A; Moro, MA; Pradillo, JM; Zarruk, JG | 1 |
| Ji, M; Li, Y; Lin, Q; Lin, R; Ren, F; Wang, W; Zhang, J | 1 |
| Chen, DR; Chien, SY; Kuo, SJ; Lin, HY | 1 |
| Gong, DJ; Guo, QQ; Yu, M; Zhang, JM; Zhuang, B | 1 |
| Kim, SH; Kim, YJ; Park, JH; Park, KH | 1 |
| Bahl, A; Biernacka, KM; Gillatt, D; Holly, JM; Perks, CM; Persad, RA; Uzoh, CC; Zeng, L | 1 |
| Pal, S; Sainis, KB; Shankar, BS | 1 |
| Bai, L; Ji, M; Lin, R; Lu, Y; Qiao, H; Ren, F; Wang, W; Yang, L; Zhang, J | 1 |
| Fujii, T; Kawana, K; Koga, K; Kozuma, S; Osuga, Y; Shirane, A; Taguchi, A; Urata, Y; Wada-Hiraike, O; Yamashita, A | 1 |
| Das, A; Kukreja, RC; Salloum, FN; Shalwala, M; Xi, L; Zhu, SG | 1 |
| Li, T; Li, W; Shi, JX; Sun, Q; Wang, CX; Zhang, X; Zhang, XS; Zhou, ML; Zhou, XM; Zhu, L; Zhuang, Z | 1 |
| Gao, SJ; He, M; Li, Q; Ye, F; Zhou, F | 1 |
| Avogaro, A; Cattelan, A; Ceolotto, G; De Kreutzenberg, SV; Fabricio, AS; Fadini, GP; Gion, M; Semplicini, A; Squarcina, E | 1 |
| Gong, R; Ponnusamy, M; Tang, J; Tolbert, E; Yan, Y; Zhao, TC; Zhou, X; Zhuang, S | 1 |
| Hong, KW; Kim, CD; Kim, HY; Lee, HR; Lee, WS; Park, SY; Rhim, BY; Shin, HK | 1 |
| Hu, J; Jing, H; Lin, H | 1 |
| Chang, YZ; Chen, MY; Hu, ML; Song, TY; Yang, NC | 1 |
| Chiu, CC; Chou, HL; Fong, Y; Lin, LL; Lin, YC; Teng, YN; Wang, HM; Wu, CY; Yuan, SS | 1 |
| Altucci, L; Antonietta, C; Botti, C; Caiafa, I; Chiara, B; Cobellis, G; Coppola, A; Cuomo, F; Francesca, C; Gilda, C; Ilaria, C; Lucia, A; Marco, M; Miceli, M | 1 |
| Hong, SC; Kang, SK; Kim, EC; Kim, YS; Lee, SY; Shin, MR | 1 |
| Ahmad, N; Ndiaye, MA; Nihal, M; Singh, CK; Wilking, MJ | 1 |
| El-Maraghy, SA; Nassar, NN; Rizk, SM | 1 |
| Chang, WY; Huang, ZC; Hwang, TL; Liu, FC; Tsai, YF; Yu, HP | 1 |
| Akam, EA; Astashkin, AV; Gautam, R; Loughrey, JJ; Tomat, E | 1 |
| Jaggi, AS; Kaur, H; Kumar, A; Singh, N | 1 |
| Chen, S; Chen, X; Cui, W; Gong, Y; He, F; Liu, T; Luo, ZP; Pan, G; Pei, M; Yang, H; Zhou, L | 1 |
| Ding, X; Hu, J; Ma, R; Xu, Y; Zhang, L | 1 |
| Abonante, S; Avino, S; Cirillo, F; De Francesco, EM; De Marco, P; Lappano, R; Maggiolini, M; Pellegrino, M; Rigiracciolo, DC; Santolla, MF; Scarpelli, A; Vivacqua, A | 1 |
| Hales, BF; Paradis, FH | 1 |
| Chen, W; Dong, X; Duan, W; Jin, Z; Liang, H; Liu, J; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, L; Yu, S; Zhai, M; Zhao, G | 1 |
| Li, P; Lin, N; Liu, A; Zhang, L; Zhou, C | 1 |
| Haga, Y; Kanda, T; Nakamoto, S; Nakamura, M; Okamoto, H; Sasaki, R; Shirasawa, H; Yokosuka, O | 1 |
| Potteti, HR; Rajamohan, SB; Rajasekaran, S; Reddy, NM; Reddy, SP; Tamatam, CR | 1 |
| González-Dávalos, L; Mora, O; Piña, E; Ramírez-Espinosa, JJ; Shimada, A; Varela-Echavarria, A | 1 |
| Ding, X; Leng, SX; Li, H; Mao, G; Meng, X; Wang, G | 1 |
| Chen, M; Duan, W; Jin, Z; Li, Q; Liu, L; Yang, Y; Yi, D; Yu, B; Yu, L; Yu, S; Zhai, M; Zhao, G | 1 |
| Collin de l'Hortet, A; Deng, CX; Guzman-Lepe, J; Meng, F; Nakao, T; Soto-Gutierrez, A; Takeishi, K; Tobita, T; Wang, Y | 1 |
| Fan, C; Feng, J; Feng, X; Hu, W; Jiang, S; Jin, Z; Li, T; Liu, J; Ma, Z; Wang, B; Xiong, H; Xu, J; Yang, Y; Zhou, Y | 1 |
| Abe-Higuchi, N; Hara, K; Higuchi, F; Hobara, T; Kobayashi, A; Uchida, S; Watanabe, Y; Yamagata, H | 1 |
| Deng, L; Dun, Y; Liu, C; Liu, J; Wan, J; Wang, T; Yuan, D; Yuan, Q; Zhang, C; Zhao, H; Zhou, Z | 1 |
| Li, YJ; Wang, YH; Zheng, GX | 1 |
| Chen, G; Jia, N; Su, Q; Sun, Q | 1 |
| Fekri, A; Hashemi, T; Namvar Aghdash, S; Safari, F; Shekarforoosh, S | 1 |
| Hang, CH; Jiang, TW; Li, W; Wu, LY; Wu, Q; Ye, ZN; Zhang, X; Zhang, XS; Zhou, ML; Zhuang, Z | 1 |
| Lu, H; Wang, B | 1 |
| Gu, ZT; Li, F; Li, L; Maegele, M; Yang, H; Zhao, KS; Zhao, M; Zhou, BY | 1 |
| Campo, VA | 1 |
| Dorfman, RG; Huang, S; Liu, J; Pan, Y; Yin, Y; Zhang, M; Zhao, S; Zhou, Q | 1 |
| Gautam, V; Sarkar, AK; Singh, A; Singh, S; Yadav, S | 1 |
| Chen, H; Feng, Z; Tao, Z; Wang, Q; Wu, Y; You, S; Zhang, H; Zheng, W | 1 |
| He, YH; Jing, T; Li, TT; Li, YX; Lin, R; Wang, WR; Yang, XF; Zhang, JY; Zhang, W | 1 |
| Chen, H; He, X; Li, X; Liu, J; Tian, Q; Wang, R; Zhen, P; Zhou, S | 1 |
| Costanzo, V; Geisler, NJ; Herzog, M; Jackson, SP; Puddu, F; Salguero, I | 1 |
| Jin, SJ; Kim, DH; Kim, MG; Lee, HR; Lee, HT; Lee, JS | 1 |
| Duhamel, LA; Eskandarpour, M; Flanagan, AM; Presneau, N; Tirabosco, R; Ye, H | 1 |
| Jiang, ZS; Li, X; Liang, XY; Tang, XQ; Tang, YY; Wang, CY; Wei, HJ; Zhang, P; Zou, W | 1 |
| Ao, X; Deng, S; Li, H; Peng, W; Xiang, J; Xiao, Z; Zhang, Y; Zhou, Q | 1 |
| Buccella, D; Gautam, R; Klyubka, Y; Rooker, DR; Tomat, E | 1 |
| Li, G; Liu, X; Wang, Y; Zou, P | 1 |
| Amler, E; Amodio, N; Caraglia, M; Di Martino, MT; Grimaldi, A; Misso, G; Russo, M; Tagliaferri, P; Tassone, P; Zappavigna, S; Zarone, MR | 1 |
| Cao, Z; Gong, K; Jiang, T; Li, Y; Pan, X; Qu, B; Yang, H; Zeng, Z | 1 |
| Choi, B; Jang, BG; Kim, MJ; Kim, S; Lee, JY | 1 |
| Cao, S; Chen, G; Chen, T; Fan, L; He, P; Li, J; Li, Q; Peng, Y; Ruan, W; Xu, H | 1 |
| Chen, YQ; Di, SY; Fan, CX; Feng, JY; Feng, X; Ha, XQ; Han, JS; Ma, ZQ; Wang, YC; Wei, Y; Wu, B; Yu, LM; Zhang, Y | 1 |
| Huang, G; Liu, J; Ma, W; Wang, K; Zhao, X | 1 |
| Chen, X; He, F; Luo, ZP; Pei, M; Yan, J; Yang, H; Zhong, D | 1 |
| Hatori, K; Kudo, H; Makino, K; Ogiso, B; Takeichi, O | 1 |
| Guo, S; He, Z; Li, Y; Liao, H; Liu, J; Tang, F; Yang, Q | 1 |
| Amicarelli, F; Artini, PG; Carta, G; D'Alessandro, AM; Di Emidio, G; Falone, S; Santini, SJ; Sferra, R; Tatone, C; Vetuschi, A | 1 |
| Berthelet, J; Grob, A; Jourdan, N; Roussel, P; Sirri, V | 1 |
| Bhutia, SK; Gupta, PK; Maiti, TK; Meher, BR; Mukhopadhyay, S; Naik, PP; Panda, PK; Patra, S; Praharaj, PP; Verma, RS | 1 |
| Baek, CH; Chang, JW; Kim, H; Lee, SK; Yang, WS | 1 |
| Guo, J; Li, Z; Xu, Y; Yang, Y | 1 |
| Bozok Cetintas, V; Duzgun, Z; Erdem, C; Eroglu, Z; Oktem, G | 1 |
| Jiang, H; Pai, SB; Patil, K; Strickland, E; Vashi, A; Wang, Y | 1 |
| Chen, X; Li, Y; Wang, J; Wei, G; Wu, Y; Zeng, Y; Zheng, X | 1 |
| Chung, HY; Im, E; Jang, JY; Jung, YS; Kang, YJ; Kim, ND; Kwon, YH; Lee, JH; Lee, S; Moon, HR; Park, Y | 1 |
| Aung, JM; Chung, DI; Goo, YK; Hong, Y; Joo, SY; Kong, HH; Moon, EK; Shin, M | 1 |
3 review(s) available for 2-naphthol and sirtinol
| Article | Year |
|---|---|
Small molecule approaches in plants.
Topics: Benzamides; Genetic Techniques; Gravitropism; Herbicides; Naphthols; Plant Development; Plant Diseases; Plant Growth Regulators; Plant Physiological Phenomena; Plants; Signal Transduction; Triazoles | 2007 |
[Sirtuin1 and lung disease].
Topics: Animals; Asthma; Benzamides; Humans; Lung Diseases; Lung Neoplasms; Naphthols; Protein Processing, Post-Translational; Pulmonary Disease, Chronic Obstructive; Resveratrol; Sirtuin 1; Stilbenes | 2012 |
Sirtuin inhibitors as anticancer agents.
Topics: Animals; Antineoplastic Agents; Benzamides; Enzyme Inhibitors; Humans; Naphthols; Neoplasms; Niacinamide; Protein Binding; Reactive Oxygen Species; Sirtuins | 2014 |
138 other study(ies) available for 2-naphthol and sirtinol
| Article | Year |
|---|---|
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Topics: Animals; Arabidopsis; Benzamides; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fungal Proteins; Gene Library; Genetic Techniques; Genotype; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Multigene Family; Mutagenesis; Naphthols; Phenotype; Precipitin Tests; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Structure-Activity Relationship; Trans-Activators; Transcription, Genetic | 2001 |
SIR1, an upstream component in auxin signaling identified by chemical genetics.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Benzamides; Binding Sites; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genes, Reporter; Indoleacetic Acids; Molecular Sequence Data; Mutation; Naphthols; Oligonucleotide Array Sequence Analysis; Phenotype; Plant Leaves; Plant Roots; Protein Structure, Tertiary; Signal Transduction; Sirtuins; Transcription, Genetic | 2003 |
AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Benzamides; Brassinosteroids; Cholestanols; Cloning, Molecular; Drug Resistance; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Gibberellins; Humans; Indoleacetic Acids; Mutation; Naphthols; Phenotype; Plant Growth Regulators; Repetitive Sequences, Nucleic Acid; Signal Transduction; Steroids, Heterocyclic; Transcription Factors | 2004 |
Auxin-induced SCFTIR1-Aux/IAA interaction involves stable modification of the SCFTIR1 complex.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Base Sequence; Benzamides; DNA, Plant; Indoleacetic Acids; Macromolecular Substances; Naphthols; Naphthoquinones; Plants, Genetically Modified; Protein Structure, Tertiary; Recombinant Fusion Proteins; SKP Cullin F-Box Protein Ligases | 2004 |
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
Topics: 3T3 Cells; Animals; Axons; Axotomy; Benzamides; Cell Line; Cell Nucleus; Cell Survival; Cells, Cultured; Ganglia, Spinal; Humans; Lentivirus; Mice; Mutation; NAD; Naphthols; Nerve Tissue Proteins; Neuroprotective Agents; Nicotinamide-Nucleotide Adenylyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Resveratrol; RNA, Small Interfering; Sirtuin 1; Sirtuins; Stilbenes; Ubiquitin-Protein Ligases; Vincristine; Wallerian Degeneration | 2004 |
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
Topics: Acetylation; Alkaloids; Animals; Apoptosis; Atrial Natriuretic Factor; Benzamides; Benzophenanthridines; Cell Nucleus; Cell Size; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Dogs; Gene Silencing; Genes, Dominant; Genes, p53; Heart Failure; Heart Ventricles; Hydroxamic Acids; Hypertrophy; Hypertrophy, Left Ventricular; Longevity; Mice; Myocytes, Cardiac; Naphthols; Niacinamide; Phenanthridines; Protein Processing, Post-Translational; Rats; Rats, Wistar; Recombinant Fusion Proteins; Sirtuin 1; Sirtuins; Transcription, Genetic; Tumor Suppressor Protein p53 | 2004 |
Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.
Topics: Aldehyde Oxidase; Arabidopsis; Benzamides; Cloning, Molecular; Coenzymes; Metalloproteins; Molybdenum Cofactors; Naphthols; Pteridines; Seedlings | 2005 |
Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.
Topics: Amino Acid Sequence; Animals; Apoptosis; Benzamides; DNA Fragmentation; DNA, Protozoan; Enzyme Inhibitors; Flow Cytometry; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Leishmania infantum; Leishmaniasis, Visceral; Molecular Sequence Data; Naphthols; Sequence Alignment; Sirtuins | 2005 |
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Topics: Benzamides; beta-Galactosidase; Breast Neoplasms; Cellular Senescence; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Histone Deacetylase Inhibitors; Humans; Insulin-Like Growth Factor I; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthols; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction; Sirtuin 1; Sirtuins; Tumor Cells, Cultured; Tyrosine | 2006 |
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Topics: Benzamides; Drug Design; Fungal Proteins; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Naphthols; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Stereoisomerism; Structure-Activity Relationship; Telomere | 2005 |
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
Topics: Acetylation; Aging; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Lung; Macrophages; Models, Immunological; Naphthols; Neutrophils; Nicotiana; Rats; Sirtuin 1; Sirtuins; Smoke; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2007 |
SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.
Topics: Animals; Benzamides; Brain; Histone Deacetylase 1; Histone Deacetylases; Homeodomain Proteins; Humans; Immunoprecipitation; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mice; Naphthols; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Resveratrol; Retinol-Binding Proteins, Cellular; Sin3 Histone Deacetylase and Corepressor Complex; Sirtuin 1; Sirtuins; Stilbenes; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2008 |
Histone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors.
Topics: Adenocarcinoma; Benzamides; Cell Line; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Naphthols; Pancreatic Neoplasms | 2008 |
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Animals, Genetically Modified; Benzamides; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Survival; Chlorocebus aethiops; COS Cells; Forkhead Transcription Factors; Gene Expression Regulation; Genes, Reporter; Histones; Humans; Multienzyme Complexes; Muscles; Muscular Dystrophy, Oculopharyngeal; Naphthols; Peptide Initiation Factors; Peptides; Protein Serine-Threonine Kinases; Resveratrol; RNA-Binding Proteins; Sirtuins; Stilbenes; Transcription Factors | 2008 |
Sirtinol attenuates hepatic injury and pro-inflammatory cytokine production following trauma-hemorrhage in male Sprague-Dawley rats.
Topics: Alanine Transaminase; Animals; Benzamides; Cytokines; Hemorrhage; Intercellular Adhesion Molecule-1; Liver; Male; Naphthols; Peroxidase; Rats; Rats, Sprague-Dawley; Treatment Outcome; Wounds and Injuries | 2008 |
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells.
Topics: Acetylation; Animals; Benzamides; Cell Shape; Cells, Cultured; Cellular Senescence; Cilostazol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Mice; Mice, Inbred BALB C; Naphthols; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Paraquat; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins c-akt; Sirtuin 1; Sirtuins; Tetrazoles; Time Factors; Tumor Suppressor Protein p53; Up-Regulation | 2008 |
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells.
Topics: Androgens; Antineoplastic Agents; Benzamides; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Humans; Male; Naphthols; Prostatic Neoplasms; Sirtuin 1; Sirtuins; Up-Regulation | 2008 |
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways.
Topics: Apoptosis; Benzamides; Brain Diseases, Metabolic; Cell Line, Tumor; Cytoprotection; Free Radicals; Humans; Naphthols; Neurodegenerative Diseases; Neurons; Nicotinamidase; Nitric Oxide Donors; Oxidative Stress; Phosphatidylserines; Signal Transduction; Sirtuin 1; Sirtuins | 2008 |
A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells.
Topics: Acetylation; Antineoplastic Agents; Benzamides; Cell Line; Cell Proliferation; Chalcones; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Naphthols; Sirtuin 1; Sirtuins; Transfection; Tumor Suppressor Protein p53 | 2008 |
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Topics: Adult; Aged; Benzamides; Cell Line, Tumor; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Male; Middle Aged; Naphthols; Neoplasm Proteins; Niacinamide; Prostatic Neoplasms; Sirtuin 1; Sirtuins; Vitamin B Complex | 2009 |
[Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells].
Topics: Apoptosis; Benzamides; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Naphthols; Niacinamide; Sirtuin 1 | 2008 |
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.
Topics: Acetaldehyde; Acetates; Acetylation; Adiponectin; Animals; Benzamides; Cell Line; Enzyme Inhibitors; Ethanol; Kupffer Cells; Lipopolysaccharides; Liver Diseases, Alcoholic; Macrophages; Mice; Mutation; Naphthols; Rats; Resveratrol; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Sirtuins; Stilbenes; Transcription Factor RelA; Transfection; Tumor Necrosis Factor-alpha | 2009 |
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
Topics: Adenosine Triphosphate; Animals; Asphyxia; Benzamides; Brain Ischemia; Carotid Artery Diseases; Disease Models, Animal; Heart Arrest; Hippocampus; Hypotension; Ion Channels; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Naphthols; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Respiration; Resveratrol; Signal Transduction; Sirtuin 1; Sirtuins; Stilbenes; Uncoupling Protein 2 | 2009 |
A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Triphosphate; Alprostadil; Benzamides; Blood Platelets; Blotting, Western; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Molecular Structure; Naphthols; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Time Factors | 2009 |
Hemeoxygenase-1 upregulation is critical for sirtinol-mediated attenuation of lung injury after trauma-hemorrhage in a rodent model.
Topics: Animals; Benzamides; Blotting, Western; Bronchoalveolar Lavage Fluid; Heme Oxygenase-1; Hemorrhage; Interleukin-10; Interleukin-6; Lung Diseases; Male; Naphthols; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; Sirtuins; Tumor Necrosis Factor-alpha; Up-Regulation; Wounds and Injuries | 2009 |
SIRT1 regulation of apoptosis of human chondrocytes.
Topics: Adult; Apoptosis; bcl-2-Associated X Protein; Benzamides; Case-Control Studies; Caspase 3; Caspase 9; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Humans; Male; Naphthols; Niacinamide; Nitric Oxide; Osteoarthritis, Knee; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Resveratrol; RNA, Small Interfering; Sirtuin 1; Sirtuins; Stilbenes | 2009 |
Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease.
Topics: Allergens; Animals; Asthma; Benzamides; Blotting, Western; Gene Expression; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Naphthols; Ovalbumin; Pneumonia; Respiratory Hypersensitivity; Sirtuin 1; Vascular Endothelial Growth Factor A | 2010 |
Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling.
Topics: Animals; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Estradiol; Estrogen Receptor alpha; Female; Fibroblasts; Humans; Mammary Glands, Animal; Mice; Mice, Knockout; Naphthols; Neoplasm Proteins; Niacinamide; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Specific Pathogen-Free Organisms; Transcription, Genetic | 2010 |
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Topics: Animals; Animals, Genetically Modified; Benzamides; Caenorhabditis elegans; Cell Movement; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Muscle Cells; Muscular Dystrophy, Oculopharyngeal; Naphthols; Poly(A)-Binding Protein I; Sirtuins | 2010 |
Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha.
Topics: Acetylation; Alternative Splicing; Animals; Benzamides; beta-Galactosidase; Cells, Cultured; Cellular Senescence; Chromatin Immunoprecipitation; DNA; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Keratinocytes; Leupeptins; Mice; Mice, Mutant Strains; Mice, Transgenic; Models, Genetic; Naphthols; Phosphoproteins; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA; RNA Interference; Sirtuin 1; Sp1 Transcription Factor; Telomerase; Trans-Activators; Transcription, Genetic; Tumor Suppressor Protein p53 | 2008 |
Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-Associated Death Protein; Benzamides; Blood Vessels; Brain; Carbazoles; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Forkhead Box Protein O3; Forkhead Transcription Factors; Glucose; Male; Mitochondria; Naphthols; Phosphatidylserines; Protein Transport; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Stilbenes; Subcellular Fractions | 2010 |
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
Topics: Acetylation; Benzamides; Carbazoles; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; G1 Phase; Gene Silencing; Humans; Lysine; Models, Molecular; Naphthols; Paclitaxel; Phenylpropionates; Protein Structure, Secondary; Sirtuin 1; Sirtuin 2; Tubulin; Tumor Suppressor Protein p53 | 2010 |
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Topics: Acetylation; Animals; Benzamides; Caenorhabditis elegans; Cell Line; Cholesterol; Down-Regulation; Fasting; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Lipids; Mice; Naphthols; Niacinamide; Protein Stability; Sirtuin 1; Sirtuins; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2 | 2010 |
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Rheumatoid; bcl-X Protein; Benzamides; Caspase 3; Caspase 9; Cell Line; Cytochromes c; Humans; Mitochondria; Naphthols; Resveratrol; Sirtuin 1; Stilbenes; Synovial Membrane; Up-Regulation | 2012 |
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells.
Topics: Apoptosis; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Design; Female; Histone Deacetylase Inhibitors; Humans; Naphthols; Sirtuin 1; Thiophenes | 2010 |
Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Humans; Naphthols; Neuroblastoma; NF-kappa B; Niacinamide; Proto-Oncogene Proteins c-akt; Resveratrol; Sirtuin 1; Stilbenes; Tumor Suppressor Protein p53; Vitamin B Complex | 2011 |
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.
Topics: Animals; Benzamides; Binding Sites; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activators; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Naphthalenes; Naphthols; Promoter Regions, Genetic; Pyrones; Resveratrol; RNA Interference; RNA, Messenger; Sirtuin 1; Stilbenes; Thromboplastin; Thrombosis; Transcription Factor RelA; Transfection | 2011 |
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.
Topics: AMP-Activated Protein Kinases; Animals; Benzamides; Blotting, Western; Carbazoles; Eating; Feeding Behavior; Ghrelin; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthols; Phosphorylation; Rats; Rats, Sprague-Dawley; Sirtuin 1; Tumor Suppressor Protein p53 | 2011 |
Angiotensin II induces microtubule reorganization mediated by a deacetylase SIRT2 in endothelial cells.
Topics: Acetylation; Angiotensin II; Animals; Aorta; Benzamides; Cell Movement; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Male; Mice; Microtubules; Naphthols; Sirtuin 2; Tubulin | 2011 |
SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.
Topics: Acetylcholine; Adolescent; Adult; Aged; Aging; Animals; Arteries; Benzamides; Cells, Cultured; Endothelium, Vascular; Female; Humans; Male; Mice; Mice, Inbred Strains; Middle Aged; Models, Animal; Naphthols; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Sirtuin 1; Vasodilation; Young Adult | 2011 |
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells.
Topics: Acetylation; Benzamides; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cell Proliferation; Chemokines; Dermis; Endothelial Cells; Furans; Gene Expression Regulation; Histones; Humans; Inflammation; Microvessels; Monocytes; Naphthols; Quinolines; Sirtuins; Time Factors | 2011 |
Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1.
Topics: Animals; Benzamides; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Hemorrhage; Male; Myocardial Contraction; Naphthols; Rats; Rats, Sprague-Dawley; Resveratrol; Sirtuin 1; Stilbenes; Wounds and Injuries | 2012 |
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.
Topics: AMP-Activated Protein Kinases; Apoptosis; Benzamides; Cell Proliferation; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Hydroxamic Acids; Inhibitor of Apoptosis Proteins; Luciferases; Naphthols; p38 Mitogen-Activated Protein Kinases; Plicamycin; Promoter Regions, Genetic; Protein Binding; Sp1 Transcription Factor; Survivin; Transcription Factors; Tumor Suppressor Proteins | 2012 |
High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Topics: Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Humans; Leukemia-Lymphoma, Adult T-Cell; Naphthols; Poly(ADP-ribose) Polymerases; RNA Interference; RNA, Small Interfering; Sirtuin 1; Sirtuins | 2012 |
Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells.
Topics: Acetylcysteine; Benzamides; Cell Line; Chemokines; Cytokines; Defensins; Extracellular Signal-Regulated MAP Kinases; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Naphthols; NF-kappa B; Niacinamide; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase C; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Resveratrol; RNA Interference; Signal Transduction; Sirtuin 1; Stilbenes; Stress, Mechanical; Toll-Like Receptors | 2012 |
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.
Topics: Animals; Benzamides; Blotting, Western; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms, Experimental; Mice; Mice, Knockout; Mice, Nude; Naphthalenes; Naphthols; Protein Binding; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sirtuin 1; Transcriptional Activation; Transplantation, Heterologous; Tumor Burden | 2012 |
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP.
Topics: Androgens; Anticarcinogenic Agents; Benzamides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP1A1; Estrogens; Humans; Insulin-Like Growth Factor I; Male; NAD(P)H Dehydrogenase (Quinone); Naphthols; Phytotherapy; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sirtuins; Up-Regulation | 2013 |
Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Cell Line; Cell Survival; Chondrocytes; Cyclooxygenase 2; Cytokines; Cytoprotection; Female; Humans; Hydrogen Peroxide; Melatonin; Naphthols; NF-kappa B; Nitric Oxide Synthase Type II; Osteoarthritis; Rabbits; Sirtuin 1 | 2012 |
DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes.
Topics: Animals; Benzamides; Cadherins; Carcinoma, Hepatocellular; Cattle; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Down-Regulation; Gene Expression Regulation; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Immunoblotting; Liver Neoplasms; Naphthols; Real-Time Polymerase Chain Reaction; Repressor Proteins; RNA, Messenger; Sensitivity and Specificity; Transfection; Tumor Cells, Cultured; Viral Core Proteins | 2012 |
Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme.
Topics: Benzamides; Coumarins; Enzyme Assays; Fluorometry; Furans; Humans; Isoenzymes; Kinetics; Lysine; Naphthols; Protein Processing, Post-Translational; Quinolines; Recombinant Proteins; Sirtuins; Structure-Activity Relationship; Substrate Specificity; Succinates; Suramin | 2012 |
Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells.
Topics: Alkaline Phosphatase; Antibodies, Neutralizing; Benzamides; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Humans; Interleukin-17; Interleukin-23; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Naphthols; NF-kappa B; Periodontal Ligament; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sirtuin 1; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2012 |
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.
Topics: Acetylation; Adenine; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Down-Regulation; Female; G1 Phase Cell Cycle Checkpoints; Histone Deacetylase Inhibitors; Humans; Microtubule-Associated Proteins; Naphthols; Sirtuins; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Expression patterns of sirtuin genes in porcine preimplantation embryos and effects of sirtuin inhibitors on in vitro embryonic development after parthenogenetic activation and in vitro fertilization.
Topics: Animals; Benzamides; Blastocyst; Embryo Culture Techniques; Embryonic Development; Fertilization in Vitro; Gene Expression Profiling; Naphthols; Niacinamide; Nuclear Transfer Techniques; Parthenogenesis; RNA, Messenger; Sirtuins; Swine | 2012 |
SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Autophagy; Benzamides; Cell Line; Humans; Inflammation; Microtubule-Associated Proteins; Naphthols; NF-kappa B; Protein Kinases; Sequestosome-1 Protein; Sirtuin 1 | 2012 |
Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates β-cell death in nonobese diabetic mice, islets, and insulinoma cells.
Topics: Animals; Benzamides; Calcium Channel Blockers; Carrier Proteins; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary Supplements; Female; Insulinoma; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; NAD; Naphthols; Pancreatic Neoplasms; Pyruvic Acid; Reactive Oxygen Species; Streptozocin; Zinc | 2012 |
Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Apoptosis; Apoptosis Regulatory Proteins; Benzamides; Blotting, Western; Caspase 3; Cell Proliferation; Cells, Cultured; Disease Susceptibility; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Humans; Imidazoles; In Situ Nick-End Labeling; Middle Aged; Naphthols; Phosphorylation; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Retinal Pigment Epithelium; RNA, Small Interfering; Sirtuin 1; Sirtuin 2; Tumor Suppressor Protein p53 | 2012 |
SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells.
Topics: Benzamides; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Naphthols; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirtuin 1; Transcription, Genetic | 2013 |
CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.
Topics: Acetylation; Aging, Premature; Antineoplastic Agents, Phytogenic; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Etoposide; Female; Humans; Naphthols; Polycomb Repressive Complex 1; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Sirtuin 1; Sirtuins; Tumor Suppressor Protein p53 | 2013 |
The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.
Topics: Animals; Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Cells, Cultured; Cytokines; Flow Cytometry; Humans; Immunity, Innate; Inflammation; Klebsiella Infections; Klebsiella pneumoniae; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Naphthalenes; Naphthols; Pyrimidinones; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shock, Septic; Sirtuins | 2013 |
Sirtinol attenuates trauma hemorrhage-induced hepatic injury through Akt-dependent pathway in rats.
Topics: Animals; Benzamides; Blotting, Western; Disease Models, Animal; Liver Failure, Acute; Male; Naphthols; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sirtuins; Up-Regulation | 2013 |
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Blotting, Western; Brain Ischemia; Cells, Cultured; Cytidine Diphosphate Choline; Drug Synergism; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Monocytes; Naphthols; Neurons; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Inbred F344; Resveratrol; Sirtuin 1; Stilbenes; Stroke | 2013 |
PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Benzamides; Blotting, Western; CD40 Antigens; Fenofibrate; Mice; Naphthols; NF-kappa B; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA, Messenger; Signal Transduction; Sirtuin 1; Thiocarbamates; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein.
Topics: Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; MCF-7 Cells; Naphthols; Proto-Oncogene Proteins c-bcl-2; Sirtuin 1 | 2013 |
Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma.
Topics: Animals; Apoptosis; Benzamides; Blotting, Western; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Therapy, Combination; Electrophoresis, Polyacrylamide Gel; Gemcitabine; Immunohistochemistry; Mice; Mice, Nude; Naphthols; Pancreatic Neoplasms; Sirtuin 1; Survival Analysis | 2013 |
The neuroprotective effect of resveratrol on retinal ganglion cells after optic nerve transection.
Topics: Animals; Benzamides; Cell Survival; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Male; Naphthols; Neuroprotective Agents; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Resveratrol; Retinal Ganglion Cells; Sirtuin 1; Stilbenes | 2013 |
Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2.
Topics: Acetylation; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Hyperglycemia; Insulin-Like Growth Factor Binding Protein 2; Male; Naphthols; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Small Interfering; Sirtuin 1; Sirtuin 2; Taxoids | 2013 |
Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells.
Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Cisplatin; Cytokines; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Janus Kinases; Lung Neoplasms; Molecular Targeted Therapy; Naphthols; Paclitaxel; Phosphatidylinositol 3-Kinases; Receptor, IGF Type 1; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Sirtuin 1; TNF-Related Apoptosis-Inducing Ligand; Transforming Growth Factor beta; Tumor Microenvironment; Tumor Necrosis Factor-alpha; Tyrphostins | 2013 |
The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells.
Topics: Acetylation; Antioxidants; Benzamides; CD40 Antigens; Cells, Cultured; Fenofibrate; Human Umbilical Vein Endothelial Cells; Humans; Hypolipidemic Agents; Inflammation; Naphthols; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiocarbamates; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2014 |
Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Cells, Cultured; Endometriosis; Endometrium; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Interleukin-8; Naphthols; Ovarian Diseases; Ovary; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Stromal Cells | 2014 |
Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.
Topics: Analysis of Variance; Animals; Benzamides; Blotting, Western; Cardiotonic Agents; Enzyme Activation; Male; Mice; Mice, Inbred ICR; Naphthols; Piperazines; Purines; Reperfusion Injury; Sildenafil Citrate; Sirtuin 1; Sulfones | 2014 |
SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Benzamides; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Disease Models, Animal; Immunohistochemistry; Male; Naphthols; Rats; Rats, Sprague-Dawley; Sirtuin 1; Subarachnoid Hemorrhage | 2014 |
Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life cycle.
Topics: Benzamides; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA Primers; Gene Expression Regulation, Viral; Gene Knockdown Techniques; Herpesvirus 8, Human; Humans; Immediate-Early Proteins; Immunoprecipitation; Luciferases; Microscopy, Confocal; Naphthols; Niacinamide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sirtuin 1; Trans-Activators; Virus Activation; Virus Latency | 2014 |
Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome.
Topics: Acetylation; Adhesiveness; Benzamides; Cell Adhesion; E-Selectin; ELAV Proteins; Endothelial Cells; Gene Expression Regulation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Leukocytes, Mononuclear; Metabolic Syndrome; Naphthols; NF-kappa B; Protein Stability; Resveratrol; Sirtuin 1; Stilbenes; Tumor Necrosis Factor-alpha | 2014 |
Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.
Topics: Actins; Animals; Benzamides; Carbazoles; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; ErbB Receptors; Fibroblasts; Fibrosis; Furans; Kidney; Male; Mice; Mice, Inbred C57BL; Naphthols; Phosphorylation; Quinolines; Receptor, Platelet-Derived Growth Factor beta; Renal Insufficiency, Chronic; Sirtuin 1; Sirtuin 2; STAT3 Transcription Factor | 2014 |
Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Benzamides; Cell Line, Tumor; Cilostazol; Cyclic AMP; Disintegrins; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 10; Mice; Naphthols; Neuroblastoma; Neuroprotective Agents; Peptide Fragments; Receptors, Retinoic Acid; RNA, Small Interfering; Sirtuin 1; Tetrazoles; Thionucleotides; Time Factors; Transfection; Up-Regulation | 2014 |
Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.
Topics: Acrylamides; Benzamides; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Cytokines; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Humans; NAD; Naphthols; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Up-Regulation | 2015 |
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression; Humans; Lung Neoplasms; Models, Biological; Naphthols; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Stem Cell Assay | 2014 |
SIRT1 inhibition affects angiogenic properties of human MSCs.
Topics: Benzamides; Cell Line; Cell Physiological Phenomena; Gene Silencing; Humans; Hypoxia; Mesenchymal Stem Cells; Naphthols; Neovascularization, Physiologic; Sirtuin 1 | 2014 |
TNF-α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Benzamides; Blotting, Western; Cell Movement; Cells, Cultured; Dental Pulp; Endothelial Growth Factors; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Naphthols; Neovascularization, Physiologic; Peptides, Cyclic; Phosphorylation; Real-Time Polymerase Chain Reaction; Signal Transduction; Sirtuin 1; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2015 |
Sirtuin deacetylases: a new target for melanoma management.
Topics: Apoptosis; Benzamides; Carbazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Group III Histone Deacetylases; Humans; Melanoma; Models, Biological; Molecular Targeted Therapy; Naphthols; Signal Transduction | 2014 |
A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats.
Topics: Animals; Apoptosis; Arginine; Benzamides; Biomarkers; Blood Glucose; Cytoprotection; Diabetes Complications; Fasting; Fibrosis; Gene Expression Regulation, Enzymologic; Glycated Hemoglobin; Insulin; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Myocardium; Naphthols; Rats; Rats, Wistar; Sirtuin 1; Streptozocin; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2014 |
Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Benzamides; Disease Models, Animal; Humans; Leukocyte Elastase; Lipopolysaccharides; Male; Mice; Naphthols; Neutrophils; Peroxidase; Protein Kinases | 2015 |
Sirtuin inhibitor sirtinol is an intracellular iron chelator.
Topics: Benzamides; Cell Proliferation; Enzyme Inhibitors; Ferric Compounds; Humans; Intracellular Space; Iron Chelating Agents; Jurkat Cells; Leukemia; Models, Molecular; Molecular Structure; Naphthols; Sirtuins; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |
Pharmacologic investigations on the role of Sirt-1 in neuroprotective mechanism of postconditioning in mice.
Topics: Animals; Benzamides; Biomarkers; Brain; Cerebral Infarction; Female; Histone Deacetylase Inhibitors; Injections, Intraperitoneal; Ischemic Postconditioning; Male; Mice; Naphthols; Reperfusion Injury; Sirtuin 1 | 2015 |
Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.
Topics: Benzamides; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Melatonin; Mesenchymal Stem Cells; Naphthols; p38 Mitogen-Activated Protein Kinases; S Phase; Sirtuin 1 | 2015 |
Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis.
Topics: Actins; Animals; Benzamides; Cell Polarity; Chromosomes, Mammalian; Cumulus Cells; Female; Histone Deacetylase Inhibitors; Meiosis; Naphthols; Niacinamide; Oocytes; Ovary; Polar Bodies; Primary Cell Culture; Sirtuins; Spindle Apparatus; Swine | 2015 |
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzamides; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; ErbB Receptors; Estradiol; Etoposide; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthols; Primary Cell Culture; Proto-Oncogene Proteins c-fos; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Sirtuin 1; Transcription Factor AP-1; Xenograft Model Antitumor Assays | 2015 |
The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis.
Topics: Animals; Apoptosis; Benzamides; Biomarkers; Cells, Cultured; Chondrogenesis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type II; Collagen Type X; Embryo, Mammalian; Female; Forelimb; Gene Expression Regulation, Developmental; Genes, Reporter; Histone Deacetylase Inhibitors; Hydroxamic Acids; Luminescent Proteins; Mice, Transgenic; Naphthols; Osteogenesis; Pregnancy; Pyridines; Pyrroles; Recombinant Fusion Proteins; Teratogens | 2015 |
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Male; Melatonin; Myocardial Reperfusion Injury; Naphthols; Oxidative Stress; Rats; Signal Transduction; Sirtuin 1 | 2015 |
Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells.
Topics: Acetylation; Apoptosis; Benzamides; Cardiovascular Diseases; Caspases; Cells, Cultured; Cytochromes c; Diabetes Mellitus; Endothelial Cells; Glycation End Products, Advanced; Humans; Insulin; Insulin Secretion; Naphthols; Oxidative Stress; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Tumor Suppressor Protein p53 | 2015 |
The sirtuin inhibitor sirtinol inhibits hepatitis A virus (HAV) replication by inhibiting HAV internal ribosomal entry site activity.
Topics: Amantadine; Animals; Antiviral Agents; Benzamides; Cell Line; Chlorocebus aethiops; COS Cells; Epigenesis, Genetic; Hepatitis A virus; Histone Deacetylase Inhibitors; Host-Pathogen Interactions; Humans; Internal Ribosome Entry Sites; Naphthols; Phosphoproteins; Protein Biosynthesis; RNA, Viral; Sirtuins; Triazoles; Virus Replication | 2015 |
Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2-Related Factor 2 Activation.
Topics: Acetylation; Acute Disease; Antioxidants; Benzamides; Caspase 3; Cell Death; Cell Nucleus; Cells, Cultured; Chronic Disease; Enzyme Activation; Epithelial Cells; Gene Knockdown Techniques; Humans; Hyperoxia; Lung; Naphthols; NF-E2-Related Factor 2; Sirtuin 1 | 2016 |
Bovine (Bos taurus) Bone Marrow Mesenchymal Cell Differentiation to Adipogenic and Myogenic Lineages.
Topics: Adipocytes; Adipogenesis; Animals; Benzamides; Benzimidazoles; Benzoates; Bezafibrate; Bone Marrow Cells; Cattle; Cell Lineage; Energy Metabolism; Linoleic Acids; Mesenchymal Stem Cells; Muscle Development; Myosin Heavy Chains; Naphthols; Peroxisome Proliferator-Activated Receptors; PPAR gamma; Real-Time Polymerase Chain Reaction; Rosiglitazone; Telmisartan; Thiazolidinediones | 2016 |
CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells.
Topics: Antineoplastic Agents; Benzamides; Cell Cycle Checkpoints; Cellular Senescence; Drug Antagonism; E2F1 Transcription Factor; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Naphthols; Oncogene Protein v-akt; Polycomb Repressive Complex 1; Retinoblastoma Protein; Signal Transduction | 2016 |
Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species.
Topics: Benzamides; Cell Line; Cellular Senescence; Cytomegalovirus; Cytomegalovirus Infections; Fibroblasts; Humans; Naphthols; Reactive Oxygen Species; Virus Activation | 2016 |
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Berberine; Caspase 3; Cell Line; Cell Survival; Creatine Kinase; Forkhead Transcription Factors; Heart Function Tests; Inflammation; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Naphthols; Nerve Tissue Proteins; Oxidative Stress; Rats, Sprague-Dawley; RNA, Small Interfering; Sirtuin 1 | 2016 |
SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids.
Topics: Benzamides; Biosynthetic Pathways; Cells, Cultured; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gluconeogenesis; Glucose; Hepatocytes; Humans; Lipid Metabolism; Lipogenesis; Male; Naphthols; Proto-Oncogene Proteins c-akt; Sirtuin 1 | 2016 |
Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzamides; Cell Survival; Cells, Cultured; Creatine Kinase, MB Form; Heart; L-Lactate Dehydrogenase; Male; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Naphthols; Organ Culture Techniques; Oxidative Stress; Phenols; Rats, Sprague-Dawley; Sirtuin 1; Ventricular Function, Left | 2016 |
Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzamides; Dendrites; Dentate Gyrus; Depression; Disease Models, Animal; Enzyme Inhibitors; Heterocyclic Compounds, 2-Ring; Hippocampus; Imipramine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Naphthols; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Stress, Psychological | 2016 |
Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways.
Topics: Antioxidants; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Naphthols; Neuroblastoma; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Saponins; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2016 |
Giardia duodenalis GlSir2.2, homolog of SIRT1, is a nuclear-located and NAD(+)-dependent deacethylase.
Topics: Amino Acid Sequence; Benzamides; Cell Nucleus; Fluorescent Antibody Technique, Indirect; Giardia lamblia; Group III Histone Deacetylases; Humans; Inhibitory Concentration 50; Naphthalenes; Naphthols; Niacinamide; Phylogeny; Pyrones; Sequence Alignment; Sirtuins | 2016 |
SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons.
Topics: Acetylation; Adenosine Triphosphate; Animals; Benzamides; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Curcumin; Electron Transport Complex IV; Glutamic Acid; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; Naphthols; Neurons; Neuroprotection; Neuroprotective Agents; Neurotoxins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirtuin 1 | 2016 |
Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.
Topics: Animals; Arrhythmias, Cardiac; Benzamides; Catalase; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naphthols; Rats, Wistar; Sirtuin 1; Sirtuin 2; Superoxide Dismutase; Time Factors | 2017 |
Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Apoptosis; Benzamides; Brain Edema; Brain Injuries; Cell Survival; Inflammation; Male; Models, Biological; Naphthols; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Subarachnoid Hemorrhage; Water | 2016 |
SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22.
Topics: Animals; Benzamides; Brain Ischemia; Caspase 3; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Inflammation; MicroRNAs; Naphthols; Neuroprotective Agents; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Reperfusion Injury; Sirtuin 1; Tumor Suppressor Protein p53 | 2017 |
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.
Topics: Adenosine Triphosphate; Animals; Benzamides; Brain Injuries, Traumatic; Caspase 3; Caspase 9; Imidazoles; Male; MAP Kinase Signaling System; Mitochondria; Naphthols; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Sirtuin 1 | 2017 |
Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.
Topics: Acetylation; Animals; Benzamides; Cell Differentiation; Chagas Disease; Chlorocebus aethiops; DNA Replication; Gene Expression; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Naphthols; Resveratrol; Stilbenes; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2.
Topics: Acetylation; Animals; Benzamides; Blood Glucose; Gluconeogenesis; HEK293 Cells; Humans; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Liver; Mice; Naphthols; Phosphoenolpyruvate Carboxykinase (GTP); Sirtuin 2 | 2017 |
Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components.
Topics: Arabidopsis; Arabidopsis Proteins; Benzamides; Cytokinins; Gene Expression Regulation, Plant; Indoleacetic Acids; Meristem; Naphthols; Organogenesis, Plant; Oxidoreductases Acting on Sulfur Group Donors; Plant Development; Plant Roots; Plant Shoots; Signal Transduction; Stem Cells | 2017 |
Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.
Topics: Aged; Animals; Anti-Inflammatory Agents; Benzamides; Cells, Cultured; Chondrocytes; Female; Flavonoids; Flavonols; Humans; Inflammation; Inflammation Mediators; Interleukin-1beta; Male; Menisci, Tibial; Mice; Mice, Inbred C57BL; Middle Aged; Naphthols; NF-kappa B; Osteoarthritis; Sirtuin 1 | 2017 |
SIRT1 Regulates the Inflammatory Response of Vascular Adventitial Fibroblasts through Autophagy and Related Signaling Pathway.
Topics: Adventitia; Animals; Autophagy; Benzamides; Cells, Cultured; Fibroblasts; Heterocyclic Compounds, 3-Ring; Interleukin-1beta; Interleukin-6; Male; Naphthols; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Small Interfering; Signal Transduction; Sirolimus; Sirtuin 1; Stilbenes; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2017 |
[Sirtuin type 1 signaling pathway mediates the effect of diosgenin on chondrocyte metabolisms in osteoarthritis].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Chondrocytes; Diosgenin; Electron Transport Complex IV; Forkhead Box Protein O1; Mice; Mice, Inbred C57BL; Mitochondria; Naphthols; Osteoarthritis; Oxidative Stress; Signal Transduction; Sirtuin 1; Succinate Dehydrogenase; Superoxide Dismutase | 2017 |
Chromatin determinants impart camptothecin sensitivity.
Topics: Benzamides; Camptothecin; Cell Cycle Proteins; Chromatin; DNA Damage; DNA Replication; DNA Topoisomerases, Type I; DNA-Binding Proteins; DNA, Fungal; DNA, Ribosomal; Humans; Naphthols; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae | 2017 |
Sirtuin inhibition leads to autophagy and apoptosis in porcine preimplantation blastocysts.
Topics: Animals; Apoptosis; Autophagy; Benzamides; Blastocyst; Naphthols; Sirtuins; Swine | 2017 |
Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.
Topics: AMP-Activated Protein Kinase Kinases; Anoikis; Antineoplastic Agents; Benzamides; Bone Neoplasms; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; MicroRNAs; Naphthols; Osteosarcoma; Protein Biosynthesis; Protein Serine-Threonine Kinases; RNA, Messenger; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases; Transfection | 2017 |
Hydrogen sulfide prevents homocysteine‑induced endoplasmic reticulum stress in PC12 cells by upregulating SIRT‑1.
Topics: Animals; Benzamides; Caspase 12; Cytoprotection; Endoplasmic Reticulum Stress; Homocysteine; HSP70 Heat-Shock Proteins; Hydrogen Sulfide; Membrane Proteins; Naphthols; PC12 Cells; Rats; Sirtuin 1; Up-Regulation | 2017 |
[Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway].
Topics: Antifungal Agents; Antimycin A; Apoptosis; Benzamides; Caspase 3; Cell Proliferation; Cells, Cultured; Cordyceps; Humans; Ischemia; Naphthols; Reperfusion Injury; RNA, Messenger; Sirtuin 1 | 2017 |
Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation.
Topics: Acylation; Benzamides; Enzyme Assays; Fluorescent Dyes; Histone Deacetylases; Humans; Lysine; NAD; Naphthols; Peptides; Sirtuins; Spectrometry, Fluorescence | 2018 |
Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1.
Topics: Animals; Benzamides; Brain Injuries, Traumatic; Caspase 1; Cerebral Cortex; Cytokines; Glutathione; Inflammasomes; Male; Malondialdehyde; Naphthols; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Sirtuin 1; Stilbenes; Superoxide Dismutase | 2018 |
Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Humans; MicroRNAs; Multiple Myeloma; Naphthols; Zoledronic Acid | 2017 |
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc.
Topics: Acetylation; Animals; Benzamides; Cell Differentiation; Glucose; Lysine; Naphthols; NF-kappa B; Osteoclasts; Osteogenesis; Palmitates; Phosphorylation; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Signal Transduction; Sirtuin 1; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2018 |
Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells.
Topics: Active Transport, Cell Nucleus; Benzamides; Cell Line, Tumor; Cell Nucleus; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Naphthols; Neurites; Neuronal Outgrowth; Sirtuins; Tretinoin | 2018 |
Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway.
Topics: Animals; Apoptosis; Benzamides; Brain Edema; Brain Injuries; Cyclic Nucleotide Phosphodiesterases, Type 4; Heterocyclic Compounds, 3-Ring; Male; Naphthols; Neuroprotective Agents; Phosphodiesterase 4 Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rolipram; Sirtuin 1; Subarachnoid Hemorrhage | 2018 |
Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage.
Topics: Animals; Benzamides; Cells, Cultured; Drugs, Chinese Herbal; Flavonoids; Male; Mice; Mice, Inbred C57BL; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naphthols; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sirtuin 1 | 2018 |
Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.
Topics: Animals; Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dichloroacetic Acid; Drug Synergism; Energy Metabolism; Furans; G1 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Mice; Mitogen-Activated Protein Kinases; Naphthols; Quinolines; Sirtuin 2 | 2018 |
Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Antioxidants; Benzamides; Bone Regeneration; Cell Differentiation; Cell Line; Cell Proliferation; Humans; Mesenchymal Stem Cells; Naphthols; Osteogenesis; Protein Kinases; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Stress, Mechanical | 2018 |
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Benzamides; Biomarkers; Cells, Cultured; Deoxyguanosine; Female; Humans; Immunohistochemistry; Macrophages; Male; Middle Aged; Naphthols; Oxidative Stress; Periapical Granuloma; Real-Time Polymerase Chain Reaction; Resveratrol; Sirtuin 1 | 2018 |
Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1.
Topics: Animals; Benzamides; Cell Survival; Hedgehog Proteins; Mice; Naphthols; NIH 3T3 Cells; Patched-1 Receptor; Resveratrol; Signal Transduction; Sirtuin 1; Smoothened Receptor; Stilbenes; Transcription, Genetic; Up-Regulation; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2018 |
SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.
Topics: Animals; Benzamides; Carbazoles; Catalase; DNA-Binding Proteins; Enzyme Inhibitors; Female; Gene Expression Regulation; Glycation End Products, Advanced; Lactoylglutathione Lyase; Mice; Mice, Inbred Strains; Mitochondrial Proteins; Naphthols; Oocytes; Ovary; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Primary Cell Culture; Pyruvaldehyde; Resveratrol; Signal Transduction; Sirtuin 1; Sirtuin 3; Superoxide Dismutase; Thiolester Hydrolases; Transcription Factors | 2019 |
Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.
Topics: Benzamides; Catalytic Domain; Chromosomal Proteins, Non-Histone; HEK293 Cells; HeLa Cells; Humans; Naphthols; Nuclear Proteins; Organelle Biogenesis; Ribosomes; RNA, Ribosomal; RNA, Small Interfering; Sirtuins | 2019 |
Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
Topics: Adenine; Apoptosis; Autophagy; Benzamides; Carbamates; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Fatty Acids, Nonesterified; Humans; Lysosomal Membrane Proteins; Male; Naphthols; PC-3 Cells; Plant Lectins; Prostatic Neoplasms; Reactive Oxygen Species; Sirtuin 1; Sterol Esterase; Thiadiazoles; Up-Regulation | 2020 |
Febuxostat, a novel inhibitor of xanthine oxidase, reduces ER stress through upregulation of SIRT1-AMPK-HO-1/thioredoxin expression.
Topics: AMP-Activated Protein Kinases; Animals; Benzamides; Cell Line; Drug Evaluation, Preclinical; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Febuxostat; Heme Oxygenase-1; Humans; Mice; Naphthols; Renal Insufficiency, Chronic; Signal Transduction; Sirtuin 1; Thioredoxins; Tunicamycin; Xanthine Oxidase | 2020 |
Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.
Topics: Acetylation; Animals; Benzamides; Carbazoles; Cellular Senescence; Collagen Type I; Down-Regulation; Embryo, Mammalian; Fibroblasts; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Mutation; Naphthols; Primary Cell Culture; Promoter Regions, Genetic; Resveratrol; RNA, Small Interfering; Sirtuin 1; Trans-Activators | 2020 |
Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells.
Topics: A549 Cells; AC133 Antigen; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Non-Small-Cell Lung; Heterocyclic Compounds, 4 or More Rings; Humans; Hyaluronan Receptors; Lung Neoplasms; Naphthols; Neoplastic Stem Cells; Resveratrol; Sirtuin 1 | 2020 |
Cellular molecular and proteomic profiling deciphers the SIRT1 controlled cell death pathways in esophageal adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Naphthols; Proteomics; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sirtuin 1 | 2021 |
Sirtuin 1 alleviates neuroinflammation-induced apoptosis after traumatic brain injury.
Topics: Animals; Apoptosis; Benzamides; Brain Injuries, Traumatic; Disease Models, Animal; Inflammation; Male; Naphthols; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sirtuin 1 | 2021 |
MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells.
Topics: Apoptosis; Benzamides; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Naphthalenes; Naphthols; Sirtuins | 2022 |
Sirtinol Supresses Trophozoites Proliferation and Encystation of Acanthamoeba via Inhibition of Sirtuin Family Protein.
Topics: Acanthamoeba castellanii; Animals; Benzamides; Cell Proliferation; Naphthols; Sirtuins; Trophozoites | 2022 |