2-methylamino-1-(3-4-methylenedioxyphenyl)butan-1-one and buphedrone

Synthetic cathinones are among the most popular new psychoactive substances, being abused for their stimulant properties, which are similar to those of amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). Considering that the liver is a likely target for cathinones-induced toxicity, and for their metabolic activation/detoxification, we aimed to determine the hepatotoxicity of three commonly abused synthetic cathinones: butylone, α-methylamino-butyrophenone (buphedrone) and 3,4-dimethylmethcathinone (3,4-DMMC). We characterized their cytotoxic profile in primary rat hepatocytes (PRH) and in the HepaRG and HepG2 cell lines. PRH was the most sensitive cell model, showing the lowest EC

Topics: 3,4-Methylenedioxyamphetamine; Animals; Autophagy; Butyrophenones; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Designer Drugs; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Male; Methylamines; Oxidative Stress; Propiophenones; Rats; Rats, Wistar