2-methoxyestradiol has been researched along with paclitaxel in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 20 (64.52) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Cushman, M; Fanwick, PE; Hamel, E; Mohanakrishnan, AK; Nampoothiri, P; Wang, Z; Yang, D | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Hergenrother, PJ; Miller, MJ; Miller, PA; Moraski, GC; Palchaudhuri, R; Peterson, RJ; Stefely, JA | 1 |
| Hergenrother, PJ; Holaday, CR; Leslie, BJ; Nguyen, T | 1 |
| Gangjee, A; Hamel, E; Lin, L; Mooberry, SL; Raghavan, S; Risinger, AL; Roberts, EG; Zhao, Y | 1 |
| D'Amato, RJ; Flynn, E; Hamel, E; Klauber, N; Parangi, S | 1 |
| Adlercreutz, H; Andersson, LC; Attalla, H; Mäkelä, TP; Westberg, JA | 1 |
| Ghilchik, MW; Purohit, A; Reed, MJ; Singh, A | 1 |
| Cushman, M; Hamel, E; Mohanakrishnan, AK; Verdier-Pinard, P; Wang, Z | 1 |
| Hejaz, HA; Potter, BV; Purohit, A; Reed, MJ; Singh, A | 1 |
| Dannenberg, AJ; Hart, JC; Norton, L; Subbaramaiah, K | 1 |
| Chau, GY; Chi, CW; Lin, HL; Liu, TY; Lui, WY | 1 |
| Heilman, DK; Miller, KD; Nozaki, S; Shen, J; Sissons, SE; Sledge, GW; Sweeney, CJ | 1 |
| Gebhard, MM; Klar, E; Ryschich, E; Schmidt, J; Werner, J | 1 |
| Basu, A; Haldar, S | 1 |
| Comninos, A; Day, JM; Leese, MP; Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Solomon, C | 1 |
| Huober, J; Mueck, AO; Seeger, H; Wallwiener, D | 1 |
| Chen, Z; Pribluda, VS; Ricker, JL; Swartz, GM; Van Waes, C; Yang, XP | 1 |
| Han, GZ; Liu, ZJ; Shimoi, K; Zhu, BT | 1 |
| Perez-Stable, C | 1 |
| Adyshev, D; Bogatcheva, NV; Mambetsariev, B; Moldobaeva, N; Verin, AD | 1 |
| Amir, S; Mabjeesh, NJ | 1 |
| Day, JM; Foster, PA; Ho, YT; Judde, JG; Lassalle, M; Leese, MP; Newman, SP; Potter, BV; Prevost, G; Purohit, A; Reed, MJ; Stengel, C | 1 |
| Chang, TC; Chen, CH; Chen, RJ; Chien, CH; Chow, SN; Lee, WJ | 1 |
| Baumunk, D; Fotopoulou, C; Schmidt, SC; Schumacher, G | 1 |
| Bogatcheva, NV; Daglis, GA; Gorshkov, BA; Kim, KM; Poirier, C; Verin, AD; Zemskova, MA | 1 |
| Cardenas, H; Díaz, P; Orihuela, PA | 1 |
| Huo, P; Liu, X; Tian, Q; Xu, X; Xu, Y; Zhang, N; Zhang, Z; Zhao, T | 1 |
31 other study(ies) available for 2-methoxyestradiol and paclitaxel
| Article | Year |
|---|---|
Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
Topics: Animals; Antineoplastic Agents; Cattle; Drug Screening Assays, Antitumor; Estradiol; Humans; Microtubules; Paclitaxel; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.
Topics: Acrylamides; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Microtubules; Oxazoles; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators | 2010 |
Phenylcinnamides as novel antimitotic agents.
Topics: Animals; Antimitotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cattle; Cinnamates; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; HeLa Cells; Humans; Microtubules; Permeability; Structure-Activity Relationship; Tubulin Modulators; U937 Cells | 2010 |
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cattle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Protein Binding; Pyrimidines; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Water | 2010 |
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Corneal Neovascularization; Estradiol; Humans; Mice; Mice, Inbred C57BL; Mice, SCID; Neoplasm Transplantation; Paclitaxel; Tumor Stem Cell Assay | 1997 |
2-Methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation.
Topics: 2-Methoxyestradiol; Calcium-Calmodulin-Dependent Protein Kinases; Demecolcine; Estradiol; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; Tubulin; Tumor Cells, Cultured; Vincristine | 1998 |
Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, paclitaxel and 2-methoxyestradiol.
Topics: 2-Methoxyestradiol; Aromatase; Aromatase Inhibitors; Breast; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Estradiol; Female; Fibroblasts; Humans; Interleukin-6; Microtubules; Paclitaxel; Receptors, Interleukin-6; Solubility; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
A steroid derivative with paclitaxel-like effects on tubulin polymerization.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents, Phytogenic; Biopolymers; Cattle; Estradiol; Glutamic Acid; Microtubule-Associated Proteins; Paclitaxel; Tubulin; Tubulin Modulators | 2000 |
Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Biological Transport, Active; Breast Neoplasms; Deoxyglucose; Estradiol; Estrone; Female; Humans; Hydroxyestrones; Insulin; Kinetics; Paclitaxel; Tumor Cells, Cultured | 2000 |
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways.
Topics: 2-Methoxyestradiol; Breast; Cell Line; Colchicine; Cyclooxygenase 2; Epithelial Cells; Estradiol; Female; Humans; Isoenzymes; Kinetics; Membrane Proteins; Microtubules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nocodazole; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Prostaglandin-Endoperoxide Synthases; Transcription, Genetic; Vinblastine; Vincristine | 2000 |
Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species.
Topics: 2-Methoxyestradiol; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; DNA Fragmentation; Docetaxel; Estradiol; Flow Cytometry; Humans; Liver Neoplasms; Microtubules; Paclitaxel; Reactive Oxygen Species; Taxoids; Tumor Cells, Cultured | 2000 |
The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Division; Docetaxel; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Estradiol; Fibroblast Growth Factor 2; Humans; Lymphokines; Mice; Mice, Nude; Neovascularization, Physiologic; Paclitaxel; Taxoids; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Apoptosis; Cyclohexanes; Estradiol; Male; Neoplasm Transplantation; O-(Chloroacetylcarbamoyl)fumagillol; Paclitaxel; Pancreatic Neoplasms; Rats; Rats, Inbred Lew; Sesquiterpenes; Time Factors; Tumor Cells, Cultured | 2003 |
Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis.
Topics: 2-Methoxyestradiol; Apoptosis; Base Sequence; bcl-X Protein; DNA Primers; Estradiol; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2003 |
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
Topics: 2-Methoxyestradiol; Apoptosis; Cell Division; Cell Separation; Estradiol; Estrone; Female; Flow Cytometry; G1 Phase; G2 Phase; Humans; Hydroxyestrones; Immunoblotting; Inhibitory Concentration 50; Male; Mitosis; Models, Chemical; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured | 2003 |
Is the combination with 2-methoxyestradiol able to reduce the dosages of chemotherapeutices in the treatment of human ovarian cancer? Preliminary in vitro investigations.
Topics: 2-Methoxyestradiol; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cyclophosphamide; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Epirubicin; Estradiol; Female; Fluorouracil; Humans; Ovarian Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine | 2004 |
2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents, Phytogenic; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Squamous Cell; Carrier Proteins; Caspase 3; Caspase 7; Caspases; Cell Division; Cell Hypoxia; Drug Therapy, Combination; Enzyme Activation; Estradiol; Female; G2 Phase; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Mice, SCID; Microcirculation; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transcription Factors; Vascular Endothelial Growth Factor A | 2004 |
Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Doxorubicin; Drug Synergism; Estradiol; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays | 2005 |
2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells.
Topics: 2-Methoxyestradiol; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cyclin B1; Cyclin-Dependent Kinases; Estradiol; Humans; Male; Paclitaxel; Prostatic Neoplasms; Tubulin Modulators; Tumor Cells, Cultured | 2006 |
Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction.
Topics: 2-Methoxyestradiol; Actomyosin; Amides; Blood-Air Barrier; Cell Membrane Permeability; Endothelial Cells; Estradiol; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microelectrodes; Microtubules; Models, Biological; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; rho-Associated Kinases; Tubulin | 2007 |
SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lactams, Macrocyclic; Neoplasm Proteins; Paclitaxel; Protein Isoforms; Recombinant Fusion Proteins; RNA Interference; RNA, Messenger; RNA, Neoplasm; Septins; Transcription, Genetic; Tubulin Modulators | 2007 |
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Estrenes; Humans; Mice; Mice, Nude; Paclitaxel; Tubulin Modulators; Xenograft Model Antitumor Assays | 2008 |
Antiproliferative effects of 2-methoxyestradiol alone and in combination with chemotherapeutic agents on human endometrial cancer cells.
Topics: 2-Methoxyestradiol; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Drug Interactions; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Estradiol; Female; Humans; Paclitaxel; Tumor Cells, Cultured | 2009 |
Additive growth inhibition after combined treatment of 2-methoxyestradiol and conventional chemotherapeutic agents in human pancreatic cancer cells.
Topics: 2-Methoxyestradiol; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cetuximab; Cisplatin; Deoxycytidine; Drug Synergism; Estradiol; Female; Flow Cytometry; Fluorescent Antibody Technique; Fluorouracil; Gemcitabine; Humans; Mice; Mice, Nude; Paclitaxel; Pancreatic Neoplasms; Tubulin Modulators | 2010 |
Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
Topics: 2-Methoxyestradiol; Animals; Capillary Permeability; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estradiol; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Indoles; Male; Maleimides; Membrane Proteins; Mice; Microfilament Proteins; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Protein Kinase C; Pyrroles; rho-Associated Kinases; Tubulin Modulators | 2011 |
Red Maca (Lepidium meyenii) did not affect cell viability despite increased androgen receptor and prostate-specific antigen gene expression in the human prostate cancer cell line LNCaP.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Synergism; Estradiol; Gene Expression; Humans; Kallikreins; Lepidium; Male; Paclitaxel; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; RNA, Messenger | 2016 |
Co-administration of paclitaxel and 2-methoxyestradiol using folate-conjugated human serum albumin nanoparticles for improving drug resistance and antitumor efficacy.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Carriers; Drug Resistance, Neoplasm; Female; Folic Acid; Humans; Mice; Nanoparticles; Paclitaxel; Rats; Rats, Sprague-Dawley; Serum Albumin, Human; Xenograft Model Antitumor Assays | 2021 |