Page last updated: 2024-08-24

2-methoxyestradiol and docetaxel anhydrous

2-methoxyestradiol has been researched along with docetaxel anhydrous in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (63.64)	29.6817
2010's	3 (27.27)	24.3611
2020's	1 (9.09)	2.80

Authors

Authors	Studies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Chau, GY; Chi, CW; Lin, HL; Liu, TY; Lui, WY	1
Heilman, DK; Miller, KD; Nozaki, S; Shen, J; Sissons, SE; Sledge, GW; Sweeney, CJ	1
Huober, J; Mueck, AO; Seeger, H; Wallwiener, D	1
Escuin, D; Giannakakou, P; Kline, ER	1
James, J; Miller, KD; Murry, DJ; Sidor, C; Sledge, GW; Storniolo, AM; Treston, AM	1
Burnstein, K; de Las Pozas, A; Gomez, LA; Perez-Stable, C; Reiner, T	1
de las Pozas, A; Gomez, LA; Perez-Stable, C; Reiner, T	1
de las Pozas, A; Parrondo, R; Perez-Stable, C; Rai, P; Reiner, T	1
Hersi, F; Noreddin, AM; Nunes, ACF; Omar, HA; Tolba, MF	1
Varisli, L	1

Trials

1 trial(s) available for 2-methoxyestradiol and docetaxel anhydrous

Article	Year
Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Investigational new drugs, 2007, Volume: 25, Issue:1 Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Estradiol; Fatigue; Female; Half-Life; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Taxoids; Treatment Outcome; Tubulin Modulators; Urinalysis; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A	2007

Article

Year

Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer.

Investigational new drugs, 2007, Volume: 25, Issue:1

Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Estradiol; Fatigue; Female; Half-Life; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Taxoids; Treatment Outcome; Tubulin Modulators; Urinalysis; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A

2007

Other Studies

10 other study(ies) available for 2-methoxyestradiol and docetaxel anhydrous

Article	Year
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer, 2000, Sep-01, Volume: 89, Issue:5 Topics: 2-Methoxyestradiol; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; DNA Fragmentation; Docetaxel; Estradiol; Flow Cytometry; Humans; Liver Neoplasms; Microtubules; Paclitaxel; Reactive Oxygen Species; Taxoids; Tumor Cells, Cultured	2000
The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer research, 2001, Apr-15, Volume: 61, Issue:8 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Division; Docetaxel; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Estradiol; Fibroblast Growth Factor 2; Humans; Lymphokines; Mice; Mice, Nude; Neovascularization, Physiologic; Paclitaxel; Taxoids; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Is the combination with 2-methoxyestradiol able to reduce the dosages of chemotherapeutices in the treatment of human ovarian cancer? Preliminary in vitro investigations. European journal of gynaecological oncology, 2004, Volume: 25, Issue:6 Topics: 2-Methoxyestradiol; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Line, Tumor; Cell Proliferation; Cyclophosphamide; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Epirubicin; Estradiol; Female; Fluorouracil; Humans; Ovarian Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine	2004
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer research, 2005, Oct-01, Volume: 65, Issue:19 Topics: 2-Methoxyestradiol; Alkaloids; Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Colchicine; Docetaxel; Down-Regulation; Epothilones; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Microtubules; Pyrones; Taxoids; Vincristine	2005
Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy. Molecular cancer therapeutics, 2007, Volume: 6, Issue:5 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cyclin B; Cyclin B1; Docetaxel; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mitosis; Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Taxoids	2007
Low dose combinations of 2-methoxyestradiol and docetaxel block prostate cancer cells in mitosis and increase apoptosis. Cancer letters, 2009, Apr-08, Volume: 276, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mitosis; Prostatic Neoplasms; RNA, Small Interfering; Taxoids; Transfection; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2009
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Molecular cancer, 2010, Jul-09, Volume: 9 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Base Sequence; Betulinic Acid; Blotting, Western; Cell Line, Tumor; DNA Primers; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mitosis; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Sesquiterpenes; Taxoids; Triterpenes	2010
The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers. Molecular and cellular endocrinology, 2019, 05-15, Volume: 488 Topics: 2-Methoxyestradiol; Aromatase; Breast Neoplasms; Catechol O-Methyltransferase; Catechols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Docetaxel; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Hormones; Humans; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Estrogen; RNA, Small Interfering; Transcription Factor RelA	2019
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol. Annals of clinical and laboratory science, 2022, Volume: 52, Issue:2 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cyclin B1; Docetaxel; Humans; Male; Mammals; Prostatic Neoplasms	2022