2-methoxyestradiol has been researched along with colchicine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldbrunner, M; Loidl, G; Mannschreck, A; Polossek, T; von Angerer, E | 1 |
| Bulman, AL; Garst, ME; Macdonald, TL; Miller, TA; Thompson, CD | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Hergenrother, PJ; Miller, MJ; Miller, PA; Moraski, GC; Palchaudhuri, R; Peterson, RJ; Stefely, JA | 1 |
| Hergenrother, PJ; Holaday, CR; Leslie, BJ; Nguyen, T | 1 |
| Cushman, M; Hamel, E; He, HM; Katzenellenbogen, JA; Lin, CM | 1 |
| D'Amato, RJ; Flynn, E; Folkman, J; Hamel, E; Lin, CM | 1 |
| D'Amato, RJ; Flynn, E; Hamel, E; Lin, CM | 1 |
| Dannenberg, AJ; Hart, JC; Norton, L; Subbaramaiah, K | 1 |
| Baranao, JL; Lattanzi, ML; Mudry, MD; Santos, CB | 1 |
| Anthony, CT; Schwimer, J; Stafford, SJ; Thomson, JL; Wang, YZ; Woltering, EA | 1 |
| Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
| Escuin, D; Giannakakou, P; Kline, ER | 1 |
| Pappano, AJ; Shen, JB | 1 |
| Agoston, GE; Burke, PA; Fogler, WE; Hamel, E; Hanson, AD; LaVallee, TM; Shah, J; Sidor, CF; Suwandi, L; Swartz, GM; Treston, AM | 1 |
| Mabeta, P; Pepper, MS | 1 |
| Akentieva, N; Chen, LH; Chen, ZW; Covey, DF; Darbandi, R; Evers, AS; Hastings, R; Lichti, CF; Reichert, DE; Townsend, RR | 1 |
| Ehteda, A; Galettis, P; Morris, DL; Pillai, K | 1 |
21 other study(ies) available for 2-methoxyestradiol and colchicine
| Article | Year |
|---|---|
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.
Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Humans; Indoles; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Structure; Polymers; Protein Binding; Spectrophotometry, Infrared; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 1997 |
Synthesis and structure-activity profiles of A-homoestranes, the estratropones.
Topics: 2-Methoxyestradiol; Animals; Cattle; Colchicine; Estradiol; Estranes; Neovascularization, Pathologic; Structure-Activity Relationship; Tubulin | 1997 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.
Topics: Acrylamides; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Microtubules; Oxazoles; Structure-Activity Relationship; Triazoles; Tubulin; Tubulin Modulators | 2010 |
Phenylcinnamides as novel antimitotic agents.
Topics: Animals; Antimitotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cattle; Cinnamates; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; HeLa Cells; Humans; Microtubules; Permeability; Structure-Activity Relationship; Tubulin Modulators; U937 Cells | 2010 |
Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Binding Sites; Biopolymers; Cattle; Cell Line; Colchicine; Estradiol; Mitosis; Rats; Receptors, Estrogen; Tubulin Modulators; Tumor Cells, Cultured | 1995 |
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.
Topics: 2-Methoxyestradiol; Animals; Binding, Competitive; Cattle; Colchicine; Estradiol; Glutamates; In Vitro Techniques; Microscopy, Electron; Microtubules; Polymers; Structure-Activity Relationship; Tubulin | 1994 |
Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.
Topics: 2-Methoxyestradiol; Binding Sites; Colchicine; Estradiol; Glutamates; Kinetics; Microtubule-Associated Proteins; Microtubules; Podophyllotoxin; Polymers; Stilbenes; Tubulin | 1996 |
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways.
Topics: 2-Methoxyestradiol; Breast; Cell Line; Colchicine; Cyclooxygenase 2; Epithelial Cells; Estradiol; Female; Humans; Isoenzymes; Kinetics; Membrane Proteins; Microtubules; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nocodazole; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Prostaglandin-Endoperoxide Synthases; Transcription, Genetic; Vinblastine; Vincristine | 2000 |
Exposure of bovine oocytes to the endogenous metabolite 2-methoxyestradiol during in vitro maturation inhibits early embryonic development.
Topics: 2-Methoxyestradiol; Animals; Antioxidants; Apoptosis; Blastocyst; Cattle; Cells, Cultured; Colchicine; Cytogenetic Analysis; Dose-Response Relationship, Drug; Estradiol; Estrogens, Catechol; Female; Fertilization in Vitro; Male; Meiosis; Oocytes; Spindle Apparatus | 2003 |
Colchicine and 2-methoxyestradiol Inhibit Human Angiogenesis.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Colchicine; Dose-Response Relationship, Drug; Estradiol; Humans; Placenta | 2005 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.
Topics: 2-Methoxyestradiol; Alkaloids; Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Colchicine; Docetaxel; Down-Regulation; Epothilones; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Microtubules; Pyrones; Taxoids; Vincristine | 2005 |
An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current.
Topics: 2-Methoxyestradiol; Animals; Calcium Signaling; Carbachol; Colchicine; Estradiol; Estrogens; Guinea Pigs; Heart; Male; Microtubules; Muscarinic Agonists; Myocytes, Cardiac | 2008 |
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.
Topics: 2-Methoxyestradiol; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Estradiol; Estrenes; G2 Phase; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Male; Mice; Mice, Inbred C57BL; Microtubules; Mitosis; Rats; Survival Analysis; Tubulin; Tubulin Modulators | 2008 |
A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Apoptosis; Bleomycin; Cattle; Cell Movement; Cell Proliferation; Colchicine; Cytoskeleton; DNA Damage; DNA Fragmentation; Endothelial Cells; Estradiol; Mitomycin; Neovascularization, Physiologic | 2009 |
A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.
Topics: 2-Methoxyestradiol; Affinity Labels; Animals; Aziridines; Binding Sites; Brain Chemistry; Cattle; Colchicine; Electrophoresis, Gel, Two-Dimensional; Estradiol; Immunoblotting; Models, Molecular; Pregnanolone; Protein Isoforms; Rats; Spectrometry, Mass, Electrospray Ionization; Tubulin | 2012 |
Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
Topics: 2-Methoxyestradiol; Albendazole; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colchicine; Colorectal Neoplasms; Cytotoxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Tubulin Modulators | 2013 |