Page last updated: 2024-08-24

2-methoxyestradiol and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

2-methoxyestradiol has been researched along with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	5 (62.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Choi, HK; Lee, K; Xia, Y	1
Amir, S; Mabjeesh, NJ	1
Chen, C; Ostrowski, RP; Tang, J; Zhang, JH; Zhou, C	1
Shi, H; Yan, J; Zhang, Z	1
Czyz, M; Duechler, M; Wilczynski, J	1
Badawi, Y; Ramamoorthy, P; Shi, H	1

Reviews

2 review(s) available for 2-methoxyestradiol and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

Article	Year
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. European journal of medicinal chemistry, 2012, Volume: 49 Topics: Animals; Antineoplastic Agents; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Models, Molecular; Neoplasms; Neovascularization, Pathologic; Small Molecule Libraries	2012
Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II. Archivum immunologiae et therapiae experimentalis, 2011, Volume: 59, Issue:4 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Clinical Trials as Topic; Estradiol; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mice; Neoplasms; NF-kappa B; Topotecan; Transcription Factors; Tumor Cells, Cultured	2011

Article

Year

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.

European journal of medicinal chemistry, 2012, Volume: 49

Topics: Animals; Antineoplastic Agents; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Models, Molecular; Neoplasms; Neovascularization, Pathologic; Small Molecule Libraries

2012

Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.

Archivum immunologiae et therapiae experimentalis, 2011, Volume: 59, Issue:4

Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Clinical Trials as Topic; Estradiol; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mice; Neoplasms; NF-kappa B; Topotecan; Transcription Factors; Tumor Cells, Cultured

2011

Other Studies

6 other study(ies) available for 2-methoxyestradiol and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents. Cancer biology & therapy, 2007, Volume: 6, Issue:12 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lactams, Macrocyclic; Neoplasm Proteins; Paclitaxel; Protein Isoforms; Recombinant Fusion Proteins; RNA Interference; RNA, Messenger; RNA, Neoplasm; Septins; Transcription, Genetic; Tubulin Modulators	2007
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:9 Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Disease Models, Animal; Estradiol; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Rats; Rats, Sprague-Dawley; Time Factors	2010
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells. Cellular and molecular life sciences : CMLS, 2012, Volume: 69, Issue:1 Topics: 2-Methoxyestradiol; Animals; Blood-Brain Barrier; Brain; Endothelial Cells; Estradiol; Glucose; Humans; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Membrane Proteins; Mice; Occludin; Permeability; Phosphoproteins; Tight Junctions; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein	2012
Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity. ASN neuro, 2012, May-30, Volume: 4, Issue:4 Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Hypoxia; Cerebral Cortex; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Drug; Enzyme Activators; Estradiol; Excitatory Amino Acids; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; L-Lactate Dehydrogenase; Rats; Rats, Sprague-Dawley	2012