2-mercaptobenzimidazole and triphosphoric-acid

2-mercaptobenzimidazole has been researched along with triphosphoric-acid* in 1 studies

Other Studies

1 other study(ies) available for 2-mercaptobenzimidazole and triphosphoric-acid

Article	Year
Polymerase incorporation of a 2'-deoxynucleoside-5'-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue. Bioorganic & medicinal chemistry letters, 2015, Aug-01, Volume: 25, Issue:15 Here, we describe the enzymatic construction of a new larger base pair formed between adenine (A) and a 4-hydroxy-2-mercaptobenzimidazole (SB) nucleobase analogue. We investigated the enzymatic incorporation of 2'-deoxynucleoside-5'-triphosphate bearing a SB nucleobase analogue (dSBTP) into oligonucleotides (ONs) by DNA polymerases. dSBTP could be effectively incorporated at the site opposite a dA in a DNA template by several B family DNA polymerases. These findings provide new insights into various aspects of biotechnology, including the design of non-natural base pairs. Topics: Adenine; Base Pairing; Base Sequence; Benzimidazoles; DNA Primers; DNA-Directed DNA Polymerase; Nucleotides; Oligonucleotides; Polymerization; Polyphosphates	2015

Article

Year

Polymerase incorporation of a 2'-deoxynucleoside-5'-triphosphate bearing a 4-hydroxy-2-mercaptobenzimidazole nucleobase analogue.

Bioorganic & medicinal chemistry letters, 2015, Aug-01, Volume: 25, Issue:15

Here, we describe the enzymatic construction of a new larger base pair formed between adenine (A) and a 4-hydroxy-2-mercaptobenzimidazole (SB) nucleobase analogue. We investigated the enzymatic incorporation of 2'-deoxynucleoside-5'-triphosphate bearing a SB nucleobase analogue (dSBTP) into oligonucleotides (ONs) by DNA polymerases. dSBTP could be effectively incorporated at the site opposite a dA in a DNA template by several B family DNA polymerases. These findings provide new insights into various aspects of biotechnology, including the design of non-natural base pairs.

Topics: Adenine; Base Pairing; Base Sequence; Benzimidazoles; DNA Primers; DNA-Directed DNA Polymerase; Nucleotides; Oligonucleotides; Polymerization; Polyphosphates

2015