2-iodomelatonin has been researched along with melatonin in 216 studies
| Studies (2-iodomelatonin) | Trials (2-iodomelatonin) | Recent Studies (post-2010) (2-iodomelatonin) | Studies (melatonin) | Trials (melatonin) | Recent Studies (post-2010) (melatonin) |
|---|---|---|---|---|---|
| 245 | 0 | 10 | 23,268 | 1,451 | 9,627 |
| Protein | Taxonomy | 2-iodomelatonin (IC50) | melatonin (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 3 | |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | 3.3323 | |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.0004 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Melatonin receptor type 1A | Homo sapiens (human) | 0.0025 | |
| Melatonin receptor type 1B | Homo sapiens (human) | 0.0035 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (5.56) | 18.7374 |
| 1990's | 139 (64.35) | 18.2507 |
| 2000's | 58 (26.85) | 29.6817 |
| 2010's | 5 (2.31) | 24.3611 |
| 2020's | 2 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Dubocovich, ML | 3 |
| Biella, G; Duranti, A; Fraschini, F; Lucini, V; Salvatori, A; Spadoni, G; Stankov, B | 1 |
| Copinga, S; Dubocovich, ML; Grol, CJ; Horn, AS; Tepper, PG | 1 |
| Andrieux, J; Brémont, B; Langlois, M; Mathé-Allainmat, M; Poncet, A; Serraz, I; Shen, S; Sicsic, S | 1 |
| Dubocovich, ML; Iacob, S; Masana, MI; Sauri, DM | 1 |
| Balsamini, C; Bordi, F; Diamantini, G; Fraschini, F; Lucini, V; Mor, M; Nonno, R; Plazzi, PV; Rivara, S; Silva, C; Spadoni, G; Stankov, BM; Tarzia, G | 1 |
| Chavatte, P; Guillaumet, G; Lesieur, D; Marot, C; Michel, A; Morin-Allory, L; Renard, P; Viaud, MC | 1 |
| Boutin, JA; Delagrange, P; Leclerc, V; Lesieur, D; Renard, P; Yous, S | 1 |
| Bedini, A; Fraschini, F; Lucini, V; Mor, M; Pannacci, M; Plazzi, PV; Rivara, S; Silva, C; Spadoni, G; Tarzia, G; Vacondio, F; Zuliani, V | 1 |
| Amossé, C; Audinot, V; Bonnaud, A; Boutin, JA; Delagrange, P; Dromaint, S; Galizzi, JP; Guillaumet, G; Lahaye-Brasseur, C; Le Gall, A; Lefoulon, F; Lesieur, D; Mailliet, F; Malpaux, B; Nagel, N; Renard, P; Rodriguez, M | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Boutin, JA; Calamini, B; Mesecar, AD; Santarsiero, BD | 1 |
| Cushman, M; Maiti, A; Marler, L; Mesecar, AD; Pegan, SD; Pezzuto, JM; Reddy, PV; Sturdy, M | 1 |
| Cecon, E; Jockers, R; Rivara, S; Witt-Enderby, PA; Zlotos, DP | 1 |
| Laborda, P; Shi, XC; Wang, SY | 1 |
| Biella, G; Capsoni, S; Cozzi, B; Fauteck, J; Fraschini, F; Lucini, V; Panara, C; Stankov, B | 1 |
| Ekström, P; Vanĕcek, J | 1 |
| Pang, SF; Poon, AM | 4 |
| Niles, LP; Pickering, DS | 3 |
| Calvo, JR; Guerrero, JM; Lopez-Gonzalez, MA; Osuna, C; Rubio, A | 1 |
| Calvo, JR; Guerrero, JM; Lopez-Gonzalez, MA; Osuna, C | 1 |
| Pang, CS; Pang, SF | 1 |
| Ebling, FJ; Hastings, MH; Humby, T; Maywood, ES | 1 |
| Audigier, S; Barberis, C; Boissin, J; Boissin-Agasse, L; Roch, G | 1 |
| Liu, ZM; Pang, SF | 2 |
| Brown, GM; Cheng, KM; Pang, CS; Pang, SF; Wang, ZP | 1 |
| Brinklow, BR; Chong, NW; Loudon, AS; Paterson, A; Sugden, D | 1 |
| Laitinen, JT; Saavedra, JM; Viswanathan, M | 1 |
| Dubocovich, ML; Krause, DN; Siuciak, JA | 2 |
| Ayre, EA; Pang, SF; Song, Y | 1 |
| Ayre, EA; Pang, SF; Yuan, H | 1 |
| Cozzi, B; Fraschini, F; Fumagalli, P; Lucini, V; Scaglione, F; Stankov, B | 1 |
| Barrett, P; Davidson, G; Hastings, MH; Lawson, W; Morgan, PJ; Thompson, M | 1 |
| Dubocovich, ML; Krause, DN; Siuciak, JA; Stanton, TL | 1 |
| Capsoni, S; Cozzi, B; Fauteck, J; Fraschini, F; Fumagalli, P; Lucini, V; Stankov, B | 1 |
| Lu, Y; Pang, SF; Yuan, H | 1 |
| Kehajova, J; Persengiev, S | 1 |
| Anis, Y; Zisapel, N | 2 |
| Niles, LP; Ying, SW | 1 |
| Carlson, LL; Provencio, I; Reppert, SM; Weaver, DR | 1 |
| Pang, SF; Yuan, H | 1 |
| Chong, NW; Sugden, D | 3 |
| Laudon, M; Zisapel, N | 2 |
| Pang, SF; Tang, F; Yuan, H | 1 |
| Blazynski, C; Dubocovich, ML | 1 |
| Flügge, G; Laitinen, JT; Saavedra, JM | 1 |
| Gitler, MS; John, C; Reba, RC; Zeeberg, BR | 1 |
| Niles, LP | 1 |
| Dubocovich, ML; Fang, JM; Siuciak, JA | 1 |
| Dubocovich, ML; Mickel, M; Shankar, G | 1 |
| Dubocovich, ML; Duncan, MJ; Takahashi, JS | 2 |
| Sugden, D | 2 |
| Laudon, M; Shaharabani, M; Zisapel, N | 1 |
| Namboodiri, MA; Reppert, SM; Weaver, DR | 1 |
| Lämsä, E; Leppäluoto, J; Rahkamaa, E; Ruotsalainen, H; Vakkuri, O | 1 |
| Fraschini, F; Lucini, V; Nonno, R; Stankov, B | 1 |
| Gan, J; Iuvone, PM | 2 |
| Brown, GM; Hamadanizadeh, A; Lee, FJ; Liu, F; Niznik, HB; Pang, SF; Pristupa, ZB; Sugamori, KS; Yuan, H | 1 |
| Barrett, P; Bittman, EL; Ebling, FJ; Hastings, MH; Maywood, ES; Morgan, P | 1 |
| Ronco, AM; Tijmes, M; Valladares, LE; Vera, H | 1 |
| Brooks, DS; Cassone, VM; Kelm, TA | 1 |
| Pang, SF; Wan, Q | 2 |
| Calvo, JR; Guerrero, JM; Harmouch, A; Pozo, D; Rafii-el-Idrissi, M | 1 |
| Chow, PH; Pang, SF; Yu, ZH | 1 |
| Chong, NW; Lewis, DF; Sugden, D | 1 |
| Brown, GM; Pang, SF; Poon, AM; Song, Y; Tam, PC | 1 |
| Niles, LP; Yie, SM; Younglai, EV | 1 |
| Duncan, MJ; Purvis, CC | 1 |
| Hastings, MH; Maywood, ES | 1 |
| Chidlow, G; Osborne, NN | 1 |
| Ayre, EA; Brown, GM; Pang, SF; Wang, ZP | 1 |
| Alonso-Gómez, AL; Gan, J; Iuvone, PM | 1 |
| Hugel, HM; Kennaway, DJ; Rowe, SA | 1 |
| George, D; Kalsbeek, A; Lakhdar-Ghazal, N; Masson-Pévet, M; Pévet, P; Saboureau, M | 1 |
| Helliwell, RJ; Williams, LM | 1 |
| Duncan, MJ | 1 |
| Capsoni, S; De Oliveira, AM; Saavedra, JM; Viswanathan, M | 1 |
| Acuña-Castroviejo, D; Burgos, A; Menéndez-Peláez, A; Pablos, MI; Reiter, RJ | 1 |
| Brown, GM; Pang, CS; Pang, SF; Tsang, KF | 1 |
| Artero, C; Canonaco, M; Facciolo, RM; Franzoni, MF; Tavolaro, R | 2 |
| Mengeaud, V; Ortonne, JP; Pevet, P; Skene, D | 1 |
| Lee, PP; Pang, SF; Poon, AM; Song, Y | 1 |
| Liu, ZM; Pang, SF; Poon, AM; Tang, F | 1 |
| Cardinali, DP; Mediavilla, MD; Recio, J; Sánchez-Barceló, EJ | 1 |
| Barrett, P; Helliwell, R; Howell, HE; Morgan, PJ | 1 |
| Pang, SF; Wang, XL; Yuan, H | 1 |
| Bernard, M; Collin, JP; Pontoire, C; Silvain, C; Voisin, P | 1 |
| Duncan, MJ; Heller, KS; Massey, BT; Purvis, CC; Stetson, MH | 1 |
| Bonnefond, C; Martinet, L; Monnerie, R; Richard, JP | 1 |
| Biella, G; Capsoni, S; Cozzi, B; Fauteck, J; Fraschini, F; Gatti, S; Gridelli, B; Lucini, V; Stankov, B | 1 |
| Wiechmann, AF; Wirsig-Wiechmann, CR | 1 |
| Aste, N; Capsoni, S; Cozzi, B; Fraschini, F; Lucini, V; Panzica, GC; Stankov, B; Viglietti-Panzica, C | 1 |
| Pang, SF; Poon, AM; Wang, XL | 1 |
| Davis, FC; Duncan, MJ | 1 |
| Crocker, C; Niles, LP; Ying, SW | 1 |
| Cova, D; Fraschini, F; Gervasoni, M; Marabini, L; Perego, R; Scaglione, F; Stankov, B | 1 |
| Besser, GM; Costa, A; Forsling, ML; Grossman, A; Hucks, D; Yasin, SA | 1 |
| Masson-Pévet, M; Pévet, P; Skene, DJ | 1 |
| Aida, K; Furukawa, K; Hara, M; Hattori, A; Iigo, M; Ohtani-Kaneko, R; Suzuki, T; Tabata, M | 1 |
| Calvo, JR; Giordano, M; Guerrero, JM; Rafii-El-Idrissi, M | 1 |
| Luk, HT; Mak, AS; Poon, AM | 1 |
| Liu, Z; Peng, S; Zhao, Y | 1 |
| Ayre, EA; Brown, GM; Pang, CS; Pang, SF; Song, Y | 1 |
| Hannah, LT; Hastings, MH; Maywood, ES; Williams, LM | 1 |
| Nowak, JZ; Zawilska, JB | 1 |
| Dubocovich, ML; Larson-Prior, LJ; Siuciak, JA | 1 |
| Martinoli, MG; Priede, IG; Smith, A; Trudeau, VL; Williams, LM | 1 |
| Adam, CL; Hannah, LT; Kyle, CE; Williams, LM | 1 |
| Brown, GM; Liao, M; Pang, SF; Wan, Q | 1 |
| Brown, GM; Chan, CW; Pang, SF; Silverman, M; Song, Y | 1 |
| Tijmes, M; Valladares, LE; Vera, H | 1 |
| Barrett, P; Canning, SJ; Conway, S; Delagrange, P; Drew, JE; Guardiola-Lemaitre, B; Jockers, R; Morgan, PJ; Strosberg, AD | 1 |
| Abramovich, DR; Barrett, P; Drew, JE; Hannah, LT; Morgan, PJ; Williams, LM | 1 |
| Iacovitti, L; Johnston, K; Stull, ND | 1 |
| Calvo, JR; García-Pergañeda, A; Guerrero, JM; Pozo, D | 1 |
| Brown, GM; Delagrange, P; Guardiola-Lemaitre, B; Ng, KW; Pang, CS; Pang, SF; Song, Y; Tang, PL | 1 |
| Benloucif, S; Dubocovich, ML; Masana, MI | 2 |
| Kennaway, DJ; Voultsios, A | 1 |
| Abramovich, DR; Barrett, P; Drew, JE; Hannah, LT; Williams, LM | 1 |
| Gauer, F; Masson-Pévet, M; Pévet, P; Recio, J; Schuster, C | 1 |
| Kokkola, T; Laitinen, JT | 1 |
| Garratt, PJ; Pickering, H; Sugden, D; Teh, MT | 1 |
| Chan, HC; Lui, KM; Poon, AM; Wong, WS | 1 |
| Angeloni, D; Fraschini, F; Lucini, V; Mazzucchelli, C; Nonno, R; Pannacci, M; Stankov, BM | 1 |
| Falcón, J; Gaildrat, P; Ron, B | 1 |
| Barrett, P; Conway, S; Drew, JE; Morgan, PJ; Williams, LM | 1 |
| Brough, PA; Chen, JJ; Fiehn-Schulze, B; Firnau, G; Snieckus, V | 1 |
| Delagrange, P; Guardiola-Lemaitre, B; Guerrero, HY; Masson-Pévet, M; Mocaer, E; Pévet, P; Recio, J | 1 |
| Al-Ghoul, WM; Dubocovich, ML; Herman, MD | 1 |
| Bucher, B; Gauer, F; Masson-Pévet, M; Pévet, P | 1 |
| Andrieux, J; Delagrange, P; Jellimann, C; Langlois, M; Mathé-Allainmat, M; Renard, P | 1 |
| Flanders, S; Lew, MJ | 1 |
| Eison, AS; Gianutsos, G; Mullins, UL | 1 |
| Angeloni, D; Fraschini, F; Lucini, V; Nonno, R; Pannacci, M; Stankov, BM | 1 |
| Goodnight, AL; Heideman, PD; Kane, SL | 1 |
| Brydon, L; Freissmuth, M; Jockers, R; Nanoff, C; Roka, F; Strosberg, AD; Waldhoer, M | 1 |
| Li, L; Pang, CS; Pang, SF; Shiu, SY; Wong, JT; Xu, JN | 1 |
| Lobb, DK; Niles, LP; Shen, L; Wang, J; Younglai, EV | 1 |
| Andrieux, J; Jellimann, C; Langlois, M; Le Gall, M; Mathé-Allainmat, M | 1 |
| Martin-Iverson, MT; Munro, JD | 1 |
| Beresford, I; Browning, C; Fraser, N; Giles, H | 1 |
| Gubitz, AK; Reppert, SM | 1 |
| Barrett, P; Canning, SJ; Conway, S; Delagrange, P; Drew, JE; Howell, HE; Lesieur, D; Morgan, PJ; Mowat, ES | 1 |
| Gauer, F; Guerrero, HY; Masson-Pévet, M; Pévet, P; Schuster, C | 1 |
| Falcón, J; Gaildrat, P | 2 |
| Konakchieva, R; Manchev, S; Masson-Pevét, M; Pevét, P | 1 |
| Brown, GM; Pang, SF; Shiu, SY; Tam, PC; Xi, SC | 1 |
| Balsamini, C; Croce, A; Esposti, D; Fraschini, F; Lucini, V; Nonno, R; Pannacci, M; Spadoni, G; Stankov, BM; Tarzia, G | 1 |
| Martin-Iverson, MT; Ruzich, M | 1 |
| Pang, SF; Poon, AM; Zhao, H | 2 |
| Fazzuoli, L; Giordano, G; Giusti, M; Valenti, S | 1 |
| Barrett, P; Conway, S; Delagrange, P; Drew, JE; Morgan, PJ; Mowat, ES | 1 |
| Boutin, JA; Canet, E; Delagrange, P; Klupsch, F; Nicolas, JP; Nosjean, O | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; De Pedro, N; Delgado, MJ; Pinillos, ML | 1 |
| Bordt, SL; Li, PK; McKeon, RM; Melan, MA; Witt-Enderby, PA | 1 |
| Bedini, A; Di Giacomo, B; Diamantini, G; Fraschini, F; Lucini, V; Mor, M; Nonno, R; Pannacci, M; Plazzi, PV; Rivara, S; Spadoni, G; Stankov, BM; Tarzia, G | 1 |
| Clemens, JW; Jarzynka, MJ; Witt-Enderby, PA | 1 |
| Chan, AS; Lai, FP; Lo, RK; Stanbridge, EJ; Voyno-Yasenetskaya, TA; Wong, YH | 1 |
| Calderón, C; Fogal, T; Mohamed, F; Muñoz, E; Pelzer, L; Penissi, A; Piezzi, R | 1 |
| Kam, JY; Lai, FP; Mody, SM; Pang, CS; Pang, SF; Wong, YH; Yung, LY | 1 |
| Brown, GM; Pang, CS; Pang, SF; Shiu, SY; Xi, SC | 1 |
| Sugden, D; Teh, MT | 1 |
| Becq, F; Falcón, J; Gaildrat, P | 1 |
| Kravtsov, G; Pang, CS; Pang, SF; Shiu, SY; Yau, MY | 1 |
| Kravtsov, GM; Pang, SF; Poon, AM | 1 |
| Lau, KW; Shiu, SY; Siu, SW; Tam, PC | 1 |
| Burkhardt, S; Dose, A; Hardeland, R; Poeggeler, B; Schoenke, M; Thuermann, S | 1 |
| Abramovich, DR; Drew, JE; Purvis, CC; Thomas, L; Williams, LM | 1 |
| Forcelledo, ML; Richter, HG; Rojas-García, P; Serón-Ferré, M; Torrealba, F; Torres-Farfan, C; Valenzuela, GJ; Valladares, LE; Vergara, M | 1 |
| Audinot, V; Bennejean, C; Bochu, C; Boutin, JA; Delagrange, P; Durieux-Poissonnier, S; Guelzim, H; Lesieur, D; Lipka-Belloli, E; Renard, P; Yous, S | 1 |
| Andrieux, J; Bennejean, C; Boutin, JA; Chahed, E; Delagrange, P; Langlois, M; Mathé-Allainmat, M; Morellato, L; Nicolas, JP; Pégurier, C | 1 |
| Castrucci, AM; Souza, AV; Visconti, MA | 1 |
| Korth, M; Motejlek, K; Olcese, J; Ruth, P; Sailer, C; Sausbier, U; Steffens, F; Wieland, T; Zhou, XB | 1 |
| Attia, J; Beauchaud, M; Besseau, L; Boeuf, G; Falcón, J; Fazzari, D; Gaildrat, P | 1 |
| Chen, Y; Fung, ML; Ip, SF; Liong, EC; Tipoe, GL; Tjong, YW | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; Delgado, MJ; Guijarro, A; Isorna, E | 1 |
| Hu, CL; Jiao, S; Mei, YA; Wu, MM; Zhang, ZH | 1 |
| Balik, A; Berka, K; Ettrich, R; Jelinkova, I; Mazna, P; Obsil, T; Obsilova, V; Sovova, Z; Svoboda, P; Teisinger, J | 1 |
| Alonso-Gómez, AL; Bayarri, MJ; Delgado, MJ; Iigo, M; Isorna, E; Madrid, JA; Muñoz-Cueto, JA; Sánchez-Vázquez, FJ | 1 |
| Gao, ZY; Hu, CL; Liu, Z; Mei, YA; Zhang, ZH | 1 |
| Chen, Y; Fung, ML; Ip, SF; Tipoe, GL; Tjong, YW | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; Delgado, MJ; Guijarro, A; Isorna, E; López-Patiño, MA | 1 |
| Balik, A; Berka, K; Jelinkova, I; Mazna, P; Obsil, T; Obsilova, V; Svoboda, P; Teisinger, J | 1 |
| Aboul-Enein, H; Al-Jammaz, I; Al-Otaibi, B; Amartey, JK | 1 |
| Cheung, KM; Leong, JC; Lu, DS; Poon, AM | 1 |
| Davidson, K; Eleutheriades, A; Hough, KA; Sugden, D; Tsotinis, A | 1 |
| Audinot, V; Balik, A; Barrett, P; Bonnaud, A; Boutin, JA; Delagrange, P; Galizzi, JP; Grandcolas, L; Hazlerigg, DG; Messager, S; Nagel, N; Rodriguez, M | 1 |
| Chan, KW; Liu, VW; Pang, B; Shiu, SY; Tam, CW; Yao, KM | 1 |
| Fujinoki, M | 1 |
| Ishii, H; Kato, M; Sakuma, Y; Sato, S; Yin, C | 1 |
| Chan, AS; Lau, WW; Lee, MM; Ng, JK; Wong, YH | 1 |
| Berthelot, P; Boutin, JA; Brayer, JL; Caignard, DH; Delagrange, P; Folleas, B; Grelak, T; Guillaumet, G; Hassler, W; Lefoulon, F; Legros, C; Matthey, U; Nosjean, O; Pedragona-Moreau, S; Suzenet, F; Thomas, E; Yous, S | 1 |
| Bass, AH; Feng, NY | 1 |
| Hirai, K; Nishiyama, K | 1 |
| Du, Y; Gong, Q; Guo, Q; Li, X; Liu, Z; Lu, Q; Tao, Y; Teng, M; Wang, Q | 1 |
6 review(s) available for 2-iodomelatonin and melatonin
| Article | Year |
|---|---|
Indole-based melatonin analogues: Synthetic approaches and biological activity.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Indoles; Ligands; Melatonin; Molecular Structure; Receptors, Melatonin; Structure-Activity Relationship | 2020 |
Melatonin receptors in the central nervous system.
Topics: Animals; Brain Chemistry; Calcium; Chickens; Circadian Rhythm; Dopamine; Hypothalamus; Mammals; Melatonin; Mice; Mice, Inbred C3H; Periodicity; Pineal Gland; Receptors, Melatonin; Receptors, Neurotransmitter; Reproduction; Retina; Seasons; Suprachiasmatic Nucleus; Tryptamines | 1991 |
Pharmacology and function of melatonin receptors.
Topics: Animals; Binding Sites; Brain; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Iodine Radioisotopes; Melatonin; Nervous System; Receptors, Melatonin; Receptors, Neurotransmitter; Retina; Structure-Activity Relationship | 1988 |
Melatonin receptors: localization, molecular pharmacology and physiological significance.
Topics: Animals; Binding Sites; Humans; Melatonin; Pituitary Gland; Receptors, Cell Surface; Receptors, Melatonin; Retina; Tissue Distribution | 1994 |
Melatonin: binding site characteristics and biochemical and cellular responses.
Topics: Animals; Arteries; Binding Sites; Humans; Melatonin; Pineal Gland; Pituitary Gland; Receptors, Cell Surface; Receptors, Melatonin; Retina; Structure-Activity Relationship; Suprachiasmatic Nucleus | 1994 |
Melatonin receptor genes.
Topics: Amino Acid Sequence; Animals; GTP-Binding Proteins; Humans; Iodine Radioisotopes; Melatonin; Molecular Sequence Data; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 1998 |
210 other study(ies) available for 2-iodomelatonin and melatonin
| Article | Year |
|---|---|
Characterization of a retinal melatonin receptor.
Topics: Animals; Calcium; Chickens; Corpus Striatum; Dopamine; In Vitro Techniques; Indoles; Melatonin; Olfactory Bulb; Rabbits; Receptors, Cell Surface; Receptors, Melatonin; Retina; Structure-Activity Relationship; Tryptamines | 1985 |
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity.
Topics: Animals; Binding Sites; Cricetinae; Male; Mesocricetus; Quail; Rabbits; Receptors, Cell Surface; Receptors, Melatonin; Structure-Activity Relationship; Tryptamines | 1993 |
2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
Topics: Animals; Binding, Competitive; Calcium; Cell Membrane; Chickens; Dopamine; Iodine Radioisotopes; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Melatonin; Retina; Structure-Activity Relationship; Tetrahydronaphthalenes | 1993 |
Three-dimensional quantitative structure-activity relationship of melatonin receptor ligands: a comparative molecular field analysis study.
Topics: Animals; Brain; Chickens; Ligands; Melatonin; Models, Molecular; Molecular Conformation; Molecular Structure; Polycyclic Compounds; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship | 1997 |
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.
Topics: Animals; Cell Line; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Presynaptic; Recombinant Proteins; Retina | 1997 |
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study.
Topics: Animals; Ligands; Melatonin; Models, Molecular; Molecular Conformation; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship; Superior Colliculi | 1998 |
Pharmacophoric search and 3D-QSAR comparative molecular field analysis studies on agonists of melatonin sheep receptors.
Topics: Animals; Brain; Ligands; Melatonin; Models, Molecular; Molecular Conformation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reproducibility of Results; Sheep; Structure-Activity Relationship | 1998 |
Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).
Topics: Acetamides; Animals; Binding Sites; Cell Line; Cricetinae; Humans; In Vitro Techniques; Indoles; Ligands; Nitro Compounds; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship | 2002 |
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Topics: Ligands; Melatonin; Models, Molecular; Models, Statistical; Pyrroles; Quantitative Structure-Activity Relationship; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 2003 |
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Topics: Animals; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Humans; Ligands; Melatonin; Protein Binding; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2 | 2003 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Kinetics; Melatonin; Models, Molecular; Molecular Structure; Protein Binding; Quinone Reductases; Thermodynamics | 2008 |
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Benzodioxoles; Casimiroa; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Fruit; Humans; Mice; Models, Molecular; Quinolones; Quinone Reductases; Structure-Activity Relationship | 2009 |
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Topics: Animals; Binding Sites; Depressive Disorder; Humans; Ligands; Melatonin; Models, Molecular; Protein Multimerization; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship | 2014 |
Melatonin signal transduction and mechanism of action in the central nervous system: using the rabbit cortex as a model.
Topics: Animals; Binding Sites; Cyclic AMP; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Melatonin; Parietal Lobe; Pertussis Toxin; Rabbits; Receptors, GABA-A; Receptors, Melatonin; Receptors, Neurotransmitter; Signal Transduction; Virulence Factors, Bordetella | 1992 |
Localization of 2-[125I]iodomelatonin binding sites in the brain of the Atlantic salmon, Salmo salar L.
Topics: Animals; Autoradiography; Brain; Cell Membrane; Circadian Rhythm; Iodine Radioisotopes; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Salmon; Tissue Distribution | 1992 |
2[125I]iodomelatonin binding sites in spleens of guinea pigs.
Topics: Animals; Binding Sites; Cell Nucleus; Circadian Rhythm; Cytosol; Female; Guinea Pigs; Iodine Radioisotopes; Kinetics; Melatonin; Microsomes; Mitochondria; Receptors, Melatonin; Receptors, Neurotransmitter; Spleen | 1992 |
Expression of nanomolar-affinity binding sites for melatonin in Syrian hamster RPMI 1846 melanoma cells.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Cricetinae; Culture Media; Cyclic AMP; Melanoma, Experimental; Melatonin; Mesocricetus; Protein Binding; Tumor Cells, Cultured | 1992 |
Melatonin potentiates cyclic AMP production stimulated by vasoactive intestinal peptide in human lymphocytes.
Topics: Cyclic AMP; Humans; In Vitro Techniques; Lymphocytes; Melatonin; Vasoactive Intestinal Peptide | 1992 |
Interaction of melatonin with human lymphocytes: evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP.
Topics: Binding, Competitive; Cell Membrane; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Lymphocytes; Melatonin; Purine Nucleotides; Pyrimidine Nucleotides; Receptors, Melatonin; Receptors, Neurotransmitter; Vasoactive Intestinal Peptide | 1992 |
High affinity specific binding of 2-[125I]iodomelatonin by spleen membrane preparations of chicken.
Topics: Animals; Chickens; Circadian Rhythm; Iodine Radioisotopes; Kinetics; Melatonin; Random Allocation; Receptors, Melatonin; Receptors, Neurotransmitter; Spleen | 1992 |
Circadian and photoperiodic time measurement in male Syrian hamsters following lesions of the melatonin-binding sites of the paraventricular thalamus.
Topics: Animals; Autoradiography; Circadian Rhythm; Cricetinae; Light; Luteinizing Hormone; Male; Melatonin; Mesocricetus; Motor Activity; Periodicity; Photic Stimulation; Receptors, Melatonin; Receptors, Neurotransmitter; Stereotaxic Techniques; Thalamic Nuclei | 1992 |
Localization of melatonin binding sites in the pars tuberalis of the mink at three times during the seasonal testicular cycle.
Topics: Animals; Autoradiography; Hypothalamus; Male; Melatonin; Mink; Pituitary Gland, Anterior; Radioligand Assay; Receptors, Melatonin; Receptors, Neurotransmitter; Seasons; Suprachiasmatic Nucleus; Testis | 1992 |
Constant light exposure increases 2-[125I]iodomelatonin binding sites in the guinea pig spleen.
Topics: Animals; Circadian Rhythm; Female; Guinea Pigs; Kinetics; Light; Male; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Spleen | 1992 |
[125I]-labelled iodomelatonin binding sites in the duck bursa of Fabricius: binding characteristics and diurnal variation.
Topics: Animals; Bursa of Fabricius; Circadian Rhythm; Ducks; Female; Iodine Radioisotopes; Male; Melatonin; Radioligand Assay; Receptors, Melatonin; Receptors, Neurotransmitter; Regression Analysis | 1992 |
Characterization of 2-[125I]iodomelatonin-binding sites in quail testes at mid-light and mid-dark.
Topics: Animals; Coturnix; Darkness; Kinetics; Light; Male; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Testis | 1992 |
Characterization of 2-[125I]iodomelatonin binding sites in the brain of a marsupial, Bennett's wallaby (Macropus rufogriseus rufogriseus).
Topics: Animals; Binding Sites; Binding, Competitive; Biological Evolution; Brain; GTP-Binding Proteins; Kinetics; Marsupialia; Melatonin; Tissue Distribution | 1992 |
Differential expression of melatonin receptors in spontaneously hypertensive rats.
Topics: Age Factors; Animals; Arteries; Autoradiography; Binding, Competitive; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Hypertension; Male; Melatonin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cell Surface; Receptors, Melatonin; Species Specificity | 1992 |
Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum.
Topics: Animals; Autoradiography; Chickens; Iodine Radioisotopes; Melatonin; Optic Nerve; Superior Colliculi | 1992 |
The identification and characterization of 125I-labelled iodomelatonin-binding sites in the duck kidney.
Topics: Animals; Binding Sites; Ducks; Female; Iodine Radioisotopes; Kidney; Male; Melatonin; Radioligand Assay | 1992 |
The identification of 125I-labelled iodomelatonin-binding sites in the testes and ovaries of the chicken (Gallus domesticus).
Topics: Animals; Binding Sites; Binding, Competitive; Chickens; Female; Iodine Radioisotopes; Kinetics; Male; Melatonin; Ovary; Radioligand Assay; Testis | 1992 |
Characterization and mapping of melatonin receptors in the brain of three mammalian species: rabbit, horse and sheep. A comparative in vitro binding study.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Horses; Kinetics; Male; Median Eminence; Melatonin; Pituitary Gland, Anterior; Preoptic Area; Rabbits; Receptors, Melatonin; Receptors, Neurotransmitter; Sheep; Suprachiasmatic Nucleus | 1991 |
Intracellular signalling in the ovine pars tuberalis: an investigation using aluminium fluoride and melatonin.
Topics: Aluminum; Aluminum Compounds; Animals; Binding Sites; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Fluorides; Inositol Phosphates; Melatonin; Pituitary Gland, Anterior; Sheep; Signal Transduction | 1991 |
The area of 2-[125I] iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation.
Topics: Animals; Autoradiography; Brain; Female; Hibernation; Iodine Radioisotopes; Male; Melatonin; Pituitary Gland, Anterior; Receptors, Melatonin; Receptors, Neurotransmitter; Sciuridae | 1991 |
Localization and characterization of melatonin binding sites in the brain of the rabbit (Oryctolagus cuniculus) by autoradiography and in vitro ligand-receptor binding.
Topics: Animals; Autoradiography; Brain Chemistry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hypothalamus; In Vitro Techniques; Iodine Radioisotopes; Ligands; Male; Melatonin; Rabbits; Receptors, Melatonin; Receptors, Neurotransmitter | 1991 |
Binding characteristics and regional distribution of [125I]iodomelatonin binding sites in the brain of the human fetus.
Topics: Binding, Competitive; Brain; Brain Chemistry; Fetus; Humans; Hypothalamus; Indoles; Melatonin; Neurotransmitter Agents; Receptors, Melatonin; Receptors, Neurotransmitter; Serotonin | 1991 |
Inhibitory action of melatonin and structurally related compounds on testosterone production by mouse Leydig cells in vitro.
Topics: 5-Methoxytryptamine; Animals; Dose-Response Relationship, Drug; Indoles; Leydig Cells; Male; Melatonin; Mice; Mice, Inbred BALB C; Testosterone | 1991 |
Castration affects brain iodomelatonin binding in hamsters maintained in long but not short days.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cricetinae; Light; Male; Melatonin; Mesocricetus; Orchiectomy; Periodicity; Testosterone; Time Factors | 1991 |
3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate-solubilized binding sites for 2-[125I]iodomelatonin in chick brain retain sensitivity to guanine nucleotides.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Chickens; Cholic Acids; Cytosol; Detergents; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Iodine Radioisotopes; Kinetics; Male; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Solubility | 1991 |
Melatonin receptors and signal transduction in photorefractory Siberian hamsters (Phodopus sungorus).
Topics: Animals; Autoradiography; Binding Sites; Brain; Cricetinae; Gonads; Light; Melatonin; Periodicity; Receptors, Melatonin; Receptors, Neurotransmitter; Signal Transduction; Time Factors; Tissue Distribution | 1991 |
[125I]Iodomelatonin-binding sites in the pigeon brain: binding characteristics, regional distribution and diurnal variation.
Topics: Animals; Brain; Cell Membrane; Cell Nucleus; Cerebellum; Circadian Rhythm; Columbidae; Female; Hypothalamus; Iodine Radioisotopes; Male; Melatonin; Mitochondria; Pons; Protein Binding; Receptors, Melatonin; Receptors, Neurotransmitter; Telencephalon | 1991 |
Pharmacological identity of 2-[125I]iodomelatonin binding sites in chicken brain and sheep pars tuberalis.
Topics: Animals; Brain; Chickens; Kinetics; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Sheep | 1991 |
Melatonin binding proteins identified in the rat brain by affinity labeling.
Topics: Affinity Labels; Animals; Binding, Competitive; Brain; Carrier Proteins; Chromatography, Thin Layer; Kinetics; Male; Melatonin; Rats; Rats, Inbred Strains; Synaptosomes | 1991 |
Binding characteristics, regional distribution and diurnal variation of [125I]-iodomelatonin binding sites in the chicken brain.
Topics: Animals; Binding, Competitive; Brain; Chickens; Circadian Rhythm; In Vitro Techniques; Kinetics; Male; Melatonin; Radioligand Assay; Receptors, Melatonin; Receptors, Neurotransmitter; Subcellular Fractions | 1990 |
Localization of 2-[125I]iodomelatonin binding sites in mammalian retina.
Topics: Animals; Binding Sites; Darkness; Iodine Radioisotopes; Light; Melatonin; Mice; Mice, Inbred BALB C; Periodicity; Rabbits; Retina; Tissue Distribution | 1991 |
Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cricetinae; Hydrogen-Ion Concentration; Hypothalamus; Iodine Radioisotopes; Kinetics; Male; Melatonin; Mesocricetus; Receptors, Melatonin; Receptors, Neurotransmitter | 1990 |
Characterization of melatonin receptors in the rat area postrema: modulation of affinity with cations and guanine nucleotides.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Calcium Chloride; Cations, Divalent; Cerebral Ventricles; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Magnesium Chloride; Male; Melatonin; Rats; Rats, Inbred Strains; Receptors, Melatonin; Receptors, Neurotransmitter; Serotonin; Thionucleotides | 1990 |
Specific in vivo binding of [125I]-iodomelatonin to melatonin receptors in rat brain.
Topics: Animals; Chromatography, Thin Layer; Iodine Radioisotopes; Male; Melatonin; Rats; Rats, Inbred Strains; Receptors, Melatonin; Receptors, Neurotransmitter; Tomography, Emission-Computed, Single-Photon | 1990 |
GTP modulates [125I]iodomelatonin binding to a picomolar-affinity site in the Syrian hamster hypothalamus.
Topics: Animals; Binding Sites; Cricetinae; Guanosine Triphosphate; Hypothalamus; Iodine Radioisotopes; Kinetics; Male; Melatonin; Membranes; Mesocricetus; Nucleotides; Temperature | 1990 |
Autoradiographic localization of 2-[125I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice.
Topics: Animals; Autoradiography; Binding Sites; Brain; Iodine Radioisotopes; Male; Melatonin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Species Specificity | 1990 |
Characterization of central melatonin receptors using 125I-melatonin.
Topics: Animals; Brain; Freezing; Hot Temperature; Hydroxyindoleacetic Acid; Iodine Radioisotopes; Kinetics; Male; Melatonin; Rats; Receptors, Cell Surface; Receptors, Melatonin; Serotonin; Synaptosomes; Trypsin | 1986 |
2-[125I]iodomelatonin labels sites with identical pharmacological characteristics in chicken brain and chicken retina.
Topics: Animals; Binding, Competitive; Brain Chemistry; Chickens; Cricetinae; In Vitro Techniques; Indoles; Iodine Radioisotopes; Melatonin; Membranes; Receptors, Melatonin; Receptors, Neurotransmitter; Retina | 1989 |
2-[125I]iodomelatonin binding sites in hamster and chick exhibit differential sensitivity to prazosin.
Topics: Animals; Brain Chemistry; Chickens; Cricetinae; Hypothalamus; In Vitro Techniques; Iodine Radioisotopes; Male; Melatonin; Mesocricetus; Prazosin; Receptors, Melatonin; Receptors, Neurotransmitter; Retina; Species Specificity; Testis | 1989 |
Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cell Membrane; Cricetinae; Hypothalamus; Iodine Radioisotopes; Light; Male; Melatonin; Protein Binding; Radioligand Assay | 1989 |
Antigonadal activity of the melatonin analogs 2-iodomelatonin and 2-chloromelatonin in the juvenile Djungarian hamster, Phodopus sungorus campbelli.
Topics: Animals; Male; Melatonin; Organ Size; Testis | 1989 |
Regulation of melatonin's activity in the female rat brain by estradiol: effects on neurotransmitter release and on iodomelatonin binding sites.
Topics: Animals; Binding Sites; Brain; Dopamine; Estradiol; Female; Hypothalamus; Melatonin; Ovariectomy; Ovary; Rats; Receptors, Melatonin; Receptors, Neurotransmitter | 1987 |
Impact of circulating testosterone on iodomelatonin binding sites in the male rat brain.
Topics: Animals; Brain; Estradiol; Hippocampus; Hypothalamus; Iodine Radioisotopes; Male; Melatonin; Mesylates; Orchiectomy; Rats; Receptors, Melatonin; Receptors, Neurotransmitter; Testosterone | 1988 |
Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain.
Topics: Animals; Binding Sites; Brain; Cricetinae; Female; Fetus; Hypothalamus; Melatonin; Pineal Gland; Pituitary Gland, Anterior; Pregnancy; Tissue Distribution | 1988 |
Characterization of 2-[125I]iodomelatonin binding sites in hamster brain.
Topics: Animals; Binding Sites; Brain; Cricetinae; In Vitro Techniques; Iodine Radioisotopes; Melatonin; Mesocricetus | 1986 |
Iodinated melatonin: preparation and characterization of the molecular structure by mass and 1H NMR spectroscopy.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Melatonin; Oxidation-Reduction | 1984 |
2-[125I]iodomelatonin binding sites in the bovine hippocampus are not sensitive to guanine nucleotides.
Topics: Animals; Autoradiography; Binding Sites; Cattle; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Hippocampus; Kinetics; Male; Melatonin | 1995 |
Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melatonin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium; Receptors, Cell Surface; Receptors, Melatonin; Retina; Second Messenger Systems; Structure-Activity Relationship; Tryptamines; Virulence Factors, Bordetella | 1994 |
Functional interaction of melatonin receptors and D1 dopamine receptors in cultured chick retinal neurons.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Benzazepines; Cells, Cultured; Chick Embryo; Cyclic AMP; GTP-Binding Proteins; Haloperidol; Inositol Phosphates; Melatonin; Models, Neurological; Neurons; Pertussis Toxin; Receptors, Cell Surface; Receptors, Dopamine D1; Receptors, Melatonin; Retina; Signal Transduction; Synaptic Transmission; Virulence Factors, Bordetella | 1995 |
Molecular and functional characterization of a partial cDNA encoding a novel chicken brain melatonin receptor.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Chickens; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Melatonin; Molecular Sequence Data; Receptors, Cell Surface; Receptors, Dopamine D1; Receptors, Melatonin; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Xenopus | 1995 |
Regional distribution of iodomelatonin binding sites within the suprachiasmatic nucleus of the Syrian hamster and the Siberian hamster.
Topics: Afferent Pathways; Animals; Arginine Vasopressin; Base Sequence; Binding Sites; Cricetinae; Male; Melatonin; Mesocricetus; Molecular Sequence Data; Phodopus; Receptors, Cell Surface; Retina; Species Specificity; Suprachiasmatic Nucleus; Visual Pathways | 1995 |
Melatonin binding sites in interstitial cells from immature rat testes.
Topics: Animals; Binding Sites; Leydig Cells; Male; Melatonin; Rats; Rats, Wistar; Sexual Maturation; Testis; Time Factors | 1993 |
Comparative distribution of 2[125I]iodomelatonin binding in the brains of diurnal birds: outgroup analysis with turtles.
Topics: Animals; Autoradiography; Biological Evolution; Birds; Brain; Brain Mapping; Circadian Rhythm; Image Processing, Computer-Assisted; Male; Melatonin; Phylogeny; Pineal Gland; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Retina; Species Specificity; Turtles; Visual Pathways | 1995 |
Segmental, coronal and subcellular distribution of 2-[125I]iodomelatonin binding sites in the chicken spinal cord.
Topics: Animals; Binding Sites; Cell Nucleus; Chickens; Cytoplasm; Female; Male; Melatonin; Nerve Tissue Proteins; Organelles; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Spinal Cord | 1994 |
Specific binding of 2-[125I]iodomelatonin by rat splenocytes: characterization and its role on regulation of cyclic AMP production.
Topics: Animals; Binding Sites; Cyclic AMP; Iodine Radioisotopes; Light; Male; Melatonin; Rats; Rats, Wistar; Spleen | 1995 |
Identification and characterization of 2[125I]-iodomelatonin binding sites in the rat epididymis.
Topics: Animals; Cricetinae; Epididymis; Genitalia, Male; Guinea Pigs; Humans; Iodine Radioisotopes; Male; Melatonin; Mesocricetus; Mice; Mice, Inbred ICR; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Melatonin; Swine | 1994 |
Structural requirements at the melatonin receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Chickens; Computer Simulation; Hydrogen Bonding; Iodine Isotopes; Isotope Labeling; Melatonin; Models, Molecular; Molecular Structure; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Structure-Activity Relationship | 1995 |
2-[125I]iodomelatonin-binding sites in the human kidney and the effect of guanosine 5'-O-(3-thiotriphosphate).
Topics: Adult; Aged; Autoradiography; Binding Sites; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Kidney Cortex; Kidney Neoplasms; Male; Melatonin; Middle Aged; Tissue Distribution | 1995 |
Melatonin receptors on human granulosa cell membranes.
Topics: Binding Sites; Binding, Competitive; Cell Membrane; Female; Granulosa Cells; Humans; Indoles; Melatonin; Receptors, Cell Surface; Receptors, Melatonin | 1995 |
Effects of aging on photoperiodic responsiveness and specific 2-[125I]-iodomelatonin binding sites in the pars tuberalis and suprachiasmatic nuclei of Siberian hamsters.
Topics: Aging; Animals; Autoradiography; Binding Sites; Cricetinae; Iodine Radioisotopes; Light; Male; Melatonin; Phodopus; Photoperiod; Pituitary Gland, Anterior; Suprachiasmatic Nucleus; Testis | 1994 |
Lesions of the iodomelatonin-binding sites of the mediobasal hypothalamus spare the lactotropic, but block the gonadotropic response of male Syrian hamsters to short photoperiod and to melatonin.
Topics: Animals; Autoradiography; Binding Sites; Cricetinae; Gonadotropins; Hypothalamus, Middle; Male; Melatonin; Mesocricetus; Photoperiod; Prolactin; Reproduction; Sex Characteristics | 1995 |
The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eye.
Topics: Animals; Autoradiography; Ciliary Body; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Iris; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Melatonin; Serotonin | 1994 |
[125I]iodomelatonin-binding sites in the bursa of Fabricius of birds: binding characteristics, subcellular distribution, diurnal variations and age studies.
Topics: Aging; Animals; Binding Sites; Birds; Bursa of Fabricius; Chickens; Circadian Rhythm; Columbidae; Coturnix; Female; Humans; Immune System; Iodine Radioisotopes; Male; Melatonin | 1993 |
Localization and characterization of [125I]iodomelatonin binding sites in duck gonads.
Topics: Animals; Autoradiography; Binding Sites; Ducks; Female; Iodine Radioisotopes; Male; Melatonin; Ovary; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Testis | 1994 |
5-Methoxytryptamine inhibits cyclic AMP accumulation in cultured retinal neurons through activation of a pertussis toxin-sensitive site distinct from the 2-[125I]iodomelatonin binding site.
Topics: 5-Methoxytryptamine; Animals; Binding Sites; Cells, Cultured; Chick Embryo; Cyclic AMP; Melatonin; Neurons; Pertussis Toxin; Retina; Virulence Factors, Bordetella | 1995 |
Characterization of the chicken brain melatonin-binding protein using iodinated and tritiated ligands.
Topics: Animals; Binding, Competitive; Brain; Chickens; Iodine Radioisotopes; Ligands; Melatonin; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Synaptosomes; Temperature; Tritium | 1994 |
An attempt to correlate brain areas containing melatonin-binding sites with rhythmic functions: a study in five hibernator species.
Topics: Animals; Brain Chemistry; Brain Mapping; Cricetinae; Female; Hedgehogs; Hibernation; Hypothalamus; Male; Melatonin; Nerve Tissue Proteins; Periodicity; Photoperiod; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Melatonin; Rodentia; Seasons; Species Specificity; Suprachiasmatic Nucleus | 1994 |
The development of melatonin-binding sites in the ovine fetus.
Topics: Animals; Autoradiography; Binding, Competitive; Fetus; Guanosine 5'-O-(3-Thiotriphosphate); Melatonin; Protein Binding; Receptors, Cell Surface; Receptors, Melatonin; Sheep; Tissue Distribution | 1994 |
Unilateral optic nerve transection decreases 2-[125I]-iodomelatonin binding in retinorecipient areas and visual pathways of chick brain.
Topics: Animals; Autoradiography; Brain Chemistry; Chickens; Melatonin; Nerve Fibers; Optic Nerve; Receptors, Cell Surface; Receptors, Melatonin; Retina; Visual Pathways | 1994 |
Photoperiodic effects on puberty and specific 2-[125I]iodomelatonin binding sites in Siberian hamsters.
Topics: Animals; Autoradiography; Cricetinae; Iodine Radioisotopes; Kinetics; Light; Male; Melatonin; Organ Size; Periodicity; Phodopus; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Melatonin; Sexual Maturation; Suprachiasmatic Nucleus; Testis | 1994 |
Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.
Topics: Animals; Binding Sites; Brain; Chickens; Guanosine Triphosphate; Iodine Radioisotopes; Kinetics; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; Regression Analysis; Temperature; Thermodynamics; Tryptamines | 1994 |
Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis.
Topics: Animals; Arteries; Circle of Willis; Colforsin; Cyclic AMP; Male; Melatonin; Nucleotides; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Melatonin; Signal Transduction | 1994 |
Characterization of high-affinity melatonin binding sites in purified cell nuclei of rat liver.
Topics: Animals; Binding, Competitive; Cell Nucleus; Kinetics; Liver; Male; Melatonin; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Melatonin | 1994 |
Specific 2-[125I]iodomelatonin binding sites in the duck adrenal gland.
Topics: Adrenal Glands; Animals; Ducks; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Membranes; Receptors, Cell Surface; Receptors, Melatonin; Subcellular Fractions; Thermodynamics | 1994 |
Combined gonadal and photic influences on 2-[125I] iodomelatonin-binding level changes in some brain areas of the quail.
Topics: Animals; Autoradiography; Brain; Coturnix; Iodine Radioisotopes; Light; Male; Melatonin; Photoperiod; Radioligand Assay; Receptors, Cell Surface; Receptors, Melatonin; Testis | 1994 |
No high affinity melatonin binding sites are detected in murine melanoma cells and in normal human melanocytes cultured in vitro.
Topics: Animals; Binding Sites; Chickens; Humans; Iodine Radioisotopes; Kinetics; Melanoma, Experimental; Melatonin; Mice; Sensitivity and Specificity; Tumor Cells, Cultured | 1994 |
Gonadal-GABAergic interaction is an important factor involved in photoperiod-induced 2-[125I] iodomelatonin binding changes in the Japanese quail brain.
Topics: Animals; Autoradiography; Bicuculline; Brain; Coturnix; gamma-Aminobutyric Acid; Iodine Radioisotopes; Male; Melatonin; Orchiectomy; Photoperiod; Radioligand Assay; Testis; Tissue Distribution | 1994 |
Putative melatonin receptors in the male guinea pig kidney.
Topics: Animals; Binding Sites; Guinea Pigs; Kidney Cortex; Kidney Medulla; Male; Melatonin; Radioimmunoassay; Receptors, Cell Surface; Receptors, Melatonin; Subcellular Fractions | 1993 |
Modulation of 2-[125I]iodomelatonin binding in the guinea pig spleen by guanine nucleotides and cations.
Topics: Animals; Binding, Competitive; Calcium; Cations; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Guinea Pigs; Iodine Radioisotopes; Melatonin; Sodium; Spleen | 1994 |
Cortisol decreases 2[125I]iodomelatonin binding sites in the duck thymus.
Topics: Adrenal Cortex Hormones; Animals; Binding Sites; Body Weight; Ducks; Hydrocortisone; Injections, Intraperitoneal; Iodine Radioisotopes; Lymphoid Tissue; Melatonin; Organ Size; Pineal Gland; Radioimmunoassay; Receptors, Cell Surface; Receptors, Melatonin; Spleen; Thymus Gland; Time Factors | 1994 |
Pharmacological profile and diurnal rhythmicity of 2-[125I]-iodomelatonin binding sites in murine mammary tissue.
Topics: Animals; Binding Sites; Binding, Competitive; Biogenic Monoamines; Cell Membrane; Circadian Rhythm; Female; Iodine Radioisotopes; Mammary Glands, Animal; Melatonin; Mice; Mice, Inbred BALB C; Receptors, Cell Surface; Receptors, Melatonin | 1994 |
Modulation of 2[125I]iodomelatonin binding sites in the guinea pig spleen by melatonin injection is dependent on the dose and period but not the time.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Guinea Pigs; Injections, Intraperitoneal; Iodine Radioisotopes; Kinetics; Male; Melatonin; Pineal Gland; Receptors, Cell Surface; Receptors, Melatonin; Spleen; Time Factors | 1994 |
Specific binding of [125I]iodomelatonin in pigeon and quail spleen membrane preparations and effect with hydrocortisone-treatment.
Topics: Animals; Binding Sites; Cell Membrane; Circadian Rhythm; Columbidae; Hydrocortisone; Iodine Radioisotopes; Melatonin; Quail; Spleen | 1993 |
Characterization of melatonin binding sites in chicken and human intestines.
Topics: Animals; Binding, Competitive; Chickens; Duodenum; GTP-Binding Proteins; Guanine Nucleotides; Humans; Hydrolysis; In Vitro Techniques; Intestinal Mucosa; Iodine Radioisotopes; Kinetics; Male; Melatonin; Membranes; Middle Aged; Pronase; Receptors, Cell Surface; Receptors, Melatonin | 1993 |
Antigonadal effects of two novel melatonin analogues in adult Djungarian hamsters.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Chickens; Cricetinae; Male; Melatonin; Organ Size; Phodopus; Photoperiod; Testis; Tryptamines | 1993 |
[125I]iodomelatonin binding sites in the chicken spinal cord: binding characteristics and diurnal variation.
Topics: Animals; Chickens; Circadian Rhythm; Female; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Male; Melatonin; Membranes; Pineal Gland; Receptors, Cell Surface; Receptors, Melatonin; Spinal Cord | 1993 |
Investigations of the regulation of specific 2-[125I]iodomelatonin binding sites in Siberian hamsters by endogenous and exogenous melatonin.
Topics: Animals; Autoradiography; Binding Sites; Cricetinae; In Vitro Techniques; Iodine Radioisotopes; Light; Male; Melatonin; Phodopus; Pineal Gland; Pituitary Gland, Anterior; Reference Values; Suprachiasmatic Nucleus | 1993 |
Melatonin and the circadian clock in mink: effects of daily injections of melatonin on circadian rhythm of locomotor activity and autoradiographic localization of melatonin binding sites.
Topics: Animals; Autoradiography; Binding Sites; Circadian Rhythm; Female; Iodine Radioisotopes; Melatonin; Mink; Motor Activity | 1993 |
Autoradiographic localization of putative melatonin receptors in the brains of two Old World primates: Cercopithecus aethiops and Papio ursinus.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Chlorocebus aethiops; Female; Guanosine 5'-O-(3-Thiotriphosphate); Male; Melatonin; Papio; Pituitary Gland; Receptors, Melatonin; Receptors, Neurotransmitter | 1993 |
Distribution of melatonin receptors in the brain of the frog Rana pipiens as revealed by in vitro autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Cyclic AMP; Iodine Radioisotopes; Melatonin; Radioligand Assay; Rana pipiens; Receptors, Melatonin; Receptors, Neurotransmitter | 1993 |
Distribution and characterization of melatonin receptors in the brain of the Japanese quail, Coturnix japonica.
Topics: Animals; Autoradiography; Brain; Coturnix; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Ligands; Male; Melatonin; Receptors, Melatonin; Receptors, Neurotransmitter; Signal Transduction | 1993 |
Characteristics of 2-[125I]iodomelatonin binding sites in the pigeon spleen and modulation of binding by guanine nucleotides.
Topics: Animals; Binding Sites; Cell Membrane; Circadian Rhythm; Columbidae; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Ligands; Melatonin; Pineal Gland; Radioimmunoassay; Receptors, Melatonin; Receptors, Neurotransmitter; Spleen | 1993 |
Developmental appearance and age related changes in specific 2-[125I]iodomelatonin binding sites in the suprachiasmatic nuclei of female Syrian hamsters.
Topics: Aging; Animals; Autoradiography; Circadian Rhythm; Cricetinae; Female; Iodine Radioisotopes; Melatonin; Mesocricetus; Pituitary Gland, Anterior; Pregnancy; Receptors, Melatonin; Receptors, Neurotransmitter; Suprachiasmatic Nucleus | 1993 |
Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin.
Topics: Adenylyl Cyclase Inhibitors; Cell Division; Cell Membrane; Colforsin; Cyclic AMP; DNA, Neoplasm; Humans; Indoles; Iodine Radioisotopes; Kinetics; Melanoma; Melatonin; Nucleotides; Receptors, Melatonin; Receptors, Neurotransmitter; Tumor Cells, Cultured | 1993 |
Primary pharmaco-toxicological evaluation of 2-iodomelatonin, a potent melatonin agonist.
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Luteinizing Hormone; Male; Melatonin; Mutagenicity Tests; Ovulation; Rats; Rats, Sprague-Dawley | 1993 |
Melatonin and its analogs inhibit the basal and stimulated release of hypothalamic vasopressin and oxytocin in vitro.
Topics: Animals; Arginine Vasopressin; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Hypothalamus; In Vitro Techniques; Kinetics; Male; Melatonin; Oxytocin; Potassium Chloride; Rats; Rats, Wistar | 1993 |
Seasonal changes in melatonin binding sites in the pars tuberalis of male European hamsters and the effect of testosterone manipulation.
Topics: Animals; Binding Sites; Cricetinae; Male; Melatonin; Orchiectomy; Organ Size; Pituitary Gland, Anterior; Regression Analysis; Seasons; Testis; Testosterone | 1993 |
Effects of pinealectomy and constant light exposure on day-night changes of melatonin binding sites in the goldfish brain.
Topics: Animals; Brain Chemistry; Circadian Rhythm; Goldfish; In Vitro Techniques; Kinetics; Light; Melatonin; Membranes; Pineal Gland; Protein Binding; Receptors, Cell Surface; Receptors, Melatonin | 1995 |
Specific binding of 2-[125I]iodomelatonin by rat spleen crude membranes: day-night variations and effect of pinealectomy and continuous light exposure.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Circadian Rhythm; Darkness; Iodine Radioisotopes; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Melatonin; Spleen; Temperature; Time Factors | 1996 |
Melatonin and 2[125I]iodomelatonin binding sites in the human colon.
Topics: Aged; Aged, 80 and over; Autoradiography; Binding Sites; Colonic Neoplasms; Female; Humans; Intestinal Mucosa; Male; Melatonin; Middle Aged; Radioimmunoassay; Receptors, Cell Surface; Rectal Neoplasms | 1996 |
Identification of 2-[125I] iodomelatonin binding sites in the thymus of mice and its significance.
Topics: Age Factors; Animals; Binding Sites; Cell Membrane; Circadian Rhythm; Female; Iodine Radioisotopes; Male; Melatonin; Mice; Mice, Inbred C57BL; Radioligand Assay; Thymus Gland | 1995 |
Melatonin receptors in the chicken kidney are up-regulated by pinealectomy and linked to adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Binding Sites; Chickens; Cyclic AMP; Kidney; Melatonin; Pertussis Toxin; Pineal Gland; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Up-Regulation; Virulence Factors, Bordetella | 1996 |
Melatonin receptors in the rat brain and pituitary.
Topics: Animals; Autoradiography; Brain; GTP-Binding Proteins; Kinetics; Male; Melatonin; Pituitary Gland; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tissue Distribution | 1995 |
Characterization of melatonin receptors in the brain of four avian species: duck, goose, pigeon, and turkey.
Topics: Animals; Birds; Brain Chemistry; Columbidae; Ducks; Female; Geese; Half-Life; Iodine Radioisotopes; Kinetics; Melatonin; Membranes; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Species Specificity; Turkeys | 1996 |
Localization of 2-[125I]iodomelatonin binding sites in visual areas of the turtle brain.
Topics: Animals; Autoradiography; Brain Chemistry; Circadian Rhythm; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Superior Colliculi; Turtles; Visual Cortex | 1996 |
Melatonin receptors are present in non-optic regions of the brain of a deep-sea fish living in the absence of solar light.
Topics: Animals; Autoradiography; Binding Sites; Brain; Darkness; Fishes; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Sunlight | 1996 |
Central melatonin receptors in red deer (Cervus elaphus).
Topics: Animals; Autoradiography; Binding Sites; Brain; Deer; In Vitro Techniques; Melatonin; NAD; Pituitary Gland; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin | 1996 |
Localization and characterization of melatonin receptors in the rabbit spinal cord.
Topics: Animals; Autoradiography; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Male; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Spinal Cord | 1996 |
Studies of the renal action of melatonin: evidence that the effects are mediated by 37 kDa receptors of the Mel1a subtype localized primarily to the basolateral membrane of the proximal tubule.
Topics: Animals; Basement Membrane; Blotting, Western; Brain; Electrophoresis, Polyacrylamide Gel; Epithelium; Female; Fluorescent Antibody Technique, Indirect; Guinea Pigs; Humans; Intestine, Small; Kidney Cortex; Kidney Tubules, Proximal; Male; Melatonin; Molecular Weight; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 1997 |
Melatonin and testicular function: characterization of binding sites for 2-[125I]-iodomelatonin in immature rat testes.
Topics: Animals; Binding Sites; Iodine Radioisotopes; Kinetics; Male; Melatonin; Radioligand Assay; Rats; Rats, Wistar; Testis | 1997 |
Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels.
Topics: Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Genomic Library; GTP-Binding Proteins; Humans; Kidney; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Signal Transduction; Tryptamines | 1997 |
Identification and characterisation of 2-[125I]iodomelatonin binding and Mel1a melatonin receptor expression in the human fetal leptomeninges.
Topics: Fetus; Gene Expression; Gene Expression Regulation, Developmental; Humans; In Situ Hybridization; Melatonin; Meninges; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger | 1997 |
Melatonin rescues dopamine neurons from cell death in tissue culture models of oxidative stress.
Topics: Animals; Antioxidants; Cell Death; Culture Techniques; Dopamine; Free Radical Scavengers; Immunoenzyme Techniques; Melatonin; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin E | 1997 |
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adult; Cyclic AMP; Diglycerides; GTP-Binding Proteins; Guanine Nucleotides; Humans; Iodine Radioisotopes; Lymphocytes; Melatonin; Middle Aged; Pertussis Toxin; Protein Binding; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Differential inhibitory effects of melatonin analogs and three naphthalenic ligands on 2-[125I]iodomelatonin binding to chicken tissues.
Topics: Aging; Animals; Binding, Competitive; Brain; Chickens; Female; Guanosine 5'-O-(3-Thiotriphosphate); Kidney; Ligands; Lung; Male; Melatonin; Membranes; Naphthalenes; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Spleen; Tryptamines | 1997 |
Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice.
Topics: Aging; Animals; Circadian Rhythm; Darkness; Gene Expression Regulation, Developmental; Light; Male; Melatonin; Mice; Mice, Inbred C3H; Motor Activity; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Suprachiasmatic Nucleus; Thalamic Nuclei; Transcription, Genetic | 1997 |
Circadian rhythm of free melatonin in human plasma.
Topics: Adult; Blood Proteins; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Osmolar Concentration; Saliva | 1998 |
Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes.
Topics: Autoradiography; Binding Sites; GTP-Binding Proteins; Humans; In Situ Hybridization; Iodine Radioisotopes; Kidney; Melatonin; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger | 1998 |
Daily and photoperiodic 2-125I-melatonin binding changes in the pars tuberalis of the Syrian hamster (Mesocricetus auratus): effect of constant light exposure and pinealectomy.
Topics: Animals; Autoradiography; Circadian Rhythm; Cricetinae; Light; Male; Melatonin; Mesocricetus; Photoperiod; Pineal Gland; Pituitary Gland, Anterior; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 1998 |
Melatonin receptor pharmacology: toward subtype specificity.
Topics: 3T3 Cells; 5-Methoxytryptamine; Acetylation; Animals; Binding Sites; Binding, Competitive; Clone Cells; Cloning, Molecular; GTP-Binding Proteins; Humans; Ligands; Melanocytes; Melanophores; Melatonin; Methylation; Mice; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Serotonin; Species Specificity; Structure-Activity Relationship; Transfection; Tryptamines; Xenopus laevis | 1997 |
Effect of melatonin on chloride secretion by human colonic T84 cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Calcium Channel Blockers; Cell Line; Chloride Channels; Chlorides; Colon; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Imines; Melatonin; ortho-Aminobenzoates; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Virulence Factors, Bordetella | 1998 |
Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells.
Topics: 3T3 Cells; Animals; Binding, Competitive; Cell Membrane; Cloning, Molecular; DNA; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Melatonin; Mice; Pertussis Toxin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Thermodynamics; Transfection; Virulence Factors, Bordetella | 1998 |
Daily and circadian variations in 2-[125I]-iodomelatonin binding sites in the pike brain (Esox lucius).
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Circadian Rhythm; Esocidae; Female; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Kinetics; Male; Melatonin; Pineal Gland | 1998 |
The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; COS Cells; Hypothalamus; Male; Melatonin; Molecular Sequence Data; Pigment Epithelium of Eye; Pituitary Gland; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Retina; RNA, Messenger; Sheep; Tissue Distribution | 1998 |
Synthesis of 2-iodo- and 2-phenyl-[11C]melatonin: potential PET tracers for melatonin binding sites.
Topics: Acetylation; Binding Sites; Carbon Radioisotopes; Humans; Indicators and Reagents; Mass Spectrometry; Melatonin; Nuclear Magnetic Resonance, Biomolecular; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tomography, Emission-Computed | 1998 |
Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat.
Topics: Acetamides; Animals; Autoradiography; Down-Regulation; Male; Melatonin; Naphthalenes; Pineal Gland; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 1998 |
Melatonin receptor subtype expression in human cerebellum.
Topics: Astrocytes; Autoradiography; Binding, Competitive; Cerebellar Cortex; Humans; In Situ Hybridization; Isomerism; Melatonin; Neuroglia; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Tissue Distribution | 1998 |
Vasoconstrictor effects of various melatonin analogs on the rat tail artery in the presence of phenylephrine.
Topics: Acetamides; Animals; Dose-Response Relationship, Drug; Drug Interactions; Endothelium; Male; Melatonin; Muscle, Smooth; Nerve Endings; Norepinephrine; Perfusion; Phenylephrine; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sympathetic Nervous System; Tail; Tryptamines; Vasoconstriction | 1999 |
Melatonergic properties of the (+)- and (-)-enantiomers of N-(4-methoxy-2,3-dihydro-1H-phenalen-2-yl)amide derivatives.
Topics: Acetamides; Animals; Brain; Chickens; Chromatography, High Pressure Liquid; In Vitro Techniques; Ligands; Melatonin; Phenalenes; Polycyclic Compounds; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Skin; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 1999 |
Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction.
Topics: Acetamides; Animals; Anticonvulsants; Arteries; Calcium Channel Blockers; Charybdotoxin; Colforsin; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Male; Melatonin; Nifedipine; Nitroprusside; Potassium Channels; Rats; Rats, Sprague-Dawley; Tail; Tryptamines; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 1999 |
Characterization of melatonin-induced fos-like immunoreactivity in the hypothalamic suprachiasmatic nucleus of the rat.
Topics: Animals; Circadian Rhythm; Gene Expression Regulation; Genes, fos; Hypothalamus, Anterior; Immunohistochemistry; Male; Melatonin; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Suprachiasmatic Nucleus | 1999 |
Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists.
Topics: 3T3 Cells; Animals; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Melatonin; Mice; Pertussis Toxin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Tryptamines; Virulence Factors, Bordetella | 1999 |
Differences in hypothalamic 2-[125I]iodomelatonin binding in photoresponsive and non-photoresponsive white-footed mice, Peromyscus leucopus.
Topics: Animals; Hypothalamus; Iodine Radioisotopes; Male; Melatonin; Peromyscus; Photoperiod; Reproduction; Tissue Distribution | 1999 |
Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.
Topics: Adenylate Cyclase Toxin; Binding, Competitive; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Iodine Radioisotopes; Ligands; Melatonin; Pertussis Toxin; Phenotype; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Virulence Factors, Bordetella | 1999 |
Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor.
Topics: Cell Division; Choriocarcinoma; Epididymis; Epithelial Cells; G1 Phase; Humans; In Situ Hybridization; Male; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Tetrahydronaphthalenes; Tumor Cells, Cultured | 1999 |
Melatonin receptor mRNA expression in human granulosa cells.
Topics: Cell Membrane; Female; Gene Expression Regulation; Granulosa Cells; Humans; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seasons; Transcription, Genetic | 1999 |
Synthesis of beta-substituted naphth-1-yl ethylamido derivatives as new melatoninergic agonists.
Topics: Animals; Chickens; Female; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Melanophores; Melatonin; Naphthalenes; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 1999 |
Circadian rhythm-dependent development of melatonin effects and tolerance to PHNO in rats.
Topics: Animals; Circadian Rhythm; Dopamine; Dopamine Agonists; Drug Tolerance; Male; Melatonin; Motor Activity; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 | 2000 |
Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Isotope Labeling; Kinetics; Melatonin; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Virulence Factors, Bordetella | 2000 |
Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Blotting, Western; Cell Membrane; COS Cells; Fluorescent Antibody Technique, Direct; Glycine; Humans; Melatonin; Molecular Sequence Data; Point Mutation; Protein Binding; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Species Specificity | 2000 |
Characterisation of human melatonin mt(1) and MT(2) receptors by CRE-luciferase reporter assay.
Topics: Acetamides; Amides; Animals; Cell Line; Cyclic AMP; Genes, Reporter; Humans; Iodine Radioisotopes; Kidney; Luciferases; Melatonin; Naphthalenes; Plasmids; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Sheep; Transfection | 2000 |
Melatonin regulates the mRNA expression of the mt(1) melatonin receptor in the rat Pars tuberalis.
Topics: Animals; Circadian Rhythm; In Situ Hybridization; Light; Male; Melatonin; Pineal Gland; Pituitary Gland; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger | 2000 |
Circadian rhythm of mt1 melatonin receptor expression in the suprachiasmatic nucleus of the C3H/HeN mouse.
Topics: Animals; Autoradiography; Circadian Rhythm; Dark Adaptation; In Situ Hybridization; Light; Male; Melatonin; Mice; Mice, Inbred C3H; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Suprachiasmatic Nucleus | 2000 |
Expression of melatonin receptors and 2-[125I]iodomelatonin binding sites in the pituitary of a teleost fish.
Topics: Amino Acid Sequence; Animals; Autoradiography; Base Sequence; Binding Sites; Chickens; Cloning, Molecular; Consensus Sequence; DNA Primers; Esocidae; Humans; Iodine Radioisotopes; Melatonin; Molecular Sequence Data; Pituitary Gland; Polymerase Chain Reaction; Protein Isoforms; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Sequence Alignment; Sequence Homology, Amino Acid; Zebrafish | 1999 |
Autoradiographic detection of 2-(125I)-iodomelatonin binding sites in immune tissue of rats.
Topics: Animals; Autoradiography; B-Lymphocytes; Cells, Cultured; Dexamethasone; Lymphocytes; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Melatonin; Spleen; T-Lymphocytes; Thymus Gland | 1999 |
Melatonin receptors in the pituitary of a teleost fish: mRNA expression, 2-[(125)I]iodomelatonin binding and cyclic AMP response.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Esocidae; Female; Gene Expression; Iodine Radioisotopes; Male; Melatonin; Molecular Sequence Data; Peptide Fragments; Pituitary Gland; Radioligand Assay; Receptors, Cell Surface; RNA, Messenger; Sequence Homology, Amino Acid | 2000 |
Potential involvement of mt1 receptor and attenuated sex steroid-induced calcium influx in the direct anti-proliferative action of melatonin on androgen-responsive LNCaP human prostate cancer cells.
Topics: Adenocarcinoma; Blotting, Western; Calcium; Cell Division; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Humans; Immunoenzyme Techniques; Male; Melatonin; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2000 |
A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties.
Topics: 3T3 Cells; Animals; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Ligands; Melatonin; Mice; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 2000 |
Pinealectomy blocks stress-induced motor stimulation but not sensitization and tolerance to a dopamine D2 receptor agonist.
Topics: Animals; Dopamine Agonists; Drug Tolerance; Melatonin; Motor Activity; Oxazines; Pineal Gland; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stress, Physiological | 2000 |
Pharmacological characterization, molecular subtyping, and autoradiographic localization of putative melatonin receptors in uterine endometrium of estrous rats.
Topics: Animals; Autoradiography; Binding, Competitive; Endometrium; Estrus; Female; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; Uterus | 2000 |
Changes in binding of iodomelatonin to membranes of Leydig cells and steroidogenesis after prolonged in vitro exposure to melatonin.
Topics: Animals; Cell Membrane; Humans; Leydig Cells; Luteinizing Hormone; Male; Melatonin; Protein Binding; Rats; Rats, Wistar; Receptors, Cell Surface; Time Factors | 2001 |
Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.
Topics: Acetamides; Amides; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; Heterotrimeric GTP-Binding Proteins; Humans; Indoles; Melatonin; Mutagenesis, Site-Directed; Naphthalenes; Protein Binding; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Serine; Structure-Activity Relationship; Transfection; Tryptamines | 2001 |
Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .
Topics: Animals; Binding, Competitive; Cells, Cultured; Cricetinae; Humans; Iodine Radioisotopes; Kinetics; Melatonin; Metallothionein 3; Mice; Rabbits; Radioligand Assay; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Species Specificity; Temperature; Tissue Distribution; Tryptamines | 2001 |
Food intake inhibition by melatonin in goldfish (Carassius auratus).
Topics: Animals; Antioxidants; Depression, Chemical; Eating; Goldfish; Injections, Intraperitoneal; Injections, Intraventricular; Melatonin; Tryptamines | 2001 |
N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin.
Topics: Animals; Iodine Radioisotopes; Kinetics; Melatonin; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurites; Neuroblastoma; Neurons; Pertussis Toxin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.
Topics: 3T3 Cells; Algorithms; Animals; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Least-Squares Analysis; Ligands; Melatonin; Mice; Models, Molecular; Protein Conformation; Quantitative Structure-Activity Relationship; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Regression Analysis | 2001 |
Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure.
Topics: Animals; Cell Membrane; Down-Regulation; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Iodine Radioisotopes; Kinetics; Melatonin; Ovarian Follicle; Ovary; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Testosterone | 2001 |
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins.
Topics: Adenylate Cyclase Toxin; Animals; Chlorocebus aethiops; COS Cells; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Molecular Weight; Pertussis Toxin; Proto-Oncogene Proteins p21(ras); rac1 GTP-Binding Protein; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; src-Family Kinases; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2002 |
Daily morphological variations in the viscacha (Lagostomus maximus maximus) retina. Probable local modulatory action of melatonin.
Topics: Animals; Binding Sites; Circadian Rhythm; Female; Image Processing, Computer-Assisted; Intracellular Membranes; Iodine Radioisotopes; Male; Melatonin; Organelles; Protein Binding; Retina; Rodentia | 2002 |
Molecular determinants for the differential coupling of Galpha(16) to the melatonin MT1, MT2 and Xenopus Mel1c receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; COS Cells; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Iodine Radioisotopes; Melatonin; Mutagenesis, Site-Directed; Oligopeptides; Peptides; Protein Binding; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Sequence Deletion; Structure-Activity Relationship; Transfection; Type C Phospholipases; Xenopus Proteins | 2002 |
2[125I]Iodomelatonin binding and interaction with beta-adrenergic signaling in chick heart/coronary artery physiology.
Topics: Animals; Autoradiography; Chick Embryo; Coronary Vessels; Female; Heart; Immunohistochemistry; Iodine Radioisotopes; Male; Melatonin; Myocardium; Radioligand Assay | 2002 |
Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible.
Topics: 5-Methoxytryptamine; Acetylation; Animals; Binding, Competitive; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Iodine Radioisotopes; Melanophores; Melanosomes; Melatonin; Monoamine Oxidase Inhibitors; Physostigmine; Pigments, Biological; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Xenopus laevis | 2002 |
First cloning and functional characterization of a melatonin receptor in fish brain: a novel one?
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Brain; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Melatonin; Molecular Sequence Data; Phylogeny; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Superior Colliculi; Tetrahydronaphthalenes | 2002 |
2[125I]Iodomelatonin binding sites in guinea pig platelets.
Topics: Adenosine Diphosphate; Age Factors; Animals; Binding Sites; Binding, Competitive; Blood Platelets; Cyclic AMP; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Iodine Radioisotopes; Light; Male; Melatonin; Platelet Aggregation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin; Sex Factors | 2002 |
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Melatonin; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels; Protein-Tyrosine Kinases; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2002 |
Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity.
Topics: Androgens; Animals; Cell Division; Cyclin D1; Epidermal Growth Factor; ErbB Receptors; Humans; Male; Melatonin; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Orchiectomy; Prostatic Neoplasms; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs.
Topics: 5-Methoxytryptamine; Free Radical Scavengers; Hydroxyl Radical; Melatonin; Molecular Biology; Oxidation-Reduction; Serotonin; Solubility; Structure-Activity Relationship; Superoxides; Tryptamines | 2002 |
Variations of mt1 melatonin receptor density in the rat uterus during decidualization, the estrous cycle and in response to exogenous steroid treatment.
Topics: Animals; Decidua; Estradiol; Estrus; Female; Melatonin; Ovariectomy; Pregnancy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Uterus | 2002 |
Melatonin receptors in human fetal brain: 2-[(125)I]iodomelatonin binding and MT1 gene expression.
Topics: Brain; Brain Stem; Fetus; Gene Expression Regulation, Developmental; Humans; Hypothalamus; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Thalamus | 2002 |
mt1 Melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by melatonin.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Autoradiography; Base Sequence; Binding Sites; Cebus; Hydrocortisone; Melatonin; Molecular Sequence Data; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger | 2003 |
Design and synthesis of 3-phenyl tetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Indicators and Reagents; Ligands; Magnetic Resonance Spectroscopy; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 2003 |
Synthesis of new arylalkoxy amido derivatives as melatoninergic ligands.
Topics: Alkanes; Amides; Animals; Binding, Competitive; Brain Chemistry; Chickens; Female; Humans; Larva; Ligands; Magnetic Resonance Spectroscopy; Male; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2003 |
Melatonin biological activity and binding sites in human melanoma cells.
Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatonin; Monophenol Monooxygenase; Prazosin; Serotonin; Tryptamines; Tumor Cells, Cultured | 2003 |
Melatonin receptor signaling in pregnant and nonpregnant rat uterine myocytes as probed by large conductance Ca2+-activated K+ channel activity.
Topics: Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Isoproterenol; Large-Conductance Calcium-Activated Potassium Channels; Melatonin; Membrane Potentials; Myometrium; Pertussis Toxin; Potassium Channels, Calcium-Activated; Pregnancy; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Type C Phospholipases | 2003 |
Melatonin modulates secretion of growth hormone and prolactin by trout pituitary glands and cells in culture.
Topics: Animals; Cells, Cultured; Culture Techniques; Cyclic AMP; Female; Growth Hormone; Immunochemistry; Melatonin; Oncorhynchus mykiss; Pituitary Gland; Prolactin | 2003 |
Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis.
Topics: Acidosis, Respiratory; Animals; Calcium; Carotid Body; Chemoreceptor Cells; Electrophysiology; Fura-2; Hypercapnia; Melatonin; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2004 |
Characterization of melatonin binding sites in the brain and retina of the frog Rana perezi.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Diencephalon; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Kinetics; Magnesium; Melatonin; Pertussis Toxin; Radioligand Assay; Ranidae; Receptors, Melatonin; Retina; Sodium; Subcellular Fractions; Superior Colliculi; Telencephalon; Tetrahydronaphthalenes; Tryptamines | 2004 |
Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K(+) current inhibition.
Topics: Animals; Apoptosis; Cerebellum; Melatonin; Neurons; Patch-Clamp Techniques; Potassium; Rats; Receptors, Melatonin | 2004 |
Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding.
Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Cattle; Cell Line; Computer Simulation; Humans; Ligands; Melatonin; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Rhodopsin; Structure-Activity Relationship | 2004 |
Binding characteristics and daily rhythms of melatonin receptors are distinct in the retina and the brain areas of the European sea bass retina (Dicentrarchus labrax).
Topics: Animals; Bass; Binding, Competitive; Brain; Circadian Rhythm; Iodine Radioisotopes; Kinetics; Melatonin; Radioligand Assay; Receptors, Melatonin; Retina | 2004 |
2-iodomelatonin prevents apoptosis of cerebellar granule neurons via inhibition of A-type transient outward K+ currents.
Topics: Animals; Apoptosis; Cerebellum; Cytoplasmic Granules; Melatonin; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2005 |
Melatonin enhances the hypoxic response of rat carotid body chemoreceptor.
Topics: Animals; Calcium; Carotid Body; Chemoreceptor Cells; Circadian Rhythm; Hypoxia; In Vitro Techniques; Melatonin; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Respiration; Tetrahydronaphthalenes; Tryptamines | 2005 |
Effects of temperature on 2-[125I]-iodomelatonin binding to melatonin receptors in the neural retina of the frog Rana perezi.
Topics: Acclimatization; Animals; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Melatonin; Ranidae; Receptors, Melatonin; Retina; Seasons; Signal Transduction; Temperature | 2005 |
Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7.
Topics: Amino Acid Substitution; Binding Sites; Cell Line; Humans; In Vitro Techniques; Kinetics; Ligands; Melatonin; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Receptor, Melatonin, MT2; Recombinant Proteins | 2005 |
Synthesis and biodistribution of 2-[123I]iodomelatonin in normal mice.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Iodine Radioisotopes; Isotope Labeling; Melatonin; Mice; Mice, Inbred CBA; Tissue Distribution | 2006 |
Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens.
Topics: Animals; Cell Fractionation; Cell Membrane; Chickens; Circadian Rhythm; Disease Models, Animal; Iodine Radioisotopes; Melatonin; Pineal Gland; Receptors, Melatonin; Scoliosis; Spinal Cord; Thoracic Vertebrae | 2006 |
Design, synthesis and melatoninergic potency of new N-acyl 8,9-dihydro-4-methoxy-7H-2-benzo[de]quinolinalkanamines.
Topics: Aldehydes; Animals; Biotransformation; Drug Design; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Melanophores; Melatonin; Mice; NIH 3T3 Cells; Quinolines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Xenopus laevis | 2007 |
Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Exons; Humans; Melatonin; Molecular Sequence Data; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sequence Analysis, DNA | 2008 |
Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.
Topics: Analysis of Variance; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Epithelial Cells; Gene Expression Regulation; Growth Substances; Humans; Immunoblotting; Immunohistochemistry; Male; Melatonin; Prostate; Prostatic Neoplasms; Protein Kinases; Receptors, Androgen; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Melatonin-enhanced hyperactivation of hamster sperm.
Topics: Animals; Calcium; Cells, Cultured; Cricetinae; Culture Media; Dose-Response Relationship, Drug; Male; Melatonin; Mesocricetus; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serum Albumin; Sperm Motility; Spermatozoa; Stimulation, Chemical; Tetrahydronaphthalenes; Time; Tryptamines | 2008 |
Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7.
Topics: Animals; Cell Line; Cell Line, Tumor; Central Nervous System Depressants; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Melatonin; Membrane Potentials; Mice; Neurons; NIH 3T3 Cells; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, GABA-A; Receptors, LHRH; RNA, Messenger; Time Factors | 2009 |
Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation.
Topics: Analysis of Variance; Blotting, Western; Cytokines; Humans; Interleukin-6; Jurkat Cells; Melatonin; Models, Biological; Phosphorylation; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2012 |
New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Kinetics; Ligands; Melatonin; Radiopharmaceuticals; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Recombinant Proteins; Regression Analysis | 2013 |
Melatonin action in a midbrain vocal-acoustic network.
Topics: Animals; Batrachoidiformes; Circadian Rhythm; Male; Melatonin; Mesencephalon; Periaqueductal Gray; Photoperiod; Sexual Behavior, Animal; Vocalization, Animal | 2014 |
In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: possible link between duration of action and dissociation rate from receptor.
Topics: Animals; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Humans; Kinetics; Melatonin; Phosphorylation; Rats; Receptor, Melatonin, MT1 | 2015 |
Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Topics: Amino Acid Motifs; Cryoelectron Microscopy; Humans; Indenes; Ligands; Melatonin; Protein Binding; Protein Conformation; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2 | 2022 |