2-iminobiotin has been researched along with biotin in 41 studies
| Studies (2-iminobiotin) | Trials (2-iminobiotin) | Recent Studies (post-2010) (2-iminobiotin) | Studies (biotin) | Trials (biotin) | Recent Studies (post-2010) (biotin) |
|---|---|---|---|---|---|
| 51 | 2 | 18 | 14,847 | 95 | 3,882 |
| Protein | Taxonomy | 2-iminobiotin (IC50) | biotin (IC50) |
|---|---|---|---|
| nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.07) | 18.7374 |
| 1990's | 10 (24.39) | 18.2507 |
| 2000's | 13 (31.71) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 5 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Becker, M; Boeden, HF; Büttner, W; Hänsicke, A; Könnecke, A; Rupprich, C; Schröder, KL | 1 |
| Fudem-Goldin, B; Orr, GA | 1 |
| Butler, JE; Cazin, J; Mock, DM; Suter, M | 1 |
| Heney, GC; Orr, GA; Zeheb, R | 1 |
| Orr, GA; Zeheb, R | 1 |
| Beard, CA; Manning, JE; Wrightsman, RA | 1 |
| Orr, GA | 1 |
| Chang, V; Orr, GA; Zeheb, R | 1 |
| Heney, G; Orr, GA | 1 |
| Grant, SK; Green, BG; Sup, SJ | 1 |
| Florin, EL; Gaub, HE; Moy, VT | 2 |
| Airenne, KJ; Bayer, EA; Kulomaa, MS; Marjomäki, VS; Oker-Blom, C; Wilchek, M | 1 |
| Athappilly, FK; Hendrickson, WA | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Katz, BA | 1 |
| Haehnel, W; Hörth, P; Mühlenhoff, U; Schilz, E; von Leoprechting, A | 1 |
| Batchelder, DN; Clarkson, J; Smith, DA | 1 |
| Gandolfo, F; Lazaridis, T; Masunov, A | 1 |
| Bär, D; Blomgren, K; Groenendaal, F; Hagberg, H; Kops, N; Koster, J; Nicolay, K; Peeters-Scholte, C; van Bel, F; van Buul-Offers, S; van den Tweel, E; Veldhuis, W; Zhu, C | 1 |
| Braun, K; Groenendaal, F; Ioroi, T; Nicolay, K; Peeters-Scholte, C; Post, I; van Bel, F; van den Tweel, E; Veldhuis, W | 1 |
| Blomgren, K; Groenendaal, F; Hagberg, H; Hamers, N; Heijnen, C; Koster, J; Peeters-Scholte, C; van Bel, F; van Buul-Offers, S; van den Tweel, E; Zhu, C | 1 |
| Groenendaal, F; Peeters-Scholte, C; van Bel, F; van den Tweel, E | 1 |
| Allen, S; Davies, MC; Patel, AB; Roberts, CJ; Tendler, SJ; Williams, PM | 1 |
| Blomgren, K; Hagberg, H; Peeters-Scholte, C; Qiu, L; Wang, X; Zhu, C | 1 |
| Groenendaal, F; Haumann, J; Heijnen, CJ; Kavelaars, A; Nijboer, CH; Peeters-Scholte, CM; van Bel, F; van den Tweel, ER | 1 |
| Anzai, J; Inoue, H | 1 |
| Groenendaal, F; Hagberg, HH; Heijnen, CJ; Kavelaars, A; Nijboer, CH; van Bel, F | 1 |
| Anzai, J; Naka, Y; Sato, K | 1 |
| Groenendaal, F; Heijnen, CJ; Kavelaars, A; Nijboer, CH; van Bel, F | 1 |
| Aricioglu, F; Gacar, N; Gocmez, SS; Ozer, C; Utkan, T | 1 |
| Bjorkman, ST; Colditz, PB; Fan, X; Ireland, Z; Peeters-Scholte, CM; Roes, KC; van der Wal, WM | 1 |
| Juul, SE; McAdams, RM | 1 |
| Albrecht, M; Parczany, K; Peeters-Scholte, C; Sommer, L; Steinfath, M; Zitta, K | 1 |
| Albrecht, M; Groenendaal, F; Peeters-Scholte, C; van Bel, F; Zitta, K | 1 |
| Akal, A; Eppinger, J; Feige, MJ; Groll, M; Hohl, A; Karan, R; Lang, K; Mideksa, YG; Rueping, M; Vogler, M | 1 |
| de Leede, LGJ; Hartstra, J; Leufkens, PWTJ; Peeters-Scholte, CMPCD; van Hoogdalem, EJ; van Lier, JJ | 1 |
| Bennet, L; Davidson, JO; Gunn, AJ; Tan, S | 1 |
| Bambi, J; Betukumesu, DM; Biselele, T; Bola, V; Kapinga, J; Makaya, P; Ndiyo, Y; Peeters-Scholte, C; Tabu, G; Tjabbes, H; Vis, P | 1 |
| Bakker, A; Egberts, TCG; Favié, LMA; Groenendaal, F; Peeters-Scholte, CMPCD; Rademaker, CMA; Tjabbes, H; van Bel, F; Vis, P | 1 |
| Berckovich, Y; Meilin, S; Peeters-Scholte, C; Westers, P | 1 |
2 review(s) available for 2-iminobiotin and biotin
| Article | Year |
|---|---|
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intellectual Disability; Melatonin; Stem Cell Transplantation; Survival Rate; Umbilical Cord; Xenon | 2016 |
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythropoietin; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intellectual Disability; Ischemic Postconditioning; Melatonin; Neuroprotective Agents; Pregnancy; Reactive Nitrogen Species; Reactive Oxygen Species | 2019 |
2 trial(s) available for 2-iminobiotin and biotin
| Article | Year |
|---|---|
First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.
Topics: Adolescent; Adult; beta-Cyclodextrins; Biotin; Dose-Response Relationship, Drug; Double-Blind Method; Excipients; Humans; Hypoxia-Ischemia, Brain; Infusions, Intravenous; Male; Middle Aged; Neuroprotective Agents; Time Factors; Tissue Distribution; Young Adult | 2020 |
A Phase IIa Clinical Trial of 2-Iminobiotin for the Treatment of Birth Asphyxia in DR Congo, a Low-Income Country.
Topics: Adult; Asphyxia; Biotin; Female; Humans; Infant, Newborn; Male; Poverty | 2020 |
37 other study(ies) available for 2-iminobiotin and biotin
| Article | Year |
|---|---|
Biospecific adsorbents on the basis of chloroformate-activated bead cellulose.
Topics: Bacterial Proteins; Biotin; Cellulose; Chromatography, Affinity; Immunoglobulin G; Immunosorbents; Insulin; Norbornanes; Streptavidin; Surface Properties; Trypsin | 1990 |
2-Iminobiotin-containing reagent and affinity columns.
Topics: Avidin; Bacterial Proteins; Biotin; Chromatography, Affinity; Indicators and Reagents; Protein Binding; Streptavidin | 1990 |
Isolation and characterization of highly purified streptavidin obtained in a two-step purification procedure from Streptomyces avidinii grown in a synthetic medium.
Topics: Bacterial Proteins; Bacteriological Techniques; Biotin; Culture Media; Filtration; Iodine Radioisotopes; Molecular Weight; Streptavidin; Streptomyces | 1988 |
Purification of avidin and its derivatives on 2-iminobiotin-6-aminohexyl-Sepharose 4B.
Topics: Avidin; Biotin; Chromatography, Affinity; Indicators and Reagents; Ovalbumin; Sepharose | 1986 |
Use of avidin-iminobiotin complexes for purifying plasma membrane proteins.
Topics: Acetylgalactosamine; Avidin; Biotin; Cell Membrane; Galactose; Galactose Oxidase; Indicators and Reagents; Membrane Proteins; Ovalbumin; Sialic Acids | 1986 |
Identification of monoclonal antibodies against the trypomastigote stage of Trypanosoma cruzi by use of iminobiotinylated surface polypeptides.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Antigens, Surface; Avidin; Biotin; Chagas Disease; Chromatography, Affinity; Humans; Hybridomas; Membrane Proteins; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Peptides; Trypanosoma cruzi | 1985 |
The use of the 2-iminobiotin-avidin interaction for the selective retrieval of labeled plasma membrane components.
Topics: alpha-Fetoproteins; Avidin; Biotin; Cell Membrane; Erythrocyte Membrane; Glycoproteins; Humans; Hydrogen-Ion Concentration; Membrane Proteins; Methods; Ovalbumin; Protein Binding; Spectrophotometry | 1981 |
An analytical method for the selective retrieval of iminobiotin-derivatized plasma membrane proteins.
Topics: Antibodies; Avidin; Biotin; Cell Membrane; Erythrocyte Membrane; Humans; Immunochemistry; Membrane Proteins | 1983 |
The purification of avidin and its derivatives on 2-iminobiotin-6-aminohexyl-Sepharose 4B.
Topics: Avidin; Biotin; Carbon Radioisotopes; Chromatography, Affinity; Ovalbumin; Rhodamines; Sepharose; Tritium | 1981 |
2-Iminobiotin is an inhibitor of nitric oxide synthases.
Topics: Amino Acid Oxidoreductases; Animals; Binding Sites; Biotin; Cell Line; Mice; Nitric Oxide Synthase; Rats; Structure-Activity Relationship | 1994 |
Intermolecular forces and energies between ligands and receptors.
Topics: Avidin; Bacterial Proteins; Biotin; Hydrogen-Ion Concentration; Ligands; Models, Chemical; Receptors, Drug; Streptavidin; Thermodynamics | 1994 |
Adhesion forces between individual ligand-receptor pairs.
Topics: Adhesiveness; Avidin; Biotin; Ligands; Microscopy; Microspheres; Receptors, Cell Surface; Sepharose | 1994 |
Production of biologically active recombinant avidin in baculovirus-infected insect cells.
Topics: Animals; Avidin; Baculoviridae; Biotin; Chickens; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Glycosylation; Protein Conformation; Protein Denaturation; Recombinant Proteins; Sepharose; Spodoptera | 1997 |
Crystallographic analysis of the pH-dependent binding of iminobiotin by streptavidin.
Topics: Bacterial Proteins; Biotin; Chromatography, Affinity; Crystallography, X-Ray; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Models, Molecular; Streptavidin | 1997 |
Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
Topics: Animals; Biotin; Citrulline; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Isothiuronium; Lysine; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Swine; Thiourea | 1997 |
Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH.
Topics: Alkynes; Ammonium Sulfate; Apoproteins; Aspartic Acid; Biotin; Crystallography, X-Ray; Dimerization; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Imidazoles; Ligands; Models, Molecular; Osmolar Concentration; Protein Conformation; Sodium Chloride; Solubility; Streptavidin | 1997 |
Identification of biotinylation sites on proteins by selective retrieval of 2-iminobiotinylated peptides from proteolytic peptide mixtures: localization of the accessible lysine residues on the photosystem I subunits PsaD and PsaE.
Topics: Affinity Labels; Amino Acid Sequence; Avidin; Bacterial Proteins; Binding Sites; Biotin; Biotinylation; Chromatography, High Pressure Liquid; Cyanobacteria; Lysine; Mass Spectrometry; Molecular Sequence Data; Peptide Mapping; Photosynthetic Reaction Center Complex Proteins; Photosystem I Protein Complex; Plant Proteins; Proteins; Recombinant Proteins; Sepharose; Sequence Analysis; Serine Endopeptidases | 1998 |
UV resonance Raman study of streptavidin binding of biotin and 2-iminobiotin: comparison with avidin.
Topics: Avidin; Binding Sites; Biotin; Macromolecular Substances; Molecular Structure; Protein Binding; Spectrum Analysis, Raman; Streptavidin; Tryptophan; Tyrosine | 2001 |
Contributions to the binding free energy of ligands to avidin and streptavidin.
Topics: Avidin; Binding Sites; Biotin; Computer Simulation; Entropy; Ligands; Models, Molecular; Models, Theoretical; Peptides; Protein Binding; Protein Conformation; Streptavidin | 2002 |
Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; Biotin; Brain; Brain Edema; Caspase 3; Caspases; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Nitric Oxide Synthase; Reperfusion Injury; Survival Rate; Swine; Treatment Outcome; Tyrosine | 2002 |
Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Cerebral Cortex; Deferoxamine; Electroencephalography; Enzyme Inhibitors; Free Radical Scavengers; Hemoglobins; Hypoxia-Ischemia, Brain; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorus Radioisotopes; Spectrophotometry; Swine; Time Factors | 2002 |
Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Biotin; Brain; Caspases; Cytokines; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Primed In Situ Labeling; RNA, Messenger; Swine | 2002 |
Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Brain; Cell Survival; Deferoxamine; Disease Models, Animal; Disease Progression; Electron Transport Complex IV; Energy Metabolism; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Neurons; Neuroprotective Agents; Oxidation-Reduction; Phosphates; Phosphocreatine; Predictive Value of Tests; Spectroscopy, Near-Infrared; Swine | 2004 |
Influence of architecture on the kinetic stability of molecular assemblies.
Topics: Biotin; Kinetics; Macromolecular Substances; Microscopy, Atomic Force; Serum Albumin, Bovine; Structure-Activity Relationship; Thermodynamics | 2004 |
Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Biomarkers; Biotin; Caspase 3; Caspases; Cell Count; Disease Models, Animal; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Female; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2004 |
Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats.
Topics: Animals; Animals, Newborn; Biotin; Brain Chemistry; Cytochromes c; Female; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Tyrosine | 2005 |
Stimuli-sensitive thin films prepared by a layer-by-layer deposition of 2-iminobiotin-labeled poly(ethyleneimine) and avidin.
Topics: Avidin; Biotin; Hydrogen-Ion Concentration; Molecular Structure; Polyethyleneimine | 2005 |
Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
Topics: Animals; Animals, Newborn; Biotin; Blotting, Western; Caspases; Enzyme Inhibitors; Female; Guanidines; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Pregnancy; Rats; Rats, Wistar; Sex Characteristics; Signal Transduction; Tyrosine | 2007 |
Effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) and avidin.
Topics: Avidin; Biosensing Techniques; Biotin; Electrochemistry; Electrodes; Hydrogen Peroxide; Hydrogen-Ion Concentration; Molecular Structure; Oxidation-Reduction; Platinum; Polyethyleneimine; Quartz; Spectrophotometry, Ultraviolet; Staining and Labeling; Surface Properties; Time Factors | 2007 |
Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.
Topics: Aging; Animals; Animals, Newborn; Biotin; Birth Injuries; Brain; Cell Death; Cytochromes c; Cytoprotection; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Male; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Sex Characteristics; Time; Treatment Outcome | 2007 |
Selective and nonselective neuronal NOS inhibitors impair cognitive function in the three panel runway and passive avoidance tasks in rats.
Topics: Animals; Arginine; Avoidance Learning; Biotin; Cognition; Emotions; Enzyme Inhibitors; Guanidines; Male; Memory, Short-Term; Models, Animal; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2012 |
Short-term dose-response characteristics of 2-iminobiotin immediately postinsult in the neonatal piglet after hypoxia-ischemia.
Topics: Animals; Asphyxia; Biotin; Brain; Caspase 3; Dose-Response Relationship, Drug; Electroencephalography; Hypoxia-Ischemia, Brain; Models, Animal; Nitric Oxide Synthase; Swine; Time Factors; Treatment Outcome | 2013 |
Insights into the neuroprotective mechanisms of 2-iminobiotin employing an in-vitro model of hypoxic-ischemic cell injury.
Topics: Biotin; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Oxidative Stress | 2016 |
Genetically Encoded Biotin Analogues: Incorporation and Application in Bacterial and Mammalian Cells.
Topics: Amino Acyl-tRNA Synthetases; Archaeal Proteins; Biotin; Biotinylation; Escherichia coli; HEK293 Cells; Humans; Lysine; Methanosarcina barkeri; Mutation; Protein Binding; Protein Processing, Post-Translational; Rec A Recombinases; Streptavidin | 2019 |
When is a potential new neuroprotective treatment ready for translation?
Topics: Biotin; Humans; Hypothermia, Induced; Infant, Newborn; Neuroprotection; Stroke | 2020 |
Translation from animal to clinical studies, choosing the optimal moment.
Topics: Animals; Biomechanical Phenomena; Biotin; Humans; Hypothermia, Induced; Infant, Newborn | 2020 |
2-iminobiotin, a selective inhibitor of nitric oxide synthase, improves memory and learning in a rat model after four vessel occlusion, mimicking cardiac arrest.
Topics: Adult; Aftercare; Animals; Biotin; Excipients; Humans; Learning Curve; Nitric Oxide Synthase; Out-of-Hospital Cardiac Arrest; Patient Discharge; Rats; Rats, Sprague-Dawley; Vascular Diseases | 2023 |