2-hydroxysaclofen has been researched along with phaclofen in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (94.44) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Douglas, WW; Kongsamut, S; Shibuya, I | 1 |
| Bartolini, A; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Lewis, DV; Morrisett, RA; Mott, DD; Swartzwelder, HS; Wilson, WA | 1 |
| Aran, S; Hammond, DL | 1 |
| Collingridge, GL; Davies, CH; Davies, SN | 1 |
| al-Dahan, MI; Tehrani, MH; Thalmann, RH | 1 |
| Humeniuk, RE; Kerr, DI; Ong, J; White, JM | 1 |
| Caddick, SJ; Chad, JE; Stanford, IM | 1 |
| Slaughter, MM; Tian, N | 1 |
| Finch, DM; Gigg, J; Tan, AM | 1 |
| Lewis, DV; Mott, DD; Swartzwelder, HS; Wilson, WA; Xie, CW | 1 |
| Lacaille, JC; Samulack, DD | 1 |
| De Koning, HP; Jenks, BG; Roubos, EW | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Snead, OC | 1 |
| Chub, N; O'Donovan, MJ | 1 |
| Kerr, DI; Ong, J; Parnas, I; Rashkovan, G | 1 |
18 other study(ies) available for 2-hydroxysaclofen and phaclofen
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Effectiveness of GABAB antagonists in inhibiting baclofen-induced reductions in cytosolic free Ca concentration in isolated melanotrophs of rat.
Topics: Animals; Baclofen; Calcium; Cytosol; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Organophosphorus Compounds; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains | 1992 |
CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen.
Topics: Analgesics; Animals; Baclofen; GABA Antagonists; GABA-A Receptor Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Muscle Relaxation; Muscles; Organophosphorus Compounds; Oxotremorine; Postural Balance; Rats; Rats, Inbred Strains; Reaction Time | 1991 |
GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus.
Topics: Animals; Baclofen; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Picrotoxin; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not delta-aminovaleric acid in the rat.
Topics: Amino Acids; Amino Acids, Neutral; Analgesia; Animals; Baclofen; Injections, Spinal; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus.
Topics: Action Potentials; Animals; Baclofen; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Picrotoxin; Rats; Synapses; Synaptic Transmission; Tetrodotoxin | 1990 |
Effect of 2-hydroxy-saclofen, an antagonist of GABAB action, upon the binding of baclofen and other receptor ligands in rat cerebrum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Baclofen; Brain; GABA Antagonists; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1990 |
Characterization of GABAB ligands in vivo.
Topics: Animals; Baclofen; beta-Alanine; Drug Interactions; Female; GABA Antagonists; GABA-B Receptor Antagonists; Ligands; Mice; Mice, Inbred BALB C; Muscle Relaxation; Organophosphorus Compounds | 1995 |
2-Hydroxy-saclofen causes a phaclofen-reversible reduction in population spike amplitude in the rat hippocampal slice.
Topics: Animals; Baclofen; Bicuculline; Evoked Potentials; GABA Antagonists; Hippocampus; Male; Microelectrodes; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-B; Synaptic Transmission | 1995 |
Pharmacology of the GABAB receptor in amphibian retina.
Topics: Ambystoma; Animals; Baclofen; Butylamines; Evoked Potentials; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; In Vitro Techniques; Membrane Potentials; Necturus; Organophosphorus Compounds; Propylamines; Receptors, GABA-B; Retina; Retinal Ganglion Cells; Stereoisomerism; Structure-Activity Relationship | 1994 |
Glutamatergic hippocampal formation projections to prefrontal cortex in the rat are regulated by GABAergic inhibition and show convergence with glutamatergic projections from the limbic thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclofen; Bicuculline; Brain Mapping; Electric Stimulation; Electrophysiology; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Neurons; Organophosphorus Compounds; Piperazines; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Thalamus | 1994 |
GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baclofen; Culture Techniques; GABA-A Receptor Antagonists; Hippocampus; Male; Membrane Potentials; Nerve Fibers; Neural Inhibition; Organophosphorus Compounds; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Synaptic Transmission; Theta Rhythm | 1993 |
Hyperpolarizing synaptic potentials evoked in CA1 pyramidal cells by glutamate stimulation of interneurons from the oriens/alveus border of rat hippocampal slices. II. Sensitivity to GABA antagonists.
Topics: Animals; Baclofen; Bicuculline; Electrophysiology; Evoked Potentials; GABA Antagonists; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Neural Inhibition; Neurons; Rats; Synapses | 1993 |
Analysis of gamma-aminobutyric acidB receptor function in the in vitro and in vivo regulation of alpha-melanotropin-stimulating hormone secretion from melanotrope cells of Xenopus laevis.
Topics: alpha-MSH; Animals; Baclofen; Butylamines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Homeostasis; In Vitro Techniques; Kinetics; Organophosphorus Compounds; Perfusion; Pituitary Gland, Posterior; Radioimmunoassay; Receptors, GABA-A; Xenopus laevis | 1993 |
Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats.
Topics: Anesthesia; Animals; Baclofen; Capsaicin; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Gastric Mucosa; Male; Organophosphorus Compounds; p-Methoxy-N-methylphenethylamine; Pepsinogens; Perfusion; Rats; Rats, Wistar; Receptors, GABA-B; Vagotomy | 1995 |
Antiabsence seizure activity of specific GABAB and gamma-Hydroxybutyric acid receptor antagonists.
Topics: Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Electroencephalography; Epilepsy, Absence; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Injections, Intraventricular; Isomerism; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 1996 |
Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclofen; Bicuculline; Chick Embryo; Cholinergic Antagonists; Dihydro-beta-Erythroidine; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine; Glycine Agents; Mecamylamine; Motor Neurons; Neuronal Plasticity; Neurotransmitter Agents; Nicotinic Antagonists; Periodicity; Spinal Cord; Strychnine | 1998 |
Tonic activation of presynaptic GABAB receptors in the opener neuromuscular junction of crayfish.
Topics: Animals; Astacoidea; Axons; Baclofen; GABA Agonists; GABA Antagonists; Logistic Models; Neural Inhibition; Neuromuscular Junction; Patch-Clamp Techniques; Pronase; Quantum Theory; Receptors, GABA-B; Receptors, Presynaptic | 1999 |