2-hydroxyimipramine has been researched along with methotrimeprazine in 2 studies
| Studies (2-hydroxyimipramine) | Trials (2-hydroxyimipramine) | Recent Studies (post-2010) (2-hydroxyimipramine) | Studies (methotrimeprazine) | Trials (methotrimeprazine) | Recent Studies (post-2010) (methotrimeprazine) |
|---|---|---|---|---|---|
| 30 | 3 | 0 | 816 | 57 | 60 |
| Protein | Taxonomy | 2-hydroxyimipramine (IC50) | methotrimeprazine (IC50) |
|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | 9.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Brøsen, K; Meyer, UA; Zeugin, T | 1 |
2 other study(ies) available for 2-hydroxyimipramine and methotrimeprazine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine.
Topics: Antibodies; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Humans; Imipramine; Isoenzymes; Kidney; Kinetics; Methotrimeprazine; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Sparteine; Transfection | 1991 |