2-hydroxyimipramine has been researched along with labetalol in 3 studies
| Studies (2-hydroxyimipramine) | Trials (2-hydroxyimipramine) | Recent Studies (post-2010) (2-hydroxyimipramine) | Studies (labetalol) | Trials (labetalol) | Recent Studies (post-2010) (labetalol) |
|---|---|---|---|---|---|
| 30 | 3 | 0 | 1,980 | 450 | 327 |
| Protein | Taxonomy | 2-hydroxyimipramine (IC50) | labetalol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 0.016 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 3.354 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.01 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.8 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.393 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 3.354 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.521 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.393 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 3.037 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.607 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.815 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR | 1 |
1 trial(s) available for 2-hydroxyimipramine and labetalol
| Article | Year |
|---|---|
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil | 1992 |
2 other study(ies) available for 2-hydroxyimipramine and labetalol
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |