2-hydroxycarbazole has been researched along with caffeine in 2 studies
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Longland, CL; Mezna, M; Michelangeli, F; Tovey, SC | 1 |
| Churchill, GC; Galione, A; Patel, S; Thomas, JM | 1 |
2 other study(ies) available for 2-hydroxycarbazole and caffeine
| Article | Year |
|---|---|
2-Hydroxycarbazole induces Ca2+ release from sarcoplasmic reticulum by activating the ryanodine receptor.
Topics: Animals; Caffeine; Calcium; Carbazoles; Dose-Response Relationship, Drug; Heart; Microsomes; Muscle, Skeletal; Myocardium; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 1998 |
Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.
Topics: Adenosine Diphosphate; Animals; Caffeine; Calcium; Carbazoles; Enzyme Inhibitors; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; NADP; Ovum; Phosphodiesterase Inhibitors; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Thapsigargin | 2001 |